Diverticulitis of colon

This study is testing a new surgical stapler, called the Signia circular stapler, in people having left-sided colon, sigmoid, or rectal surgery. The goal is to see if it lowers the chance of a leak where the colon is reconnected. About 137 adults will take part, and the main focu…

This study looks at whether having surgery soon after a severe diverticulitis attack (within 7-10 days) leads to better quality of life than waiting 6-8 weeks. About 136 patients with complicated or recurrent diverticulitis will be randomly assigned to one of the two timing group…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study is comparing two approaches for people with recurrent, uncomplicated diverticulitis: elective surgery to remove part of the colon versus conservative (non-surgical) management. The goal is to see which approach leads to better bowel function and quality of life. Resear…

This study follows 250 people with chronic diverticular disease to see if elective sigmoidectomy (surgery) improves quality of life compared to conservative care (diet, pain relievers, laxatives). Participants are recruited from a surgical clinic in Denmark. The main outcomes are…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…