New combo aims to wipe out lingering leukemia before transplant
NCT ID NCT06668558
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial tests whether a combination of venetoclax and azacitidine can clear measurable residual disease (MRD) in adults with acute myeloid leukemia (AML) who still have or develop leftover cancer cells after initial chemotherapy, and before a stem cell transplant. About 29 participants will receive up to 12 or 24 cycles of the drugs, depending on their risk group. The main goal is to see if the treatment can make MRD disappear, which could lower the chance of the leukemia coming back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
venetoclax and azacitidine
What this could lead to
If successful, this could offer a way to eliminate leftover leukemia cells before a stem cell transplant, potentially reducing the risk of relapse.
What could go wrong
This is a small, early-phase trial with only 29 participants, so results may not apply to all patients. The drugs can cause side effects like low blood counts and infections.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fundacio Assistencial De Mutua De Terrassa
RECRUITINGTerrassa, Catalonia, 08221, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clinic De Barcelona
RECRUITINGBarcelona, Catalonia, 08036, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clinico Universitario De Valencia
RECRUITINGValencia, Valencia, 46010, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital De La Santa Creu I Sant Pau
RECRUITINGBarcelona, Catalonia, 08025, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Del Mar
RECRUITINGBarcelona, Catalonia, 08003, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital General Universitario Gregorio Maranon
RECRUITINGMadrid, Madrid, 28009, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Son Llatzer
RECRUITINGPalma de Mallorca, Balearic Islands, 07198, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida
RECRUITINGLleida, Catalonia, 25196, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari Joan XXIII De Tarragona
RECRUITINGTarragona, Catalonia, 43005, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari Vall D Hebron
RECRUITINGBarcelona, Catalonia, 08035, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Catala D oncologia Badalona
RECRUITINGBadalona, Catalonia, 08916, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Catala D oncologia Girona
RECRUITINGGirona, Catalonia, 17007, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Catala D oncologia Hospitalet
RECRUITINGL'Hospitalet de Llobregat, Catalonia, 08908, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Hospital Son Espases
RECRUITINGPalma de Mallorca, Balearic Islands, 07120, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact