Hope for mitochondrial disease: new drug targets debilitating fatigue
NCT ID NCT06451757
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This study tests whether the drug sonlicromanol can reduce fatigue and improve physical abilities like balance and leg strength in adults with a specific genetic form of mitochondrial disease. About 220 participants will take either the drug or a placebo twice daily for 52 weeks. The main outcomes are changes in fatigue scores and a sit-to-stand test.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sonlicromanol
What this could lead to
If it works, this could provide a treatment to ease fatigue and improve daily physical abilities for people with mitochondrial disease.
What could go wrong
This is a Phase 3 trial, but it's still experimental. The drug may not prove better than placebo, and side effects are possible. Results may not apply to all mitochondrial disease types.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CHU de Bordeaux - Hôpital Pellegrin Service Gynecologie Obstetrique
NOT_YET_RECRUITINGBordeaux, Gironde, 33000, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic Neurological Institute Mellen Center
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
Contact Email: •••••@•••••
Contact
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Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITINGMilan, 20133, Italy
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Groupe Hospitalier Pitie-Salpetriere - Charles-Foix Clinical Investigation Center Paris-Est
NOT_YET_RECRUITINGParis, Paris, 75013, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum der Universität München Friedrich-Baur-Institut
RECRUITINGMünchen, 80336, Germany
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Massachusetts General Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radboud University Medical Center
RECRUITINGNijmegen, Gelderland, 6525, Netherlands
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Rigshospitalet, University of Copenhagen
NOT_YET_RECRUITINGKopenhagen, Region Sjælland, DK2100, Denmark
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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University College London Hospitals NHS Foundation Trust National Hospital for Neurology and Neurosurgery
RECRUITINGLondon, Greater London, WC1N 3BG, United Kingdom
Contact Email: •••••@•••••
Contact