Breakthrough trial shows promise for controlling deadly Organ-Damaging disease
NCT ID NCT03201965
Summary
This large, completed Phase 3 trial tested whether adding a drug called daratumumab to a standard three-drug therapy (CyBorD) works better for people newly diagnosed with AL amyloidosis. AL amyloidosis is a serious disease where abnormal proteins build up and damage organs like the heart and kidneys. The study involved 416 participants and aimed to see if the four-drug combination led to better control of the disease in the blood and better organ health compared to the standard three-drug therapy alone.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A.O.U. Città della Salute e della Scienza
Torino, 10126, Italy
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Aarhus University Hospital
Aarhus N, DK-8200, Denmark
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Akdeniz University Medical Faculty
Antalya, 7059, Turkey (Türkiye)
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Alberta Health Services
Edmonton, Alberta, T6G 1Z2, Canada
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Alexandra General Hospital of Athens
Athens, 11528, Greece
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Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Ankara Universitesi Tip Fakultesi Cebeci Hastanesi
Ankara, 06590, Turkey (Türkiye)
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Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, T2N 5G2, Canada
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Assaf Ha'Rofeh Medical Center
Ẕerifin, 70300, Israel
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Az Groeninge
Kortrijk, 8500, Belgium
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Boston University Medical Center
Boston, Massachusetts, 02118, United States
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Box Hill Hospital
Box Hill, 3128, Australia
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CHU Bretonneau
Tours, 37044, France
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CHU De Poitiers
Poitiers, 86000, France
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CHU Dijon
Dijon, 21000, France
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CHU Rangueil
Toulouse, 31400, France
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CHU de Limoges - Fédération Hépatologie
Limoges, 87000, France
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CHU de Nancy_ Hopital Brabois
Vandœuvre-lès-Nancy, 54511, France
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Carmel Hospital
Haifa, 34362, Israel
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Casa di Cura La Maddalena
Palermo, 90146, Italy
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Centre hospitalier Lyon-Sud
Pierre-Bénite, 69495, France
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Centro de Investigación Farmacéutica Especializada
Guadalajara, 44160, Mexico
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Charite Campus Benjamin Franklin
Berlin, 12203, Germany
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Chu Hotel Dieu
Nantes, 44035, France
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City of Hope
Duarte, California, 91010, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Clinica Sao Germano
São Paulo, 01455 010, Brazil
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Clinica Univ. de Navarra
Pamplona, 31008, Spain
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Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215-5418, United States
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Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely
Budapest, 1097, Hungary
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Dep. of Hematology, Rigshospitalet
Copenhagen, 2400, Denmark
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Dipartimento Di Biotecnologie Cellulari Ed Ematologia-Università ''La Sapienza'',Policlinico Umberto I
Roma, 00161, Italy
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Dokuz Eylul Universitesi Tip Fakultesi
Izmir, 35340, Turkey (Türkiye)
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Erasmus MC
Rotterdam, 3015 CN, Netherlands
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Erciyes University Medical Faculty
Talas, 38039, Turkey (Türkiye)
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First affiliated Hospital of Zhejiang University
Hangzhou, 310020, China
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Fukushima Medical University Hospital
Fukushima, 960 1295, Japan
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Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
São José do Rio Preto, 15090-000, Brazil
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HOPA-Hämatologisch-Onkologische Praxis Altona MVZ GmbH
Hamburg, 22767, Germany
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Hadassah Medical Center
Jerusalem, 91120, Israel
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Haga ziekenhuis
The Hague, 2545 AA, Netherlands
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Heinrich-Heine-Universität Düsseldorf
Düsseldorf, 40225, Germany
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Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
Hiroshima, 730-8619, Japan
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Hopital Claude Huriez
Lille, 59037, France
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Hopital Saint Louis
Paris, 75475, France
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Hosp Clinic de Barcelona
Barcelona, 08036, Spain
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Hosp Clinico Univ de Salamanca
Salamanca, 37007, Spain
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Hosp Univ Fund Jimenez Diaz
Madrid, 28040, Spain
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Hosp Univ Vall D Hebron
Barcelona, 08035, Spain
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Hosp. Univ. 12 de Octubre
Madrid, 28041, Spain
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Hosp. Univ. Dr. Peset
Valencia, 46017, Spain
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Hosp. Univ. Ramon Y Cajal
Madrid, 28034, Spain
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Hosp. Univ. de Canarias
San Cristóbal de La Laguna, 38320, Spain
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Hospital Das Clinicas Da Faculdade De Medicina Da USP
São Paulo, 05403-010, Brazil
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Hospital Sao Rafael
Salvador, 41253 190, Brazil
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Hospital Universitario Dr Jose Eleuterio Gonzalez
Monterrey, 64460, Mexico
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Hospital das Clinicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
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Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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Inst. Cat. D'Oncologia-Badalona
Badalona, 08916, Spain
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Institut Jules Bordet
Anderlecht, 1070, Belgium
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Institut Paoli Calmettes
Marseille, 13273, France
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Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE
São Paulo, 04039-004, Brazil
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Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)
Rio de Janeiro, 22775 001, Brazil
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Instytut Hematologii i Transfuzjologii
Warsaw, 02 776, Poland
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Istanbul University Istanbul Medical Faculty
Istanbul, 34093, Turkey (Türkiye)
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Istituto di Ematologia Seràgnoli azienda ospedaliera univeristaria Policlinico S.Orsola-Malpighi
Bologna, 40138, Italy
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Japanese Red Cross Medical Center
Shibuya City, 150-8935, Japan
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Kanazawa University Hospital
Kanazawa, 920 8641, Japan
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Kumamoto University Hospital
Kumamoto, 860-8556, Japan
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Kyoto Kuramaguchi Medical Center
Kyoto, 603-8151, Japan
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Levine Cancer Institute
Charlotte, North Carolina, 28204, United States
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London Health Sciences Center
London, Ontario, N6A 5W9, Canada
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Matsuyama Red Cross Hospital
Matsuyama, 790-8524, Japan
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Maxima Medisch Centrum
Veldhoven, 5504 DB, Netherlands
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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Mayo Clinic Arizona
Phoenix, Arizona, 85054, United States
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Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
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McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
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Nagoya City University Hospital
Nagoya, 467 8602, Japan
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National Hospital Organization Okayama Medical Center
Okayama, 701-1192, Japan
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Odense Universitets Hospital
Odense, 5000, Denmark
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Ondokuz Mayis Universitesi Tip Fakultesiy
Atakum, 55270, Turkey (Türkiye)
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Oregon Health And Science University
Portland, Oregon, 97239, United States
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Peking University First Hospital
Beijing, 100034, China
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Peking University People s Hospital
Beijing, 100044, China
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Policlinico di Bari
Bari, 70124, Italy
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Princess Alexandra Hospital
Woolloongabba, 4102, Australia
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Pusan National University Hospital
Busan, 49241, South Korea
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Ruijin Hospital Shanghai Jiao Tong University
Shanghai, 200025, China
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SKPP UM w Poznaniu
Poznan, 60-569, Poland
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Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich
Chorzów, 41-500, Poland
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Samsung Medical Center
Seoul, 06351, South Korea
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Seattle Cancer Care Alliance
Seattle, Washington, 98109-1023, United States
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Semmelweis Egyetem I.Belgyogyaszati Klinika
Budapest, 1083, Hungary
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Semmelweis Egyetem I.Belgyogyaszati Klinika
Budapest, 1088, Hungary
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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Sheba Medical Center
Ramat Gan, 52621, Israel
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Shinshu University Hospital
Matsumoto, 390 8621, Japan
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Sir Charles Gairdner Hospital
Nedlands, 6009, Australia
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Skanes universitetssjukhus
Lund, 221 85, Sweden
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Sociedade Pernambucana de Combate ao Cancer
Recife, 50040-000, Brazil
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Sourasky Medical Center
Tel Aviv, 6423906, Israel
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South Elvsborg Hospital
Borås, 501 82, Sweden
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Stanford University
Stanford, California, 94305, United States
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Teine Keijinkai Hospital
Hokkaido, 006-8555, Japan
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The Catholic University of Korea Seoul St Marys Hospital
Seoul, 06591, South Korea
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The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, 325000, China
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The Ohio State University
Columbus, Ohio, 43210, United States
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Tokushima University Hospital
Tokushima, 770-8503, Japan
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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UMC Utrecht
Utrecht, 3584 CX, Netherlands
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UMCG
Groningen, 9713 GZ, Netherlands
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UZ Gent
Ghent, 9000, Belgium
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Universitaetsklinikum Heidelberg Medizinische Klinik V
Heidelberg, 69120, Germany
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Universitaetsklinikum Tuebingen der Eberhard-Karls-Universitaet, Abteilung fuer Innere Medizin II,
Tübingen, 72076, Germany
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Universitair Ziekenhuis Leuven
Leuven, 3000, Belgium
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Universitatsklinikum Essen
Essen, 45122, Germany
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University College Hospital
London, NW1 2PG, United Kingdom
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University General Hospital of Rio
Pátrai, 26500, Greece
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University Health Network UHN Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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University Hospitals Birmingham NHS Trust,
Birmingham, B15 2TH, United Kingdom
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Colorado
Aurora, Colorado, 80045, United States
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University of Maryland
Baltimore, Maryland, 21201, United States
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University of Pennsylvania Medical Center
Philadelphia, Pennsylvania, 19104, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Texas, MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Universitätsklinikum Würzburg Med. Klinik U. Poliklinik Ii
Würzburg, 97080, Germany
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Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Wake Forest University Health Sciences - Cardiovascular Medicine
Winston-Salem, North Carolina, 27157, United States
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Washington University School Of Medicine
St Louis, Missouri, 63110, United States
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Weill Cornell Medical College
New York, New York, 10065, United States
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Westmead Hospital
Westmead, 2145, Australia
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Winship Cancer Institute Emory University
Atlanta, Georgia, 30322, United States
Conditions
Explore the condition pages connected to this study.