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Eye infection study: does early surgery save sight better than drugs?

NCT ID NCT07514845

Knowledge-focused Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked back at 170 adults with a serious eye infection called endophthalmitis to see if early surgery (within 48 hours) helps vision more than starting with medicine alone. Researchers compared how well people could see one month after treatment. The goal is to find out which approach works best and what factors affect recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

170 people

The number who actually took part.

Started

Jan 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This retrospective cohort includes adult patients diagnosed with acute endophthalmitis and managed at two referral centers (University Hospital of Brest and Pasteur Clinic, France) between January 2014 and December 2024. Patients were identified using International Classification of Diseases, 10th Revision (ICD-10) codes and included a broad spectrum of etiologies (postoperative, post-intravitreal injection, traumatic, bleb-related, and endogenous endophthalmitis), reflecting real-world clinical practice.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Clinically diagnosed acute endophthalmitis * Onset within 6 weeks following intraocular procedure (cataract surgery, intravitreal injection, anterior or posterior segment surgery) * Endophthalmitis associated with trauma, infectious keratitis, bleb-related infection, or endogenous infection * Availability of clinical data including visual acuity and treatment information Exclusion Criteria: * Age \< 18 years * Chronic endophthalmitis (\> 6 weeks after procedure) * Non-infectious conditions (e.g., toxic anterior segment syndrome, postoperative inflammatory reaction) * Documented refusal or opposition to use of clinical data * Insufficient clinical data, particularly missing visual acuity or treatment informationcuity or treatment information

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Conditions

The condition(s) this trial relates to.

acute endophthalmitis endophthalmitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endophthalmitis

Contacts and locations

Locations

  • Chu Brest

    Brest, 29200, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.