Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain pacemaker that adapts to you: hope for rare Parkinson's-Like disease

NCT ID NCT05197816

Disease control Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small study tested a new type of deep brain stimulation (DBS) that automatically adjusts electrical pulses based on a person's activity or body position. The goal was to improve walking, blood pressure, bladder control, and sleep in people with Multiple System Atrophy (MSA), a rare and severe neurological disorder. Only 3 people took part, and the study looked at changes in quality of life and symptoms before and after the device was turned on.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep brain stimulation (adaptive electrical pulses from an implanted device)
What this could lead to
If it works, this could point toward a more personalized, responsive way to manage symptoms of Multiple System Atrophy.
What could go wrong
This is a very early, tiny study (only 3 people) with no control group. The approach may not work for others or may cause side effects like falls or sleep disruption.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

3 people

The number who actually took part.

Started

Dec 2021

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of MSA with disabling autonomic symptoms * \>6/12 in the autonomic subsection (Q9-12) of the UMSAR scale * Patient willing and able to give informed consent to involvement in the study. * Male or female aged 55 years or over * Able to walk (to perform gait analysis) * Have an anticipated prognosis \> 2 years Exclusion Criteria: * Female of child-bearing age * The patient is unwilling to participate or unable to give informed consent. * The patient has been deemed unfit for stimulator insertion by their healthcare team i.e. surgical contraindications to DBS: * Bleeding or coagulation disorder * Not fit for general anaesthetic * Unable to deal with implanted DBS system (turn on and off and recharging where applicable, although it is acceptable if a carer can do this) * Untreated anxiety or depression * Unable to undergo preoperative MRI (e.g. metal implants) * Subject is currently participating in a clinical investigation that includes an active treatment arm.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Msa - multiple system atrophy are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

multiple system atrophy Shy-Drager Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Msa - multiple system atrophy

Contacts and locations

Locations

  • John Radcliffe Hospital

    Oxford, Oxfordshire, OX3 9DU, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.