Breakthrough trial shows promise for controlling deadly Organ-Damaging disease

NCT ID NCT03201965

Summary

This large, completed Phase 3 trial tested whether adding a drug called daratumumab to a standard three-drug therapy (CyBorD) works better for people newly diagnosed with AL amyloidosis. AL amyloidosis is a serious disease where abnormal proteins build up and damage organs like the heart and kidneys. The study involved 416 participants and aimed to see if the four-drug combination led to better control of the disease in the blood and better organ health compared to the standard three-drug therapy alone.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O.U. Città della Salute e della Scienza

    Torino, 10126, Italy

  • Aarhus University Hospital

    Aarhus N, DK-8200, Denmark

  • Akdeniz University Medical Faculty

    Antalya, 7059, Turkey (Türkiye)

  • Alberta Health Services

    Edmonton, Alberta, T6G 1Z2, Canada

  • Alexandra General Hospital of Athens

    Athens, 11528, Greece

  • Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Ankara Universitesi Tip Fakultesi Cebeci Hastanesi

    Ankara, 06590, Turkey (Türkiye)

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Assaf Ha'Rofeh Medical Center

    Ẕerifin, 70300, Israel

  • Az Groeninge

    Kortrijk, 8500, Belgium

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Boston University Medical Center

    Boston, Massachusetts, 02118, United States

  • Box Hill Hospital

    Box Hill, 3128, Australia

  • CHU Bretonneau

    Tours, 37044, France

  • CHU De Poitiers

    Poitiers, 86000, France

  • CHU Dijon

    Dijon, 21000, France

  • CHU Rangueil

    Toulouse, 31400, France

  • CHU de Limoges - Fédération Hépatologie

    Limoges, 87000, France

  • CHU de Nancy_ Hopital Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • Carmel Hospital

    Haifa, 34362, Israel

  • Casa di Cura La Maddalena

    Palermo, 90146, Italy

  • Centre hospitalier Lyon-Sud

    Pierre-Bénite, 69495, France

  • Centro de Investigación Farmacéutica Especializada

    Guadalajara, 44160, Mexico

  • Charite Campus Benjamin Franklin

    Berlin, 12203, Germany

  • Chu Hotel Dieu

    Nantes, 44035, France

  • City of Hope

    Duarte, California, 91010, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinica Sao Germano

    São Paulo, 01455 010, Brazil

  • Clinica Univ. de Navarra

    Pamplona, 31008, Spain

  • Colorado Blood Cancer Institute

    Denver, Colorado, 80218, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215-5418, United States

  • Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely

    Budapest, 1097, Hungary

  • Dep. of Hematology, Rigshospitalet

    Copenhagen, 2400, Denmark

  • Dipartimento Di Biotecnologie Cellulari Ed Ematologia-Università ''La Sapienza'',Policlinico Umberto I

    Roma, 00161, Italy

  • Dokuz Eylul Universitesi Tip Fakultesi

    Izmir, 35340, Turkey (Türkiye)

  • Erasmus MC

    Rotterdam, 3015 CN, Netherlands

  • Erciyes University Medical Faculty

    Talas, 38039, Turkey (Türkiye)

  • First affiliated Hospital of Zhejiang University

    Hangzhou, 310020, China

  • Fukushima Medical University Hospital

    Fukushima, 960 1295, Japan

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base

    São José do Rio Preto, 15090-000, Brazil

  • HOPA-Hämatologisch-Onkologische Praxis Altona MVZ GmbH

    Hamburg, 22767, Germany

  • Hadassah Medical Center

    Jerusalem, 91120, Israel

  • Haga ziekenhuis

    The Hague, 2545 AA, Netherlands

  • Heinrich-Heine-Universität Düsseldorf

    Düsseldorf, 40225, Germany

  • Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

    Hiroshima, 730-8619, Japan

  • Hopital Claude Huriez

    Lille, 59037, France

  • Hopital Saint Louis

    Paris, 75475, France

  • Hosp Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hosp Clinico Univ de Salamanca

    Salamanca, 37007, Spain

  • Hosp Univ Fund Jimenez Diaz

    Madrid, 28040, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Dr. Peset

    Valencia, 46017, Spain

  • Hosp. Univ. Ramon Y Cajal

    Madrid, 28034, Spain

  • Hosp. Univ. de Canarias

    San Cristóbal de La Laguna, 38320, Spain

  • Hospital Das Clinicas Da Faculdade De Medicina Da USP

    São Paulo, 05403-010, Brazil

  • Hospital Sao Rafael

    Salvador, 41253 190, Brazil

  • Hospital Universitario Dr Jose Eleuterio Gonzalez

    Monterrey, 64460, Mexico

  • Hospital das Clinicas de Porto Alegre

    Porto Alegre, 90035-903, Brazil

  • Huntsman Cancer Institute

    Salt Lake City, Utah, 84112, United States

  • Inst. Cat. D'Oncologia-Badalona

    Badalona, 08916, Spain

  • Institut Jules Bordet

    Anderlecht, 1070, Belgium

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE

    São Paulo, 04039-004, Brazil

  • Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)

    Rio de Janeiro, 22775 001, Brazil

  • Instytut Hematologii i Transfuzjologii

    Warsaw, 02 776, Poland

  • Istanbul University Istanbul Medical Faculty

    Istanbul, 34093, Turkey (Türkiye)

  • Istituto di Ematologia Seràgnoli azienda ospedaliera univeristaria Policlinico S.Orsola-Malpighi

    Bologna, 40138, Italy

  • Japanese Red Cross Medical Center

    Shibuya City, 150-8935, Japan

  • Kanazawa University Hospital

    Kanazawa, 920 8641, Japan

  • Kumamoto University Hospital

    Kumamoto, 860-8556, Japan

  • Kyoto Kuramaguchi Medical Center

    Kyoto, 603-8151, Japan

  • Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • London Health Sciences Center

    London, Ontario, N6A 5W9, Canada

  • Matsuyama Red Cross Hospital

    Matsuyama, 790-8524, Japan

  • Maxima Medisch Centrum

    Veldhoven, 5504 DB, Netherlands

  • Mayo Clinic

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic Arizona

    Phoenix, Arizona, 85054, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • McGill University Health Centre

    Montreal, Quebec, H4A 3J1, Canada

  • Nagoya City University Hospital

    Nagoya, 467 8602, Japan

  • National Hospital Organization Okayama Medical Center

    Okayama, 701-1192, Japan

  • Odense Universitets Hospital

    Odense, 5000, Denmark

  • Ondokuz Mayis Universitesi Tip Fakultesiy

    Atakum, 55270, Turkey (Türkiye)

  • Oregon Health And Science University

    Portland, Oregon, 97239, United States

  • Peking University First Hospital

    Beijing, 100034, China

  • Peking University People s Hospital

    Beijing, 100044, China

  • Policlinico di Bari

    Bari, 70124, Italy

  • Princess Alexandra Hospital

    Woolloongabba, 4102, Australia

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Ruijin Hospital Shanghai Jiao Tong University

    Shanghai, 200025, China

  • SKPP UM w Poznaniu

    Poznan, 60-569, Poland

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich

    Chorzów, 41-500, Poland

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98109-1023, United States

  • Semmelweis Egyetem I.Belgyogyaszati Klinika

    Budapest, 1083, Hungary

  • Semmelweis Egyetem I.Belgyogyaszati Klinika

    Budapest, 1088, Hungary

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Sheba Medical Center

    Ramat Gan, 52621, Israel

  • Shinshu University Hospital

    Matsumoto, 390 8621, Japan

  • Sir Charles Gairdner Hospital

    Nedlands, 6009, Australia

  • Skanes universitetssjukhus

    Lund, 221 85, Sweden

  • Sociedade Pernambucana de Combate ao Cancer

    Recife, 50040-000, Brazil

  • Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • South Elvsborg Hospital

    Borås, 501 82, Sweden

  • Stanford University

    Stanford, California, 94305, United States

  • Teine Keijinkai Hospital

    Hokkaido, 006-8555, Japan

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591, South Korea

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000, China

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • Tokushima University Hospital

    Tokushima, 770-8503, Japan

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • UMC Utrecht

    Utrecht, 3584 CX, Netherlands

  • UMCG

    Groningen, 9713 GZ, Netherlands

  • UZ Gent

    Ghent, 9000, Belgium

  • Universitaetsklinikum Heidelberg Medizinische Klinik V

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,

    Tübingen, 72076, Germany

  • Universitair Ziekenhuis Leuven

    Leuven, 3000, Belgium

  • Universitatsklinikum Essen

    Essen, 45122, Germany

  • University College Hospital

    London, NW1 2PG, United Kingdom

  • University General Hospital of Rio

    Pátrai, 26500, Greece

  • University Health Network UHN Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • University Hospitals Birmingham NHS Trust,

    Birmingham, B15 2TH, United Kingdom

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

  • University of Pennsylvania Medical Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester Medical Center

    Rochester, New York, 14642, United States

  • University of Texas, MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Universitätsklinikum Würzburg Med. Klinik U. Poliklinik Ii

    Würzburg, 97080, Germany

  • Vancouver General Hospital

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest University Health Sciences - Cardiovascular Medicine

    Winston-Salem, North Carolina, 27157, United States

  • Washington University School Of Medicine

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medical College

    New York, New York, 10065, United States

  • Westmead Hospital

    Westmead, 2145, Australia

  • Winship Cancer Institute Emory University

    Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.