AL AMYLOIDOSIS

This study is testing an investigational drug called teclistamab in people with AL amyloidosis who have already tried other treatments. The goal is to see if teclistamab can effectively reduce the harmful proteins produced by the disease. Researchers will measure how many partici…

This study is testing a drug called elranatamab in people with AL amyloidosis that has returned or hasn't responded to previous treatments. The first part finds the safest dose, and the second part checks how well it works at that dose. About 49 participants will receive the drug…

This study is testing a drug called belantamab mafodotin for people with AL amyloidosis that has come back or hasn't responded to other treatments. The goal is to find a safe and effective dose and see if it can reduce the disease in the blood and improve organ function, especial…

This study is for adults newly diagnosed with AL amyloidosis, a disease where abnormal proteins damage organs like the heart and kidneys. It aims to find out if adding a stem cell transplant to a standard chemotherapy regimen works better than the chemotherapy regimen alone. Afte…

This study aims to find the best length of maintenance therapy for people with AL amyloidosis, a rare disease where abnormal proteins damage organs. After successful initial treatment, 96 participants will receive either a shorter (3-6 cycles) or longer (18 cycles) course of the …

This study aims to find the best first treatment for patients with a rare, serious blood disorder called AL amyloidosis who have a specific genetic change. All participants start on the same three-drug combination. After just one week, doctors check how well the disease is respon…

This early-phase study is testing the safety and best dose of a three-drug combination (venetoclax, ixazomib, and dexamethasone) for adults with light chain amyloidosis that has returned or stopped responding to prior treatments. The study is specifically for patients who have a …

This study is testing a new type of PET scan to see if it can accurately diagnose a serious heart condition called cardiac AL amyloidosis. The test uses a special imaging dye to look for harmful protein buildup in the heart. Researchers will compare the scan results to current di…

This study is creating a large registry of patients in Ohio with multiple myeloma and related blood disorders. Researchers will track patients' treatments, health outcomes, and quality of life over time to understand these diseases better. The registry also helps connect patients…

This study aims to understand why a specific gene (IGLV1-44) causes two rare and serious blood disorders: AL amyloidosis and POEMS syndrome. Researchers will analyze blood and bone marrow samples from 100 patients to identify unique patterns in the gene. The goal is to improve ea…

This study aims to create a large collection of biological samples and health information from people with amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will collect blood, urine, and tissue samples, along with detailed medical records, from …

This study aims to understand how a specific sugar modification on certain proteins might cause AL amyloidosis, a serious disease where proteins clump together and damage organs. Researchers will analyze blood and bone marrow samples from 100 people with related blood cell disord…