MITOCHONDRIAL DISEASES

This study is testing a new, tiny sensor designed to measure oxygen levels inside muscle tissue. Researchers want to see if it can reliably tell the difference between healthy people and those with mitochondrial myopathy, a rare muscle disease. The goal is to create a better tool…

This study is testing whether a medicine called sonlicromanol can reduce fatigue and improve physical abilities like balance and leg strength in adults with a specific type of mitochondrial disease. About 220 participants will take either the real medicine or a placebo pill twice…

This study aims to understand why people with type 2 diabetes are more likely to develop heart failure. Researchers will observe 500 participants with heart failure, some with and some without diabetes, to see how their heart cells produce energy. The goal is to gather knowledge …

This study aims to understand how the body uses energy during exercise in people with primary mitochondrial diseases, which cause severe muscle weakness and fatigue. Researchers will compare 90 participants—some with the disease and some healthy—during different activities, inclu…

This study is creating a national registry and sample bank for people with mitochondrial disorders—rare genetic diseases that affect the body's energy production. By collecting health information and tissue samples from up to 1,000 participants, researchers aim to build a shared …

This study aims to understand how exercise training affects the muscles and nerves of adults with mitochondrial myopathy, a rare disease that causes muscle weakness and fatigue. Researchers will have 22 participants (some with the disease, some healthy) complete a 3-4 week exerci…