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New study tracks Acalabrutinib's Real-World success in CLL patients

NCT ID NCT05999877

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This study follows 192 people with chronic lymphocytic leukemia (CLL) in Spain who started taking acalabrutinib for the first time. Researchers want to see how many patients stay on the drug for at least 24 months and how it works in different groups, like those new to treatment or switching due to side effects from an older drug. The goal is to understand real-world outcomes, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
acalabrutinib
What this could lead to
If successful, this could show that acalabrutinib is a well-tolerated and effective first-line treatment for chronic lymphocytic leukemia, helping patients stay on therapy longer.
What could go wrong
This is an observational study, not a controlled trial, so results may not prove cause and effect. It only includes patients in Spain, so findings may not apply to other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA

Contacts and locations

Locations

  • Research Site

    Almería, Andalusia, 4009, Spain

  • Research Site

    Córdoba, Andalusia, 14004, Spain

  • Research Site

    Granada, Andalusia, 18014, Spain

  • Research Site

    Jaén, Andalusia, 23007, Spain

  • Research Site

    Marbella, Andalusia, 29603, Spain

  • Research Site

    Málaga, Andalusia, 29010, Spain

  • Research Site

    Seville, Andalusia, 41013, Spain

  • Research Site

    Zaragoza, Aragon, 50009, Spain

  • Research Site

    Palma de Mallorca, Balearic Islands, 7010, Spain

  • Research Site

    Palma de Mallorca, Balearic Islands, 7198, Spain

  • Research Site

    Las Palmas de Gran Canaria, Canary Islands, 35016, Spain

  • Research Site

    Las Palmas de Gran Canaria, Canary Islands, 35019, Spain

  • Research Site

    San Cristóbal de La Laguna, Canary Islands, 38320, Spain

  • Research Site

    Santander, Cantabria, 39008, Spain

  • Research Site

    Salamanca, Castille and León, 37007, Spain

  • Research Site

    Segovia, Castille and León, 40002, Spain

  • Research Site

    Valladolid, Castille and León, 47003, Spain

  • Research Site

    Valladolid, Castille and León, 47012, Spain

  • Research Site

    Guadalajara, Castille-La Mancha, 19002, Spain

  • Research Site

    Toledo, Castille-La Mancha, 45004, Spain

  • Research Site

    Barcelona, Catalonia, 8003, Spain

  • Research Site

    Barcelona, Catalonia, 8025, Spain

  • Research Site

    Barcelona, Catalonia, 8035, Spain

  • Research Site

    Barcelona, Catalonia, 8036, Spain

  • Research Site

    Granollers, Catalonia, 8402, Spain

  • Research Site

    L'Hospitalet de Llobregat, Catalonia, 8908, Spain

  • Research Site

    Lleida, Catalonia, 25198, Spain

  • Research Site

    Terrassa, Catalonia, 8221, Spain

  • Research Site

    Ourense, Galicia, 32005, Spain

  • Research Site

    Santiago de Compostela, Galicia, 15706, Spain

  • Research Site

    Vigo, Galicia, 36312, Spain

  • Research Site

    Madrid, Madrid, 28006, Spain

  • Research Site

    Madrid, Madrid, 28031, Spain

  • Research Site

    Madrid, Madrid, 28034, Spain

  • Research Site

    Madrid, Madrid, 28040, Spain

  • Research Site

    Madrid, Madrid, 28041, Spain

  • Research Site

    Madrid, Madrid, 28046, Spain

  • Research Site

    Madrid, Madrid, 28905, Spain

  • Research Site

    Madrid, Madrid, 28911, Spain

  • Research Site

    Majadahonda, Madrid, 28222, Spain

  • Research Site

    El Palmar, Murcia, 30120, Spain

  • Research Site

    Murcia, Murcia, 30008, Spain

  • Research Site

    Oviedo, Principality of Asturias, 33011, Spain

  • Research Site

    Alicante, Valencia, 3010, Spain

  • Research Site

    Valencia, Valencia, 46010, Spain

  • Research Site

    Valencia, Valencia, 46014, Spain

  • Research Site

    Valencia, Valencia, 46026, Spain

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