Promising drug targets rare protein disease in phase 2 trial

NCT ID NCT04617925

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 41 times

Summary

This study tested a drug called belantamab mafodotin in 35 people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. All participants had already received at least one prior treatment. The goal was to see how many patients achieved a significant reduction in disease markers, while also monitoring side effects. The trial is complete, and results will help determine if this drug offers a new option for controlling this condition.

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Contacts and locations

Locations

  • Centre hospitalier Universitaire de Limoges -

    Limoges, 87042, France

  • Fondazione I.R.C.C.S Policlinico "San Matteo"

    Pavia, 27100, Italy

  • General Hospital of Athens "Alexandra"

    Athens, 115 28, Greece

  • Royal Free Hospital - London,

    London, United Kingdom

  • UMC Utrecht

    Utrecht, 3584 CX, Netherlands

  • University Hospital Heidelberg

    Heidelberg, 69120, Germany

Conditions

Explore the condition pages connected to this study.