Acute disease

This trial is testing a new type of immune cell therapy called CD123 CAR-NK cells in people with relapsed or refractory acute myeloid leukemia (AML) or blastic plasmacytoid dendritic cell neoplasm (BPDCN). The cells are designed to find and attack cancer cells that carry a protei…

This trial is for adults with relapsed or refractory acute myeloid leukemia (AML) who have no standard curative options. Researchers are testing whether giving the drug gemtuzumab ozogamicin followed by an infusion of donor white blood cells can stimulate the immune system to att…

This study tests a personalized vaccine made from a patient's own leukemia cells fused with immune cells, combined with a drug that blocks PD-1, to help the immune system recognize and destroy any remaining leukemia cells after chemotherapy. The goal is to prevent the cancer from…

This trial tests an experimental oral vaccine, WRSs2, designed to protect against Shigella sonnei, a common cause of severe diarrhea. Healthy adults aged 18-49 receive either the vaccine or a placebo, then are later exposed to the live bacteria in a controlled setting to see if t…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine is designed to protect against three coronaviruses: SARS-CoV-2 (which causes COVID-19), SARS-CoV-1, …

This Phase 2 trial tested the BNT162b2 mRNA vaccine in 960 healthy Chinese adults aged 18 to 85. Participants received two doses of either the vaccine or a placebo, 21 days apart. The main goal was to check safety and measure the immune response, specifically neutralizing antibod…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This trial tests whether continuously monitoring patients in the acute admission ward with a small chest-worn sensor can help doctors decide who is safe to go home. The sensor tracks heart rate, breathing, posture, and activity. Researchers will compare outcomes like discharge ra…

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This phase 1 trial is testing an investigational drug called AEB1102 in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or stopped responding to standard treatments. AEB1102 is a modified human enzyme that breaks down arginine, an amin…

This trial is testing whether a chemotherapy drug called treosulfan, given in different doses along with fludarabine, can safely prepare patients with advanced blood cancers for a stem cell transplant. The study focuses on patients who are not eligible for the standard, more inte…

This early-stage trial tests a combination of two drugs, venetoclax and azacitidine, in people with a serious type of myelodysplastic syndromes (MDS) who have not had treatment before. The goal is to find the safest dose and see how well the drugs work together to control the dis…

This trial is testing an experimental drug called BST-236 in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not improved after initial treatment. Participants receive BST-236 as a one-hour intravenous infusion for six …

This trial investigates whether a blood-filtering procedure called immunoadsorption (IA), combined with the drug rituximab, can improve neurological function in children aged 0-18 with severe anti-NMDAR encephalitis. Participants receive 10 IA sessions over 28 days plus weekly ri…

This trial tests whether a cardiac rehabilitation program based on a socio-ecological model can improve recovery in adults who have had a first heart attack and undergone a stent procedure. The program goes beyond standard care by providing guidance on exercise, diet, medication,…

This phase II trial investigates whether eltrombopag, a drug that stimulates platelet production, can help older adults with acute myeloid leukemia (AML) recover their platelet counts faster after initial chemotherapy. Older patients often experience slow platelet recovery, which…

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and g…

This trial tests two different concentrations of citrate solution used to prevent blood clotting during continuous kidney replacement therapy in critically ill patients with acute kidney injury. The goal is to see which concentration leads to fewer metabolic complications, such a…

This phase 2 trial is testing whether a combination of two drugs, venetoclax and azacitidine, can effectively treat adults aged 18 to 59 who have been newly diagnosed with acute myeloid leukemia (AML) and have not yet received any treatment. Participants take both drugs in cycles…

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this …

This study tests whether the drug APX-115 can prevent kidney injury caused by contrast dye used in heart procedures. About 230 adults with kidney disease will receive either the drug or a placebo before and after their procedure. The goal is to see if the drug reduces kidney dama…

This trial compares two modes of noninvasive ventilation in adults with acute respiratory failure: standard pressure support (PSV) and a newer mode called Neurally Adjusted Ventilatory Assist (NAVA). NAVA uses electrical signals from the diaphragm to trigger breathing support, wh…

This study tests whether using MRI to guide transcranial magnetic stimulation (TMS) works better than the usual scalp-based method for treating depression. It involves 54 participants, including those with treatment-resistant depression and others with COVID-related distress. The…

This trial tests whether epidural analgesia—pain medicine delivered near the spinal cord—can help people with severe acute pancreatitis breathe better and avoid needing a breathing machine. About 148 ICU patients with severe pancreatitis will be randomly assigned to receive eithe…

This pilot study tested whether women with kidney infections could safely stop antibiotics once their symptoms resolved, instead of taking a full 10-day course. 35 women were randomly assigned to either standard treatment or a patient-directed approach. The main goal was to see i…

This trial tests whether a 7-day antibiotic course—starting with an intravenous dose of ceftriaxone followed by oral cefixime—can effectively treat acute uncomplicated pyelonephritis (a kidney infection) in women aged 18 to 65. The goal is to see if this shorter regimen works as …

This trial is investigating whether a targeted drug called CMC-544 (inotuzumab ozogamicin), given alone or later combined with rituximab, can control acute lymphoblastic leukemia (ALL) that has returned or not responded to standard treatment. The study enrolls adults and older ch…

This phase 2 trial tests whether a single injection of selatogrel can rapidly prevent platelets from clumping together in adults having a heart attack. Participants receive either an 8 mg or 16 mg dose in the thigh, and researchers measure how quickly platelet activity drops. The…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This phase 3 trial investigates whether adding alpha-1 antitrypsin (AAT) to standard corticosteroid therapy improves outcomes for people with high-risk acute graft-versus-host disease (GVHD) after a stem cell transplant. Participants receive either AAT plus steroids or a placebo …

This trial tests whether a personalized diet and exercise program, delivered by phone and online, can help adult survivors of childhood leukemia who are overweight or obese lose weight. Participants are randomly assigned to either the active coaching program or a self-directed ap…

This Phase 2 trial tests whether the oral drug gilteritinib works better than midostaurin for adults with a specific genetic subtype of acute myeloid leukemia (FLT3-mutated AML). All 181 participants also receive standard chemotherapy. The goal is to see which drug leads to more …

This study follows about 269 people with chronic lymphocytic leukemia (CLL) who are starting venetoclax, a targeted pill. Researchers will track how well the drug shrinks or controls the cancer over the first year, and how long it takes before patients need another treatment. The…

This trial investigates whether gentle electrical stimulation of the ear (specifically the vagus nerve area) during emergency heart attack treatment can reduce heart muscle damage and improve recovery. Researchers are enrolling 110 adults having their first major heart attack who…

This study tests whether adding the targeted drug venetoclax to standard chemotherapy helps more adults with acute myeloid leukemia (AML) achieve remission. It enrolls people aged 18 to 65 with intermediate- or high-risk AML who have not yet been treated. The main goal is to see …

This study tests whether adding a traditional Chinese herbal enema (Tongfu Qinghua Decoction) and an external herbal powder (Ruyi Jinhuang Powder) to standard medical care can help adults with acute pancreatitis recover faster. The trial enrolled 100 people aged 18 to 75 with the…

This study tests whether an interactive avatar-based game on a tablet can help people who have had a heart attack learn how to manage their health after leaving the hospital. Participants are randomly assigned to either standard face-to-face discharge education or the tablet game…

This study tests whether endoscopic ultrasound-guided gallbladder drainage can be safely performed using conscious sedation given by the endoscopist, instead of deep sedation or general anesthesia. The trial enrolls elderly, high-risk patients with acute cholecystitis who are not…

This phase III trial tests whether the drug tipifarnib can prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. Participants include adults over 60 in first remission, those in second or later remission, or those who achieved remission a…

This trial compares two noninvasive breathing support methods—heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP)—in premature infants (born at 28-34 weeks) with moderate respiratory distress syndrome. The goal is to see which …

This study looked at over 17,000 people who had a heart attack to compare two blood thinners: prasugrel and ticagrelor. Hospitals switched from ticagrelor to prasugrel in a stepwise way to see which drug better prevents death, another heart attack, or stroke. The goal is to find …

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This trial tests whether adding the targeted drug ponatinib to standard chemotherapy (cytarabine) can help prevent relapse in adults with a specific, high-risk genetic form of acute myeloid leukemia (FLT3-ITD AML) who are already in first remission. The study includes two age gro…

This study tests whether giving full-strength chemotherapy (either CPX-351 or a combination called CLAG-M) can help medically less-fit adults with acute myeloid leukemia live longer and achieve remission. About 60 participants will receive one of the two treatments. The goal is t…

This study tests a drug called FT-2102 (olutasidenib) in people with acute myeloid leukemia or myelodysplastic syndrome whose cancers have a specific IDH1 gene mutation. The drug is given alone or combined with standard chemotherapy drugs (azacitidine or cytarabine). The goal is …

This Phase 3 trial tested the drug blinatumomab in 111 children with high-risk relapsed B-precursor acute lymphoblastic leukemia (ALL). Blinatumomab is an immunotherapy that helps the body's immune cells attack cancer cells. The study compared blinatumomab to standard chemotherap…

This study looked at whether taking oral azacitidine (Onureg) as maintenance therapy can help older adults with acute myeloid leukemia (AML) stay in remission longer after treatment with CPX-351 chemotherapy. The study included 100 patients aged 65 and older who had achieved remi…

This study looked at whether follow-up visits by phone or video are as safe as in-person visits for people who had a heart attack and received a stent. 88 patients were split into two groups: one had telemedicine check-ups at 1, 3, and 6 months, and the other had standard office …

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This large phase 3 trial studied nearly 1,900 children and young adults with newly diagnosed T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma. Researchers compared different chemotherapy combinations, including varying doses of methotrexate and adding the drug…

This phase 2 trial tested the immunotherapy drug pembrolizumab (Keytruda) alone or combined with idelalisib or ibrutinib in 65 patients with chronic lymphocytic leukemia (CLL) or low-grade B-cell non-Hodgkin lymphoma (NHL) that had returned or stopped responding to treatment. The…

This study tested a chemotherapy drug called CPX-351 in 59 adults aged 60 to 75 with a high-risk form of acute myeloid leukemia (AML). The goal was to see how well it could put the cancer into remission. Participants received the drug through an IV, and some also had a stem cell …

This completed trial tested whether giving epinephrine and verapamil directly into the heart arteries could help restore blood flow in heart attack patients whose vessels remain blocked despite standard treatment. 104 adults with ST-elevation heart attacks were enrolled. The stud…

This study tests whether adding the targeted drug inotuzumab ozogamicin to a milder chemotherapy regimen improves survival in adults over 55 with a specific type of acute lymphoblastic leukemia (ALL) that is Philadelphia chromosome-negative and CD22-positive. Participants receive…

This phase 3 trial is testing whether a combination of three drugs—azacitidine, venetoclax, and ATRA—can safely and effectively treat adults newly diagnosed with acute myeloid leukemia (AML). The drugs work together to stop cancer cell growth by demethylating DNA, promoting cell …

This study tested a daily pill called E7820 in 12 adults with relapsed or treatment-resistant acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. All participants had specific mutations in splicing factor genes. The goal was to see if the drug c…

This trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…

This study tested the drug RAD001 (everolimus) in 29 patients with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and myelofibrosis. The goal was to find the safest highest dose and see if it helps control the disease. It was a small early-phase trial at a singl…

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study tested whether giving sodium bicarbonate (a common substance that neutralizes acid) to critically ill patients with severe metabolic acidosis and moderate-to-severe acute kidney injury could improve survival at 90 days. The trial enrolled 640 adults in the ICU who had …

This phase II trial tested whether inhaling low doses of carbon monoxide (200 ppm for 90 minutes daily for 3 days) is safe and helpful for people with acute respiratory distress syndrome (ARDS), a severe lung condition. Only 4 intubated adults participated, making this a very sma…

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This study reviewed medical records of 37 adults with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) who took asciminib because other treatments stopped working or caused side effects. Researchers wanted to see how many patients achieved complete remission within th…

This study tested a new drug called EQ001 in 30 people who developed acute graft-versus-host disease (aGVHD) after a stem cell transplant. aGVHD is a serious condition where donor immune cells attack the patient's body. The goal was to see if EQ001 is safe and can help control th…

This study looked at whether giving a sedative called propofol to very premature babies (under 32 weeks) before a less invasive breathing treatment (LISA) is safe and reduces the need for a breathing machine. The trial involved 233 infants with breathing problems. Researchers com…

This phase 2 trial tested a combination of two drugs, ibrutinib and blinatumomab, in 19 adults with B-cell acute lymphoblastic leukemia that had come back or wasn't responding to treatment. The goal was to see how many patients achieved complete remission. The study is completed,…

This study tested a new formulation of two chemotherapy drugs (CPX-351) in 56 adults with newly diagnosed acute myeloid leukemia (AML) who were at high risk of not responding to standard treatment. The goal was to find the best dose and see how well it worked to stop cancer cells…

This study tested whether early hemofiltration, a continuous dialysis procedure, could improve survival in children who develop respiratory failure after a bone marrow transplant. Only 6 children took part. The idea was to filter out inflammatory molecules that drive lung damage.…

This study looked at 120 critically ill patients with acute kidney injury and shock who needed dialysis. Researchers compared a special method called sodium profiling dialysis to standard dialysis to see if it helped keep blood pressure stable and reduced fluid buildup in the lun…

This study tested whether adding a drug called oblimersen to standard chemotherapy (daunorubicin and cytarabine) helps older adults (60+) with untreated acute myeloid leukemia live longer or achieve remission. About 500 participants were randomly assigned to receive chemo with or…

This study tested whether a blood test (GVHD biomarkers) can help doctors safely reduce steroid doses in children with graft-versus-host disease (GVHD) after a bone marrow transplant. Fifty children with newly diagnosed GVHD received prednisone, and those with low biomarker level…

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This phase 2 trial tested a combination of intravenous busulfan, etoposide, and low-dose total-body irradiation before a donor stem cell or bone marrow transplant in 30 patients with advanced leukemia or myelodysplastic syndromes. The goal was to see how well this regimen control…

This study tested whether removing a specific type of immune cell (naïve T cells) from donor stem cell grafts could prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial enrolled 84 patients who received high- or medium-intensity chemo…

This study tested a new treatment for adults with a high-risk form of acute promyelocytic leukemia (APL). The experimental therapy combined arsenic trioxide, ATRA, and a low dose of idarubicin, aiming to improve survival and reduce side effects compared to the standard chemothera…

This pilot study tested whether giving critically ill children on breathing machines extra protein along with a personalized exercise program could help preserve muscle mass and improve recovery. The trial enrolled 18 children in the ICU and measured how feasible and safe the app…

This phase 2 trial tested whether certain biomarkers in bone marrow can predict how well patients with high-risk acute myeloid leukemia (AML) respond to treatment with sirolimus plus standard chemotherapy (MEC). The study enrolled 39 adults with AML that was hard to treat or had …

This large phase 3 trial enrolled over 9,000 children with newly diagnosed standard-risk B-ALL or localized B-LLy. Researchers tested different combinations and doses of chemotherapy drugs to see which worked best with the fewest side effects. The goal was to improve disease-free…

This study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…

This study tested whether a drug called dexrazoxane, given through a vein, can reduce permanent heart muscle damage in people having a severe heart attack (STEMI). Fifty adults received either the drug or a placebo during their standard stent procedure. The goal was to see if the…

This early-phase trial tested whether a new type of immune cell therapy (CD22 CAR T cells) could be safely made and given to 10 children and young adults whose B-cell leukemia or lymphoma had come back or stopped responding to treatment. The therapy uses the patient's own immune …

This study tested a new way to give extra oxygen to the heart after a heart attack. Twenty patients received a special oxygen treatment for one hour through a thin tube placed in the heart artery. The main goal was to see if the procedure was safe and could be done without proble…

This study tested a new drug called S65487, which blocks a protein that helps leukemia cells survive, combined with the standard drug azacitidine. The trial included 57 adults with untreated acute myeloid leukemia who were not healthy enough for intensive chemotherapy. Researcher…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracke…

This study tested a combination of three drugs (low-dose cytarabine or azacitidine, plus venetoclax and quizartinib) in 113 adults aged 60 and older with newly diagnosed acute myeloid leukemia (AML) who were not eligible for standard chemotherapy. The goal was to quickly control …

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This study tested a new way to monitor kidney oxygen levels during liver surgery to try to prevent acute kidney injury (AKI). 80 adults having liver surgery were randomly assigned to either standard care or extra monitoring that triggered a step-by-step treatment plan if oxygen l…

This study tested whether adding regional citrate anticoagulation (RCA) to standard heparin can reduce clotting in continuous kidney dialysis circuits for patients on ECMO. Eighteen ICU adults with ARDS and acute kidney injury were enrolled. Each patient received alternating peri…

This study looked at 484 high-risk surgical patients with acute cholecystitis (gallbladder inflammation) who first received a standard drainage tube through the skin. Some then had a newer procedure using an endoscope to place a metal stent inside the gallbladder. Researchers com…

This study looked back at 400 critically ill patients with septic shock and kidney failure who needed dialysis. Researchers compared those who received a special filter (Oxiris) that removes toxins and inflammation-causing substances to those who got standard filters. The goal wa…

This study tested whether an oral medication (CC-486) could help elderly patients with a serious blood disorder called myelodysplastic syndrome (MDS) maintain their improvement after initial injectable treatment. Eleven patients who had responded to injectable azacitidine switche…

This early-stage study tested a new drug called LYT-200 in 101 adults whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) had come back or stopped responding to treatment. The main goals were to check the drug's safety and find the right dose. While not…

This clinical trial tested a drug called sivelestat sodium in 324 adults with acute respiratory distress syndrome (ARDS) and systemic inflammation. The drug aims to block a harmful enzyme that damages lung tissue. Researchers measured whether it improved oxygen levels and reduced…

This early-phase trial tested a three-part treatment for non-Hodgkin lymphoma: freezing tumors (cryoablation), injecting a personalized dendritic cell vaccine made from the patient's own cells, and giving the immunotherapy drug pembrolizumab (Keytruda). The goal was to find the s…

This study tested a combination of two drugs, rivaroxaban and ticagrelor, in 40 patients with atrial fibrillation who had a stent placed. The goal was to see if this combo causes less bleeding and prevents heart attacks or strokes better than current treatments. Patients took the…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study observed 45 people with chronic lymphocytic leukemia (CLL) who were taking the drug acalabrutinib (Calquence) along with a direct oral anticoagulant (DOAC), a type of blood thinner. The main goal was to see how many patients had serious bleeding events while on this co…

This early-stage study tested a single dose of mesenchymal stromal cells in 7 COVID-19 patients with severe acute respiratory distress syndrome (ARDS) who were on ventilators. The main goal was to check safety, looking for serious side effects like heart problems or blood clots w…

This study tested different drug combinations to prevent graft-versus-host disease (GVHD) in 174 people with blood cancers receiving stem cells from an unrelated donor. GVHD is a serious side effect where donor cells attack the patient's body. The goal was to find which drug regi…

This study tested a new medicine called CDR132L in 294 people who had a recent heart attack and had weak heart pumping (ejection fraction 45% or less). Participants received one of two doses of CDR132L or a placebo, added to standard care, for 6 months. The goal was to see if the…

This study tested whether a newer breathing support method called NAVA helps patients with ARDS come off mechanical ventilation faster than standard PSV. 130 tracheotomy patients were randomly assigned to one of the two methods. The main goal was to see how many days patients wer…

This study looked at over 3,400 people with acute coronary syndrome (a heart attack or unstable angina) who received a stent to open blocked arteries. Researchers compared two types of stents (biostable vs. biodegradable polymer) and two doses of the blood thinner prasugrel (5 mg…

This study tested a combination of chemotherapy drugs in 318 adolescents and young adults (ages not specified but typically 15-39) with newly diagnosed acute lymphoblastic leukemia (ALL). The goal was to see how well the treatment worked at killing cancer cells and stopping the d…

This completed phase 2 study tested a combination of two drugs, isatuximab and cemiplimab, in 37 adults with relapsed or refractory NK/T-cell lymphoma, a rare and aggressive blood cancer. The goal was to see if the combination could shrink tumors or stop the cancer from growing. …

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested a combination of two drugs—vemurafenib (taken by mouth) and rituximab (given by IV)—in 15 people with hairy cell leukemia, a rare blood cancer. The goal was to see if this treatment works as well as or better than standard chemotherapy, but with fewer side effec…

This study tested whether three common drugs—metformin, ivermectin, and fluvoxamine—could prevent severe illness and long COVID in 1,323 adults with early COVID-19. Participants were overweight or obese and not hospitalized. The key finding was that metformin reduced the risk of …

This study tested a new combination of chemotherapy drugs for children and young adults with acute lymphoblastic leukemia (ALL) that had returned or not responded to first treatment. The goal was to find the safest dose of clofarabine when given with other medicines. Twenty parti…

This study tested whether using lung CT images to guide ventilator settings could reduce deaths in people with ARDS. 420 adults were assigned to either standard ventilator care or a strategy based on their lung morphology. The goal was to see if personalized ventilation could imp…

This early-phase study tested a two-drug combination (pevonedistat plus decitabine) in 12 people with high-risk acute myeloid leukemia (AML), including those who had relapsed or couldn't tolerate standard chemo. The main goal was to find the safest dose and identify side effects.…

This study tested whether inhaling sevoflurane, a gas usually used for anesthesia, for the first 48 hours could improve oxygen levels and reduce inflammation in 50 adults with moderate to severe ARDS. Participants were randomly assigned to receive either sevoflurane or a standard…

This study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse certain DNA changes that lower the activity of a gene important for heart function. Only one person took…

This study tested whether using sevoflurane (an inhaled anesthetic) for sedation could lower death rates and shorten time on a ventilator in patients with acute respiratory distress syndrome (ARDS). 700 adults were randomly assigned to receive either sevoflurane or standard propo…

This early-phase trial tested the drug enasidenib in 17 people with low-risk myelodysplastic syndrome or a related leukemia who had anemia and did not have a specific gene mutation. The goal was to see if the drug could safely improve red blood cell counts and reduce the need for…

This early-phase study tested whether adding the targeted drug palbociclib to standard chemotherapy is safe for children with acute lymphoblastic leukemia that has returned or not responded to treatment. Only 2 children took part, and the main goal was to find the highest tolerab…

This study tested whether methylene blue, a dye that affects blood vessel function, can prevent dangerous drops in blood pressure during kidney dialysis. It involved 261 critically ill adults with acute kidney injury who needed dialysis. The goal was to see if the treatment could…

This study tested a two-step stem cell transplant for people with blood cancers like leukemia and lymphoma. First, patients received low-dose chemotherapy and radiation to prepare their bodies. Then, they got donor stem cells followed by drugs to prevent the donor cells from atta…

This study tested a new anti-infective eyedrop called SCH1 in 30 adults with acute infectious conjunctivitis (pink eye). Participants received either the active eyedrop or a placebo. The goal was to see if the drug could completely clear redness and discharge. The trial is comple…

This study tested whether a short course of doxycycline, a common antibiotic, can prevent heart damage after a heart attack. 174 adults who had a severe heart attack received either doxycycline or a placebo twice daily for one week. Researchers then used MRI scans to check heart …

This study tested a new drug, crenolanib, against the standard drug midostaurin in adults with a specific genetic type of acute myeloid leukemia (FLT3-mutated AML). All 214 participants received standard chemotherapy and, if eligible, a bone marrow transplant, plus one of the two…

This study tested whether a combination of two drugs, venetoclax and azacitidine, can help adults with acute myeloid leukemia (AML) stay in remission after initial chemotherapy. The goal was to find the right dose and see if it safely delays the cancer from coming back. The study…

This study looked at two ways to treat heart attack patients who have multiple blocked arteries. One group had all blockages fixed in a single procedure, while the other group had the main blockage fixed first and the others in a separate procedure later. The goal was to see if t…

This study tested a combination of two drugs, azacitidine and venetoclax, in 42 elderly patients (age 60+) with newly diagnosed acute myeloid leukemia (AML) who could not have standard chemotherapy. The treatment was given as an initial 'induction' phase, followed by a 'maintenan…

This study tested whether adding the drug crenolanib to standard chemotherapy helps adults up to age 75 with a hard-to-treat form of acute myeloid leukemia (AML) that has a specific genetic change (FLT3 mutation). Participants received either crenolanib or a placebo alongside che…

This study tested a personalized geriatric optimization plan (GO!) in 30 adults aged 60 and older who were getting a donor stem cell transplant for blood cancers or bone marrow failure. The plan included tailored advice on diet, sleep, activity, and medications to improve physica…

This study tested a combination of thalidomide, bortezomib, and high-dose melphalan followed by a stem cell transplant in 29 patients with advanced multiple myeloma who had already failed one round of treatment. The goal was to find the safest dose of thalidomide and see how well…

This study tested a drug called GO-203-2C, which targets a protein (MUC1) found on cancer cells while sparing healthy cells. It was given alone or with another drug (decitabine) to 33 adults with acute myeloid leukemia that had returned or not responded to treatment. The main goa…

This study looked at 128 heart attack patients who had a procedure to open blocked arteries. Some patients received an extra blood thinner called cangrelor on top of standard ticagrelor. The goal was to see if the combination improved blood flow to the heart and reduced leftover …

This study tested a new treatment called CTX131 for adults with certain blood cancers (T-cell lymphoma, B-cell lymphoma, or acute myeloid leukemia) that had returned or stopped responding to standard therapy. CTX131 uses a patient's own immune cells, modified with CRISPR gene edi…

This study tested whether adding a powerful HIV drug called FUZEON® to standard antiretroviral therapy could help people with HIV who also have a rare brain infection called PML. PML is caused by a virus that attacks the brain when the immune system is weak. The goal was to see i…

This study looked at whether a stem cell transplant can help people under 65 with untreated chronic lymphocytic leukemia (CLL) live longer without their cancer getting worse. 241 participants received either standard treatment or a transplant. The main goal was to see how long th…

This phase 2 trial tested a combination of chemotherapy (FCR) plus the drug lenalidomide in 21 people with previously untreated chronic lymphocytic leukemia (CLL). The goal was to see if adding lenalidomide could help more patients achieve a complete response, meaning no signs of…

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plu…

This phase II trial tested whether adding the drug itacitinib to standard medications (tacrolimus and sirolimus) can better prevent graft-versus-host disease (GVHD) in 59 patients with blood cancers receiving donor stem cell transplants. GVHD occurs when donor immune cells attack…

This study tested whether a new type of immune cell therapy, called CD22 CAR T cells, could be made from patients' own blood cells and safely given to adults with hard-to-treat B-cell leukemia or lymphoma. The main goals were to see if the cells could be produced successfully and…

This study tested an experimental drug called CM4620-IE in 21 people with severe pancreatitis that caused body-wide inflammation (SIRS). The goal was to see if the drug is safe and to find the best dose for future studies. Participants received the drug plus standard care or stan…

This study tested whether giving a single, strong dose of steroids to people right after a major heart attack (STEMI) could reduce the amount of heart muscle that gets permanently damaged. The steroid was given before the standard emergency procedure to open the blocked artery. T…

This study tested a new method of cord blood transplantation in 13 children and young adults with high-risk myeloid cancers. The approach uses a molecule called UM171 to grow more stem cells from a single cord blood unit, aiming to speed up recovery and reduce complications. Earl…

This study tested a new way to prepare patients with relapsed or hard-to-treat acute leukemia for a donor stem cell transplant. It combined a precise form of radiation therapy (IMRT) with two chemotherapy drugs (etoposide and cyclophosphamide) before the transplant. The goal was …

This study tested a new way to give radiation before a stem cell transplant for people aged 16 to 45 with acute lymphoblastic leukemia (ALL). The goal was to see if targeting radiation only to the bone marrow and lymph nodes (called TMLI) is safe and works as well as full-body ra…

This study tested a new way to prepare cord blood for transplant in 30 people with high-risk leukemia or myelodysplasia. The cord blood was treated with a molecule called UM171 to help it grow more stem cells. The goal was to see if this approach is safe and helps patients recove…

This study looked at whether using only ticagrelor (a blood thinner) after heart attack stenting is safe, instead of the usual two-drug combination. It included 200 adults who had a stent placed during a heart attack. The main goal was to check for serious heart problems or stent…

This study tested a procedure called EUS-guided gallbladder drainage (EGBD) as an alternative to gallbladder removal surgery for 30 adults with acute cholecystitis (gallbladder inflammation). The goal was to see if it could safely resolve symptoms like fever and pain without need…

This phase 2 trial tested a two-step stem cell transplant approach for 47 patients with high-risk blood cancers like leukemia and lymphoma. The method uses the drug cyclophosphamide to lower the chance of graft-versus-host disease (GVHD), a common complication. The goal was to se…

This study tested whether a single dose of stem cells (mesenchymal stromal cells) could help patients with severe COVID-19 lung inflammation breathe better. Twenty adults with confirmed COVID-19 and acute respiratory distress syndrome were randomly assigned to receive either the …

This completed study tested a breathing machine strategy that uses lung pressure measurements to guide settings, aiming to protect the right side of the heart in patients with acute respiratory distress syndrome (ARDS). Forty adults on ventilators for less than 72 hours were incl…

This study tested a new treatment for people who had a severe heart attack and still have weak heart pumping. Doctors took the patients' own blood stem cells, grew more of them in a special machine, and injected them into the heart. The goal was to see if this could improve heart…

This early-phase study tested a combination of two drugs, venetoclax and omacetaxine, in 6 adults with acute myeloid leukemia (AML) whose cancer had stopped responding to venetoclax-based treatments. The main goal was to find the safest dose of omacetaxine when given with venetoc…

This study tested adding lenalidomide to a standard chemotherapy regimen (EPOCH-R) in 55 people with aggressive B-cell lymphomas linked to the MYC gene. The goal was to find the best dose and see if the combination improves how long patients live without their cancer getting wors…

This early-phase trial tested a new type of stem cell transplant called a microtransplant in 25 people with myeloid blood cancers (like leukemia) who were too old or frail for a standard transplant. Unlike a regular transplant, this one used stem cells from a partially matched fa…

This study tested a single intravenous infusion of stem cells (PROCHYMAL) in 220 adults who had their first heart attack within the prior week. The goal was to see if the treatment could safely improve heart function, as measured by MRI scans at 3 months. Participants were random…

This study tested a new, simpler method called JINS for placing drug-coated stents in heart arteries. Researchers wanted to see if it could help achieve better stent placement while reducing extra radiation and complications from balloon inflation. The study involved 161 people w…

This early-phase trial tested a combination of two drugs, ibrutinib and lenalidomide, in 4 patients with myelodysplastic syndrome (MDS) who had not responded to or could not tolerate standard treatments. The main goal was to find the safest dose and identify side effects. While t…

This study compares two medicines, terlipressin and octreotide, for treating hepatorenal syndrome—a serious kidney complication of advanced liver disease. Sixty adults aged 30 to 70 will receive one of the drugs, and doctors will check kidney function after 48 hours to see which …

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This study tested whether giving oral care with maternal breast milk every 3 hours to preterm babies on breathing machines could improve outcomes. 70 infants born before 34 weeks were included. Researchers measured how long babies needed ventilation, hospital stay length, and rat…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This early-phase trial tested a cancer vaccine (CDX-1401) along with an immune booster, chemotherapy, and an immunotherapy drug in 8 people with myelodysplastic syndrome (MDS) or low-blast acute myeloid leukemia (AML). The goal was to see if the combination is safe and helps the …

This study looked at how well blinatumomab works and how safe it is in 92 adults with B-cell acute lymphoblastic leukemia that had come back or was not responding to treatment. Patients received the drug through a French compassionate use program. Researchers measured survival, r…

This study looked at 556 people with coronary artery disease to confirm that the Orsiro drug-eluting stent is safe and effective in everyday use. The stent releases sirolimus to prevent artery re-narrowing. Researchers tracked how many patients had heart-related death, heart atta…

This study tests whether a non-invasive light-based monitor, called near-infrared spectroscopy (NIRS), can detect kidney injury early in newborns with hypoxic-ischemic encephalopathy (HIE) who are undergoing cooling therapy. The monitor measures oxygen levels in the kidneys and b…

This study tests whether a software tool called AutocathFFR can accurately measure the severity of coronary artery blockages from standard 2D angiogram images, compared to the gold-standard invasive FFR measurement. The software uses machine learning to analyze images taken durin…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This study tests whether artificial intelligence can read a standard ECG to predict how much heart muscle is damaged after a heart attack. Researchers will compare AI-ECG results with MRI images, the current gold standard, in 461 patients who had a heart attack and underwent a pr…

This study is testing whether measuring a protein called copeptin in the blood, alongside the standard troponin test, can help doctors quickly rule out a heart attack in people arriving at the emergency room with chest pain. Participants with chest pain that started within the la…

This study tests whether a non-invasive ultrasound measurement called the renal resistive index (RRI) can predict if acute kidney injury (AKI) will progress to a severe stage in intensive care unit (ICU) patients. Researchers will measure RRI in 120 adults with early-stage AKI wi…

This study tests whether a furosemide stress test can predict if acute kidney injury will get worse in ICU patients. Researchers will give furosemide to 140 patients and measure urine output over 2 hours. The goal is to see if the test can identify who will need dialysis, helping…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study tests whether a quick urine measurement after a single dose of furosemide (a water pill) can predict which ICU patients with low albumin levels will develop severe acute kidney injury. Researchers will compare this test to blood biomarkers to see which is more accurate…

This study tested a new one-hour diagnostic algorithm using a protein called FABP to quickly confirm or rule out a type of heart attack called NSTEMI. It involved 20 male patients who arrived at the hospital within 4 hours of chest pain. The goal was to see if measuring FABP leve…

This pilot study tested a special microscope-like camera (endocytoscopy) to diagnose upper gut graft-versus-host disease (aGVHD) in 14 patients who had a stem cell transplant. The camera was used during a standard endoscopy to see cells in real time. The goal was to see if this t…

This study tested whether a urine test measuring two proteins (TIMP2 and IGFBP7) can tell which septic shock patients will recover normal kidney function within 72 hours. Researchers analyzed data from 77 patients in French ICUs. The goal is to help doctors decide who needs aggre…

This study explores whether ultrasound can identify the reasons some patients fail to come off a mechanical ventilator. Researchers will scan the heart, lungs, and diaphragm of adults who have been on a ventilator for at least 24 hours and have not passed a spontaneous breathing …

This study tested whether the Nephrocheck™ device can predict if early acute kidney injury will reverse within 72 hours in patients with septic shock. Researchers enrolled 184 adults in the ICU and measured the device's accuracy. The goal is to help doctors decide who might recov…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This completed early-phase study tested a new radioactive tracer called 18F-BL40 for PET/CT scans in 10 adults with certain blood cancers (like lymphoma and leukemia). The goal was to see if it safely and accurately detects tumors by targeting a receptor common in many cancers. R…

This study tested whether a special PET-CT scan using a radioactive tracer (18F-FDG) can improve diagnosis of infectious endocarditis on natural heart valves. Researchers scanned 31 adults with suspected endocarditis within 5 days of starting care. The goal was to see how well th…

This study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…

This study tested whether a special heart ultrasound (2D strain imaging) can detect early signs of heart damage caused by anthracycline chemotherapy in 100 leukemia patients. The goal is to catch problems sooner, so doctors can adjust treatment and reduce the risk of permanent he…

This study looked at whether a special light-based monitor (near-infrared spectroscopy) placed on the skin can help predict kidney injury after heart surgery. Researchers measured oxygen levels in the kidneys of 113 adults during surgery and checked if low levels were linked to l…

This completed study looked at whether certain proteins in the blood (called biomarkers) can help predict acute graft-versus-host disease (aGVHD) in 500 patients who had a stem cell transplant for blood cancers. Researchers measured levels of REG3, ST2, IL-6, IL-8, and TNF R ever…

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack a…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This early-phase study tested a new radioactive tracer called [18F]-Fludarabine for PET scans in 10 people with untreated chronic lymphocytic leukemia or diffuse large B-cell lymphoma. The goal was to see how the tracer spreads in the body and how well it highlights cancer cells.…

This study looked at whether a special ultrasound technique called fetal lung elastography can predict respiratory distress syndrome (RDS) in preterm babies. Researchers measured lung stiffness in 80 unborn babies between 24-33 weeks of pregnancy and compared those who later deve…

This study looks at whether giving L-Arginine soon after heart surgery that uses a heart-lung machine can lower the chance of acute kidney injury. It will follow over 5,000 adults in the intensive care unit after their operation. The goal is to see if this simple amino acid might…

This trial tests whether giving the steroid budesonide directly into the windpipe, together with surfactant, can prevent bronchopulmonary dysplasia — a chronic lung disease — in very preterm infants (born before 32 weeks or weighing under 1500 grams) who have respiratory distress…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study tested a drug called abatacept, given as a shot under the skin, to prevent a serious complication called graft-versus-host disease (GVHD) in 29 adults with blood cancers. Participants received a stem cell transplant from a half-matched donor. The goal was to see if aba…

This study tested whether fosfomycin, an older antibiotic, works as well as ciprofloxacin for preventing serious infections in people with blood cancers like leukemia or those receiving a stem cell transplant. 177 adults from 11 Spanish hospitals took part. The main goal was to s…

This study tested whether giving rectal indomethacin (an anti-inflammatory drug) along with extra fluids before an ERCP procedure could prevent pancreatitis, a painful complication. The trial included 60 patients who needed ERCP. The goal was to see if this simple, low-cost appro…

This study tested a 60% ethanol (alcohol) lock solution to prevent serious catheter infections in 1,460 ICU patients with acute kidney failure needing dialysis. The ethanol lock is placed inside the catheter to kill germs. The goal was to see if it reduces major catheter-related …

This study tested whether sending text message reminders to parents could increase routine vaccination rates in children aged 0-2 years. Over 1,000 families in Brooklyn, New York, whose children were behind on vaccines received texts when shots were due or coming due. The goal wa…

This study tested whether specially built houses (Star Homes) could reduce malaria, respiratory infections, and diarrhea in children under 13 in rural Tanzania. Over 1,100 children lived either in a Star Home or a traditional mud house. The Star Homes have screened windows, solar…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This early-stage trial tested a new drug called rfhSP-D in 18 premature babies born before 30 weeks. The goal was to find the safest dose that might prevent chronic lung disease, a common complication in preemies. The drug was given along with standard care to babies on breathing…

This study tested whether taking oral N-Acetyl cysteine before an ERCP procedure could prevent pancreatitis as well as the standard treatment, rectal diclofenac. Forty-six adults at risk for pancreatitis after ERCP received one of the two drugs. The goal was to see which drug bet…

This study tested whether a single dose of hydrocortisone, given within 6 hours of a traumatic event, could prevent PTSD. 201 trauma survivors from two hospitals received either hydrocortisone or a placebo. Researchers tracked their mental health for 28 weeks to see if the drug r…

This study looked at 192 children having an ERCP procedure to see which drug—rectal indomethacin or IV ketorolac—better prevents post-ERCP pancreatitis. Both are anti-inflammatory medicines given before the procedure. The goal is to find the most effective option for kids.

This study tested whether giving the acid-reducing drug pantoprazole during heart surgery could prevent acute kidney injury, a common complication. One hundred adults at moderate-to-high risk for kidney damage were randomly assigned to receive either pantoprazole or another acid …

This study tests whether low-cost virtual reality (VR) tools, like 360° video and a new VR Photoscan process, can help people with post-traumatic stress disorder (PTSD) engage more easily with trauma-focused therapy. Participants will receive standard therapy (TF-CBT) either alon…

This trial tests a new inflatable cushion called the BathMat, designed to help reposition patients lying on their stomachs (proned) in the ICU. Proning helps patients with severe breathing problems get more oxygen, but repositioning them every few hours currently requires at leas…

This study tests whether a medically supervised 12-week ketogenic diet is practical for 6 adults with PTSD in Germany. The main goal is to see if people can stick to the diet and complete the study. It is not designed to measure how well the diet works for PTSD symptoms, but it m…

This study tests an electronic program that combines mindfulness and music therapy for people undergoing stem cell transplants for blood cancers. The goal is to see if it improves quality of life and reduces symptoms like pain. About 60 adults will participate, and the program in…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have survived a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is …

This early-stage study looked at whether giving two standard chemotherapy drugs (cytarabine and daunorubicin) in a different way could be safer for the heart in adults newly diagnosed with acute myeloid leukemia (AML). Researchers used heart MRI scans to monitor for damage. The g…

This trial tests whether an intensive version of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), delivered during a hospital stay, helps children and teens aged 11–17 with PTSD after sexual abuse. Researchers compare the inpatient program to standard outpatient therapy to s…

This pilot trial tests whether a brief group therapy called EMDR-IGTP-OTS can reduce posttraumatic stress symptoms in migrants attending an adult education center in Italy. Participants receive four structured group sessions on consecutive days and are compared with a control gro…

This trial tests whether a gentle electrical stimulation of the vagus nerve through the ear (tVNS) can help athletes recover more quickly after intense training. About 121 professional athletes in sports like swimming, athletics, and gymnastics will use the device daily for 60 mi…

This trial tests whether a local anesthetic injection (ropivacaine) can keep children aged 6 to 12 awake and comfortable during upper limb surgery, avoiding general anesthesia. Children watch cartoons on a tablet for distraction while the anesthetic is given. The study aims to se…

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested two non-invasive breathing machines in 49 newborns (born at 33 weeks or later) with respiratory distress. One machine is the standard nasal CPAP, and the other is a newer device called nasal high frequency percussive ventilation. Researchers measured brain oxyge…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study tested whether giving extra oxygen through a small tube in the nose during breathing tube placement can prevent dangerous drops in oxygen levels in newborns. About 110 infants in the NICU took part. The approach is simple and could make a common emergency procedure saf…

This study tested a treatment called radial shock wave phonophoresis for people with shoulder impingement syndrome. 70 adults aged 25-40 with shoulder pain were split into two groups: one got shock wave therapy plus standard physical therapy, the other got shock waves alone. The …

This study looked at whether electroacupuncture (a type of acupuncture with mild electric pulses) can lower inflammation and help people recover after a stroke. 17 adults who had their first ischemic stroke took part. Researchers measured changes in symptoms and blood markers to …

This study looked at whether emergency gallbladder removal (laparoscopic cholecystectomy) can be performed as an outpatient procedure, meaning patients go home the same day. Researchers measured patient satisfaction using a simple scale. The study enrolled 25 adults with acute ch…

This study tested whether acupressure, a technique that applies pressure to specific points on the body, can reduce anxiety and improve vital signs like blood pressure and heart rate in people hospitalized with acute coronary syndrome (ACS). Sixty-eight adults with a first-time A…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This study tested whether a high-flow oxygen system (Optiflow) works better than a standard oxygen mask for patients with breathing failure. About 100 adults in intensive care who needed non-invasive ventilation (NIV) took part. The goal was to see if Optiflow keeps oxygen levels…

This study tested whether rivastigmine can safely reverse delirium caused by poisoning from certain drugs like clozapine or tricyclic antidepressants. 100 patients at a poison center received rivastigmine, and doctors measured their consciousness and agitation levels. The goal wa…

This study tested whether a curcumin supplement (NatureU Cheers Friends Curcumin) could reduce hangover symptoms in 12 healthy adult men. Participants took either the curcumin or a standard hangover product before drinking alcohol, then reported their hangover severity the next m…

This study tested whether giving propofol sedation during a lung exam (bronchoscopy) under noninvasive ventilation helps patients with severe breathing failure stay more comfortable and maintain oxygen levels. Forty-six adults with acute respiratory failure needing a diagnostic l…

This study looked at whether a special therapy called EMDR or antidepressant medication (SSRIs) helps people with PTSD grow and recover after trauma. 130 adults with PTSD were randomly assigned to one of the two treatments. The main goal was to see which approach leads to more pe…

This completed study tested two common PTSD treatments head-to-head: EMDR therapy (a talking therapy with eye movements) and SSRI antidepressants. Sixty adults with PTSD were randomly assigned to one treatment for six weeks. Researchers measured how many people achieved symptom r…

This study looked at whether lying face down (prone positioning) helps hospitalized COVID-19 patients who have low oxygen levels but are not candidates for breathing machines. About 596 adults took part. The goal was to see if this simple position change could lower the chance of…

This study tested a team-based approach to managing sedation in children with acute respiratory failure who need a breathing machine. The goal was to reduce the number of days on the ventilator. Over 2,400 children from multiple hospitals participated, comparing the team approach…

This study tested a personalized dose of a dye called indocyanine green (ICG) to help surgeons see bile ducts more clearly during emergency gallbladder removal. 21 patients with acute cholecystitis received a dye dose calculated from their MRI scans. The goal was to improve surgi…

This study tested a wearable device called NightWare that uses an Apple Watch to detect when a person is having a nightmare and gently vibrates to wake them just enough to stop the nightmare without fully waking them. The trial included 270 veterans and active-duty service member…

This study tested whether adding transcranial magnetic stimulation (TMS) to standard exercise can reduce fatigue, pain, and improve walking in people with postpolio syndrome. 26 adults who had polio earlier in life and now have new symptoms took part. Half got TMS plus exercise, …

This study tested a web-based program to help children aged 10-19 with chronic or recurring pancreatitis manage their abdominal pain. The program teaches cognitive behavioral skills to reduce pain and improve quality of life. 90 participants were enrolled, and the study measured …

This small study tested whether 8 sessions of brief exposure therapy combined with moderate exercise can reduce PTSD symptoms in adults. Twelve participants attended twice-weekly sessions for 4 weeks and completed questionnaires. The goal was to see if this treatment is acceptabl…

This study tested whether weekly nurse phone calls could help people with chronic lymphocytic leukemia (CLL) stick to their chemotherapy plan and reduce side effects. Sixty patients were split into two groups: one received regular care, and the other also got a weekly call to che…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This study tested whether warming the intravenous (IV) mannitol fluid before giving it to people with sudden high eye pressure can reduce pain and improve comfort. 142 adults took part, with half getting warmed mannitol and half getting standard (room temperature) mannitol. The g…

This study tested whether wearing an eye-ear sleep band, which blocks light and noise, could improve sleep quality in 100 adults admitted to a coronary care unit with acute coronary syndrome. Each patient spent one night with the band and one night with standard care, in random o…

This study looks at whether ethnic minority adolescents who have experienced racial discrimination show stronger biological stress responses when faced with subtle racism. Researchers will measure blood pressure, stress hormones, and other markers while teens take part in a simul…

This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to…

This study looks at 377 adults with severe lung failure (ARDS) who were treated with prone positioning (lying face down to help breathing). Researchers will use computer models to predict which patients are at highest risk of dying in the ICU. The goal is to help doctors make bet…

This study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…

This trial investigates whether a recruitment maneuver—a brief procedure to open collapsed lung areas—affects blood levels of sRAGE, a marker of lung cell injury, in patients with diffuse acute respiratory distress syndrome (ARDS). The study involves 24 mechanically ventilated IC…

This study tests whether gradually tilting patients with acute respiratory distress syndrome (ARDS) upright—from lying flat to a 90° seated position—improves how their lungs handle mechanical ventilation. Researchers will measure lung pressure, aeration, and oxygen levels at each…

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study aims to find out which germs cause summer diarrhea in children who visit the emergency room. Researchers will collect stool samples from children aged 0 to 16 and test them for viruses, bacteria, and parasites. The goal is to better understand the causes of these infec…

This study looks at how lung function, respiratory muscle strength, balance, and quality of life relate in Paralympic athletes. Researchers will measure breathing capacity, muscle strength, and balance in 24 athletes from sports like athletics, swimming, archery, and wheelchair b…

This trial investigates why many children with diarrhea do not receive oral rehydration salts (ORS), a simple and inexpensive treatment that can prevent most diarrhea-related deaths. Researchers will send anonymous standardized patients to private healthcare providers, posing as …

This study looks back at medical records of people who had an allogeneic stem cell transplant to see whether romiplostim helped their platelets recover faster. Platelets are blood cells that help clotting, and low counts are common after transplant. The researchers will compare p…

This study follows adults who had a severe form of acute kidney injury (AKI) during a hospital stay. Researchers will use non-invasive tests to measure body composition and kidney size, and review medication plans. Participants will also be contacted by phone at 90 days and 12 mo…

This study looks at whether the way you sleep before heart surgery is connected to problems like confusion (delirium) or kidney damage after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to find patterns that …

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This study examines a rare brain disease called anti-LGI1 encephalitis, where the immune system attacks a protein in the brain, causing memory loss, confusion, and seizures. Researchers will review medical records from 112 patients across five hospitals in Eastern China to see ho…

This study aims to improve how emergency dialysis is delivered in Alberta hospitals. Researchers will test a new care pathway in 18 intensive care units to see if it can lower costs and improve patient outcomes. About 4,500 adults and children receiving acute dialysis will take p…

This study uses a research-dedicated 3T MRI scanner to develop and optimize imaging protocols in healthy adults. Researchers aim to reduce image distortions, improve contrast and resolution, and create new sequences for functional MRI. The work will help enable future studies in …

This study looks at whether placing patients face-down (prone) to help them breathe can damage nerves in the shoulder area. Researchers will use electrical tests to check for nerve injury in adults with severe lung failure who are sedated and on a ventilator. The goal is to find …

This study analyzes data from over 3 million patients in China's Chest Pain Center registry to understand how people with acute chest pain are diagnosed and treated in real hospitals. It focuses on conditions like heart attacks, unstable angina, aortic dissection, and pulmonary e…

This study tests a data visualization tool called the Trial Enrollment Diversity Dashboard (TEDD) designed to help doctors see how diverse their clinical trial enrollments are. The goal is to overcome racial and ethnic disparities in leukemia trial participation. The study enroll…

This study developed and tested HistoMX, an automated platform that analyzes gene activity in kidney transplant biopsy samples. Researchers used over 2,400 archived biopsies from adult kidney transplant recipients to see if the platform could accurately identify different types o…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study tests whether machine learning can predict death in the intensive care unit for patients with acute hypoxemic respiratory failure (AHRF), a common cause of ICU admission. Researchers will analyze data from over 1,200 patients, using several machine learning algorithms …

This study analyzes data from over 377,000 people who had a heart attack and were prescribed blood thinners (clopidogrel, ticagrelor, or prasugrel) in Germany and the United States between 2011 and 2024. Researchers aim to describe how often each drug is used and how much it cost…

This study investigates why COVID-19 causes severe lung injury (ARDS) by looking at tiny blood vessels in the lungs. Researchers will compare 39 patients with COVID-19 ARDS to those with ARDS from other causes. They measure 'alveolar dead space' — lung areas that get air but not …

This study tests whether machine learning can predict if a patient with acute hypoxemic respiratory failure will need a breathing machine for a week or longer. Researchers analyzed data from over 1,200 ICU patients in Spain, using information from the first 48 hours to build a pr…

This pilot study looks at how common iron deficiency is in people who have recently had a heart attack. Researchers will test iron levels in up to 70 patients and review their medical records. The goal is to gather early data to plan a larger study on whether treating low iron co…

This study tests whether a tool called the HEART score can accurately predict the risk of serious heart problems in people who come to the emergency room with chest pain. The HEART score uses medical history, EKG results, age, risk factors, and a blood test to classify patients a…

This study investigates whether electrical impedance tomography (EIT) — a non-invasive imaging technique — can help doctors choose the best ventilator settings for each patient with acute respiratory distress syndrome (ARDS). Researchers will compare different methods of setting …

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This study investigates whether certain genetic differences make children with nephroblastoma (kidney cancer) or acute lymphoblastic leukemia (blood cancer) more likely to develop a serious liver condition called hepatic veno-occlusive disease (VOD) during chemotherapy. Researche…

This study uses a dye called iohexol to measure how well the kidneys are working in patients leaving the intensive care unit after acute kidney failure. The goal is to find out how many patients still have reduced kidney function even though their standard blood tests look normal…

This study tested a new breathing test to decide when to remove breathing tubes in patients with acute hypoxic respiratory failure. The test uses noninvasive ventilation to see if patients can breathe on their own earlier. Researchers hope this approach reduces time on invasive v…

This study looked at 516 patients who had surgery for a torn aorta (aortic dissection). Researchers checked if a high ankle-brachial index (a simple test of blood flow in the legs) before surgery was linked to kidney problems afterward. The goal was to see if this test could help…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study looked at 110 adults having nose surgery (septoplasty) to see if different blood pressure targets during surgery affect kidney injury. Patients were split into two groups: one with a lower blood pressure target (50-57 mmHg) and one with a higher target (58-65 mmHg). Ki…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This study looked at 287 patients with acute kidney injury caused by tubular necrosis. Researchers measured two substances in urine (PIIINP and NGAL) to see if they could predict whether kidney function would return or if chronic kidney disease would develop. The goal is to find …

This study looked back at the medical records of 57 children and young adults (under 25) who received CAR T-cell therapy for B-cell acute lymphoblastic leukemia (B-ALL). The goal was to understand how well the treatment worked and what side effects occurred, especially in those w…

This study looked at 398 adults who needed a temporary dialysis catheter, comparing those who got it in the emergency department versus those who got it in the dialysis unit. Researchers tracked infections and blood clots in the catheter for 10 days after placement. The goal is t…

This study looked at 155 critically ill patients on ventilators to see if the difference between carbon dioxide in their breath and blood could predict acute kidney injury. Researchers measured this gap over the first 24 hours in the ICU. The goal was to find a simple, early warn…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study looked at whether a narrower oxygen saturation target range helps an automated oxygen control system work better for very low birth weight infants on breathing support. Eleven babies were randomly assigned to either a 3% or a shifted 3% target range. The goal was to se…

This study looked at 583 children who had liver transplants and later developed narrowing or blockage of the liver artery. Researchers wanted to find out how common these problems are and what treatments work best. The goal is to improve care and outcomes for future patients.

This completed study from France examined whether a specific type of immune cell (innate CD8+ T cells) is linked to how quickly resistance mutations develop in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Researchers analyzed blood…

This completed study looked at whether a breathing treatment called Intrapulmonary Percussive Ventilation (IPV) can improve lung stiffness (compliance) in critically ill children who are on breathing machines. Researchers measured lung function before and after one IPV session in…

This study followed 400 intensive care patients receiving beta-lactam antibiotics to see how often these drugs cause brain-related side effects like confusion or agitation. Researchers measured antibiotic levels in the blood and checked patients' neurological status several times…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study looked at 174 adults in the intensive care unit (ICU) to find out how often acute kidney injury happens and what factors make it more likely. Researchers tracked patients who stayed in the ICU for at least 48 hours, excluding those with kidney problems at the start. Th…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This completed study looked at 170 adults who needed emergency hemodialysis for acute kidney injury. Researchers measured three blood markers (Activin A, Nostrin, and Angiopoetin-2) before dialysis to see if they could predict whether the kidneys would recover or if the patient w…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looked at 148 children with T-cell acute lymphoblastic leukemia to see if a high-tech gene test could find tiny amounts of cancer left after treatment. Researchers used next-generation sequencing to check for specific gene changes in immune cells. They then compared th…

This study tested how a new form of nalmefene (a drug that reverses opioid overdoses) behaves in the body when given as a shot or through an IV. 13 healthy adults received single doses of both the new and standard versions. The goal was to see how quickly the drug reaches the blo…

This study looked at two breathing treatments—high-flow oxygen and non-invasive ventilation—in 16 adults with sudden breathing failure from pneumonia. The goal was to see which one better opens up the lungs. The results showed no major difference in lung opening, though non-invas…

This study looked at whether the phase of a woman's menstrual cycle affects her chances of getting acute mountain sickness (AMS) when traveling to high altitude. Researchers followed 91 healthy women as they spent two days at 3600 meters (about 11,800 feet). The goal was to see i…

This study looked at 150 patients who had a heart attack 12 to 36 hours earlier. Researchers wanted to see if opening the blocked artery right away was better than waiting a few days. They used MRI scans to measure heart muscle damage and function.

This study looked at 1416 very sick adults in the ICU to see how well different stages of acute kidney injury (AKI) match the kidneys' actual ability to filter waste. Researchers used a urine test to measure kidney function and compared two common ways to diagnose AKI: one based …

This study tested whether a special heart ultrasound (speckle tracking echocardiography) can predict which patients need an implantable defibrillator (ICD) after a large heart attack. Researchers followed 200 patients for 90 days to see whose heart function stayed low enough to q…

This completed study looked at 211 people with sepsis, some of whom also had acute kidney injury. Researchers measured specific microRNAs and other markers in the blood to understand how kidney damage happens. The goal was to find new targets for diagnosis or treatment, not to te…

This study measured the peak tidal inspiratory flow (PTIF)—how fast infants breathe in—in 50 babies under 6 months old with moderate to severe viral bronchiolitis. Researchers used a spirometer to record 20 breaths per infant within 24 hours of hospital admission. The goal was to…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study tested whether a single 15-minute session of Butterfly Tapping, a self-administered EMDR technique, could change brain activity in 46 young adults with PTSD. Participants either did the tapping or sat still while their brain waves were recorded. The tapping group showe…

This completed study looked at how immune cells recover in 61 adults who received a stem cell transplant for blood cancers. Researchers measured the function of T and NK cells by testing their cytokine profiles after stimulation. The goal was to see if these measurements could he…

This study looked at 800 emergency ICU patients to see if simple checks and gut feelings from nurses and students can predict who will survive, just as well as complex scoring systems. The goal was to collect data and compare different prediction methods to find the easiest and m…

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study looked at whether neck muscle activity during sleep affects breathing recovery in 17 COVID-19 patients who were on ventilators in the ICU. Researchers used sleep tests and activity monitors to track sleep quality and breathing patterns. The goal was to understand why s…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study tested whether a mobile health app called LIVEBORN can help nurse midwives improve how they support newborns who have trouble breathing right after birth. Over 14,000 newborns and their nurses took part. The app gave either real-time guidance or a summary after the eve…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This study looked at 50 ICU patients with acute respiratory failure to see if a heart ultrasound test (measuring how the main vein collapses) could predict who would die or need a breathing tube. The goal is to help doctors give fluids more safely. It was an observational study, …

This study looked at whether giving antibiotics before a kidney drainage procedure (called percutaneous nephrostomy) prevents urinary tract infections in cancer patients whose urinary tract is blocked by a tumor. Researchers reviewed records of 320 cancer patients who had the pro…

This completed study tested whether an AI system could improve how ventilators are set for children (ages 1 month to 18 years) in the pediatric ICU with breathing problems like pneumonia or respiratory failure. Researchers compared AI-generated recommendations to the actual adjus…

This study tested a 10-item questionnaire called DEPITAC, designed for nurses to screen road traffic accident patients for post-traumatic stress disorder (PTSD) while they are still in the surgical unit. Researchers enrolled 274 hospitalized accident victims to see if the simple …

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study looked back at 621 children in Denmark who had chemotherapy for acute leukemia between 2008 and 2022. The goal was to find out how many got serious mold infections and what factors made it more likely. The results will help doctors better protect children during treatm…

This study looked at whether using a heart ultrasound probe (TEE) during low-risk coronary artery bypass surgery should be done routinely or only when needed. Researchers enrolled 40 patients and checked if it was possible to randomly assign them to one of two groups. The goal is…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This study looked at nearly 30,000 older adults (65+) having non-cardiac surgery to see if levels of homocysteine, a natural amino acid, could predict serious complications like kidney injury or death. Researchers measured homocysteine before and after surgery. The goal was to se…

This study looked at ways to improve the care, environment, and daily routines of children in the pediatric intensive care unit (PICU) to support their healing and natural sleep-wake cycles. Researchers observed 56 children aged 6 months to 18 years who were on breathing machines…

This study looked at 100 critically ill adults with severe kidney failure who were receiving continuous kidney replacement therapy. Researchers used a special ultrasound technique to check for fluid buildup in the body, which can harm organs. The goal was to see how common fluid …

This study tested whether giving a gas sedative (isoflurane) instead of standard IV drugs could reduce the energy delivered to the lungs by the breathing machine in 40 ICU patients. The goal was to see if this approach might lower the risk of lung injury. The trial was small and …

This study looked at 10 adults with moderate-to-severe ARDS who were on breathing machines. Researchers used a non-invasive imaging method (EIT) to adjust ventilator pressure settings and then checked how the heart's right side responded using ultrasound. The goal was to find the…

This study looked at 500 adults on breathing machines to see if measuring airway pressure at a specific moment (P1) versus a later moment (P2) better predicts lung damage. The goal is to find which measurement helps doctors set safer ventilator settings. No new treatment was test…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This study looked at whether certain cells and substances in the blood can help predict if a person who has had a heart attack or unstable angina will have another heart problem within a year. Researchers took blood samples from 180 patients and tracked their health for one year.…

This study looked at whether chest ultrasound can predict which premature babies (born before 34 weeks) will need surfactant—a substance that helps their immature lungs work better. Doctors currently decide based on oxygen levels, which can delay treatment. Researchers performed …

This study checks on 137 COVID-19 patients who were in the ICU and used awake prone positioning (lying on their belly) while on high-flow oxygen. Researchers want to see if this technique affects quality of life and survival more than two years later. Participants answer a phone …

This study observed 150 adults with a specific type of leukemia (Ph-negative ALL) to see how many developed serious fungal infections during their first weeks of chemotherapy. Researchers tracked infection rates and deaths linked to these infections. The goal was to better unders…

This study looked at 30 people who had a heart attack and were treated with a procedure to open blocked arteries. Researchers used a special heart scan soon after treatment to see how much heart muscle was saved. They then checked if that scan could predict how well the heart wou…

This completed study looked at 141 people with acute pancreatitis to understand how blood clotting changes during the illness. Researchers took blood samples over several days and will analyze them for markers that might predict whether the disease becomes mild, moderate, or seve…

This study looked at how a 10 km run and a 1.5 km swim affect kidney function in 40 healthy, active adults. Researchers used sensitive urine tests to detect subtle kidney changes that standard blood tests might miss. The goal was to better understand temporary kidney stress from …

This early-stage study tested the safety and tolerability of a new drug called EP395 in 78 healthy adults aged 18-65. Participants received either EP395 or a placebo capsule, and researchers monitored side effects, vital signs, and hearing. The goal was to find a safe dose range …

This study observed over 4,000 patients in Chinese ICUs who needed breathing support for acute respiratory failure. Researchers tracked treatments, outcomes, and costs to better understand the disease burden. The goal is to improve care and identify risk factors, not to test a ne…

This study looked at how well CPAP therapy works for COVID-19 patients who have trouble breathing. Researchers collected data from 250 patients in a hospital to see how they responded to treatment. The goal was to learn more about managing severe COVID-19 in real-life settings.

This study looked at 1435 patients with acute cholangitis (a bile duct infection) who had an ERCP procedure. Researchers analyzed bile samples to understand which bacteria were causing the infections and how resistant they were to antibiotics. The goal was to find patterns that c…

This study tested whether an asymmetrical high-flow nasal cannula reduces the work of breathing compared to a conventional one in 40 patients with acute respiratory failure. Participants received both devices at different flow rates, and researchers measured diaphragm and chest m…

This study looked at 174 older adults (ages 65-80) having lumbar fusion surgery to see whether using sodium acetate Ringer's solution or sodium lactate Ringer's solution during the operation better protects the kidneys. Researchers measured early kidney injury markers in urine an…

This study followed 38 children who survived acute respiratory distress syndrome (ARDS), a severe lung condition. One year after leaving the hospital, researchers checked for lasting breathing problems like cough, wheeze, and lung stiffness using scans and tests. The goal was to …

This completed study looked at 530 heart attack survivors from 25 Spanish hospitals to see if women and men differ in how well they follow prevention advice, like taking medications, eating healthy, exercising, and joining rehab programs. Researchers matched women and men by age …

This study tested a virtual reality (VR) afterschool program for 32 children ages 9-17. The goal was to see if kids would use and enjoy the VR system, and to measure their physical activity. This was a pilot study to gather information, not to treat or cure any disease.

This study collected blood, bone marrow, skin, and cheek cell samples from 650 adults with acute leukemia, myelodysplastic syndromes, or myeloproliferative disorders. Researchers analyzed the samples to find genetic, epigenetic, and drug sensitivity patterns that might predict ho…

This completed study collected blood, urine, and kidney tissue from 90 COVID-19 patients with acute kidney injury. Researchers aimed to build a biorepository and analyze samples to better understand how COVID-19 affects the kidneys. The goal is to speed up discoveries and improve…

This study looked back at 170 adults with a serious eye infection called endophthalmitis to see if early surgery (within 48 hours) helps vision more than starting with medicine alone. Researchers compared how well people could see one month after treatment. The goal is to find ou…

This study looked at the gut bacteria of 200 heart attack patients, comparing those with high blood sugar to those with normal levels. Researchers collected stool samples before treatment and again at 6 and 12 months to see if changes in gut bacteria relate to survival. The goal …

This study tested whether a miniaturized ultrasound probe placed in the esophagus could help predict outcomes in 50 patients with acute respiratory distress syndrome (ARDS). The probe measures a blood vessel collapse index that may indicate heart strain. Researchers tracked how m…

This study looked at 513 children with a severe lung condition called ARDS to find different subtypes of the disease. Researchers collected blood samples to measure proteins and gene activity. The goal was to better understand the disease and help design more targeted treatments …

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study looked at how two different breathing devices affect the lungs of extremely low birth weight babies. Researchers compared a high-flow nasal cannula to nasal CPAP in 80 stable premature infants. They measured lung function using a special imaging technique to see which …

This study looked at whether proteins in ostomy fluid (waste from the intestine) can signal rejection after an intestinal transplant. Currently, doctors must take tissue samples through a scope to check for rejection, which is invasive and not always accurate. Researchers analyze…

This study looked at a new way to set breathing machines for people with severe lung injury (ARDS). The method uses pressure measurements inside the lungs to adjust settings. Nine adults took part to see if the approach is safe and works well. The goal was to learn more, not to c…

This study tested a new device (AP003) that delivers naloxone as a nasal spray to reverse opioid overdoses. Twenty-four healthy adults received multiple doses to see how the drug moves through the body and to check for side effects. The goal was to compare the new spray with an e…

This study looked at how often acute kidney injury happens in people with liver cirrhosis, and what factors might increase the risk. Researchers at Sohag University Hospital followed 180 adult patients with cirrhosis, excluding those with pre-existing kidney disease or other majo…

This study tests whether measuring two substances in the blood—FLT3L and IL-6—during chemotherapy can help predict survival in people with acute myeloid leukemia (AML). Researchers will track 201 newly diagnosed AML patients across 25 French hospitals. The goal is to confirm that…

This study looked at 100 people who had a heart attack to see if certain inflammation markers in the blood could predict who might die or develop heart failure within 6 months. Researchers measured these markers at several time points after the attack. The goal was to better unde…

This study followed 16 people who had already received a special immune cell treatment (CLBR001 CAR-T) for various types of B-cell blood cancers like lymphoma and leukemia. The goal was to check for any new or long-term side effects that might appear months or years after treatme…

This completed study tested blood samples from 878 people in Limousin, France, for antibodies against tick-borne encephalitis virus (TBEV). The goal was to see if the virus is present in the region, especially in patients with Lyme disease or neurological symptoms. Researchers al…

This study tested a predictive analytics tool called PROVIDENT to forecast where overdose deaths might happen next. Researchers randomly assigned 39 Rhode Island municipalities to either use the tool or continue with standard prevention efforts. The goal was to see if directing r…

This completed study looked at whether levels of a protein called angiotensinogen in blood and urine can predict long-term kidney function in people who had acute kidney injury. Researchers followed 80 patients for three years to see if this biomarker could help identify those at…

This study looked at 264 patients who had a heart attack complicated by cardiogenic shock. Researchers examined whether the ratio of red blood cell distribution width to albumin (RAR) in the blood could predict major heart problems like death, another heart attack, or stroke duri…

This study looked at whether a telehealth program could help paramedics treat people having a severe heart attack (STEMI) more quickly. Researchers measured times from first contact to treatment in 11 patients in Wilkes County. The goal was to see if remote support from doctors c…

This completed trial compared two ways to start CPR in a simulated child cardiac arrest: starting with chest compressions (AHA method) versus starting with rescue breaths (ERC method). Researchers used a manikin to measure how much air reached the lungs in the first minute. 28 he…

This study reviewed medical records of over 640,000 people in the US who had acute respiratory distress syndrome (ARDS) and were in the ICU. Researchers wanted to find out what new health problems—physical, mental, or emotional—arise after such a stay, known as post-intensive car…

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This study tested a new breathing machine mode called NAVA in 15 patients recovering from acute lung injury. The goal was to see how their bodies responded to different levels of support from the machine. The study did not aim to treat or cure the lung injury, but to gather infor…

This study tested whether giving high-flow oxygen through the nose just before removing a breathing tube is safe and acceptable for patients in intensive care with severe breathing problems. Only 2 patients took part, and the main goal was to see if a larger study is possible. Th…

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This completed study looked at whether a protein called vasorin in the blood can help predict how severe kidney injury will be in people with septic shock. Researchers took blood samples from 50 intensive care patients on day 0 and day 3. The goal was to see if vasorin levels are…

This study looked at how well hospitals follow the standard protocol for giving heparin, a blood thinner, to patients with blood clots or heart issues. Researchers checked 100 patients to see if their heparin doses were adjusted correctly based on blood test results. The goal was…

This study looked at over 5,000 critically ill children from hospitals worldwide to learn more about acute kidney injury (AKI). The goal was to better understand how common AKI is, what puts children at risk, and how to predict it using a tool called 'renal angina.' The study did…

This study measured the amount of xylazine—a dangerous animal sedative often mixed with opioids—in the blood and urine of 75 emergency room patients who had a non-fatal opioid overdose. The goal was to see how common xylazine is and how well test strips can detect it. The finding…

This completed study reviewed medical records of 50 obese adults with HSV encephalitis (a brain infection) to see how different ways of calculating acyclovir dose affect survival. Researchers looked at patients treated between 2013 and 2019 at six hospitals. The goal was to find …

This study looked at whether a blood test measuring suPAR levels can predict which adults hospitalized with COVID-19 will develop severe breathing failure requiring a breathing tube. Researchers analyzed stored blood samples from about 367 patients. The goal was to see if a suPAR…

This study followed 100 patients who had infectious endocarditis, a serious heart infection, to see how brain lesions found on MRI scans change over time. Researchers compared initial MRI results with follow-up scans and tested thinking and memory skills. The goal was to understa…

This study combined data from over 5,000 people to see if a simple blood test (troponin) and risk scores used by paramedics can accurately identify those having a heart attack before they reach the hospital. The goal is to improve how patients are triaged and treated early. No ne…

This study tested a new device called Neola® that monitors the lungs of newborn babies. Ten preterm and term infants were enrolled to see if the device is safe and works well. The main goal was to check for any skin reactions or other side effects.

This completed study tracked 832 heart attack patients in China who developed new-onset atrial fibrillation during their hospital stay. Researchers used continuous heart monitoring to see how the amount of AFib affected risks like death, another heart attack, or heart failure. Th…

This study tracked how much older adults (65+) move during a hospital stay and tested whether a screen showing real-time activity to staff could encourage more movement. Researchers also validated a Danish version of a mobility assessment. The goal is to help hospitals better sup…

This study looked at 100 people who recently had a major heart attack to better understand blood clots that can form in the heart's main pumping chamber. Using special PET/MR scans, researchers tracked clot activity in the heart and brain over several months. The goal was to lear…

This study tested whether a combined breathing muscle training program is safe and practical for adult ICU patients who are on or recently off a ventilator. Twenty-two patients received the training alongside usual care. The main goal was to see if patients could stick with the p…

This study looked at 43 critically ill adults with acute kidney injury who needed continuous kidney replacement therapy (CRRT). Researchers measured how much of certain nutrients—like carnitine, vitamins, and amino acids—were removed during dialysis. The goal was to understand if…

This study reviewed medical records of 139 people with advanced chronic kidney disease who had a heart attack. Researchers wanted to see if getting a coronary angiogram (a special X-ray of the heart arteries) soon after the heart attack was linked to living longer and needing dia…

This study looks at whether heparin or citrate locks used in dialysis catheters leak into the bloodstream. It involves 76 adults with acute kidney failure. Researchers measure blood clotting and calcium levels before and after injecting the lock to check for leakage and potential…

This study looked at how changing the speed at which a ventilator reaches its target pressure affects breathing in 17 newborns on breathing support. The researchers tested different settings and measured changes in airway pressure and gas exchange. The goal was to find out if thi…

This completed study looked at 250 adults who had a severe type of heart attack (STEMI) treated with a stent. Researchers used portable heart monitors to check how often dangerous heart rhythms occurred in people whose heart attack involved bleeding. The goal was to better unders…

This completed study looked at over 6,000 heart attack patients to see how different antiplatelet medications affect the risk of bleeding inside the heart. Researchers compared outcomes like heart-related events, bleeding complications, and death within 30 days. The goal is to he…

This study measured certain proteins in the blood and urine of 20 newly diagnosed multiple myeloma patients before and 30 days after starting daratumumab. The goal was to see if these markers could help detect early kidney injury. Participants provided samples during routine lab …

This study followed over 1,000 people who had a heart attack and were given a quick-acting intravenous blood thinner called cangrelor during a procedure to open blocked arteries. Researchers wanted to see how often bleeding occurred when patients then switched to a different oral…