Lifestyle overhaul may shield aging brains from memory loss
NCT ID NCT03688126
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether lifestyle changes—like a healthy diet, physical and mental exercise, and managing health risks—can protect memory and thinking in older adults at risk for Alzheimer's disease. Researchers enrolled 2,000 Americans who were sedentary and had a low-quality diet but no memory problems. Participants were split into two groups: one received tools and support to make their own lifestyle changes, while the other followed a structured program. The goal was to see if these changes could slow or prevent cognitive decline.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Lifestyle intervention (diet, physical and cognitive exercise, social activity, and cardiometabolic risk management)
What this could lead to
If successful, this could show that lifestyle changes can help prevent memory loss and cognitive decline in older Americans at risk for Alzheimer's disease.
What could go wrong
This is a completed study, but results may not apply to everyone. Lifestyle changes can be hard to maintain, and the effect may be modest or not work for all individuals.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Chicagoland--Advocate Aurora Health
Downers Grove, Illinois, 60068, United States
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Chicagoland--Rush
Chicago, Illinois, 60304, United States
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Houston
Houston, Texas, 77030, United States
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New England--Rhode Island
Providence, Rhode Island, 02906, United States
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North Carolina
Winston-Salem, North Carolina, 27157, United States
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Northern California
Sacramento, California, 95616, United States