PET scans may reveal hidden leukemia spots before CAR t treatment
NCT ID NCT05969002
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 7 times
Summary
This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to see how common these hidden spots are and whether they affect treatment success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 18F-FDG PET-CT imaging
- What this could lead to
- If successful, this imaging approach could help doctors better detect hidden leukemia before CAR T-cell therapy, potentially improving treatment outcomes.
- What could go wrong
- This is a very small pilot study with only 10 participants, so results may not apply to all patients. The imaging is for observation only and does not directly treat the disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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