Mini muscle sensor could spot mitochondrial disease

NCT ID NCT04086329

Recruiting now Diagnosis Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a small nanosensor placed under the skin in the forearm to measure oxygen levels in muscle, which reflects how well mitochondria are working. Researchers will compare results from 24 people—some with mitochondrial myopathy and some healthy—to see if the sensor can tell the difference. If it works, this tool could help diagnose mitochondrial diseases and evaluate new treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nanosensor device
What this could lead to: If successful, this could provide a new way to measure mitochondrial function in muscle, helping diagnose mitochondrial diseases and track treatment effects.
What could go wrong: This is a very early, small Phase 1 study with only 24 participants. The nanosensor has never been tested in humans before, so it may not work as expected or could cause discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

inborn mitochondrial metabolism disorder inborn mitochondrial myopathy mitochondrial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MITOCHONDRIAL DISEASES MITOCHONDRIAL MYOPATHIES

Contacts and locations

Locations

The Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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