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New cell therapy aims to wipe out stubborn leukemia in kids

NCT ID NCT03876769

Ongoing Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 28 times

Summary

This study tests a treatment called tisagenlecleucel (a type of CAR-T cell therapy) in children and young adults aged 1 to 25 with high-risk B-cell acute lymphoblastic leukemia. Participants have cancer cells still present after initial chemotherapy. The treatment uses the patient's own immune cells, modified to attack the leukemia. The goal is to see if this therapy can keep the cancer away without needing a stem cell transplant.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Children s Hospital of Alabama

    Birmingham, Alabama, 35233, United States

  • Children s Mercy Hospital

    Kansas City, Missouri, 64108, United States

  • Childrens Healthcare of Atlanta

    Atlanta, Georgia, 30342, United States

  • Childrens Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Childrens Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Childrens Hospital of Orange County

    Orange, California, 92868-3874, United States

  • Childrens Hospital of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Childrens National Hospital

    Washington D.C., District of Columbia, 20010, United States

  • Cinn Children Hosp Medical Center

    Cincinnati, Ohio, 45229-3039, United States

  • City of Hope National Medical

    Duarte, California, 91010, United States

  • Columbia University Medical Center

    New York, New York, 110032, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Hackensack Uni Medical Center

    Hackensack, New Jersey, 07601, United States

  • Indiana University

    Indianapolis, Indiana, 46202-5225, United States

  • Johns Hopkins All Childrens

    St. Petersburg, Florida, 33701, United States

  • Johns Hopkins Oncology Center

    Baltimore, Maryland, 21231, United States

  • Mattel Childrens Hospital UCLA

    Los Angeles, California, 90095, United States

  • Memorial Sloan Kettering Cancer Ctr

    New York, New York, 10065, United States

  • Methodist Childrens Hospital

    San Antonio, Texas, 78229, United States

  • Novartis Investigative Site

    Ghent, 9000, Belgium

  • Novartis Investigative Site

    Calgary, Alberta, T3B 6A8, Canada

  • Novartis Investigative Site

    Toronto, Ontario, M5G 1X8, Canada

  • Novartis Investigative Site

    Montreal, Quebec, H3T 1C5, Canada

  • Novartis Investigative Site

    Copenhagen, DK-2100, Denmark

  • Novartis Investigative Site

    Paris, 75019, France

  • Novartis Investigative Site

    Roma, RM, 00165, Italy

  • Novartis Investigative Site

    Utrecht, 3584 CS, Netherlands

  • Novartis Investigative Site

    Oslo, 0424, Norway

  • Novartis Investigative Site

    Esplugues, Barcelona, 08950, Spain

  • Novartis Investigative Site

    Gothenburg, SE 416 85, Sweden

  • Novartis Investigative Site

    London, NW1 2BU, United Kingdom

  • Novartis Investigative Site

    London, WC1N 3JH, United Kingdom

  • Oregon Health and Science University

    Portland, Oregon, 97239-3098, United States

  • Phoenix Childrens Hospital

    Phoenix, Arizona, 85016, United States

  • Rady Children s Hospital

    San Diego, California, 92123, United States

  • Roswell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • Stanford University Medical Center

    Stanford, California, 94304, United States

  • Texas Childrens Cancer and Hematology Center

    Houston, Texas, 77030, United States

  • The Childrens Hosp of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • UCSF Medical Center

    San Francisco, California, 94143, United States

  • Univ of Texas Southwest Med Center

    Dallas, Texas, 75390-9034, United States

  • University of Utah Clinical Trials Office

    Salt Lake City, Utah, 84108, United States

Conditions

Explore the condition pages connected to this study.

B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA