Engineered donor cells take aim at returning blood cancers

NCT ID NCT01087294

First seen Nov 01, 2025 · Last updated May 10, 2026 · Updated 23 times

Summary

This study tested a new treatment for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took immune cells from the original donor, modified them to better recognize and attack cancer cells, and gave them to 85 patients. The goal was to see if this approach is safe and can help control the cancer, though it is not expected to be a cure and may require ongoing management.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • National Marrow Donor Program

    Minneapolis, Minnesota, 55401, United States

Conditions

Explore the condition pages connected to this study.