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New combo aims to wipe out lingering leukemia before transplant

NCT ID NCT06668558

Recruiting now Disease control Sponsor: Grupo Cooperativo de Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tests whether a combination of venetoclax and azacitidine can clear measurable residual disease (MRD) in adults with acute myeloid leukemia (AML) who still have or develop leftover cancer cells after initial chemotherapy, and before a stem cell transplant. About 29 participants will receive up to 12 or 24 cycles of the drugs, depending on their risk group. The main goal is to see if the treatment can make MRD disappear, which could lower the chance of the leukemia coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
venetoclax and azacitidine
What this could lead to
If successful, this could offer a way to eliminate leftover leukemia cells before a stem cell transplant, potentially reducing the risk of relapse.
What could go wrong
This is a small, early-phase trial with only 29 participants, so results may not apply to all patients. The drugs can cause side effects like low blood counts and infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

  • Fundacio Assistencial De Mutua De Terrassa

    RECRUITING

    Terrassa, Catalonia, 08221, Spain

  • Hospital Clinic De Barcelona

    RECRUITING

    Barcelona, Catalonia, 08036, Spain

  • Hospital Clinico Universitario De Valencia

    RECRUITING

    Valencia, Valencia, 46010, Spain

  • Hospital De La Santa Creu I Sant Pau

    RECRUITING

    Barcelona, Catalonia, 08025, Spain

  • Hospital Del Mar

    RECRUITING

    Barcelona, Catalonia, 08003, Spain

  • Hospital General Universitario Gregorio Maranon

    RECRUITING

    Madrid, Madrid, 28009, Spain

  • Hospital Son Llatzer

    RECRUITING

    Palma de Mallorca, Balearic Islands, 07198, Spain

  • Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida

    RECRUITING

    Lleida, Catalonia, 25196, Spain

  • Hospital Universitari Joan XXIII De Tarragona

    RECRUITING

    Tarragona, Catalonia, 43005, Spain

  • Hospital Universitari Vall D Hebron

    RECRUITING

    Barcelona, Catalonia, 08035, Spain

  • Institut Catala D oncologia Badalona

    RECRUITING

    Badalona, Catalonia, 08916, Spain

  • Institut Catala D oncologia Girona

    RECRUITING

    Girona, Catalonia, 17007, Spain

  • Institut Catala D oncologia Hospitalet

    RECRUITING

    L'Hospitalet de Llobregat, Catalonia, 08908, Spain

  • University Hospital Son Espases

    RECRUITING

    Palma de Mallorca, Balearic Islands, 07120, Spain

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