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Waterhouse-Friderichsen syndrome

MONDO:0006015

A serious disorder characterized by massive adrenal gland hemorrhage secondary to a bacterial infection, most often Neisseria meningitidis infection. It is manifested with decreased blood pressure, shock, disseminated intravascular coagulation, and adrenocortical insufficiency.

Also known as: WFS, meningococcal hemorrhagic adrenalitis, Waterhouse–Friderichsen syndrome, fatal pneumococcal Waterhouse-Friderichsen syndrome

10 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Endocrine system disorder (61) Syndromic disease (24) Adrenocortical insufficiency (23) Acute disease (18) Human disease (14) Adrenal gland disorder (8) Primary adrenal insufficiency (3) Acute adrenal insufficiency (0) Adrenal cortex disorder (0)
Trials to join now! 6 Not yet recruiting 1 Not yet finished but already full! 2 Completed 1
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  • Tiny trial to see if a dye helps adrenal surgery

    Knowledge-focused Not yet recruiting

    This study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…

    Sponsor: University of Roma La Sapienza • Aim: Knowledge-focused

    Last updated Jun 27, 2026 12:32 UTC

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