New chemo combo aims to boost leukemia survival after transplant

NCT ID NCT07232953

Ongoing Disease control Sponsor: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests a combination of two chemotherapy drugs, fludarabine and treosulfan, given before a stem cell transplant in adults aged 40-65 with acute myeloid leukemia (AML) in remission. The goal is to see if this conditioning regimen improves the chance of being alive and leukemia-free one year after transplant. About 82 participants will receive the treatment and be monitored for safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fludarabine and Treosulfan (chemotherapy drugs)
What this could lead to: If successful, this conditioning regimen could improve leukemia-free survival after stem cell transplant for AML patients.
What could go wrong: This is a phase 2 trial with only 82 participants, so results may not apply broadly. Chemotherapy can cause serious side effects like infection and organ damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloblastic leukemia with maturation acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKAEMIA (AML) HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT)

Contacts and locations

Locations

ASST degli Spedali Civili di Brescia

Brescia, Lombardy, 25123, Italy
Azienda Ospedaliera S. Croce e Carle

Cuneo, Piedmont, 12100, Italy
Azienda Ospedaliera Universitaria Integrata Verona

Verona, Veneto, 37126, Italy
Azienda Ospedaliera Universitaria di Modena

Modena, Emilia-Romagna, 41124, Italy
Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli

Naples, Campania, 80131, Italy
Azienda Ospedaliero Universitaria Careggi

Florence, Tuscany, 50134, Italy
Azienda Sanitaria Universitaria Friuli Centrale

Udine, Friuli Venezia Giulia, 33100, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico,

Milan, Lombardy, 20122, Italy
Grande Ospedale Metropolitano "Bianco Melacrino Morelli"

Reggio Calabria, Calabria, 89124, Italy
IRCCS Ospedale San Raffaele

Milan, Lombardy, 20132, Italy
Ospedale C e G Mazzoni

Ascoli Piceno, The Marches, 63100, Italy
Ospedale dell'Angelo

Mestre, Veneto, 30174, Italy
Ospedali Riuniti di Ancona

Ancona, The Marches, 60126, Italy

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