Brain pacemaker that adapts to you: hope for rare Parkinson's-Like disease

NCT ID NCT05197816

Completed Disease control Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small study tested a new type of deep brain stimulation (DBS) that automatically adjusts electrical pulses based on a person's activity or body position. The goal was to improve walking, blood pressure, bladder control, and sleep in people with Multiple System Atrophy (MSA), a rare and severe neurological disorder. Only 3 people took part, and the study looked at changes in quality of life and symptoms before and after the device was turned on.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: deep brain stimulation (adaptive electrical pulses from an implanted device)
What this could lead to: If it works, this could point toward a more personalized, responsive way to manage symptoms of Multiple System Atrophy.
What could go wrong: This is a very early, tiny study (only 3 people) with no control group. The approach may not work for others or may cause side effects like falls or sleep disruption.

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Conditions

The condition(s) this trial relates to.

multiple system atrophy Shy-Drager Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MSA - MULTIPLE SYSTEM ATROPHY

Contacts and locations

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Locations

John Radcliffe Hospital

Oxford, Oxfordshire, OX3 9DU, United Kingdom

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