Blood test may spot deadly transplant complication earlier
NCT ID NCT04284904
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at whether certain proteins in the blood (called biomarkers) can help predict acute graft-versus-host disease (aGVHD) in 500 patients who had a stem cell transplant for blood cancers. Researchers measured levels of REG3, ST2, IL-6, IL-8, and TNF R every two weeks for three months after transplant. The goal was to see if changes in these markers could signal aGVHD before symptoms appear, which might allow earlier treatment and better outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- aGVHD biomarker monitoring (blood tests for REG3, ST2, IL-6, IL-8, TNF R)
- What this could lead to
- If successful, this could lead to a simple blood test that helps doctors predict and catch aGVHD earlier, potentially improving treatment and survival for stem cell transplant patients.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly change patient care. The markers may not prove reliable enough for routine use, and results may not apply to all transplant patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chinese PLA General Hospital
Beijing, Beijing Municipality, 100853, China
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