Antibiotics may not be needed for mild diverticulitis, new US trial suggests
NCT ID NCT07625267
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tests whether people with mild diverticulitis can be safely treated at home with just pain medicines (ibuprofen and acetaminophen) instead of antibiotics. 556 participants will be randomly assigned to receive either pain medicines alone or pain medicines plus an antibiotic for 7 days. The study will compare hospital admission rates and other complications between the two groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ibuprofen and acetaminophen
- What this could lead to
- If this trial succeeds, it could show that many people with mild diverticulitis can avoid antibiotics and still recover safely at home.
- What could go wrong
- This is a Phase 4 trial, but it has not yet started recruiting. The results may not apply to everyone, and some people might still need antibiotics if symptoms worsen.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Montefiore Medical Center
The Bronx, New York, 10467, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.