Engineered donor cells take aim at returning blood cancers

NCT ID NCT01087294

Completed Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and gave them back to the patient. The main goal was to check safety, with 85 participants enrolled, and the treatment required a hospital stay and long-term follow-up.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm Hodgkins lymphoma Leukemia, B-Cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA, B-CELL LYMPHOMA, B-CELL LYMPHOMA, HODGKINS LYMPHOMA, NON-HODGKINS

Contacts and locations

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Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States
National Marrow Donor Program

Minneapolis, Minnesota, 55401, United States