Massive trial tests antibiotic jab to stop blinding infection after cataract surgery

NCT ID NCT03244072

Not yet recruiting Prevention Sponsor: Jason Ahee, M.D. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test whether a single antibiotic injection given during cataract surgery can prevent endophthalmitis, a rare but severe eye infection. About 60,000 people with cataracts will receive either the antibiotic or a placebo. The goal is to see if the antibiotic reduces the number of infections after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: moxifloxacin (antibiotic eye injection)
What this could lead to: If it works, this could become a standard way to prevent a rare but serious eye infection after cataract surgery.
What could go wrong: This is a large but still early-phase trial. The infection is already rare, so proving a benefit is challenging, and there is a small risk of allergic reaction or injection-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cataract endophthalmitis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOPHTHALMITIS

Contacts and locations

Locations

Zion Eye Institute

St. George, Utah, 84790, United States

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