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Italian study tracks how venetoclax works for CLL patients in everyday practice

NCT ID NCT04282811

Ongoing Knowledge-focused Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study follows 321 Italian patients with relapsed or refractory chronic lymphocytic leukemia (CLL) who are treated with venetoclax-based regimens outside of clinical trials. The goal is to describe their clinical features and outcomes, such as how long they live without the disease worsening. By collecting real-world data from March 2016 to June 2025, researchers hope to better understand the effectiveness and safety of venetoclax in routine care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Venetoclax
What this could lead to
If successful, this study could provide real-world evidence on how well venetoclax works for CLL patients outside of clinical trials, potentially guiding better treatment decisions.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by patient selection and other factors. It does not test a new treatment but observes existing ones.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia leukemia refractory hematologic cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA REFRACTORY LEUKEMIA RELAPSE LEUKEMIA

Contacts and locations

Locations

  • Ao Brotzu, Presidio Ospedaliero A. Businco - Cagliari - Sc Ematologia E Ctmo

    Cagliari, Italy

  • Ao Di Catanzaro "Pugliese-Ciaccio", Presidio Ospedaliero "Ciaccio - de Lellis" - Ematologia

    Catanzaro, Italy

  • Ao Di Cosenza, Presidio Ospedaliero Annunziata - Uoc Ematologia

    Cosenza, Italy

  • Ao Di Perugia, Ospedale S. Maria Della Misericordia - Ematologia E Trapianto Midollo Osseo

    Perugia, Italy

  • Ao Ospedali Riuniti "Papardo Piemonte" - Po Papardo - Messina - Sc Ematologia

    Messina, Italy

  • Ao Ospedali Riuniti Villa Sofia Cervello - Palermo - Uo Ematologia Con Utmo

    Palermo, Italy

  • Ao S. Maria - Terni - Sc Onco Ematologia

    Terni, Italy

  • Aon Ss. Antonio E Biagio E C. Arrigo - Alessandria - Soc Ematologia

    Alessandria, Italy

  • Aou Arcispedale Sant'Anna - Cona (Fe) - Uoc Ematologia E Fisiopatologia Della Coagulazione

    Cona, Ferrara, Italy

  • Aou Careggi - Firenze - Sod Ematologia

    Florence, Italy

  • Aou Città Della Salute E Della Scienza, Ospedale S. Giovanni Battista Molinette - Torino - Sc Ematologia - Università Degli Studi Di Torino

    Torino, Italy

  • Aou Città Della Salute E Della Scienza, Ospedale S. Giovanni Battista Molinette - Torino - Sc Ematologia 2

    Torino, Italy

  • Aou Consorziale Policlinico - Bari - Uo Ematologia Con Trapianto

    Bari, Italy

  • Aou Di Modena - Sc Ematologia

    Modena, Italy

  • Aou Integrata Di Verona, Policlinico G.B. Rossi - Uoc Ematologia

    Verona, Italy

  • Aou Maggiore Della Carita' Di Novara - Scdu Ematologia

    Novara, Italy

  • Aou Pisana - Uo Ematologia Universitaria

    Pisa, Italy

  • Asst Dei Sette Laghi, Ospedale Di Circolo E Fondazione Macchi - Uoc Ematologia

    Varese, Italy

  • Asst Grande Ospedale Metropolitano Niguarda - Milano - Sc Ematologia

    Milan, Italy

  • Ausl Della Romagna, Ospedale "Santa Maria Delle Croci" - Ravenna - Ematologia

    Ravenna, Italy

  • Ausl Di Reggio Emilia - Arcispedale Santa Maria Nuova, Irccs - Sc Ematologia

    Reggio Emilia, Italy

  • Ctc U.O Di Ematologia Con Trapianto Di Midollo Osseo - Catania

    Catania, Italy

  • Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico - Milano - Ematologia - Padiglione Marcora

    Milan, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli Irccs - Roma - Area Ematologica

    Roma, Italy

  • Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli" Po E. Morelli - Reggio Calabria - Uoc Ematologia

    Reggio Calabria, Italy

  • Irccs Ospedale S. Raffaele - Milano - Unità Neoplasie Linfocitarie B

    Milan, Italy

  • Università Degli Studi Di Roma "Sapienza" - Dipartimento Di Medicina Traslazionale E Di Precisione - U.O.C. Ematologia

    Roma, Italy

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