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New cell therapy aims to tame deadly transplant complication in kids

NCT ID NCT06075706

Ongoing Disease control Sponsor: medac GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment called MC0518 (made from donor cells) in children who have severe graft-versus-host disease (GvHD) after a stem cell transplant and did not get better with steroids. GvHD happens when the donor's immune cells attack the child's body. The trial compares MC0518 to the best available standard treatments. About 49 children will take part to see if MC0518 can improve or resolve GvHD within 28 days.

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Conditions

The condition(s) this trial relates to.

acute graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STEROID-REFRACTORY ACUTE GRAFT-VERSUS-HOST DISEASE

Contacts and locations

Locations

  • A.O.U. Citta della Salute e della Scienza di Torino Ospedale Infantile Regina Margherita

    Turin, 10126, Italy

  • CHRU Nancy, Hopitaux de Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • CHRU de Strasbourg - Hopital de Hautepierre

    Strasbourg, 67000, France

  • CHU Grenoble Alpes - Hopital Couple Enfant (HCE)

    La Tronche, 38700, France

  • CHU de Bordeaux - Hopital des Enfants

    Bordeaux, 33000, France

  • CHU de Marseille-Hopital de la Timone

    Marseille, 13385, France

  • CHU de Nantes - Hopital Mere Enfant

    Nantes, 44093, France

  • CHU de Rouen - Hopital Charles Nicolle

    Rouen, 73038, France

  • Centre Hospitalier Regional Universitaire (CHRU) Montpellier - hopital Arnaud de Villeneuve

    Montpellier, 34295, France

  • Centre Hospitalier Universitaire de Lille CHU Lille - Hopital Jeanne de Flandre HJF

    Lille, 59037, France

  • Clinica Universitaria de Navarra

    Pamplona, Navarre, 31008, Spain

  • Department of Pediatric Hematology, Oncology and BMT, Wroclaw Medical University

    Wroclaw, Lower Silesian Voivodeship, 50-556, Poland

  • Department of Pediatrics, Jena University Hospital

    Jena, 7747, Germany

  • Dzieciecy Szpital Kliniczny im. A.Gebali w Lublinie

    Lublin, 20-093, Poland

  • Hematology and Cellular Therapy Ospedale Bambino Gesu

    Rome, 165, Italy

  • Hopital Robert Debre

    Paris, 75019, France

  • Hospital Infantil Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Niño Jesus

    Madrid, Madrid, 28009, Spain

  • Hospital Sant Joan de Deu Barcelona (HSJDB)

    Barcelona, 8950, Spain

  • Hospital Universitari I politecnic La Fe Jose

    Valencia, 46026, Spain

  • Hospital Universitario Vall dHebron

    Barcelona, 8035, Spain

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola Malpighi

    Bologna, 40138, Italy

  • Institut d'Hematologie et d'Oncologie Pediatrique (IHOPe)

    Lyon, 69373, France

  • Instituto Murciano de Investigacion Biosanitaria (IMIB) Virgen de la Arrixaca

    Murcia, 30120, Spain

  • Instituto de Investigacion Biomedica de Malaga IBIMA - sede Hospital Regional Universitario de Malaga HRUM Hospital Carlos Haya

    Málaga, 29011, Spain

  • Justus-Liebig-Universitaet Giessen

    Giessen, 35392, Germany

  • Klinikum der Johann Wolfgang Goethe

    Frankfurt, 60596, Germany

  • Medizinische Hochschule Hannover MHH

    Hanover, 30625, Germany

  • Pediatric Clinic Onco Hematology San Gerardo Hospital

    Monza, 20052, Italy

  • Szpital Kliniczny im. Karola Jonschera UM

    Poznan, 60-572, Poland

  • U.O.C. Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Uniklinik RWTH Aachen, Klinik fur Kinder- und Jugendmedizin

    Aachen, 52074, Germany

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • Universitaetsklinikum Freiburg - Zentrum fuer Kinder- und Jugendmedizin (ZKJ)

    Freiburg im Breisgau, 79106, Germany

  • Universitaetsklinikum Leipzig - Abteilung fuer Paediatrische Onkologie, Haematologie und Haemostaseologie

    Leipzig, 4103, Germany

  • Universitaetsklinikum Muenster (UKM) - Klinik fuer Kinder- und Jugendmedizin - Paediatrische Haematologie und Onkologie

    Münster, 48129, Germany

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