Trauma pill: One-Time hormone dose may stop PTSD before it starts

NCT ID NCT04924166

First seen Mar 19, 2026 · Last updated May 04, 2026 · Updated 7 times

Summary

This study tested whether giving a single dose of hydrocortisone (a stress hormone) within six hours of a traumatic event could help prevent post-traumatic stress disorder (PTSD). 201 adults who came to the emergency room after trauma and showed high distress were randomly given either hydrocortisone or a placebo. Researchers tracked their mental health for 28 weeks to see if the drug reduced PTSD symptoms and boosted recovery.

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Contacts and locations

Locations

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Mount Sinai Morningside Emergency Department

    New York, New York, 10025, United States

  • The Chaim Sheba Medical Center

    Ramat Gan, Israel

Conditions

Explore the condition pages connected to this study.