Can genes predict liver damage from childhood cancer drugs?
NCT ID NCT04168788
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This study investigates whether certain genetic differences make children with nephroblastoma (kidney cancer) or acute lymphoblastic leukemia (blood cancer) more likely to develop a serious liver condition called hepatic veno-occlusive disease (VOD) during chemotherapy. Researchers will analyze blood samples from 85 children treated in France between 2000 and 2018 to look for genetic markers linked to this toxicity. The goal is to better understand why some children experience this severe side effect, which can interrupt treatment and be life-threatening.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If genetic markers are found, doctors could identify children at higher risk for liver damage and adjust their cancer treatment to avoid it.
What could go wrong
This is an observational study that looks back at past cases, so it cannot prove cause and effect. The results may not apply to all children or treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Centre Oscar Lambret
Lille, 59020, France
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Hôpital La Timone
Marseille, 13385, France
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Hôpital Trousseau
Paris, 75571, France
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University Hospital of Bordeaux
Bordeaux, 33000, France
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University Hospital of La Réunion
Saint-Denis, 97400, France
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University Hospital of Nice
Nice, 06200, France
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University Hospital of Poitiers
Poitiers, 86000, France
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University Hospital of Rennes
Rennes, 35203, France
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University Hospital of Tours
Tours, 37044, France
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University of Brest
Brest, 29609, France
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Univesity Hostipal of Amiens
Amiens, 80054, France