New PET tracer could sharpen amyloidosis diagnosis

NCT ID NCT05235269

Completed Diagnosis Sponsor: Attralus, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 2 trial tested a radioactive tracer called 124I-AT-01 to see how well it can measure amyloid buildup in organs like the heart, kidneys, liver, and spleen using PET/CT scans. 33 adults with systemic amyloidosis received the tracer twice, six weeks apart. The goal was to check if the imaging results were consistent between visits. This approach could eventually help doctors better diagnose and monitor amyloidosis without invasive biopsies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 124I-AT-01 (a radioactive tracer for PET imaging)
What this could lead to: If successful, this imaging method could help doctors more accurately detect and track amyloid deposits in organs, leading to better diagnosis and treatment monitoring for amyloidosis.
What could go wrong: This is a small, early-phase study focused on repeatability of imaging, not on treatment. The tracer may not prove reliable enough for widespread use, and results may not apply to all types of amyloidosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AL amyloidosis amyloidosis wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYLOIDOSIS

Contacts and locations

Locations

Northern California PET Imaging Center

Sacramento, California, 95816, United States
PET/CT Imaging of Berkeley

Berkeley, California, 94705, United States
PET/CT Imaging of San Jose

San Jose, California, 95128, United States

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