One pill to prevent PTSD? hydrocortisone shows promise after trauma
NCT ID NCT04924166
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a single dose of hydrocortisone, given within 6 hours of a traumatic event, could prevent PTSD. 201 trauma survivors from two hospitals received either hydrocortisone or a placebo. Researchers tracked their mental health for 28 weeks to see if the drug reduced PTSD symptoms and boosted recovery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hydrocortisone
What this could lead to
If it works, this could provide a simple, one-time treatment to prevent PTSD after a traumatic event.
What could go wrong
This is a Phase 2 trial with 201 participants, so results are still early. The effect may be small or not apply to everyone, and side effects from a single high dose of hydrocortisone are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Mount Sinai Morningside Emergency Department
New York, New York, 10025, United States
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The Chaim Sheba Medical Center
Ramat Gan, Israel