New cell therapy aims to tame deadly transplant complication in kids
NCT ID NCT06075706
First seen Feb 01, 2026 · Last updated May 23, 2026 · Updated 14 times
Summary
This study tests a treatment called MC0518, made from special cells, for children who have severe graft-versus-host disease (GvHD) after a stem cell transplant and did not get better with steroids. About 49 children will either get MC0518 or the best available therapy. The goal is to see if MC0518 can improve or resolve GvHD symptoms by day 28.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A.O.U. Citta della Salute e della Scienza di Torino Ospedale Infantile Regina Margherita
Turin, 10126, Italy
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CHRU Nancy, Hopitaux de Brabois
Vandœuvre-lès-Nancy, 54511, France
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CHRU de Strasbourg - Hopital de Hautepierre
Strasbourg, 67000, France
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CHU Grenoble Alpes - Hopital Couple Enfant (HCE)
La Tronche, 38700, France
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CHU de Bordeaux - Hopital des Enfants
Bordeaux, 33000, France
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CHU de Marseille-Hopital de la Timone
Marseille, 13385, France
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CHU de Nantes - Hopital Mere Enfant
Nantes, 44093, France
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CHU de Rouen - Hopital Charles Nicolle
Rouen, 73038, France
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Centre Hospitalier Regional Universitaire (CHRU) Montpellier - hopital Arnaud de Villeneuve
Montpellier, 34295, France
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Centre Hospitalier Universitaire de Lille CHU Lille - Hopital Jeanne de Flandre HJF
Lille, 59037, France
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Clinica Universitaria de Navarra
Pamplona, Navarre, 31008, Spain
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Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University
Wroclaw, Lower Silesian Voivodeship, 50-556, Poland
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Department of Pediatrics, Jena University Hospital
Jena, 7747, Germany
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Dzieciecy Szpital Kliniczny im. A.Gebali w Lublinie
Lublin, 20-093, Poland
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Hematology and Cellular Therapy Ospedale Bambino Gesu
Rome, 165, Italy
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Hopital Robert Debre
Paris, 75019, France
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Hospital Infantil Universitario La Paz
Madrid, 28046, Spain
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Hospital Niño Jesus
Madrid, Madrid, 28009, Spain
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Hospital Sant Joan de Deu Barcelona (HSJDB)
Barcelona, 8950, Spain
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Hospital Universitari I politecnic La Fe Jose
Valencia, 46026, Spain
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Hospital Universitario Vall dHebron
Barcelona, 8035, Spain
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IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola Malpighi
Bologna, 40138, Italy
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Institut d'Hematologie et d'Oncologie Pediatrique (IHOPe)
Lyon, 69373, France
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Instituto Murciano de Investigacion Biosanitaria (IMIB) Virgen de la Arrixaca
Murcia, 30120, Spain
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Instituto de Investigacion Biomedica de Malaga IBIMA - sede Hospital Regional Universitario de Malaga HRUM Hospital Carlos Haya
Málaga, 29011, Spain
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Justus-Liebig-Universitaet Giessen
Giessen, 35392, Germany
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Klinikum der Johann Wolfgang Goethe
Frankfurt, 60596, Germany
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Medizinische Hochschule Hannover MHH
Hanover, 30625, Germany
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Pediatric Clinic Onco Hematology San Gerardo Hospital
Monza, 20052, Italy
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Szpital Kliniczny im. Karola Jonschera UM
Poznan, 60-572, Poland
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U.O.C. Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Uniklinik RWTH Aachen, Klinik fur Kinder- und Jugendmedizin
Aachen, 52074, Germany
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Universitaetsklinikum Essen
Essen, 45147, Germany
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Universitaetsklinikum Freiburg - Zentrum fuer Kinder- und Jugendmedizin (ZKJ)
Freiburg im Breisgau, 79106, Germany
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Universitaetsklinikum Leipzig - Abteilung fuer Paediatrische Onkologie, Haematologie und Haemostaseologie
Leipzig, 4103, Germany
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Universitaetsklinikum Muenster (UKM) - Klinik fuer Kinder- und Jugendmedizin - Paediatrische Haematologie und Onkologie
Münster, 48129, Germany
Conditions
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