Scientists track rare liver diseases in kids to unlock clues

NCT ID NCT01148550

Terminated Knowledge-focused Sponsor: Arbor Research Collaborative for Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows up to 90 children and young adults with mitochondrial liver diseases to learn how these conditions progress over time. Researchers will collect medical data and samples to better understand the diseases and find markers that predict outcomes. The goal is to improve care and guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this study could improve understanding of mitochondrial liver diseases and help identify biomarkers to predict disease progression.

What could go wrong

This is an observational study, not a treatment trial, so it offers no direct benefit to participants. It is currently suspended, which may delay results.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute liver failure cholestasis chronic liver failure disorder of fatty acid oxidation and ketogenesis End Stage Liver Disease fatty liver disease Fibrosis inborn mitochondrial metabolism disorder inherited fatty acid metabolism disorder liver disorder mitochondrial disease mitochondrial oxidative phosphorylation disorder mitochondrial respiratory chain complex deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LIVER FAILURE DISORDER OF FATTY ACID OXIDATION END STAGE LIVER DISEASE MITOCHONDRIAL DISEASES RESPIRATORY CHAIN DEFICIENCIES, MITOCHONDRIAL

Contacts and locations

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Locations

Ann & Robert H. Lurie Children's Hospital

Chicago, Illinois, 60611, United States
Children's Healthcare of Atlanta - Emory University

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
Johns Hopkins School of Medicine

Baltimore, Maryland, 21287, United States
Mount Sinai Medical Center

New York, New York, 10029, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Texas Children's Hospital (Baylor College of Medicine)

Houston, Texas, 77030, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
University of California at San Francisco (UCSF)

San Francisco, California, 94143, United States
University of Utah

Salt Lake City, Utah, 84113, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States