New hope for tough blood cancers? early trial of JNJ-89853413 begins

NCT ID NCT06618001

Ongoing Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This early-stage trial tests a new drug called JNJ-89853413 in 64 people whose acute myeloid leukemia (AML) or myelodysplastic neoplasms (MDS) have come back or stopped responding to treatment. The main goal is to check safety and find the right dose, with a second part looking at whether it helps fight the cancer. It's a first-in-human study, so results are very preliminary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JNJ-89853413
What this could lead to: If it works, this could point toward a new treatment option for people with hard-to-treat blood cancers like AML or MDS.
What could go wrong: This is a very early Phase 1 trial with only 64 participants, so safety and dosing are still being figured out. It may not work or could have serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKEMIA, MYELOID, ACUTE MYELODYSPLASTIC NEOPLASMS

Contacts and locations

Locations

Addenbrookes Hospital

Cambridge, Cb2 2qq, United Kingdom
Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada
Clinica Univ. de Navarra

Pamplona, 31008, Spain
Hosp Clinic de Barcelona

Barcelona, 08036, Spain
Hosp Univ Fund Jimenez Diaz

Madrid, 28040, Spain
Princess Margaret Hospital

Toronto, Ontario, M5G 2C1, Canada
The Christie NHS Foundation Trust Christie Hospital

Manchester, M20 4BX, United Kingdom
University College London Hospitals

London, W1T 7HA, United Kingdom
Vancouver General Hospital

Vancouver, British Columbia, V5Z 1M9, Canada

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