New radiation technique aims to make stem cell transplants safer for leukemia patients

This study tested a new way to give radiation before a stem cell transplant for people aged 16 to 45 with acute lymphoblastic leukemia (ALL). The goal was to see if targeting radiation only to the bone marrow and lymph nodes (called TMLI) is safe and works as well as full-body radiation, but with fewer side effects. The study included 14 patients with ALL in first remission or relapse who had a suitable donor. Results focused on early death rates, serious side effects, and disease control after transplant.