Disease by molecular mechanism

This Phase 2 study tested ABvac40, a vaccine designed to help the immune system target and clear a protein called amyloid-beta 40, which builds up in the brains of people with Alzheimer's. The trial included 134 adults aged 55-80 with mild cognitive impairment or very mild Alzhei…

This early-phase trial tests whether MIB-626, a drug that activates sirtuin-NAD pathways, can reach the brain and affect aging-related markers in people with mild Alzheimer's. 22 participants will take either MIB-626 or a placebo for 90 days. The study primarily checks if the dru…

This study tests a 10-week nutrition program in 61 older adults (ages 55-85) from rural North Florida, some with mild cognitive impairment and some without. Participants follow either a Mediterranean diet or a modified Mediterranean-ketogenic diet. The goal is to see if the progr…

This early-phase trial tests whether a daily vitamin B3 supplement called nicotinamide riboside can improve brain energy and reduce stress in people with mild cognitive impairment or mild Alzheimer's disease. Fifty participants will take the supplement for 12 weeks while research…

This early-phase study tested the drug baricitinib in 17 people with Alzheimer's disease, ALS, or mild cognitive problems. The goal was to see if the drug reaches the brain and lowers inflammation linked to these diseases. Participants took baricitinib pills for 24 weeks, and res…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This large Phase 3 trial tested whether the diabetes drug semaglutide, taken as a daily pill, can slow cognitive decline in people with early Alzheimer's disease. About 1,840 participants received either semaglutide or a placebo for up to 3 years and 4 months. The study measured …

This early-phase trial tested a combination of three drugs—daratumumab, ixazomib, and dexamethasone—in 21 people with AL amyloidosis, a rare disease where abnormal protein builds up in organs. The main goal was to find the safest dose and check for side effects. Researchers also …

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This completed Phase 2 trial tested an oral drug called LY3372689 in 327 people with early symptomatic Alzheimer's disease. The goal was to see if the drug could safely slow down declines in thinking and daily living skills compared to a placebo. The study focused on participants…

This study tested the safety and effects of nilotinib, a cancer drug, in 43 people with Dementia with Lewy Bodies (DLB). DLB is a common type of dementia that shares features with Parkinson's and Alzheimer's. The goal was to see if nilotinib is safe and changes brain biomarkers, …

This study tested a drug called ALXN2060 (acoramidis) in 25 Japanese patients with a rare heart condition called ATTR-CM, which causes heart failure. The drug is taken as a tablet twice daily. Researchers measured how far patients could walk in 6 minutes and tracked heart-related…

This study tested whether adding slow, paced breathing exercises to computer-based brain training could improve thinking skills and slow dementia in older adults with mild cognitive impairment. Over 8 weeks, 113 participants either did both breathing and brain training, brain tra…

This study tested whether N-acetylcysteine (NAC), an antioxidant drug, can improve motor skills and learning in children with neurofibromatosis type 1 (NF1). Twenty-five children aged 8 to 16 took NAC or a placebo for 8 weeks. The goal was to see if NAC is safe and helps with mov…

This phase 2 trial tested whether TAK-341, given as an IV infusion every 4 weeks for a year, can slow the progression of multiple system atrophy (MSA), a rare and serious brain disorder. The study enrolled 158 adults with MSA across North America, Europe, and Asia. Researchers me…

This early-stage study tested whether multiple infusions of donor stem cells are safe for people with mild to moderate Alzheimer's disease. Six participants received the treatment and were monitored for serious side effects and changes in thinking skills. The goal was to check sa…

This phase 2 trial tested two drugs, selumetinib and sirolimus, in 21 people with advanced malignant peripheral nerve sheath tumors (MPNST), a rare cancer often linked to neurofibromatosis type 1. The goal was to see if the combination could shrink or stabilize tumors. The study …

This study looked at how safe and effective weekly weight loss injections (like Mounjaro) are for adults with Bardet-Biedl Syndrome (BBS), a rare genetic condition that often causes severe obesity. Researchers compared weight changes in 300 patients who took the medication versus…

This study tested the drug patisiran in 10 adults with a rare condition called ATTR amyloidosis that causes nerve damage. Participants received an IV infusion every 21 days for 24 months. Researchers measured changes in nerve function, autonomic symptoms, and quality of life to s…

This large Phase 3 study tested an experimental drug called remternetug in over 1,600 people with early symptoms of Alzheimer's disease. The main goal was to see if the drug could safely clear amyloid plaques from the brain, a hallmark of Alzheimer's. Participants received either…

This study looked at how safe and effective Vyndaqel is for people with a rare heart condition called transthyretin amyloid cardiomyopathy. Over 1,200 patients in Japan were followed while taking the drug in regular medical practice. The main goal was to track side effects and su…

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for chan…

This early-stage trial tested an experimental drug called SHR-1707 in 33 people with mild memory problems or mild Alzheimer's disease. The drug is an antibody given through a vein, designed to target and clear amyloid plaques in the brain. The main goal was to check safety and si…

This early-phase trial tested an inhaled mRNA therapy called RCT1100 in 14 adults with primary ciliary dyskinesia (PCD) caused by a specific genetic mutation (DNAI1). The goal was to see if the treatment could improve mucociliary clearance — the lungs' ability to clear mucus and …

This study looked at medical records of 50 people with a rare heart condition called ATTR-CM to see if high-dose tafamidis (Vyndamax) slows nerve damage. Researchers compared how fast nerve problems got worse before and after starting the drug. The goal was to see if the medicati…

This pilot study tested whether a short course of low-dose radiation to the brain could reduce amyloid plaques, a hallmark of Alzheimer's disease. Twenty people with early Alzheimer's and positive amyloid scans were enrolled. Half received radiation over 5 days, while the other h…

This completed phase 1 study tested whether taking choline, a dietary supplement, for 6 months could improve fat metabolism in the brain of people with the APOE4 gene, which raises Alzheimer's risk. Fifteen participants aged 55-80 took choline capsules twice daily. The main goal …

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This phase 3 trial tested the drug patisiran in 360 people with ATTR amyloidosis with cardiomyopathy, a condition where abnormal protein builds up in the heart, making it stiff and weak. Participants received either patisiran or a placebo intravenously. The study measured how far…

This completed Phase 2a study tested an oral drug called neflamapimod in 26 people with dementia with Lewy bodies. The main goal was to check safety and how the drug moves through the body over 24 weeks. Researchers also looked at changes in thinking and memory as a secondary mea…

This completed Phase 3 trial tested whether oral semaglutide (a drug used for diabetes and weight loss) can slow cognitive decline in 1840 people with early Alzheimer's disease. Participants received either semaglutide or a placebo daily for up to 3 years and 4 months. The study …

This Phase 2 study tested a once-daily combination pill (polypill) in 121 adults aged 50–85 with very mild to severe Alzheimer's disease. Over 180 days, researchers measured changes in thinking, memory, and daily function using standard dementia scales. The goal was to estimate w…

This study looked at whether a plant-based ketogenic diet combined with intermittent fasting (called Ketoflex 12/3) could slow the progression of early-to-mid stage Alzheimer's disease. Sixty participants followed the diet, and researchers measured changes in memory and thinking …

This completed trial tested a ketogenic diet (high-fat, low-carb) in 32 people with mild to moderate Alzheimer's disease. Participants followed the diet or a placebo for 26 weeks. Researchers measured changes in cognitive function using a standard test. The goal was to see if the…

This study tested a drug called donanemab (LY3002813) in 272 people with early symptoms of Alzheimer's disease. The goal was to see if the drug is safe and can slow down memory loss and daily functioning problems. Participants received either the drug or a placebo, and researcher…

This early-stage trial tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The vaccine is designed to train the immune system to attack abnormal clumps of a protein called alpha-synuclein, which are linked to these brain disorders. The …

This study tested whether a non-invasive brain stimulation method called tACS could reduce amyloid and tau proteins in people with mild to moderate Alzheimer's. Seventeen participants received daily sessions of tACS or a sham treatment for 2-4 weeks. The goal was to see if the st…

This study tested an experimental drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. Participants received different doses of the drug or a placebo every 2 or 4 weeks for 18 months. The go…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This study looked at whether semaglutide, a medicine used for diabetes and weight loss, can reduce inflammation in the brain and body of people with early Alzheimer's disease. Twenty-three participants with mild memory problems or mild dementia received either semaglutide or a pl…

This early-stage study tested a new drug called ALN-TTRSC04 in 96 healthy people to see if it is safe and how the body processes it. The drug aims to lower a harmful protein that causes transthyretin amyloidosis, a serious disease affecting nerves and the heart. Participants rece…

This study tested an experimental drug called NNC6019-0001 in 105 people with transthyretin amyloid cardiomyopathy, a condition where abnormal proteins build up in the heart, causing heart failure. Participants received either the drug or a placebo by infusion every 4 weeks for a…

This phase 2 trial tested a gel called NFX-179 on skin tumors in 199 adults with neurofibromatosis type 1. Participants applied the gel daily for 26 weeks. The study measured safety and whether tumors shrank in size or height. Results suggest the gel may help reduce tumor volume,…

This study tested whether a personalized treatment plan—based on each person's test results—works better than standard care for people with mild cognitive impairment or early-stage dementia. 73 adults aged 45-76 took part, receiving either the tailored plan or usual care for 9 mo…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study tested a low dose of nilotinib, a drug used for leukemia, in 37 people with mild to moderate Alzheimer's disease. The goal was to see if the drug is safe and can reach the brain to affect proteins linked to Alzheimer's, like tau and amyloid. Participants took the drug …

This early-stage trial tests NTLA-2001, a CRISPR-based gene editing therapy, in 72 adults with hereditary ATTR amyloidosis—a condition where abnormal protein builds up in nerves or the heart. The treatment aims to turn off the faulty gene to reduce protein levels. The study focus…

This completed study tested whether two diabetes medications, sitagliptin and dapagliflozin, are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 participants took either a drug or a placebo daily for a short time. The goal w…

This study tested a mobile app designed to help gay and bisexual men reduce their methamphetamine use and risky sexual behaviors. The app includes games, lessons, and resources. 226 men who use meth took part. The goal was to see if the app could help them cut back on meth and lo…

This study tested a device that uses focused ultrasound to temporarily open the blood-brain barrier in 35 people with Alzheimer's disease. The goal was to see if this procedure is safe and could help treatments reach the brain more effectively. Participants were between 50 and 85…

This study tested a new drug called vutrisiran in 164 people with a rare inherited disease that damages nerves and organs. Participants received either vutrisiran as a shot every 3 months or the standard treatment patisiran as an IV infusion every 3 weeks. The goal was to see if …

This study tested a drug called MCI-196 in 245 adults on dialysis who have high phosphate levels, a common problem in advanced kidney disease. After a 4-week washout and 12-week dose adjustment, patients were randomly assigned to continue MCI-196 or switch to a placebo for 4 week…

This study tested the long-term safety of a drug called MCI-196 (Colestilan) in 116 adults with stage 5 chronic kidney disease who are on dialysis and have high phosphorus levels. Participants took flexible doses of the drug for 52 weeks. The main goal was to see how many side ef…

This Phase 3 trial tested MCI-196, a drug that binds phosphorus and lowers cholesterol, in 642 adults on dialysis with chronic kidney disease. Participants received either MCI-196 or a placebo for 12 weeks. The goal was to see if the drug could safely reduce both serum phosphorus…

This study tested the long-term safety of a drug called MCI-196 in 632 adults with chronic kidney disease on dialysis who have high phosphorus levels. Participants took the drug for up to 52 weeks to see how it affected their phosphorus and cholesterol. The goal was to help contr…

This early-stage trial tested an oral drug called JAB-3312 in 40 adults with advanced solid tumors (like lung, colon, or breast cancer) that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects. Researchers also looked …

This first-in-human study tested a new drug called IBC-Ab002 in 40 people with early Alzheimer's disease. The drug is an antibody that targets PD-L1, a protein involved in immune regulation. The main goal was to check safety and how the drug moves through the body, not yet to pro…

This study tested an oral drug called ALZ-801 in 84 people with early Alzheimer's who carry the APOE4 gene variant, which increases risk. Researchers measured changes in blood and brain scan markers of Alzheimer's over 65 weeks to see if the drug slows disease progression. The go…

This study tested an experimental drug called ABBV-916 in people with early Alzheimer's disease. Participants received either the drug or a placebo intravenously every 4 weeks for 6 months, with an optional 2-year extension where everyone gets the drug. The goal was to check safe…

This study tested different doses of nicotinamide riboside (a form of vitamin B3) in 80 people with early Alzheimer's disease. The goal was to find the dose that best boosts brain energy levels and changes brain metabolism with the fewest side effects. Participants took placebo o…

This study tested whether adding daratumumab to standard chemotherapy (CyBorD) helps people newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins build up in organs. About 416 adults took part. The goal was to see if the combination leads to better blood res…

This study looked at how well the drug tafamidis 61mg works for Korean patients with a rare heart condition called transthyretin amyloid cardiomyopathy (ATTR-CM). Researchers tracked 13 patients who were already prescribed the drug in real-world clinics. They measured changes in …

This study looked at the safety of a drug called Tafamidis (brand name VyndaMx) in 6 people in India with a rare heart condition called transthyretin amyloid cardiomyopathy (ATTR-CM). In ATTR-CM, faulty proteins build up in the heart and make it harder to pump blood. Researchers …

This Phase 3 trial tested a new drug called AP301 in 474 Chinese adults on dialysis who had high phosphorus levels. Participants took AP301, a low dose of AP301, or the standard drug sevelamer carbonate with meals. The main goal was to see how well AP301 lowers phosphorus compare…

This completed Phase 2 trial tested a drug called DAAOI-P in 61 people with Parkinson's disease who also have dementia. The goal was to see if the drug could improve walking, reduce falls, and ease neuropsychiatric symptoms. Participants received either DAAOI-P or a placebo pill …

This small study tested a new type of deep brain stimulation (DBS) that automatically adjusts electrical pulses based on a person's activity or body position. The goal was to improve walking, blood pressure, bladder control, and sleep in people with Multiple System Atrophy (MSA),…

This small pilot study tested daratumumab, a cancer drug, in 16 people with mild to moderate Alzheimer's. The goal was to see if it could improve thinking and memory. Participants received daratumumab injections under the skin. The study was open-label, meaning everyone knew they…

This study tested an experimental drug called ALZ-801 in 325 people with early Alzheimer's disease who carry two copies of the APOE4 gene, a strong risk factor. Participants received either the drug or a placebo for a year. Researchers measured changes in memory, thinking, and da…

This early-stage study tested the safety of a new drug called BMS-984923 in 51 healthy older adults and people with Alzheimer's disease. Participants received either the drug or a placebo to check for side effects and how the body processes the medication. The goal was to see if …

This study tested an experimental drug called AL002 in 356 people with early Alzheimer's disease. The goal was to see if it could slow down memory and thinking problems compared to a placebo. Participants received either the drug or a dummy injection, and their symptoms were trac…

This study tested whether a nasal insulin spray and a diabetes pill called empagliflozin, alone or together, could improve memory and brain function in 47 adults aged 55-85 with mild cognitive impairment or early Alzheimer's disease. The goal was to see if these treatments are sa…

This early-stage trial tested a gene therapy called LX1001 in 15 people with Alzheimer's who have two copies of the APOE4 gene, a high-risk form. The therapy delivers a healthy APOE2 gene to try to change the course of the disease. The main goal was to check safety and side effec…

This early-phase study tests an inhaled mRNA therapy called RCT1100 in 7 adults with primary ciliary dyskinesia caused by DNAI1 gene mutations. The goal is to see if the treatment is safe and can help restore ciliary function in the lungs. It is a small, open-label trial focused …

This study tested a drug called MEK162 in 105 children with low-grade gliomas or other tumors that have a specific overactive growth signal. The goal was to find the best dose, check for side effects, and see if the drug could shrink tumors. Children took the drug by mouth twice …

This study tested whether daily nicotine patches could improve memory and daily function in 348 people with mild cognitive impairment (MCI). Participants wore either a nicotine patch (up to 21 mg) or a placebo patch for two years. The goal was to see if nicotine, known to affect …

This study tested whether the antiviral drug valacyclovir (Valtrex) can slow memory loss in people with mild Alzheimer's disease who also carry the herpes simplex virus. About 120 participants received either the drug or a placebo for 18 months. The goal was to see if treating th…

This early study tested a nasal spray called Protollin in 16 people with early Alzheimer's disease. The main goal was to see if it is safe and tolerable. The spray is designed to boost the immune system in the brain, possibly helping to clear away harmful proteins linked to Alzhe…

This study tested a new drug called 50561 in 68 people with mild to moderate Alzheimer's disease. Participants received either a high dose, low dose, or a placebo. The main goal was to see if the drug could slow down cognitive decline over 24 weeks using a standard memory and thi…

This study tested whether digital analysis of voice recordings can help doctors tell apart Parkinson's disease and multiple system atrophy, two brain disorders with similar early symptoms. Researchers recorded the voices of 28 people (patients with each condition and healthy cont…

This study checked if a Turkish version of the MoCA-B test can correctly tell the difference between healthy people, those with mild memory problems, and those with dementia. The test was given to 166 adults aged 50-100 with little or no schooling. The goal was to find the best c…

This study tested a new genetic screening approach to find cases of a rare inherited nerve disease called TTR-FAP in 130 patients with chronic neuropathy of unknown cause. The goal was to see how many of these patients actually have TTR-FAP, which is often missed due to varied sy…

This completed Phase 3 study tested whether a radioactive tracer called [18F]Florbetaben, used in PET scans, can accurately diagnose cardiac AL amyloidosis—a condition where abnormal proteins build up in the heart. 244 adults with suspected cardiac amyloidosis received a single P…

This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imagi…

This study looked at whether a portable sleep monitor used during a short hospital stay can accurately diagnose sleep apnea in people with multiple system atrophy (MSA), compared to the standard overnight lab test. Thirty adults with probable MSA took part. The goal was to see if…

This study tested whether an artificial intelligence system could detect mild cognitive impairment and Alzheimer's disease by analyzing simple self-figure drawings. Over 3,400 older adults drew themselves on paper, and the AI learned to spot patterns linked to cognitive decline. …

This study tested a new imaging drug called I-124 evuzamitide to see if it can accurately diagnose cardiac amyloidosis, a condition where abnormal proteins build up in the heart. 204 adults with suspected cardiac amyloidosis received a single dose followed by a PET/CT scan. The g…

This study tested whether a special type of heart MRI, called T1 mapping, can accurately diagnose cardiac amyloidosis—a condition where abnormal proteins build up in the heart muscle. Researchers studied 112 older adults with heart failure and thickened heart walls. They compared…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This completed study looked at whether combining an online memory test with a blood test can help find Alzheimer's disease early in people 65 and older. Over 1,400 volunteers took part. The goal is to make early detection easier and faster, so treatment can start sooner.

This study tested a low-cost method to find undiagnosed dementia in primary care. Researchers used electronic health records to identify patients at risk. Over 1,200 adults without a prior dementia diagnosis took part. The goal was to see if this approach could increase new demen…

This study tested whether a special PET/MR scan using a radioactive tracer called F-18 florbetapir can detect amyloid protein buildup in the nerves of people with amyloidosis. Eight adults with confirmed nerve amyloidosis or other nerve diseases took part. The goal was to see if …

This study compared different ways to detect early nerve damage in people with hereditary TTR amyloidosis, a condition that can cause progressive nerve problems. Researchers used blood tests, skin imaging, and standard nerve exams in 47 participants. The goal was to see which too…

This completed study tested a new radioactive tracer called [18F] - FD17 for PET imaging to detect clumps of a protein called alpha-synuclein in the brain. These clumps are linked to Parkinson's disease, multiple system atrophy, and a sleep disorder that often precedes Parkinson'…

This study tested whether an artificial intelligence (AI) tool could help doctors detect cardiac amyloidosis, a rare but serious heart condition, earlier using standard ECG tests. Over 20,000 patients were involved, with some doctors using the AI-enhanced ECG and others continuin…

This study tested whether a computer program called SCALE PET helps doctors more accurately spot signs of Alzheimer's disease in brain scans. Researchers looked at 190 past scans from people with Alzheimer's or mild memory problems. Four doctors read the scans twice—once with the…

This study looked at whether measuring a protein called amyloid beta 1-40 in spinal fluid can help doctors diagnose Alzheimer's disease more accurately. Researchers collected spinal fluid from 204 people with memory problems. They want to see if adding this new measurement to exi…

This study tested a smartphone app that analyzes voice recordings to see if it can accurately diagnose mild cognitive impairment (MCI) and Alzheimer's disease. Researchers compared the app's diagnosis to a doctor's diagnosis in 150 adults aged 50 and older. The goal was to see if…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, compared to the current standard of testing spinal fluid. Researchers measured specific proteins in the blood of 342 adults visiting memory clinics. The goal was to see if these blood markers c…

This study tested a new blood test that uses a microfluidic chip to detect Alzheimer's disease. Researchers collected blood and urine samples from 150 people, including those with Alzheimer's, other brain diseases, and healthy volunteers. The goal was to see if the test could acc…

This study is working on a blood test to help diagnose Alzheimer's disease. Researchers are measuring two specific markers in the blood of 200 people—some with Alzheimer's and some healthy—to see if these markers can reliably tell the difference. The goal is to create a simple, n…

This study looked at whether a finger prick blood sample can accurately measure a key Alzheimer's biomarker (pTau-217) compared to a standard blood draw. 49 adults already in another Alzheimer's study provided both types of samples. The goal was to see if the finger prick method …

This study tested a computer model that uses a patient's age, sex, medical history, and heart tests (ECG and echocardiogram) to estimate their risk of having cardiac amyloidosis, a serious but often undiagnosed heart condition. Researchers invited 50 high-risk patients for furthe…

This pilot study tested whether a radioactive tracer called F-18 florbetapir (Amyvid) can detect amyloid protein buildup in the heart using a PET scan. Researchers enrolled 23 people with known cardiac amyloidosis and a control group without the condition. The goal was to see if …

This study tested whether a special forehead thermometer called SpotOn can accurately measure core body temperature in children during surgery. Researchers enrolled 70 children aged 1 day to 16 years having elective surgery. The goal was to see if this non-invasive sensor could r…

This study screened 646 elderly Black and Hispanic patients with heart failure to find out how many have cardiac amyloidosis, a condition where abnormal proteins build up in the heart. Researchers used a special heart scan and blood tests to detect the disease. The goal was to le…

This study tested whether a simple, non-invasive brain wave test (EEG) can help diagnose Alzheimer's disease at different stages. Researchers collected EEG data from 29 people, including those with mild cognitive impairment, Alzheimer's at various stages, dementia with Lewy bodie…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether a structured lifestyle program—including diet, exercise, and cognitive training—can help prevent cognitive decline in older adults at risk for dementia. Over 1,000 participants aged 60-77 from 12 Latin American countries took part. The goal was to see if…

This study looked at whether 6 months of moderate aerobic exercise could improve memory and brain health in older adults (ages 60-80) who are inactive but cognitively healthy. Some participants carried a gene (APOE-ε4) that raises Alzheimer's risk. They were randomly assigned to …

This early-stage trial tests a vaccine called AV-1959R, designed to prevent Alzheimer's disease by targeting a protein linked to the condition. Sixteen healthy adults aged 40-60 will receive three shots of the vaccine or a placebo over 14 weeks. Researchers will monitor for side …

This study tested a 4-week sleep health program in 30 adults aged 45-64 to see if it could improve sleep and potentially delay Alzheimer's disease. Participants learned strategies to enhance their sleep health. The study measured how acceptable and effective the program was, usin…

This study tested a 4-week program called Zinde Zihin ("Fit Mind") in 62 adults aged 65-80 living in nursing homes. The program included brain games, exercise, nutrition advice, and stress management. Researchers measured changes in Alzheimer's risk scores and found that the prog…

This study tested whether lifestyle changes—like a healthy diet, physical and mental exercise, and managing health risks—can protect memory and thinking in older adults at risk for Alzheimer's disease. Researchers enrolled 2,000 Americans who were sedentary and had a low-quality …

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while researche…

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study tested whether older adults with mild cognitive impairment or early Alzheimer's can use a tablet-based brain-training app at home. 52 participants played 12 different games for 8 minutes each, daily for two weeks. The goal was to see if the app was easy to use and acce…

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This trial investigates whether applying a heated pack to the arm for 5 or 10 minutes before inserting a dialysis needle can reduce pain in people with an arteriovenous fistula. About 51 adults on hemodialysis will be randomly assigned to receive heat for 5 minutes, 10 minutes, o…

This study tests whether the drug mevidalen can safely improve thinking, memory, and daily function in people with mild-to-moderate Alzheimer's disease. About 300 participants will receive either mevidalen or a placebo for 26 weeks. The main goal is to see if the drug eases sympt…

This study tested a program where a pharmacist worked with people living with dementia, their care partners, and their doctors to review and reduce unnecessary medications. The goal was to simplify medication routines and lower treatment burden. The study included 138 participant…

This study looked at whether a weekly hour of adapted physical activity for 12 weeks could improve self-esteem and motivation in 17 older adults with mild to major cognitive disorders like Alzheimer's. Researchers measured changes in self-esteem, motivation, and apathy. The goal …

This study tested whether combining a gentle brain stimulation technique called tDCS with memory and thinking exercises could help people with early Alzheimer's. Twenty-two participants received either real or fake stimulation during 10 sessions of cognitive training. Researchers…

This study tested whether playing a gentle sound called 'pink noise' during deep sleep could strengthen memory in people with early Alzheimer's disease. Nineteen participants wore a special headband that delivered the noise on some nights and not on others. The goal was to see if…

This study tests whether adding a caregiver training program to a visual mapping assistive technology (MapHabit) improves daily life for people with Alzheimer's or dementia and reduces stress for their caregivers. Fifty patient-caregiver pairs will use either the technology alone…

This study tested two 8-week stress management programs delivered via secure video calls for 196 adolescents aged 12–17 with neurofibromatosis (NF1 or NF2). The goal was to see if these programs could improve emotional, social, and physical quality of life. Both programs taught c…

This study tested if immersive virtual reality (VR) can improve memory and thinking in people with Alzheimer's disease. 33 participants wore VR headsets to explore scenes from 1960s Burgos, Spain, designed to trigger personal memories. Researchers measured changes in cognitive te…

This study tested a non-invasive brain stimulation technique called rTMS, guided by each person's unique brain activity map, to see if it could improve thinking and memory in 46 people with mild Alzheimer's disease. Participants received either real or fake (placebo) stimulation …

This study tested a gentle brain stimulation technique (HD-tDCS) combined with computer-based memory exercises in 60 people with early Alzheimer's. The goal was to see if this combination could improve thinking and memory more than either treatment alone. Researchers also used br…

This study tested whether personalized magnetic brain stimulation (TMS) is safe and helpful for people with early Alzheimer's disease. Forty participants received either real or fake TMS to see if it could improve memory and thinking. The goal was to find a non-drug way to ease s…

This study tested a prescription smartphone app called RiSolve for women with overactive bladder (OAB). The app provides an 8-week program of bladder training, pelvic floor exercises, and digital cognitive behavioral therapy. Researchers enrolled 46 women in Ireland to see if the…

This study tested a safe, non-invasive brain stimulation technique called tACS in 26 people with mild cognitive impairment due to Alzheimer's. The goal was to see if a 40 Hz electrical current applied to the brain could improve memory. Participants completed memory tests before, …

This study looked at whether different lengths of light exposure can improve sleep, mood, and agitation in people with Alzheimer's disease. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to see which light schedule work…

This study tested an online training program called CHATO for nursing home staff who care for people with Alzheimer's or other dementias. The training aimed to improve how staff communicate, which may reduce behavioral symptoms like agitation or rejection of care. Over 5,000 staf…

This pilot study tested a website tool called WeCareToFeedDysphagia designed to reduce feelings of burden in caregivers of people with Alzheimer's or related dementias who also have trouble swallowing. Eighty caregivers were split into two groups: one got access to the tool plus …

This study looked at 157 women with breast cancer who had a mastectomy. It compared two ways to drain fluid after surgery: active drainage (using suction) and passive drainage (gravity). The goal was to see which method led to less fluid buildup (seroma), shorter drain time, and …

This completed trial tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease build a habit of walking at least 250 steps each hour. The 12-week program used goal setting, action planning, self-monitoring, and prompts to encourage reg…

This study tested whether partnered rhythmic dance is safe and helpful for people with early Alzheimer's disease. 76 participants were randomly assigned to either dance classes or a walking program for 12 months. The goal was to see if dance improves the ability to think and move…

This early-stage study tested an experimental drug, NMRA-323511, in healthy older adults and people with Alzheimer's disease who experience agitation. The goal was to see if the drug is safe and can reduce agitated behaviors like pacing or yelling. The study involved 87 participa…

This study tested whether adding acupuncture to standard care can slow down memory and thinking problems in people with mild Alzheimer's disease. Researchers compared real acupuncture to a fake (sham) procedure in 160 participants to see if the effects were real or just a placebo…

This study tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease develop a regular walking habit. Over 12 weeks, participants received texts with goal-setting, action plans, and reminders to walk at least 1,000 steps in a set hour …

This study tested a program called EnACT for family caregivers of people with dementia. The program uses group sessions where caregivers watch scenarios, practice responses, and reflect on their choices. The goal is to help caregivers feel more prepared and less stressed when dea…

This study tested a personalized counseling and support program for 130 people with multiple system atrophy (MSA) and their caregivers. The program aimed to identify individual needs and improve daily life management. Researchers measured quality of life and depression symptoms t…

This pilot study tested whether applying methylene blue (a dye) to skin lesions and then shining red light on them could improve skin roughness in people with lichen amyloidosis, a condition causing itchy, bumpy patches. Fifteen Asian adults with the condition received the treatm…

This pilot study tested a 308-nm excimer laser on 15 Asian adults with lichen amyloidosis, a condition that causes itchy, rough patches on the skin. The goal was to see if the laser could improve skin roughness. The study is small and early, so results are not conclusive.

This study tested a Dialectical Behavior Therapy skills training program for older adults (age 50+) who care for a family member with Alzheimer's disease or related dementias. The goal was to reduce suicidal thoughts and feelings. Nine caregivers participated, and the program foc…

This study tested a set of tablet games called VibrantMinds, designed to be easy and fun for older adults, including those with dementia. 26 participants aged 65+ with mild cognitive impairment played games like Whack-A-Mole and Word Search. Researchers measured changes in thinki…

This study tested whether a special type of lighting, called a tailored lighting intervention, could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. Sixty-one participants living in assisted living or nursing ho…

This study tested whether a socially assistive robot could reduce apathy in older adults with mild cognitive impairment or Alzheimer's disease living in long-term care. 142 participants were randomly assigned to either usual activities or usual activities plus robot-led sessions.…

This study tested a personalized approach to manage agitation in people with Alzheimer's disease living at home. A nurse worked with doctors and caregivers to create a custom care plan, using video calls and training. The goal was to reduce hospitalizations and ease caregiver str…

This study tested whether tongue-strengthening exercises using a special device could improve swallowing in people with Alzheimer's disease and related dementias. 76 participants with mild to moderate dementia did exercises over 8 weeks. The goal was to reduce food or liquid goin…

This study tested whether a long-term light treatment could improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used a special light device, and researchers measured changes in thinking skills and sleep qua…

This study tested a software system that uses a humanoid robot to give cognitive and motor tests to people with early Alzheimer's or other mild to moderate dementia. The goal was to see if the robot could effectively administer tests like the Mini Mental State Exam (MMSE) and hel…

This study tested an experimental drug called neflamapimod in 159 people with dementia with Lewy bodies (DLB). The goal was to see if it could improve memory, problem-solving, and attention compared to a placebo. Participants took the drug or a dummy pill for a set period, and re…

This study tested a new drug called phenserine in 16 people with early or mild Alzheimer's disease. The goal was to see how it affects brain cell health and inflammation compared to the standard drug donepezil. Participants took the drug for 8 weeks and had regular checkups. The …

This study tested whether a 12-month therapeutic education program is feasible for people with multiple system atrophy (MSA) and their caregivers. The program includes in-person visits and online activities to help understand symptoms and adapt to daily life. Fifteen patient-care…

This study tested an automated abdominal binder that inflates when a person stands, applying pressure to help maintain blood pressure. It included 28 adults with autonomic failure and disabling orthostatic hypotension. Participants wore either the active binder or a sham version …

This study tested a new behavioral program called SEMAT that teaches people with early-stage Alzheimer's or mild cognitive impairment how to use memory aids like calendars and reminders. The goal was to help them stay independent in daily life. 68 older adults took part, and rese…

This early-stage study tested the safety of a new drug called MK-8189 (elpipodect) in 29 people with Alzheimer's disease who also had symptoms like agitation, aggression, or psychosis. The main goal was to see if the drug was safe and tolerable. Researchers monitored side effects…

This study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…

This study tested whether N-acetylcysteine (NAC), an over-the-counter antioxidant, could improve learning and motor skills in children with neurofibromatosis type 1 (NF1). Five children aged 8 to 16 took NAC or a placebo to see if it helped with movement and attention problems. T…

This study tested a training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to recreate familiar situations, aiming to improve orientation to time, place, and person. 126 participants were assigned to either the training…

This study tested a ketogenic drink made from medium chain triglycerides (MCTs) in 43 people with Alzheimer's disease or a type of frontotemporal dementia. The goal was to see if it was safe and tolerable, and to measure ketone levels in the blood. It was a small, early-stage tri…

This completed study tested a structured music improvisation program for older adults with mild to moderate dementia and their caregivers. Seven participants took part in three-hour sessions led by professional musicians. The goal was to see if this non-drug approach could improv…

This study tested whether simple brain function measures can predict which Alzheimer's patients will respond to the drug memantine. 53 participants with mild-to-moderate Alzheimer's took memantine or placebo, then all received memantine for 24 weeks. The goal was to see if early …

This study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …

This study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…

This study tested whether lowering the temperature of the dialysis fluid from 36.5°C to 36°C could reduce the tiredness patients often feel after dialysis. Fifty-seven adults on maintenance hemodialysis received three sessions of 'cold dialysis' over one week. Researchers measure…

This study tested whether a painless, non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's disease. Researchers used MRI…

This study tested a drug called droxidopa (L-threo DOPS) in 107 adults with multiple system atrophy (MSA) who experience dizziness or fainting when standing up due to low blood pressure. Participants received either the drug or a placebo for 12 weeks. The goal was to see if the d…

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study tested a web-based program called RELOAD-C designed to reduce loneliness in people caring for a family member or friend with Alzheimer's disease. The program uses short videos and online group discussions based on Meaning-Centered Psychotherapy to help caregivers find …

This study tested if a gentle, non-invasive brain stimulation device used at home can help improve memory and thinking in people with mild to moderate Alzheimer's disease. One hundred older adults used the device for 30 minutes a day, five times a week, for six months. The goal w…

This study tested a new way to follow up with gynecologic cancer survivors. Instead of seeing a doctor every time, patients saw a nurse at every other visit and used a smartphone app to help manage their health. The goal was to see if this approach improved self-management skills…

This study tested whether adding a virtual reality experience to an online education program could help reduce stress and anxiety in people caring for a loved one with mild-to-moderate Alzheimer's disease. About 127 unpaid caregivers took part, with some receiving only the educat…

This pilot study tested whether combining exercise with a gentle brain stimulation technique called tDCS can improve memory in 60 older adults with mild cognitive impairment or Alzheimer's disease. Participants exercised and received either real or sham tDCS. The goal was to see …

This study tested whether a six-week sleep therapy program (CBT-I) could improve thinking and memory in older adults aged 60-85 with insomnia. Two hundred participants were randomly assigned to either CBT-I or a sleep education program. A small group also had brain scans to see i…

This study tested a sleep improvement program designed for both people with Alzheimer's disease and the family members who care for them. The program was tailored to address sleep problems in both the patient and caregiver at the same time. The goal was to see if this approach co…

This completed study tested whether wearing a special graphene cap that emits far-infrared heat could improve thinking and mood in older adults with mild cognitive decline or Alzheimer's. 126 participants were split into groups based on their cognitive level and received either t…

This study tested two types of mental exercises in 514 older adults with mild to moderate Alzheimer's disease. One group used a computer program with brain games, while the other used physical puzzles and memory cards. The goal was to see if these activities could improve thinkin…

This study tested whether a virtual group therapy program called Cognitive Stimulation Therapy (V-CST) could help slow cognitive decline in people with mild to moderate dementia. 133 participants were randomly assigned to either receive a referral for V-CST or continue with stand…

This study tested a video-based program called Tele-STELLA for family members caring for someone with moderate to late-stage Alzheimer's or related dementia. The program connects caregivers with a guide to find ways to manage upsetting behaviors. The goal was to see if it could r…

This study tested a virtual program called MASC (Mindful and Self-Compassionate Care) for caregivers of people with Alzheimer's or related dementias. The program teaches mindfulness, self-compassion, and behavioral management skills through six group sessions and home practice. T…

This study tested a drug called CT1812 in 130 people with mild to moderate Dementia with Lewy Bodies. Over 6 months, researchers checked if the drug was safe and if it helped with thinking, sleep, or other symptoms. The goal was to see if it might ease the burden of this challeng…

This study tested a web-based program called Diapason for family caregivers of people with Alzheimer's disease. The program provides information, relaxation techniques, and a forum to connect with other caregivers. Researchers measured stress levels in 49 caregivers over 6 months…

This study tested whether a program called Strategy Training can help older adults with mild cognitive impairment (MCI) manage everyday tasks like shopping, paying bills, and taking medication. The training, delivered by occupational therapists, teaches goal-setting, scheduling, …

This completed pilot study from Emory University tested whether a daily citicoline supplement could improve sleep quality, daytime sleepiness, and memory in 100 older adults with mild cognitive impairment (MCI). Participants took 1000 mg of citicoline for 3 months and completed s…

This study tested a hearing care program for older adults with both hearing loss and dementia. Speech-language pathologists delivered the program at home. The goal was to see if better hearing could reduce troubling symptoms like agitation and improve quality of life. 77 people t…

This study tested a smartphone app called Compas-Y, designed to help people with cancer manage emotional distress through self-compassion exercises. 28 adults who had finished cancer treatment and felt low well-being used the app for 6 weeks. Researchers measured changes in self-…

This study tested whether caregivers prefer a fast-dissolving memantine tablet (Sinolvir®) or the standard tablet (Eutebrol®) for people with moderate to severe Alzheimer's disease. About 105 patients took one form daily for two months, and their primary caregivers filled out a s…

This study tested whether a special light therapy, used for 6 months, could improve sleep, mood, thinking, and daily behavior in 100 people with Alzheimer's disease or mild cognitive impairment. Participants either received the active light treatment or a placebo light. The goal …

This study tested a device that plays soft sounds during deep sleep to help memory in people with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's. 37 participants received either real or silent (placebo) sounds while sleeping. Researchers me…

This pilot study tested a 6-session virtual program called MASC that teaches mindfulness, self-compassion, and behavior management skills to caregivers of people with Alzheimer's or related dementias. 82 caregivers participated to see if the program is feasible and acceptable. Th…

This study tested whether an online program for insomnia (called SHUTi) could help heavy drinkers reduce their alcohol use. 113 adults who drank heavily and had trouble sleeping took part. The goal was to see if improving sleep would also lead to less drinking and fewer binge epi…

This study tested a 10-week remote nursing program for family caregivers of people with early-stage Alzheimer's dementia. Caregivers used a website called 'Take Care of Yourself' to access training modules and support. The goal was to see if this approach could reduce caregiver b…

This study tested a program called MEMORI Corps, where trained volunteers aged 55+ provide companionship and personalized activities to people with dementia living at home. The program was delivered virtually over 12 weeks. Researchers measured changes in mood, quality of life, a…

This study tested a non-invasive electrical stimulation device on the scalp in 80 adults aged 50+ with mild cognitive impairment. Participants learned word pairs while receiving either real or sham stimulation. Their memory was tested right after, and again at 7 and 28 days. The …

This study tested whether an Apple Watch paired with a special app and weekly health coaching could help dementia caregivers improve their sleep and mood. Twenty-one caregivers wore the watch to track their activity and sleep, and received personalized feedback and motivational c…

This study tested a web-based app called Gotcha! designed to help people with mild-to-moderate dementia remember names of people they know. 48 participants practiced daily for 6 weeks using a tablet at home. The goal was to see if the therapy improves name recall and whether it c…

This study tested whether a procedure called a stellate ganglion block (SGB), given with standard medication, could improve thinking and memory in people with Alzheimer's disease. Forty participants were randomly assigned to receive either SGB plus standard drugs or standard drug…

This study tested whether doing paper-based cognitive training (like memory and attention exercises) could help 70 Vietnamese patients with early Alzheimer's disease. Participants did the training for 12 weeks, and researchers measured changes in memory, thinking, and daily livin…

This study tested a program called ABC ANSWERS for veterans with Alzheimer's disease or traumatic brain injury and their informal caregivers (family or friends). The program added extra support and education to regular primary care. Researchers measured changes in quality of life…

This study tested a medicine called BXCL501 for calming sudden episodes of agitation in people with dementia. It involved 151 participants who took the medicine only when needed over 12 weeks. The goal was to see if it safely reduces severe restlessness, tension, or aggression.

This study tested two stress and symptom management programs for adults with neurofibromatosis (NF1, NF2, or schwannomatosis). The programs were delivered through live videoconferencing over 8 weekly sessions. Researchers measured changes in quality of life and emotional well-bei…

This study tested a new exercise device called FitMi AD in 31 people with mild cognitive impairment or mild dementia due to Alzheimer's. The device uses sensors to track movements while users follow exercises shown on a computer screen. Researchers measured improvements in balanc…

This study tested a distance-learning program for family caregivers of people with Alzheimer's dementia or traumatic brain injury. The goal was to reduce care-resistant behaviors like agitation and aggression, and improve quality of life for both patients and families. 88 caregiv…

This study tested an online program called LEAF that teaches positive emotion skills to family caregivers of people with Alzheimer's. 386 caregivers were randomly assigned to a Zoom group, a self-guided group, or a control group. The goal was to see if learning these skills could…

This study tested a new, drug-free approach to help older adults with mild cognitive impairment or Alzheimer's disease. The method combined gentle electrical brain stimulation, cognitive training, and near-infrared light therapy delivered through the nose. The goal was to see if …

This study tested whether hearing aids can improve thinking, daily behavior, and quality of life in people with mild to moderate Alzheimer's disease who also have age-related hearing loss. Fifty-one participants were split into two groups: one got real hearing aids for 12 months,…

This study tested a mobile health program designed to support family caregivers of people with both dementia and diabetes. The program added weekly online support and resources to standard home visits. Researchers measured changes in caregiver burden and social support after 12 w…

This study tested a special palliative care program for people with late-stage Alzheimer's or related dementias and their family caregivers. The program started during a hospital stay and included caregiver education and support to reduce hospital transfers and improve symptom co…

This study tested whether gentle reminders (nudges) to doctors and caregivers could help reduce risky medications in people with dementia. Researchers enrolled 250 patients and their primary care providers. The goal was to see if this approach is practical and can be measured in …

This study looked at whether two specific diets—the ketogenic diet and the Therapeutic Lifestyles Changes diet—could improve thinking and memory in people with Alzheimer's disease. Researchers measured changes in cognitive test scores over three months in 84 adults aged 50 to 90 …

This study tested whether daily singing of personally meaningful songs can boost memory and language in people with Alzheimer's disease or mild cognitive impairment. One hundred participants worked with a music therapist and sang a 'song of kin' at home for 12 months. Researchers…

This study looked at whether a long-term exercise program can help people with dementia living in nursing homes keep their ability to do daily tasks like bathing and dressing. 140 participants were split into an exercise group and a social activity group. The goal was to see if e…

This study tested whether a smartphone app called ARTHE-e helps people with knee osteoarthritis follow their exercise routines better than standard care. 120 participants used the app for 6 months, and researchers measured exercise adherence using a questionnaire. The goal is to …

This study looked at the long-term safety and effectiveness of a drug called AXS-05 for treating agitation in people with Alzheimer's disease. A total of 456 participants who had already been in earlier studies took part. The goal was to see if the drug could safely reduce agitat…

This pilot study tested whether a dietary supplement called citicoline could improve sleep and cognitive function in 20 people with Alzheimer's disease. Participants took either citicoline or a placebo for 3 months, and researchers measured sleep quality, daytime sleepiness, and …

This study tested whether a daily 20-minute nerve stimulation (TENS) applied to the ankle could improve bladder control in people with Parkinson's disease or multiple system atrophy. A total of 110 participants used either an active or a sham device for 3 months. The main goal wa…

This study tested an experimental drug called AXS-05 to see if it can safely reduce agitation in people with Alzheimer's disease. About 408 participants took either the drug or a placebo for several weeks. The goal was to measure changes in agitation using a standard rating scale…

This study tested a smart cloth care system for people with dementia living at home. The system includes a vest with a hidden monitor and home sensors that send information to family caregivers. Researchers wanted to see if it could improve safety, daily function, and caregiver w…

This study looked at whether doing physical and mental tasks at the same time (dual-task training) can help people with mild to moderate Alzheimer's. 34 participants completed the program. The goal was to see if this training could improve balance, reduce fear of falling, boost t…

This study tested whether cooling the skin before or during laser and injection treatments for neurofibromatosis type 1 (NF1) skin bumps can reduce pain. Thirteen adults with NF1 received four different treatments (two lasers and two injections) on both cooled and non-cooled skin…

This study tested whether music therapy can prevent hospital-related confusion (delirium) in people with Parkinson's disease or Lewy body dementia. 30 hospitalized adults took part, receiving either music therapy sessions, self-directed music listening, or standard care. Research…

This study tested a home device called Care4AD (Nili) designed to help caregivers coordinate daily activities for people with Alzheimer's or related dementia. The device provided reminders for tasks, social engagement, and medication. Researchers measured changes in caregiver bur…

This completed trial tested a virtual program for people with Alzheimer's or related dementias and their caregivers. Nearly 1,000 participants received monthly video or phone visits from nurses or social workers over a year. The program focused on managing symptoms, reducing care…

This study tested whether spironolactone, a blood pressure medication, is safe for older African Americans with mild memory and thinking problems. Twenty-five participants took either the drug or a placebo daily for one year. The main goal was to check safety and tolerability, wi…

This study tested a program called UPLIFT-AD that brings palliative care—focused on comfort and quality of life—to nursing home residents with moderate to severe Alzheimer's disease. Over 1,300 residents, family members, and staff took part. The program included staff training, a…

This Phase 2 study tested an experimental drug called ABBV-552 in 263 people with mild Alzheimer's disease. Participants took either the drug or a placebo daily for 12 weeks. The goal was to see if the drug could safely improve memory and thinking. The results will help decide if…

This study tested an 8-week telehealth program for people with Alzheimer's or related dementias living at home with a caregiver. The program used Zoom to teach caregivers how to improve daily activities and reduce challenging behaviors. 84 people (person with dementia and their c…

This early-stage trial tested the safety and how the body handles a new drug called MK-1167 in 28 people with Alzheimer's who were already taking donepezil. The study was completed and focused on side effects and drug levels in the blood. It does not yet show whether MK-1167 help…

This small study tested whether a home-use brain stimulation device (tDCS) is safe and acceptable for people with Alzheimer's who have behavioral symptoms like agitation or apathy. Only 3 participants completed the trial, with caregivers helping to set up the device. The main goa…

This study tested whether playing an immersive video game called Bandit the Dolphin could improve thinking and movement in adults who had a traumatic brain injury years ago. The game involves moving your arms to control a dolphin in an ocean environment, combining physical and me…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can improve memory and thinking in 32 veterans aged 55+ with mild cognitive impairment or dementia. Participants received either real rTMS or a sham (fake) treatment. The main goal was to see …

This study tested a cognitive training software called SUPERBRAIN DEX in 140 people aged 50–85 with mild cognitive impairment (MCI), a condition that can lead to dementia. Participants used the software for 15–30 minutes daily, while a control group received an educational bookle…

This study tested an online tool called WeCareAdvisor that helps caregivers of people with dementia manage behavioral and psychological symptoms. 262 caregivers used the tool for 6 months, with some receiving extra prompts. The goal was to see if it reduces caregiver distress and…

This study tested a new way of caring for people with Parkinson's disease. The goal was to help 214 participants achieve their personal goals and improve their quality of life. The approach involved proactive, integrated care and patient empowerment, compared to standard care.

This study tested whether adding game-like features to a visual mapping app helps people with mild to moderate Alzheimer's or related dementias stay engaged in daily activities. Sixty participants and their caregivers used the app for six months, with half getting the gamified ve…

This study tested a technology-based program called TACAD, designed to support Asian American midlife women who care for a family member with Alzheimer's disease. The program included social media groups, online educational modules, resources, and a virtual reality component. Res…

This study tested a new program called 'Dementia Care Quality at Home' in two home-based primary care clinics. The program trained clinic staff to assess the needs of people with dementia and their caregivers, provide educational materials, and hold team meetings to address chall…

This study tested whether listening to personalized music can improve thinking and daily function in people with advanced-stage Alzheimer's disease. Researchers enrolled 54 older adults and had them listen to either their favorite music or a classical piece. The goal was to see i…

This study tested whether a tailored light intervention could improve thinking, sleep, and metabolism in 25 people with mild cognitive impairment or mild Alzheimer's disease. Participants received either active or placebo lighting at home. The goal was to see if light exposure co…

This study tested an in-home technology system that uses sensors and wearable devices to monitor people with dementia and alert their caregivers about worrisome behaviors like falls or wandering. The goal was to see if this system could reduce caregivers' anxiety, burden, and dep…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study is the first time Leucettinib-21 is being tested in humans. It aims to check the drug's safety and how the body processes it. The trial includes healthy volunteers and people with Down syndrome or Alzheimer's disease. No treatment benefit is expected at this early stag…

This study looked at people with neurofibromatosis type 1 (NF1) to better understand how harmless tumors (plexiform neurofibromas) turn into a rare cancer called MPNST. Ten participants had MRI, PET scans, and tumor biopsies. Researchers tested whether a special PET scan (FLT PET…

This study uses advanced heart imaging to understand how blood flows inside the heart in people with cardiac amyloidosis, a condition where abnormal proteins build up in heart tissue. Researchers will compare these images with those from healthy volunteers to find unique patterns…

This completed Phase 2 study tested whether a special PET scan using a tracer called UCB-J can measure synaptic density—the connections between brain cells—in people with Alzheimer's disease. Researchers scanned 100 participants across different stages, from healthy to dementia, …

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study followed 78 people with GNE myopathy, a rare genetic disease that causes progressive muscle weakness starting in young adulthood. Researchers collected medical history, blood samples, and muscle function tests over up to two years to understand how the disease progress…

This completed study looked at the experiences of 275 extended family members (like grandchildren, siblings, and nieces/nephews) who care for a person with dementia. Researchers interviewed caregivers about their daily tasks, stress, and use of support services. The goal is to us…

This study measured the activity of an enzyme called glucocerebrosidase in 236 people with and without Lewy body dementia. The goal was to see if lower enzyme activity could help identify patients who might benefit from treatments already used for Gaucher disease. The study did n…

This study looks at whether a specific gene variant (ApoE4) is more common in people with certain brain MRI patterns that suggest cerebral amyloid angiopathy (CAA), a condition where proteins build up in brain blood vessels. Researchers will analyze genetic samples from 100 patie…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This completed study looked at people with genetic conditions that affect how the lungs clear mucus, such as cystic fibrosis and primary ciliary dyskinesia. Researchers examined 87 participants, including healthy volunteers, to understand why these patients get repeated lung infe…

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…

This study looked at whether regular physical activity can improve thinking and memory in middle-aged adults (40-65) who have a family history of Alzheimer's disease. About 180 participants were randomly assigned to an exercise program or a comparison group and were followed for …

This study looked at how the brain chemical serotonin works in people with multiple system atrophy (MSA), a rare and serious nerve disease. Researchers used special PET scans to measure serotonin receptors in the brains of 53 adults with MSA or Parkinson's disease. The goal was t…

This completed study in Russia checked how many people with carpal tunnel syndrome also have a rare inherited nerve condition called hereditary transthyretin amyloidosis. Researchers reviewed medical records of 721 patients and will test some for the genetic mutation. The goal is…

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This study tested whether a digital tool that scans electronic health records could help find older adults (65+) who might have undetected mild cognitive impairment or Alzheimer's disease. Over 3,400 patients from primary care clinics were identified as high-risk by the tool. Res…

This study looked at whether regular exercise can help slow down memory and thinking problems in older adults with early Alzheimer's disease and in healthy older adults. Researchers tested a program combining aerobic and strength exercises against stretching and balance exercises…

This pilot study tested whether a virtual reality reaction time test can help predict fall risk and cognitive decline in older adults with memory problems. Twenty participants aged 65 and older with cognitive impairment completed a VR task and standard tests. The goal was to see …

This study examined whether older adults with disrupted sleep or irregular daily rhythms show early brain changes linked to Alzheimer's disease. Researchers used wrist-worn activity monitors and brain MRI scans in 47 people over 65 without major memory problems. The goal was to s…

This completed study looked at inherited disorders common in Amish and Mennonite populations. Researchers collected medical histories, blood or cheek swab samples from 157 participants to find the genes behind these conditions. They also built a computer database of family trees …

This study checked how often nerve damage (neuropathy) occurs in people with a rare heart condition called wild-type TTR cardiac amyloidosis. Researchers examined 65 patients using interviews, physical exams, and nerve tests (electromyograms). The goal was to find out if nerve pr…

This study looked at MRI scans from 72 people with two common types of small vessel disease in the brain: hypertensive arteriopathy and cerebral amyloid angiopathy. Researchers focused on tiny fluid-filled spaces in a part of the brain called the dentate nucleus. The goal was to …

This study looked at 30 healthy older adults to see if changes in a small brain area called the locus coeruleus could be an early sign of Alzheimer's disease. Researchers used brain scans, sleep tests, and spinal fluid analysis to measure brain function, sleep quality, and attent…

This study looked at whether a partnered dance program (adapted tango) could improve inflammation, memory, and mood in African-American women who care for a family member with Alzheimer's disease. Fifty women between 45 and 65 years old took part. Researchers measured changes in …

This study looked at whether a case management program called PartnerED could help reduce unnecessary hospital stays for people with Alzheimer's disease living in assisted living facilities. Researchers worked with care managers who gave emergency room doctors real-time informati…

This study looked at how common dementia and memory problems are in older Mexican Americans compared to non-Hispanic whites. Researchers tracked changes in thinking skills over time and also asked caregivers what help they need. The goal is to find better ways to support patients…

This study collected blood samples from over 2,200 people with Alzheimer's or other dementias, plus healthy volunteers, to search for genes linked to these diseases. Researchers aimed to identify new genetic causes and better understand how genes affect disease risk and progressi…

This study looked at how often cardiac amyloidosis occurs in older Tunisian patients with a type of heart failure called HFpEF. Researchers used heart scans and imaging to find cases and identify early warning signs. The goal is to make diagnosis easier and faster for this seriou…

This study used special brain scans (SPECT imaging) to look at two key brain chemicals—acetylcholine and dopamine—in people with dementia with Lewy bodies. Researchers aimed to see if differences in these chemicals could help diagnose the disease and identify subtypes. The study …

This completed study involved 250 adults with AL amyloidosis, a rare disease where abnormal proteins damage organs. Researchers analyzed patient samples and data to find biological markers that predict how well someone will respond to initial treatments. The goal is to help docto…

This study looked at brain scans of 304 retired farmers aged 65 and older living in rural France. None had memory complaints at the start. Researchers used MRI and PET scans to measure brain areas linked to Alzheimer's, like the hippocampus. The goal was to find very early imagin…

This study looked at whether a quick, painless eye scan can detect early signs of Alzheimer's disease. Researchers measured the thickness of the retina's nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye changes could serve …

This completed trial tested an online tool called 'Safety in Dementia' that guides caregivers through decisions about firearm access for a person with dementia. 500 informal caregivers across the U.S. participated. The tool helps clarify options, risks, and personal values, aimin…

This study looked at how older adults with and without Alzheimer's disease move in time with music. Researchers wanted to understand if this rhythmic movement relates to emotional expression and communication. The study involved 240 participants and measured how accurately they t…

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like…

This study looked at whether advanced MRI scans and a nerve test called MUNIX can detect the earliest signs of nerve damage in people who carry a gene mutation for familial amyloid neuropathy. Researchers studied 60 adults with the TTR mutation, comparing those with and without s…

This study used eye-tracking to see how people with Alzheimer's, Parkinson's, or frontotemporal dementia look at faces when trying to recognize emotions. Researchers compared their eye movements to healthy adults. The goal was to understand if different visual strategies explain …

This completed study looked at 344 frail older adults (70+) with memory issues to see how many have Alzheimer's-related brain changes. Participants had MRI and PET scans to detect amyloid plaques. The goal was to understand the link between frailty, memory loss, and Alzheimer's p…

This completed study observed 31 adults with primary ciliary dyskinesia (PCD), a rare lung condition, along with healthy volunteers. Researchers measured lung function, mucus clearance, and lung structure using tests like spirometry and CT scans. The goal was to better understand…

This completed study collected blood and urine samples from 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed these samples to find biological markers that could predict how the disease will progress. The goal is to develo…

This study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…

This study looked at pain thresholds in people with multiple system atrophy (MSA) and Parkinson's disease. Researchers tested how levodopa, a common Parkinson's drug, affects pain perception. The goal is to better understand the causes of pain in MSA and improve future treatment.

This study looked at how an abdominal compression binder (like a tight belt) helps people with autonomic failure who get dizzy or faint when standing due to low blood pressure. Researchers compared the binder to a standard medication (midodrine) and a placebo in 21 adults. The go…

This study looked at whether being physically active over a lifetime is linked to developing a rare heart disease called wild-type transthyretin amyloid cardiomyopathy. Researchers compared the exercise histories of 180 people over age 60, including those with the disease, those …

This study tested a communication tool called 'Best Case/Worst Case' for older adults with advanced kidney disease. Doctors were trained to discuss best, worst, and most likely outcomes for treatment options. The goal was to see if this approach helps patients receive more pallia…

This completed study at Rutgers University looked at how the brain and body communicate in 30 people with conditions like autism, ADHD, Alzheimer's, and Parkinson's. Participants performed natural movements like walking and pointing while their brain, heart, and motion signals we…

This study tested two training programs (in-person and online) for staff in long-term care facilities in Minnesota. The goal was to improve care for LGBTQ+ residents with Alzheimer's or other dementias. Over 700 staff members participated, and researchers measured changes in poli…

This study tested a program called Promoting Positive Care Interactions (PPCI) in assisted living facilities. The goal was to see if it's feasible and acceptable to train staff—like nurses and housekeepers—to improve daily interactions with residents who have Alzheimer's or relat…

This completed study looked at how muscle oxygen levels change during exercise in people with various neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee-extension exercise while a device measured muscle oxygen. The goal was to understand diff…

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study looked at how older adults, including those with Alzheimer's or mild cognitive impairment, make decisions about where to live as they age. Researchers followed 293 participants to understand what factors—like memory, health knowledge, and support from family—influence …

This study looked at 30 people newly diagnosed with cardiac AL amyloidosis, a rare disease where abnormal proteins damage the heart. Researchers used advanced MRI, echocardiogram, and PET scans to see if these images could predict survival and show how well chemotherapy works. Th…

This completed study looked at over 11,000 adults in Trøndelag, Norway, to find out how many people have dementia and how many are undiagnosed. Researchers used standard tests to measure memory and thinking skills. The goal is to get a clearer picture of dementia rates across Nor…

This study tested a program called PorchLight Project, where trained senior companions helped families caring for someone with Alzheimer's or dementia. The goal was to connect families with community services and improve their interactions with doctors. Researchers measured thing…

This study looked at 70 people who had a brain hemorrhage (bleeding stroke) to see if a special PET scan could tell whether the bleeding was caused by amyloid buildup in blood vessels or by high blood pressure. Participants received an injection of a radioactive tracer called Flo…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…

This study used brain imaging and memory tests to find early signs of Alzheimer's disease. Researchers followed 242 volunteers, including healthy young, middle-aged, and older adults, to track changes over time. The goal was to understand how the disease develops and identify mar…

This study tested a new version of NPT 2042 soft-gelatin capsules to see if it is absorbed better than the original version. Eight healthy adults took single doses of both formulations. The goal was to measure how the drug moves through the body, not to treat any disease.

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia remember personal events from their past. Researchers tested 39 participants using a detailed scale to see if memories were specific (like a single event in time and place) or more gener…

This study tested whether a special PET imaging probe called [68Ga]CBP8 can measure scarring (fibrosis) in the hearts of people with cardiac amyloidosis, a rare condition where abnormal proteins build up in the heart. Researchers compared 18 participants with cardiac amyloidosis …

This study looked at sleep disturbances in people with Alzheimer's disease. Researchers tracked sleep diaries, activity levels, and behavior in 70 participants to understand how disrupted sleep relates to daily cycles and daytime alertness. The goal was to learn more about the li…

This completed study looked at 200 people with cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels, raising the risk of bleeding and cognitive decline. Researchers collected clinical data, brain scans, and samples of spinal fluid and bloo…

This study examined 186 people with Alzheimer's, Lewy body, frontotemporal, or corticobasal dementia, plus healthy controls, to see if subtle physical signs (like coordination or reflexes) differ between dementia types. Participants had simple exams and cognitive tests. The goal …

This study looked at a process called autophagy, which is how cells clean out damaged parts, in 82 women over 65 with osteoporosis. Some also had Alzheimer's disease. Researchers measured autophagy levels in bone cells from hip samples to see if poor cell cleanup links bone loss …

This study aimed to create a communication tool to help people with Alzheimer's or dementia and their caregivers discuss and plan for future medical care. Researchers worked with 38 participants to see if the tool improved their readiness to make advance care plans. The goal was …

This completed study looked at how people with Alzheimer's disease search for objects in realistic scenes and real-life settings. Researchers tracked eye movements in 48 participants to understand which attention and memory processes are impaired. The goal was to link visual expl…

This study tested whether a focused ultrasound device can safely and temporarily open the blood-brain barrier in 20 people with mild-to-moderate Parkinson's disease dementia. The goal was to see if the procedure is safe and feasible, not to treat the disease itself. Researchers m…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients did standard 4-hour sessions three times a week, while others did shorter 2-hour sessions six times a week. The goal was to find out whic…

This study tested whether a gentle electrical current applied to the scalp at 40 Hz can strengthen brain rhythms linked to memory in healthy adults aged 50-80. Thirty participants received the stimulation while performing a working memory task. The goal was to see if this approac…

This study tested whether combining two non-invasive brain stimulation techniques (tACS and iTBS) can enhance gamma brain waves and working memory in 30 healthy adults. The goal is to develop better stimulation protocols that could one day help people with Alzheimer's disease. Pa…

This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, …

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This completed study measured levels of two substances (IGF-I and IGFBP-3) in the blood of 693 older adults: some with Alzheimer's disease, some with mild cognitive impairment, and some with normal memory. The goal was to see if these levels differ between groups and relate to th…

This study aimed to find out how often people in Reunion Island start dialysis as an emergency and what social or medical factors lead to that. Researchers followed 233 adult patients beginning dialysis at local centers. The goal was to gather information to improve care and redu…

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This study followed 404 older adults for 10 years after hip fracture surgery. Researchers checked whether early signs of Alzheimer's in spinal fluid or cognitive tests were linked to how long patients lived. The goal is to understand if hidden Alzheimer's changes affect long-term…

This study followed 544 older couples (ages 65+) over three years to see how dementia affects their relationship and well-being. Both partners answered surveys every six months about their mental health, physical health, and caregiving experiences. The goal was to learn how being…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This study looked at health records from nearly 295,000 older adults with gout to see if two common gout medications, probenecid and allopurinol, affect the risk of developing dementia or Alzheimer's disease. The goal was to find out if one drug might be better at protecting the …

This study tested whether a medication used for sleep can boost the brain's natural waste-clearing system, called the glymphatic system, in healthy older adults. The goal was to see if this approach could help remove harmful proteins linked to Alzheimer's disease. Thirty-one part…

This study collected blood and DNA samples from 26 people with early-onset Alzheimer's disease and their close family members. Researchers analyzed the samples to find genetic changes and biomarkers that could help doctors diagnose, treat, and monitor the disease in the future. T…

This study checked how common smell and taste problems are in 51 people with cardiac amyloidosis, a rare disease where abnormal proteins build up in the heart. Researchers used a simple smell test called Sniffin' Sticks to measure these senses. The goal was to see if these issues…

This study tested whether mailing educational materials to caregivers of people with Alzheimer's could reduce the use of risky medications like sedatives and antipsychotics. Over 11,000 older adults with Alzheimer's took part. The goal was to see if this simple approach could mak…

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This study looked at whether certain gene variations (ABCB1) make it harder for the brain to clear a protein called amyloid beta, which is linked to Alzheimer's disease. Researchers compared 510 people with and without Alzheimer's to see if these gene changes are more common in t…

This completed study looked at 88 children with cystic fibrosis (CF) or primary ciliary dyskinesia (PCD) to compare how well they can exercise, how their muscles use oxygen, and how strong their breathing muscles are. Researchers used walking tests and muscle oxygen monitors to m…

This completed study followed over 6,000 Medicare patients with memory problems to see if a special brain scan (amyloid PET) helps doctors make better care decisions. The study included a diverse group of participants to ensure findings apply to everyone. It did not test a new dr…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This study looked at whether people with mild cognitive impairment or Alzheimer's-type dementia can understand and decide about receiving their PET scan results for amyloid and tau proteins. Researchers educated 152 participants and their care partners, then assessed their abilit…

This completed study looked for chemical markers in blood and urine that could help detect Alzheimer's disease early. Researchers analyzed samples from 95 people with mild cognitive impairment or Alzheimer's, comparing them to healthy older adults. The goal was to find biomarkers…

This completed Phase 4 trial looked at how two common anesthetics—desflurane and propofol—affect the optic nerve sheath diameter (a measure of pressure around the eye) in 146 adults undergoing laparoscopic gallbladder removal. The goal was simply to observe differences between th…

This study tested a program where a care coordinator helps people with Alzheimer's and their caregivers manage doctor visits, medications, and support. Over 2,000 people took part to see if this approach reduces emergency room visits and delays nursing home stays. The goal was to…

This completed study investigated whether a variation in the CR1 gene makes people more likely to develop Alzheimer's disease. Researchers compared 200 Caucasian participants—some with Alzheimer's and some without—to see if the gene difference is a risk factor. The study did not …

This completed study looked at 110 people with cardiac amyloidosis, a condition where protein deposits build up in the heart. Researchers implanted a small device under the skin to continuously monitor heart rhythms for up to several years. The goal was to learn more about when a…

This study used a very powerful 7 Tesla MRI to look for tiny brain changes in 15 people with idiopathic REM sleep behavior disorder (iRBD) compared to 15 healthy volunteers. iRBD is a sleep condition that often leads to Parkinson's disease years later. The goal was to find early …

This early-stage study tested the safety of a new drug called NH280105 in 32 healthy adults. Researchers gave single and multiple doses to see if it causes side effects and how the body processes it. This is a first step to see if the drug is safe enough to test in people with Al…

This study tested whether an online platform can effectively share Alzheimer's gene and biomarker test results with 681 participants, compared to a video call with a healthcare provider. The goal was to see if the self-guided method causes similar levels of anxiety, distress, and…

This study tested a special training and tool for home hospice nurses and social workers to help them better care for people with dementia and support their families. About 93 participants, including clinicians and family caregivers who are Black or White, took part. The goal was…

This completed study followed 378 people with moderate-to-severe Lewy body dementia and their caregivers for up to three years. Researchers collected surveys and some physical exams to track symptoms, caregiver stress, and quality of life. The goal was to find clues that signal w…

This study tested whether showing videos about care options to hospitalized patients aged 65 and older, or those with dementia, helps them make better advance care plans. Over 11,000 patients took part at two hospitals. The goal was to see if these video discussions lead to more …

This study tested whether daily paced breathing combined with brain training games could improve attention, memory, and reduce Alzheimer's-related markers in healthy adults aged 50-70. Participants did brain training and paced breathing at home for 10 weeks, and provided blood an…

This completed study looked at 1,200 people with neurocutaneous syndromes (NF1, TSC, SWS, VHL) in Western China. Researchers compared those who received genetic testing, targeted drugs, and coordinated specialist care against those who got standard care. The goal was to see if pr…

This completed study tested a new radioactive tracer called [18F]-SynVesT-1 to measure brain synapse density in 134 people with Alzheimer's disease, frontotemporal degeneration, dementia with Lewy bodies, or late-life psychiatric disorders. Researchers compared this new scan to t…

This study looked at whether giving doctors educational materials about a new blood test for Alzheimer's disease helps them make better care decisions. 178 neurologists and dementia specialists in the US participated in virtual patient cases. The researchers measured changes in d…

This study tested whether two types of belly-focus meditation, practiced 40 minutes daily for a week, could change blood markers linked to Alzheimer's disease in healthy adults aged 18-35. Participants provided blood samples and completed memory tests before and after the meditat…

This study gathered test results from 1,300 healthy adults aged 50 and older to create a reference database for a quick, tablet-based brain function test called BrainCheck. The goal was to establish normal score ranges and check if the test gives consistent results over time. No …

This study looked at whether doing memory and thinking tests over a video call at home works as well as doing them in person for people with suspected Alzheimer's disease. 116 older adults (ages 60-90) with mild memory problems took part. The goal was to see if video assessments …

This study followed 170 older adults who had a type of stroke caused by cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels. Researchers wanted to see if a specific finding on MRI scans, called cortical superficial siderosis (cSS), could …

This study looked at medical records of 683 older adults with dementia to see if their use of antiplatelet drugs (like aspirin) matched official guidelines. Researchers found that prescribing patterns varied across different types of dementia. The goal was to understand real-worl…

This completed study looked at whether using adult day services helps reduce stress in Black caregivers of family members with dementia. Forty-two caregivers provided saliva samples and filled out stress surveys on days when their loved one used adult day services and on days the…

This study surveyed 219 family caregivers of people with dementia to explore how swallowing problems (dysphagia) affect their burden and needs. Caregivers completed a one-time online questionnaire about their experiences, stress, and knowledge. The goal is to better understand an…

This completed study followed 229 stroke survivors over time to understand what factors might lead to dementia or cognitive problems after a stroke. Researchers looked at medical history, brain scans, and medications. The goal was to identify clues that could help predict and pos…

This study looked at how children with Noonan syndrome process energy and sugar. Researchers measured insulin sensitivity in 20 children with the condition to see if they have unique metabolic traits. The goal was to better understand the disease, not to test a new treatment.

This pilot study gave the BCG vaccine (used for tuberculosis) to 20 healthy older adults aged 55-80. Researchers measured changes in immune markers and Alzheimer's-related proteins in blood and spinal fluid over 90 days. The goal was to see if this common vaccine might influence …

This study tested a program called APPROACHES in nearly 500 nursing homes across the U.S. The program trained staff to better discuss and document care preferences for residents with Alzheimer's or related dementias. The goal was to see if this approach could reduce unwanted hosp…

This completed study followed 105 children and adults with primary ciliary dyskinesia (PCD), a rare lung condition, to track how their breathing and quality of life change during respiratory flare-ups. Researchers measured lung function, symptoms, and daily impacts to gather info…

This study looked at 15 stroke patients with a condition called cerebral amyloid angiopathy (CAA), which makes blood vessels in the brain fragile and prone to bleeding. All patients received a clot-busting drug (thrombolysis) and were checked for brain bleeding 24 hours later. Re…

This completed study involved 100 adults aged 50-80 who gave blood samples weekly for 9 weeks. Researchers measured a protein called pTau-217, which is linked to Alzheimer's disease. The goal was to see how much this biomarker naturally fluctuates from week to week, which could h…

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This study followed 83 people with Parkinson's disease and healthy volunteers to see if daily walking patterns measured at home can track how the disease progresses. Participants wore special insoles for 10 days at a time to record their gait. The goal was to find simple, real-wo…

This study looked at brain scans from 315 people with two types of small vessel disease: cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA). Researchers wanted to see if the pattern of white matter changes around the brain's fluid-filled spaces could help tell t…

This study looked at 111 people with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. Researchers used MRI scans to check for iron deposits in the cerebellum, a part of the brain that controls balance and coordination. The goal was to learn where …

This completed study at Stanford University looked at the DNA of over 1,000 adults with Neurofibromatosis Type 1 (NF1) to find genetic differences that might explain why some people develop more skin neurofibromas than others. Participants provided blood or saliva samples for gen…

This completed study looked for genetic and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including Parkinson's patients, people with related brain diseases, and healthy voluntee…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study looked at driving skills in 60 people over age 70 with early-stage Alzheimer's disease (MMSE score 24 or higher) and compared them to healthy older drivers. The goal was to identify common driving mistakes and suggest adaptive measures or technology to help them drive …

This study followed 150 people with a confirmed genetic form of nephronophthisis, a rare kidney disease, to see how it progresses over the long term. Researchers tracked both kidney function and damage to other organs. The goal was to better understand the disease's natural histo…

This study exposed 40 healthy, non-smoking adults to diesel exhaust and clean air to see how pollution affects the olfactory system (the part of the nose that detects smells). Researchers took biopsies from the nose and tested thinking and smell abilities. The goal is to understa…

This completed study looked at how brain wave patterns change with age during desflurane anesthesia. Researchers recorded brain activity from 47 adults and elderly patients undergoing surgery. They analyzed different brain wave features to understand how aging affects the brain's…

This study tested a program to support families right after a dementia diagnosis. 82 caregivers from Iowa took part. The program provided education and help connecting to community services. The goal was to reduce caregiver burden and improve knowledge of available support.

This study looked at how giving people information about their genetic risk for Alzheimer's disease affects them emotionally and behaviorally. It involved 374 Latino adults aged 40-64 in New York City who did not have Alzheimer's. Some participants learned their risk based only o…

This completed study from the University of East Anglia looked at how gut bacteria break down certain plant compounds (flavan-3-ols) in people with different versions of the APOE gene, which is linked to Alzheimer's risk. 49 healthy adults donated stool and saliva samples. The go…

This completed study analyzed blood test results from 100 people over age 50 to see if there is a connection between gum inflammation and Alzheimer's disease. Researchers measured gum health and looked at various blood cell counts. The goal was to find blood markers that might li…

This study tested whether giving doctors tailored information about the benefits of community-based palliative care helps more people with dementia and their families accept it. Researchers worked with 301 Medicare Advantage members who were eligible for palliative care. The goal…

This study looked at health records from over 800,000 older adults to see if certain blood pressure drugs (propranolol or carvedilol) are linked to a lower risk of dementia compared to other similar drugs (atenolol, bisoprolol, or sotalol). The goal was to find if repurposing exi…

This study tested whether a pharmacist-led program could help older adults with dementia and their caregivers reduce unnecessary medications. The program included an educational brochure, a telehealth visit with a pharmacist, and tailored recommendations for the patient's doctor.…

This study looked at why people with Lewy body dementia often have sudden changes in alertness. Researchers tested if a brain chemical called acetylcholine is involved and if gentle brain stimulation could help. Fifteen participants took part to gather information for future trea…

This study looked at whether text message reminders help people over 55 with normal thinking skills follow a daily morning light routine. The light is meant to help reset the body's internal clock. Twenty healthy adults took part, and researchers measured their light exposure and…

This study looked at 167 adults with chronic kidney disease on either hemodialysis or peritoneal dialysis to compare their blood levels of calcium, phosphorus, and other minerals linked to bone health. The goal was to see if one dialysis method is associated with fewer mineral an…

This study looked at whether shining a special light on the head (called transcranial photobiomodulation) can improve blood flow in the brain and boost thinking skills. 24 healthy adults aged 18 to 80 took part. The goal was to gather information, not to treat or cure any disease…

This study used special brain scans (PET imaging) to measure amyloid plaques in 60 people with Alzheimer's disease or related conditions like posterior cortical atrophy and logopenic progressive aphasia. The goal was to understand how age influences the amount of amyloid in the b…

This study looked at how people with dementia with Lewy bodies experience their sense of self, including memory and self-concept. Researchers compared 61 participants with dementia, Alzheimer's, and healthy aging using memory tests and brain scans. The goal was to understand whic…

This completed observational study looked at whether poor sleep quality, specifically slow wave sleep, is linked to brain changes that raise Alzheimer's risk, and whether this link differs between African-American and white older adults. Researchers recruited 210 cognitively norm…

This study tested a nutrition training program for home care workers to help people with dementia eat better at home. Researchers worked with 139 participants, including people with dementia, their families, and care staff, to see if the program was practical and acceptable. The …

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, such as family history, loss of smell, blood pressure drops, or a sleep disorder. Participants underwent brain scans, spinal taps, and other tests over several y…

This completed study looked at how often thinking, memory, and behavior problems happen after a stroke. Researchers tested over 1600 people, including stroke patients and healthy volunteers, using a French version of a standard cognitive battery. The goal was to better understand…