New drug combo takes aim at High-Risk leukemia
NCT ID NCT03734198
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 pilot study is testing whether combining two drugs, ibrutinib and daratumumab, can improve outcomes for people with relapsed or refractory chronic lymphocytic leukemia (CLL) that has a p53 gene problem. The 29 participants will take ibrutinib daily and receive daratumumab infusions on a schedule. The main goal is to see how many achieve a complete response within 12 months, while also monitoring safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ibrutinib and daratumumab
- What this could lead to
- If successful, this combination could offer a more effective treatment option for people with hard-to-treat CLL that has not responded to prior therapies.
- What could go wrong
- This is a small, early-phase pilot study with only 29 participants. The combination may not prove more effective than existing treatments and could cause side effects like infusion reactions or infections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CH Annecy Genevois - Hématologie A3
Annecy, 74374, France
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CHD Vendée
La Roche-sur-Yon, 85925, France
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CHLS - Lyon Pierre Bénite - Service Hématologie
Lyon, 69495, France
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CHU Bordeaux - Hôpital Haut-Lévèque - CFM Maladies du sang
Pessac, 33604, France
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CHU Caen - IHBN - Hématologie Clinique
Caen, 14033, France
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CHU Estaing - Hématologie Clinique Adulte
Clermont-Ferrand, 63000, France
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CHU Grenoble - Hématologie
Grenoble, 388043, France
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CHU Hôtel Dieu - Hématologie Clinique
Nantes, 44093, France
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CHU Jean Minjoz - Hématologie
Besançon, 25000, France
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CHU Pontchaillou - Hématologie Clinique BMT-HC
Rennes, 35033, France
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Centre Henri Becquerel - Service Hématologie Clinique
Rouen, 76038, France
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Centre Hospitalier du Mans
Le Mans, 72000, France
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Centre Léon Bérard - Hématologie
Lyon, 69373, France
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Chu Amiens Sud
Amiens, 80054, France
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Hôpital Avicenne - Centre de Recherche Clinique
Bobigny, 93009, France
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Hôpital Bretonneau - Hématologie et Thérapie Cellulaire
Tours, 37044, France
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Hôpital Pitié Salpétrière - Hématologie
Paris, 75651, France
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Hôpital Robert Debré - Hématologie Clinique
Reims, 51092, France
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Hôpital Saint-Eloi - Hématologie Clinique
Montpellier, 34295, France
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Hôpital de la Milétrie - Hématologie et Thérapie Cellulaire
Poitiers, 86021, France
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Hôpitaux de Brabois - Hématologie Adulte
Vandœuvre-lès-Nancy, 54511, France
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ICANS
Strasbourg, 67098, France
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IUCT ONCOPOLE - Hématologie
Toulouse, 31059, France
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Institut Paoli-Calmettes - Hématologie Clinique
Marseille, 13273, France
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