New trial aims to stop leukemia relapse after transplant

NCT ID NCT03821610

Ongoing Disease control Sponsor: University of Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial compares two different chemotherapy and radiation regimens given before a stem cell transplant for adults aged 40-70 with acute lymphoblastic leukemia (ALL) in remission. The goal is to see if a stronger regimen (using total body irradiation and cyclophosphamide) can reduce the chance of the cancer returning without increasing the risk of dying from the transplant. About 242 patients will be randomly assigned to one of the two regimens and followed for at least 3 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fludarabine, Melphalan, Alemtuzumab, Cyclophosphamide, Mesna, Total Body Irradiation (8Gy)
What this could lead to: If successful, this could identify a better pre-transplant regimen that reduces the chance of leukemia returning after a stem cell transplant.
What could go wrong: This is a Phase 2 trial, so results are still preliminary. The stronger regimen may increase side effects or transplant-related deaths, and it may not work for all patients.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA

Contacts and locations

Locations

Barts Health Nhs Trust

London, E11BB, United Kingdom
Cambridge University Hospitals Nhs Foundation Trust

Cambridge, CB20QQ, United Kingdom
Cardiff and Vale University Health Board

Cardiff, CF144XW, United Kingdom
Central Manchester University Hospitals Nhs Foundation Trust

Manchester, United Kingdom
Heart of England Nhs Foundation Trust

Birmingham, B95ST, United Kingdom
Imperial College Healthcare Nhs Trust

London, W21NY, United Kingdom
Kings College Hospital

London, SE5 9RS, United Kingdom
Leeds Teaching Hospitals Nhs Trust

Leeds, LS9 7TF, United Kingdom
NHS Greater Glasgow and Clyde

Glasgow, G12 0YN, United Kingdom
Nottingham University Hospitals Nhs Trust

Nottingham, NG72UH, United Kingdom
Oxford University Hospitals Nhs Foundation Trust

Oxford, OX3 9DU, United Kingdom
Plymouth Hospitals Nhs Trust

Plymouth, PL68DH, United Kingdom
Sheffield Teaching Hospitals Nhs Foundation Trust

Sheffield, S57AU, United Kingdom
The Christie Nhs Foundation Trust

Manchester, M204BX, United Kingdom
The Clatterbridge Cancer Centre Nhs Foundation Trust

Liverpool, CH634JY, United Kingdom
The Newcastle Upon Tyne Hospitals Nhs Foundation Trust

Newcastle, United Kingdom
The Royal Marsden Nhs Foundation Trust

London, SW3 6JJ, United Kingdom
University College London Hospitals Nhs Foundation Trust

London, NW12PG, United Kingdom
University Hospital Southampton Nhs Foundation Trust

Southampton, SO16 6YD, United Kingdom
University Hospitals Birmingham Nhs Foundation Trust

Birmingham, United Kingdom
University Hospitals Bristol Nhs Foundation Trust

Bristol, BS13NU, United Kingdom
University Hospitals of Leicester Nhs Trust

Leicester, LE15WW, United Kingdom

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