New CLL drug acalabrutinib takes on ibrutinib in Head-to-Head trial

NCT ID NCT02477696

Ongoing Disease control Sponsor: Acerta Pharma BV Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether acalabrutinib is as effective as ibrutinib for people with high-risk chronic lymphocytic leukemia (CLL) who have already tried other treatments. About 533 participants will receive either acalabrutinib or ibrutinib pills. The main goal is to see how long people live without their cancer getting worse. The study also tracks serious infections and other side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

acalabrutinib

What this could lead to

If acalabrutinib works as well as ibrutinib but with fewer side effects, it could become a preferred treatment option for people with high-risk CLL.

What could go wrong

This is a non-inferiority trial, so acalabrutinib may not prove better than ibrutinib. Both drugs have risks like infections and bleeding. Results may not apply to all CLL patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA

Contacts and locations

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Locations

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Majadahonda, 28222, Spain
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Murcia, 30008, Spain
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Santander, 39008, Spain
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Ankara, 6230, Turkey (Türkiye)
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Ankara, 6560, Turkey (Türkiye)
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Instabul, 34365, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Izmir, 35340, Turkey (Türkiye)
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Kayseri, 38030, Turkey (Türkiye)
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Birmingham, B9 5SS, United Kingdom
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Bournemouth, BH7 7DW, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Cardiff, CF14 4XW, United Kingdom
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Greater London, E1 2AD, United Kingdom
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Hull, HU32JZ, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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Leicester, LE1 7RH, United Kingdom
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Liverpool, L7 8XP, United Kingdom
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London, SE5 9RS, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Southampton, SO16 6YD, United Kingdom
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Surrey, SM2 5PT, United Kingdom
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Bruges, 8000, Belgium
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Yvoir, 5530, Belgium
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Aalborg, 9100, Denmark
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Indgang 27B, DK-4000, Denmark
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Bobigny, 93000, France
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Créteil, 94010, France
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Pierre-Bénite, 69310, France
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Rennes, 35000, France
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Rouen, 76038, France
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Toulouse, 31059, France
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München, 81241, Germany
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Ulm, 89081, Germany
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Budapest, 1083, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Kaposvár, 7400, Hungary
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Haifa, 31000, Israel
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Haifa, 31096, Israel
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Haifa, 34362, Israel
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Jerusalem, 9103102, Israel
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Nahariya, 22100, Israel
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Petah Tikvah, 49102, Israel
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Tel Litwinsky, 52621, Israel
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Tiberias, 15208, Israel
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Bologna, 40138, Italy
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Cagliari, 9121, Italy
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Cona, 44124, Italy
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Florence, 50134, Italy
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Meldola, 47014, Italy
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Milan, 20132, Italy
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Milan, 20162, Italy
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Modena, 41100, Italy
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Ravenna, 48121, Italy
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Rome, 168, Italy
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Almere Stad, 1315 RA, Netherlands
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Amsterdam, 1105 AZ, Netherlands
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Blaricum, 1261, Netherlands
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Breda, 4818 CK, Netherlands
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Delft, 2600 GA, Netherlands
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Dordrecht, 3317, Netherlands
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Geleen, 6162 BG, Netherlands
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Groningen, 9700, Netherlands
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Haarlem, 2035 RC, Netherlands
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Leiden, 2333, Netherlands
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Rotterdam, 3062 PA, Netherlands
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Rotterdam, 3083 AN, Netherlands
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Utrecht, 3584, Netherlands
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Zutphens, 7207 AE, Netherlands
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Addington, 8011, New Zealand
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Auckland, ?0620, New Zealand
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Tauranga, 3112, New Zealand
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Bydgoszcz, 85-168, Poland
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Gdansk, 80-129, Poland
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Gdynia, 81-519, Poland
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Krakow, 30-727, Poland
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Lodz, 93-510, Poland
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Olsztyn, 10-228, Poland
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Opole, 46-020, Poland
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Phoenix, Arizona, 85054, United States
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Anaheim, California, 92801, United States
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Berkeley, California, 94704, United States
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Duarte, California, 91010, United States
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La Jolla, California, 92093, United States
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Los Angeles, California, 90095, United States
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Palo Alto, California, 94304, United States
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Santa Rosa, California, 95403, United States
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Jacksonville, Florida, 32224, United States
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Tampa, Florida, 33612, United States
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Athens, Georgia, 30607, United States
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Harvey, Illinois, 60426, United States
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Peoria, Illinois, 61615, United States
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Wichita, Kansas, 67214, United States
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Minneapolis, Minnesota, 55426, United States
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Rochester, Minnesota, 55905, United States
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Billings, Montana, 59102, United States
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Hackensack, New Jersey, ?07601, United States
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Lake Success, New York, 11042, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10021, United States
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New York, New York, 10029, United States
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New York, New York, 10065, United States
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Durham, North Carolina, 27710, United States
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Columbus, Ohio, 43210, United States
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Philadelphia, Pennsylvania, 19104, United States
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Houston, Texas, 77030, United States
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Round Rock, Texas, 78665, United States
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Charlottesville, Virginia, 22908, United States
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Tacoma, Washington, 98405, United States
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Northwest WA, Wisconsin, 20007, United States
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Darlinghurst, 2010, Australia
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Frankston, 3199, Australia
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Melbourne, 3000, Australia
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St Leonards, 2065, Australia
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Waratah NSW, 2298, Australia
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Wollongong, 2500, Australia
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Słupsk, 76-200, Poland
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Wroclaw, 50-001, Poland
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Barcelona, 8907, Spain
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Barcelona, ?08041, Spain
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Madrid, 28006, Spain
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Madrid, 28009, Spain
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Madrid, 28031, Spain
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Madrid, 28041, Spain