A simple care bundle may shield kidneys after major surgery
NCT ID NCT05275218
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This trial tests whether a structured bundle of supportive care measures—such as careful fluid management, blood pressure control, and medication adjustments—can lower the risk of persistent severe acute kidney injury in patients who develop moderate or severe kidney injury within 72 hours after major surgery. Researchers will compare this extended KDIGO bundle against standard care in 480 adults, with participants grouped by a biomarker (CCL14) that may indicate risk. The goal is to see if this proactive approach can prevent the injury from worsening or lasting.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A structured supportive care bundle (KDIGO bundle) including measures like fluid management, blood pressure control, and medication review
- What this could lead to
- If effective, this bundle could become a standard supportive approach to prevent persistent severe kidney injury after major surgery, potentially reducing the need for dialysis and improving recovery.
- What could go wrong
- This is a single-center trial, and the bundle's success depends on consistent implementation across many care decisions. It may not show a clear benefit over standard care, and individual patient responses can vary.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 480 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2023
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult patients (age ≥18 years) 2. Moderate or severe AKI ((defined by the 2012 KDIGO criteria, KDIGO stage 2 and 3), determined by either serum creatinine or urine output) within 72h after a surgical procedure 3. Written informed consent Exclusion Criteria: 1. Dialysis-dependent chronic kidney disease 2. Prior kidney transplant 3. Infections with human immunodeficiency virus or hepatitis 4. Hepatorenal syndrome 5. Pregnancy or breast-feeding 6. Participation in another interventional trial that investigates a drug that affects the kidney function within the last 3 months 7. Persons held in an institution by legal or official order 8. Persons with any kind of dependency on the investigator or employed by the responsible institution or investigator
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University Hospital Münster; 1Department of Anesthesiology, Intensive Care Medicine and Pain Medicine
Münster, Germany
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