New pill for early Alzheimer's shows promise in small trial

NCT ID NCT05771428

Completed Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study tested an experimental drug called ABBV-552 in 263 people with mild Alzheimer's disease. Participants took either the drug or a placebo daily for 12 weeks. The goal was to see if the drug could safely improve memory and thinking. The results will help decide if larger studies are worthwhile.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-552 (oral capsule)
What this could lead to: If successful, this could point toward a new treatment to ease cognitive symptoms in early Alzheimer's disease.
What could go wrong: This is an early Phase 2 trial with only 263 participants over 12 weeks. The drug may not improve cognition or could cause side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE(AD)

Contacts and locations

Locations

ANESC Research LLC /ID# 246958

El Paso, Texas, 79912, United States
Adams Clinical /ID# 248358

Watertown, Massachusetts, 02472, United States
Alliance for Research Alliance for Wellness /ID# 246492

Long Beach, California, 90807, United States
Allied Biomedical Res Inst Inc /ID# 246971

Miami, Florida, 33155, United States
Alzheimer's Research and Treatment Center - Stuart /ID# 246484

Stuart, Florida, 34997-5765, United States
Alzheimer's Research and Treatment Center - Wellington /ID# 246491

Wellington, Florida, 33414, United States
American Clinical Research Institute (ACRI) - Beavercreek /ID# 246930

Beavercreek, Ohio, 45432-2886, United States
Australian Alzheimer's Res Fou /ID# 249097

Nedlands, Western Australia, 6009, Australia
Box Hill Hospital /ID# 249095

Box Hill, Victoria, 3128, Australia
CGM Research Trust /ID# 249439

Christchurch Central, 8011, New Zealand
Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 248078

Berlin, 12203, Germany
Clinica Universidad de Navarra - Pamplona /ID# 248415

Pamplona, Navarre, 31008, Spain
Columbus Memory Center /ID# 249534

Columbus, Georgia, 31909, United States
Combined Research Orlando Phase I-IV /ID# 247697

Orlando, Florida, 32814, United States
Conquest Research /ID# 262078

Winter Park, Florida, 32789, United States
Duplicate_Kawashima Neurology Clinic /ID# 253561

Fujisawa-shi, Kanagawa, 251-0038, Japan
Duplicate_Summit Headlands LLC /ID# 250678

Portland, Oregon, 97210, United States
Epic Medical Research /ID# 249141

Red Oak, Texas, 75154-3981, United States
Finlay Medical Research - West Palm Beach /ID# 246970

Greenacres City, Florida, 33467-2979, United States
Health Synergy Clinical Research LLC /ID# 247726

Okeechobee, Florida, 34972-2568, United States
Hizen Psychiatric Center /ID# 252363

Kanzaki-gun, Saga-ken, 842-0192, Japan
Hospital Internacional Ruber - Grupo Quiron Salud /ID# 248856

Madrid, 28034, Spain
Hospital Universitari General de Catalunya /ID# 249100

Sant Cugat del Vallès, Barcelona, 08195, Spain
Hospital Universitari Mútua Terrassa /ID# 248448

Terrassa, Barcelona, 08221, Spain
Hospital Universitario Marques de Valdecilla /ID# 248454

Santander, Cantabria, 39008, Spain
Hospital Universitario de Salamanca /ID# 249101

Salamanca, 37711, Spain
Indiana University Health, Inc. /ID# 248300

Fort Wayne, Indiana, 46804, United States
Irvine Clinical Research /ID# 250030

Irvine, California, 92614, United States
Ivetmar Medical Group, LLC. /ID# 247670

Miami, Florida, 33155, United States
Josephson-Wallack-Munshower Neurology - Northeast /ID# 248554

Indianapolis, Indiana, 46256, United States
Juntendo University Hospital /ID# 252373

Bunkyo-ku, Tokyo, 113-8431, Japan
K2 Medical Research - Ocoee /ID# 251029

Ocoee, Florida, 34761-4547, United States
K2 Medical Research - Orlando - South Orlando Avenue /ID# 250904

Orlando, Florida, 32751, United States
K2 Medical Research - The Villages /ID# 250820

Lady Lake, Florida, 32159-8975, United States
Kerwin Medical Center /ID# 248662

Dallas, Texas, 75231-4316, United States
NHO Hiroshima-Nishi Medical center /ID# 256947

Otake-shi, Hiroshima, 739-0696, Japan
NHO Niigata National Hospital /ID# 254207

Kashiwazaki-shi, Niigata, 945-8585, Japan
Nara Medical University Hospital /ID# 252564

Kashihara-shi, Nara, 634-8522, Japan
NeuroClin Limited(Previously Glasgow Memory Clinic) /ID# 249787

Motherwell, Lanarkshire, ML3 4UF, United Kingdom
NeuroMedical Clinic of Central Louisiana /ID# 246960

Alexandria, Louisiana, 71301-3900, United States
NeuroScience Research Center - Canton /ID# 248552

Canton, Ohio, 44718-2784, United States
Neurology Diagnostics - South /ID# 246931

Dayton, Ohio, 45459-4296, United States
New England Institute for Clinical Research /ID# 246488

Stamford, Connecticut, 06905, United States
New Horizon Research Center /ID# 248298

Miami, Florida, 33165-3372, United States
New Life Medical Research Center - Hialeah /ID# 247536

Hialeah, Florida, 33012, United States
Northwest Clinical Trials /ID# 248663

Boise, Idaho, 83704, United States
Oita University Hospital /ID# 253679

Yufu, Oita Prefecture, 879-5503, Japan
Re:Cognition Health - London /ID# 249005

London, W1G 9JF, United Kingdom
Re:Cognition Health Birmingham /ID# 249796

Birmingham, B16 8LT, United Kingdom
Re:Cognition Health Bristol /ID# 249795

Bristol, BS32 4SY, United Kingdom
Sentara Neurology Specialists - Norfolk /ID# 248578

Norfolk, Virginia, 23510-1065, United States
Shonan Kamakura General Hospital /ID# 256664

Kamakura-shi, Kanagawa, 247-8533, Japan
Southern Neurology - Kogarah /ID# 249098

Kogarah, New South Wales, 2217, Australia
St Pancras Clinical Research /ID# 249006

London, EC2Y 8EA, United Kingdom
St Vincent's Centre for Applied Medical Research /ID# 249843

Darlinghurst, New South Wales, 2010, Australia
Tandem Clinical Research, LLC /ID# 246973

Marrero, Louisiana, 70072-3156, United States
Teikyo University Mizonokuchi Hospital /ID# 253259

Kawasaki, Kanagawa, 213-8507, Japan
Universitaetsklinikum des Saarlandes /ID# 248077

Homburg, Saarland, 66424, Germany
University of Kentucky Sanders-Brown Center on Aging /ID# 251139

Lexington, Kentucky, 40504, United States
Vanderbilt Ingram Cancer Center /ID# 248801

Nashville, Tennessee, 37232-0021, United States
Velocity Clinical Research - Hallandale Beach /ID# 246896

Hallandale, Florida, 33009-4427, United States
Velocity Clinical Research, Inc /ID# 249837

Raleigh, North Carolina, 27607, United States
Vertex Research Group Inc /ID# 248295

Clermont, Florida, 34711-5037, United States
Wake Research - Pharmacology Research Institute (WR-PRI), LLC (Alamitos) /ID# 248891

Los Alamitos, California, 90720, United States

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