Hope for mitochondrial patients: new drug targets debilitating fatigue
NCT ID NCT06451757
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 27 times
Summary
This study tests whether the experimental drug sonlicromanol can reduce fatigue and improve physical abilities like balance and leg strength in adults with a specific genetic mitochondrial disease (m.3243A>G mutation). About 220 participants will receive either the drug or a placebo twice daily for 52 weeks. The main outcomes are changes in fatigue scores and a sit-to-stand test.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU de Bordeaux - Hôpital Pellegrin Service Gynecologie Obstetrique
NOT_YET_RECRUITINGBordeaux, Gironde, 33000, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic Neurological Institute Mellen Center
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
Contact Email: •••••@•••••
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Fondazione IRCCS Istituto Neurologico Carlo Besta
NOT_YET_RECRUITINGMilan, Milano, 20133, Italy
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Groupe Hospitalier Pitie-Salpetriere - Charles-Foix Clinical Investigation Center Paris-Est
NOT_YET_RECRUITINGParis, Paris, 75013, France
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum der Universität München Friedrich-Baur-Institut
NOT_YET_RECRUITINGMünchen, 80336, Germany
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Massachusetts General Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radboud University Medical Center
RECRUITINGNijmegen, Gelderland, 6525, Netherlands
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rigshospitalet, University of Copenhagen
NOT_YET_RECRUITINGKopenhagen, Region Sjælland, DK2100, Denmark
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Texas Health Science Center at Houston
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery
RECRUITINGLondon, Greater London, WC1N 3BG, United Kingdom
Contact Email: •••••@•••••
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Conditions
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