New antibody combo shows promise for Tough-to-Treat blood cancers

NCT ID NCT04623541

Ongoing Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 05, 2026 · Updated 5 times

Summary

This study tests an experimental antibody called epcoritamab, which helps the immune system target and kill cancer cells. It is being tested alone or with other drugs in about 194 people with relapsed/refractory chronic lymphocytic leukemia (CLL) or Richter's syndrome. The goal is to see if it is safe and effective, with treatment lasting up to 2 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epcoritamab (an antibody that helps the immune system attack cancer cells), given alone or with other drugs like venetoclax, pirtobrutinib, lenalidomide, or R-CHOP chemotherapy.
What this could lead to: If successful, this could provide a new treatment option for people with hard-to-treat CLL or Richter's syndrome, potentially improving response rates and extending survival.
What could go wrong: This is an early-phase trial (1b/2), so safety and effectiveness are not yet proven. Side effects like cytokine release syndrome or nerve problems are possible, and the treatment may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA RICHTER'S SYNDROME SMALL LYMPHOCYTIC LYMPHOMA TREATMENT-NAÏVE HIGH RISK CHRONIC LYMPHOCYTIC LEUKEMIA

Contacts and locations

Locations

AOC Arcispedale Saint'Anna

Coaña, Ferarra, Spain
AOU Arcispedale Sant'Anna

Ferrara, Cona, 44124, Italy
AOU Città della Salute e della Scienza di Torino

Torino, 10126, Italy
AOU Policlinico Sant'Orsola Malpighi IRCCS

Bologna, 00161, Italy
AOU Policlinico Umberto I

Roma, 00161, Italy
AZ Sint-Jan

Bruges, 8000, Belgium
Aalborg University Hospital

Aalborg, 9100, Denmark
Aidport sp z o.o.

Skorzewo, Poland
Albert Schweitzer Ziekenhuis, Dordwijk

Dordrecht, South Holland, 3318 AT, Netherlands
Alfred Health

Melbourne, Victoria, 3004, Australia
Amsterdam UMC

Amsterdam, 1105 AZ, Netherlands
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)

Brescia, Italy
Barwon Health

Geelong, Victoria, Australia
Bnai Zion Medical Center

Haifa, Israel
CHU Clermont Ferrand

Clermont-Ferrand, Puy De Dome, 63000, France
CHU Hôpital Haut-Lévêque Bordeaux

Pessac, Gironde, 33404, France
CHU Hôpital de Brabois Nancy

Vandœuvre-lès-Nancy, Meurthe Et Moselle, 54500, France
CHU de Montpellier Hôpital Saint Eloi

Montpellier, Cedex 5, 34090, France
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Chaim Sheba Medical Center

Ramat Gan, Israel
City of Hope National Medical Center

Duarte, California, 91010, United States
Columbia University Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
David Geffen School of Medicine

Los Angeles, California, 90095, United States
Duke University Medical Center

Durham, North Carolina, 27708, United States
Fakultni Nemocnice Ostrava

Ostrava, Poruba, Czechia
Fakultni nemocnice Brno

Brno, 625 00, Czechia
Fakultni nemocnice Hradec Kralove

Hradec Králové, Nový Hradec Králové, 500 05, Czechia
Fakultni nemocnice Olomouc

Olomouc, 779 00, Czechia
Flinders Medical Centre

Bedford Park, South Australia, 5042, Australia
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Hackensack Meridian Hospital

Hackensack, New Jersey, 07601, United States
Hadassah University Hospital - Ein Kerem

Jerusalem, Israel
Henry Ford Medical Group

Detroit, Michigan, 48202, United States
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hospital Clinico Universitario de Valencia

Valencia, València, 46010, Spain
Hospital Universitario Fundacion Jiménez Díaz

Madrid, 28040, Spain
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen Macarena

Seville, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Spain
Hôpital Privé du Confluent

Nantes, Pays de la Loire Region, 44000, France
Hôpital Saint-Louis

Paris, 75010, France
Hôpital Universitaire Pitié-Salpêtrière

Paris, 75013, France
IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST

Meldola, Forli - Cesena, 47014, Italy
IRCCS Policlinico Universitario Agostino Gemelli

Rome, Lazio, 00136, Italy
Istituto di Candiolo

Torino, Candiolo, 10060, Italy
Maastricht University Medical Center

Maastricht, Limburg, 6229 HX, Netherlands
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Healthcare System

Pembroke Pines, Florida, 33024, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Mount Sinai Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States
National Institutes of Health

Bethesda, Maryland, 20892, United States
Northwell Health Cancer Institute

Lake Success, New York, 11043, United States
O'Neal Comprehensive Cancer Center at University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
Odense University Hospital

Odense, 5000, Denmark
Ospedale Maggiore di Novara

Novara, 28100, Italy
Ospedale San Raffaele

Milan, 20132, Italy
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Pratia Malopolskie Medical Center Krakow (Pratia Małopolskie Centrum Medyczne Krakow)

Krakow, Poland
Pratia Medical Center Katowice (Centrum Medyczne Pratia Katowice)

Katowice, Poland
Rabin Medical Center-Beilinson Campus

Petah Tikva, 4941492, Israel
Rigshospitalet

Copenhagen, Capital Region, 2100, Denmark
Roskilde Sygehus

Roskilde, 4000, Denmark
St. George Hospital

Kogarah, New South Wales, Australia
Stanford Cancer Center

Palo Alto, California, 94305, United States
Tel Aviv Sourasky Medical Center

Tel Aviv, Israel
The Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
The University of Texas Southwestern Medical Centre

Dallas, Texas, 75390, United States
UZ Leuven

Leuven, 3000, Belgium
Universitaetsklinikum Koeln

Cologne, 50937, Germany
Universitaetsklinikum Schleswig-Holstein- Karl-Lennart-Krebscentrum

Kiel, 24105, Germany
Universitair Medisch Centrum Groningen

Groningen, 9713 GZ, Netherlands
Universitair Medisch Centrum Utrecht

Utrecht, 3584 CX, Netherlands
Universitair Ziekenhuis Gent

Ghent, 9000, Belgium
University of California Davis Medical Center Sacramento

California City, California, 95817, United States
University of Cincinnati

Cincinnati, Ohio, 45221, United States
University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48190, United States
University of Pennsylvania School of medicine

Philadelphia, Pennsylvania, 19104, United States
Vejle Sygehus

Vejle, 7100, Denmark
Vseobecna Fakultni Nemocnice

Prague, Nové Město, 128 08, Czechia
Århus University Hospital

Aarhus, 8000, Denmark

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