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Can a pill tame a common blood cancer in the real world?

NCT ID NCT03415035

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study follows about 269 people with chronic lymphocytic leukemia (CLL) who are starting venetoclax, a targeted pill. Researchers will track how well the drug shrinks or controls the cancer over the first year, and how long it takes before patients need another treatment. The goal is to see if venetoclax works as well in routine medical care as it did in earlier clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
venetoclax
What this could lead to
If successful, this study could confirm that venetoclax works well outside of clinical trials, helping doctors better understand its real-world benefits for CLL patients.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by patient selection or other treatments. It does not test a new drug or compare venetoclax to other options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

269 people

The number who actually took part.

Started

Mar 2018

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients starting venetoclax treatment for CLL.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants with diagnosed Chronic Lymphocytic Leukemia (CLL) and eligible for venetoclax as per label. * Participants for whom the physician has decided to initiate CLL treatment with venetoclax. * Participants the physician believes he can personally follow over all the study period. * Participants who have been informed verbally and in writing about this study, and who do not object to their data being electronically processed or subjected to data quality control. Exclusion Criteria: \- Participating in a clinical trial with an investigative drug for CLL within 30 days prior to treatment initiation.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer - chronic lymphocytic leukemia

Contacts and locations

Locations

  • AP-HP - Hopital Bicetre /ID# 170747

    Le Kremlin-Bicêtre, Paris, 94270, France

  • CH Annecy Genevois - Site Annecy /ID# 200826

    Epagny Metz Tessy, 74370, France

  • CH Bretagne Atlantique /ID# 200191

    Vannes, Morbihan, 56017, France

  • CH CARCASSONNE - Antoine Gayraud /ID# 202530

    Carcassonne, Aude, 11000, France

  • CH Cannes - les Broussailles /ID# 201108

    Cannes, Alpes-Maritimes, 06414, France

  • CH Libourne - Hopital Robert Boulin /ID# 170739

    Libourne, 33500, France

  • CH Mont de MARSAN /ID# 169955

    Mont-de-Marsan, 40024, France

  • CH Princesse Grace /ID# 200196

    Monaco, 98000, France

  • CH Périgueux /ID# 169458

    Périgueux, 24019, France

  • CH Roubaix - Hopital Victor Provo /ID# 170909

    Roubaix, Hauts-de-France, 59100, France

  • CH Saint-Brieuc /ID# 171076

    Saint-Brieuc, 22000, France

  • CH Victor Dupouy /ID# 169946

    Argenteuil, 95100, France

  • CH William Morey /ID# 169939

    Chalon-sur-Saône, 71321, France

  • CH de Saint-Malo - Hôpital Broussais /ID# 169935

    St-Malo, Ille-et-Vilaine, 35400, France

  • CH de la Haute-Saône - Vesoul /ID# 205150

    Vesoul, Bourgogne-Franche-Comté, 70014, France

  • CHI POISSY - Saint-Germain-en-Laye /ID# 169966

    Saint-Germain-en-Laye, Yvelines, 78100, France

  • CHR Metz-Thionville - Hopital Bel-Air /ID# 170722

    Thionville, Moselle, 57100, France

  • CHRU Tours - Hopital Bretonneau /ID# 169469

    Tours, Indre-et-Loire, 37044, France

  • CHRU de Brest - Hopital Morvan /ID# 169457

    Brest, 29200, France

  • CHU Amiens-Picardie Site Sud /ID# 170724

    Amiens, Somme, 80054, France

  • CHU Clermont-Ferrand /ID# 170736

    Clermont, Auvergne-Rhône-Alpes, 63100, France

  • CHU Grenoble - Hopital Michallon /ID# 170741

    La Tronche, Isere, 38700, France

  • CHU Limoges - Dupuytren 1 /ID# 200193

    Limoges, Franche-Comte, 87042, France

  • CHU Montpellier - Hopital Saint Eloi /ID# 200192

    Montpellier, Herault, 34295, France

  • CHU Poitiers - La miletrie /ID# 169470

    Poitiers, Vienne, 86000, France

  • CHU Reims - Hôpital Robert Debre /ID# 170917

    Reims, Marne, 51092, France

  • CHU de CAEN - Hopital de la Cote de Nacre /ID# 169941

    Caen, Calvados, 14033, France

  • CHU de RENNES /ID# 169944

    Rennes, Brittany Region, 35033, France

  • Centre De Lutte Contre Le Cancer - Centre Henri Becquerel Normandie Rouen /ID# 169948

    Rouen, Seine-Maritime, 76038, France

  • Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz /ID# 170721

    Besançon, Doubs, 25000, France

  • Centre Hospitalier Regional Universitaire de Nancy - Hopitaux de Brabois /ID# 170855

    Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511, France

  • Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 169453

    Orléans, 45067, France

  • Centre Hospitalier de CHOLET /ID# 171215

    Cholet, 49300, France

  • Centre Hospitalier de Cornouaille /ID# 169937

    Quimper, Finistere, 29000, France

  • Centre Hospitalier de Perpignan /ID# 170743

    Perpignan, 66000, France

  • Centre Hospitalier de Versailles André Mignot /ID# 169950

    Le Chesnay, 78150, France

  • Centre Hospitalier de la Cote Basque /ID# 170735

    Bayonne, Pyrenees-Atlantiques, 64100, France

  • Centre Hospitalier du Mans /ID# 169451

    Le Mans, Sarthe, 72037, France

  • Centre Joseph BELOT /ID# 170853

    Désertines, 03030, France

  • Centre Leon Berard /ID# 170018

    Lyon, Rhone, 69373, France

  • Ch Agen /Id# 170742

    Agen, 47923, France

  • Ch Blois /Id# 170727

    Blois, 41016, France

  • Ch Mulhouse /Id# 170726

    Mulhouse, 68100, France

  • Clinique Pole santé République /ID# 204658

    Clermont-Ferrand, Auvergne, 63050, France

  • Clinique Victor Hugo /ID# 169973

    Le Mans, Sarthe, 72000, France

  • Clinique de la Sauvegarde /ID# 169904

    Lyon, 69009, France

  • Hopital Avicenne - APHP /ID# 169940

    Bobigny, Île-de-France Region, 93000, France

  • Hopital Nord Franche Comté /ID# 170744

    Trévenans, 90400, France

  • Hopital Pitie Salpetriere /ID# 169974

    Paris, Île-de-France Region, 75013, France

  • Hopital Prive Sevigne /Id# 170718

    Cesson-Sévigné, 35510, France

  • Hopital Saint Vincent de Paul /ID# 169956

    Lille, 59020, France

  • Hopital Saint-Louis /ID# 170856

    Paris, 75010, France

  • Hopital d'Instruction des Armées PERCY /ID# 170740

    Clamart, 92141, France

  • Hopital de Melun /ID# 202569

    Melun, Seine-et-Marne, 77011, France

  • Hopital de la Conception /ID# 201981

    Marseille, Provence-Alpes-Côte d'Azur Region, 13005, France

  • IUCT Oncopole /ID# 170749

    Toulouse, Occitanie, 31059, France

  • Institut Bergonie /ID# 170746

    Bordeaux, Gironde, 33000, France

  • Institut Gustave Roussy /ID# 202436

    Villejuif, Val-de-Marne, 94805, France

  • Medipole de Savoie /ID# 169454

    Challes-les-Eaux, 73190, France

  • Polyclinique le LANGUEDOC /ID# 169925

    Narbonne, 11100, France

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