Heart scans reveal hidden protein buildup in rare disease

NCT ID NCT06073574

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses MRI scans to measure amyloid protein buildup in the hearts of up to 150 people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). Participants are already enrolled in a larger treatment trial. The goal is to see how amyloid levels change over time, not to test a new treatment directly.

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Conditions

The condition(s) this trial relates to.

amyloidosis cardiomyopathy wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Azienda Ospedale Università di Padova

    Padova, 35128, Italy

  • Azienda Ospedaliero - Universitaria Careggi

    Florence, 50139, Italy

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Hospital Universitario Puerta de Hierro

    Majadahonda, 28222, Spain

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Richmond Pharmacology

    London, SE1 1YR, United Kingdom

  • Royal Free London NHS Foundation Trust

    London, NW3 2QG, United Kingdom

  • Synexus - Manchester Clinical Research Centre

    Manchester, M15 6SE, United Kingdom

  • Synexus - Scotland Clinical Research Centre

    Bellshill, ML4 3NJ, United Kingdom

  • Synexus - Wales

    Cardiff, CF15 9SS, United Kingdom

  • Synexus Midlands Clinical Research Centre

    Birmingham, B15 2SQ, United Kingdom