Can genes predict liver damage from childhood cancer drugs?

NCT ID NCT04168788

Completed Knowledge-focused Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study investigates whether certain genetic differences make children with nephroblastoma (kidney cancer) or acute lymphoblastic leukemia (blood cancer) more likely to develop a serious liver condition called hepatic veno-occlusive disease (VOD) during chemotherapy. Researchers will analyze blood samples from 85 children treated in France between 2000 and 2018 to look for genetic markers linked to this toxicity. The goal is to better understand why some children experience this severe side effect, which can interrupt treatment and be life-threatening.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If genetic markers are found, doctors could identify children at higher risk for liver damage and adjust their cancer treatment to avoid it.
What could go wrong: This is an observational study that looks back at past cases, so it cannot prove cause and effect. The results may not apply to all children or treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia hepatic veno-occlusive disease Precursor Cell Lymphoblastic Leukemia-Lymphoma Wilms tumor Wilms tumor 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA HEPATIC VENO-OCCLUSIVE DISEASE NEPHROBLASTOMA

Contacts and locations

Locations

Centre Oscar Lambret

Lille, 59020, France
Hôpital La Timone

Marseille, 13385, France
Hôpital Trousseau

Paris, 75571, France
University Hospital of Bordeaux

Bordeaux, 33000, France
University Hospital of La Réunion

Saint-Denis, 97400, France
University Hospital of Nice

Nice, 06200, France
University Hospital of Poitiers

Poitiers, 86000, France
University Hospital of Rennes

Rennes, 35203, France
University Hospital of Tours

Tours, 37044, France
University of Brest

Brest, 29609, France
Univesity Hostipal of Amiens

Amiens, 80054, France

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