New drug shows promise for rare heart disease in Long-Term safety trial
NCT ID NCT05667493
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 31 times
Summary
This study looks at the long-term safety of a drug called eplontersen in people with a heart condition known as ATTR-CM, where abnormal proteins build up in the heart. About 1400 adults who completed earlier studies or have this diagnosis will receive the drug and be monitored for side effects and changes in heart function. The goal is to see if eplontersen is safe to use over a longer period.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A Beneficência Portuguesa de São Paulo - Unidade Mirante
São Paulo, 01323-030, Brazil
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AES - Synexus - Midlands
Edgbaston, England, B15 2SQ, United Kingdom
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AES - Synexus - Scotland Clinical Research Centre
Bellshill, England, ML4 3NJ, United Kingdom
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AES - Synexus - Wales
Cardiff, Wales, CF15 9SS, United Kingdom
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Advara HeartCare
Joondalup, Western Australia, 6027, Australia
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Advara HeartCare - Joondalup
Joondalup, 6027, Australia
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Advara HeartCare Murdoch
Murdoch, Western Australia, 6150, Australia
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Advara HeartCare Murdoch
Murdoch, 6150, Australia
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Advara Heartcare Leabrook
Leabrook, 5068, Australia
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Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan
Bruges, 8000, Belgium
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Allina Health Minneapolis Heart Institute - Abbott Northwestern's Heart Hospital
Minneapolis, Minnesota, 55407, United States
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Altman Clinical and Translational Research Institute - Center for Clinical Research
La Jolla, California, 92037, United States
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Azienda Ospedale Università di Padova
Padova, 35128, Italy
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Azienda Ospedaliera - Universitaria Sant' Andrea
Roma, 00189, Italy
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Azienda Ospedaliero - Universitaria Careggi
Florence, 50134, Italy
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Azienda Ospedaliero Universitaria Delle Marche
Ancona, 60126, Italy
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Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
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Boston University School of Medicine
Boston, Massachusetts, 02118, United States
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Box Hill Hospital
Clayton, 3168, Australia
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Carl and Edyth Lindner Research Center at The Christ Hospital
Cincinnati, Ohio, 45219, United States
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Cedars-Sinai Medical Center
Beverly Hills, California, 90211, United States
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Centre Hospitalier Départemental Vendée
La Roche-sur-Yon, 85925, France
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Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec
Nantes, 44093, France
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Centre Hospitalier de l'Université de Montréal (CHUM)
Montreal, Quebec, H2X 0C1, Canada
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Centro Avançado de Pesquisa e Estudos para o Diagnóstico CAPED
São Paulo, 14026-900, Brazil
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Centro Hospitalar Universitário de São João
Porto, 4200-319, Portugal
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Centro Hospitalar Universitário do Porto - Hospital Geral de Santo Antonio
Porto, 4099-001, Portugal
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Cleveland Clinic Florida
Weston, Florida, 33331, United States
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Cleveland Clinic Main Campus
Cleveland, Ohio, 44195, United States
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Columbia University Irving Medical Center
New York, New York, 10034, United States
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Complejo Hospitalario Universitario de Santiago (CHUS)
Santiago de Compostela, 15706, Spain
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Emory Heart and Vascular Center - Emory Clifton Campus
Atlanta, Georgia, 30322, United States
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Fakultní Nemocnice u sv. Anny v Brně
Brno, 656 91, Czechia
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Fondazione IRCCS Policlinico San Matteo
Pavia, 27100, Italy
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Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica
Pisa, 56124, Italy
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General Hospital of Athens "Alexandra"
Athens, 115 28, Greece
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Gordon and Leslie Diamond Health Care Centre
Vancouver, V5Z 1M9, Canada
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Hadassah University Hospital Ein Kerem
Jerusalem, 9112001, Israel
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Hamamatsu University Hospital
Hamamatsu, 4313192, Japan
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Henry Ford Health System
Detroit, Michigan, 48202, United States
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Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, 30120, Spain
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Hospital Italiano de Buenos Aires
Buenos Aires, C1199ABB, Argentina
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Hospital Moinhos de Vento
Porto Alegre, 90560-030, Brazil
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Hospital Universitari Vall d'Hebrón
Barcelona, 08035, Spain
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Hospital Universitario Puerta de Hierro
Majadahonda, 28222, Spain
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Hospital da Senhora da Oliveira
Guimarães, 4835-044, Portugal
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Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto
Ribeirão Preto, 14040-030, Brazil
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Hôpital Haut-Lévêque
Pessac, 33604, France
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Hôpital Rangueil
Toulouse, 31059, France
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Hôpital Regional de Rimouski
Rimouski, G5L 5T1, Canada
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Hôpital de la Timone
Marseille, 13005, France
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Hôpitaux Universitaires Henri Mondor
Créteil, 94010, France
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Indiana University Health University Hospital
Indianapolis, Indiana, 46202, United States
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Institut Klinické a Experimentální Medicíny
Prague, 140 21, Czechia
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Instituto Cardiovascular de Buenos Aires
Buenos Aires, C1428ART, Argentina
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Instituto Dante Pazzanese de Cardiologia
São Paulo, 04012-909, Brazil
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Instituto do Coração de São Paulo
São Paulo, 05403-000, Brazil
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Kaplan Medical Center
Rehovot, 7661041, Israel
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Keio University Hospital
Shinjuku-Ku, 160-8582, Japan
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Krakowski Szpital Specjalistyczny im. Jana Pawła II
Krakow, 31- 202, Poland
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Kumamoto University Hospital
Kumamoto, 860-8556, Japan
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Kurume University Hospital
Kurume-Shi, Fukuoka, 830-0011, Japan
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Kurume University Hospital
Kurume, 830-0011, Japan
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Lancaster General Hospital
Lancaster, Pennsylvania, 17602, United States
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Liverpool Hospital
Liverpool, 2170, Australia
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Scottsdale, Arizona, 85259, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Medizinische Universität Graz
Graz, 8036, Austria
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Medizinische Universität Innsbruck
Innsbruck, 6020, Austria
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Medizinische Universität Wien
Vienna, 1090, Austria
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New York University Langone Cardiology Associates
New York, New York, 10016, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Okayama University Hospital
Okayama, 700-8558, Japan
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Osaka Metropolitan University Hospital
Osaka, 545-8586, Japan
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Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
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Piedmont Atlanta Hospital
Fayetteville, Georgia, 30214, United States
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Piedmont Heart of Fayetteville
Atlanta, Georgia, 30309, United States
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Princess Alexandra Hospital
Woolloongabba, 4102, Australia
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Rambam Health Care Campus
Haifa, 3109601, Israel
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Richmond Pharmacology
London, SE1 1YR, United Kingdom
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Rigshospitalet
Copenhagen, 2100, Denmark
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Royal Free London NHS Foundation Trust
Hampstead, NW3 2PF, United Kingdom
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Royal Hobart Hospital
Hobart, 7000, Australia
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Sahlgrenska Universitetssjukhuset
Gothenburg, 413 45, Sweden
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Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111, United States
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Saiseikai Fukuoka General Hospital
Fukuoka, Hukuoka [Fukuoka], 810-0001, Japan
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Saiseikai Fukuoka General Hospital
Fukuoka, 810-0001, Japan
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Sapporo Medical University Hospital
Sapporo, 060-8543, Japan
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Shinshu University Hospital
Matsumoto, 390-8621, Japan
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Skellefteå lasarett
Skellefteå, 931 86, Sweden
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Stanford University (Leland Stanford Junior University)
Stanford, California, 94305, United States
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Synexus - Manchester Clinical Research Centre
Manchester, England, M15 6SE, United Kingdom
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Synexus - Merseyside Clinical Research Centre
Liverpool, L22 0LG, United Kingdom
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Synexus - Merseyside Clinical Research Centre
Manchester, M15 6SE, United Kingdom
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The George Washington Medical Faculty Associates - Foggy Bottom North Pavilion
Washington D.C., District of Columbia, 20037, United States
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The Ohio State University College of Medicine
Columbus, Ohio, 43210, United States
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Toronto General Hospital
Toronto, Ontario, M5G 2C4, Canada
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Unidade Local de Saúde de Santo António, E. P. E - Hospital Geral de Santo Antonio
Porto, 4099-001, Portugal
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Unidade Local de Saúde de São José, E. P. E - Hospital de Santa Marta
Lisbon, 1169-024, Portugal
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Unidade Local de Saúde de São João, EPE
Porto, 4200-319, Portugal
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Unidade Local de Saúde do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimarães)
Guimarães, 4835-044, Portugal
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Uniklinik Köln
Cologne, 50937, Germany
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Universidade Estadual de Campinas
São Paulo, 13083881, Brazil
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Universitaetsklinikum Heidelberg - Zentrum für Innere Medizin
Heidelberg, 69120, Germany
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University Hospital - London Health Sciences Centre
London, Ontario, N6A 5A5, Canada
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University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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University Of California San Francisco Urology Practice
San Francisco, California, 94143, United States
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University of Calgary
Calgary, Alberta, T2N 4Z6, Canada
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University of Colorado Hospital - Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
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University of Kansas Medical Center (KUMC)
Kansas City, Kansas, 66160, United States
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University of Maryland Medical Center
Baltimore, Maryland, 21201, United States
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University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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University of Washington
Seattle, Washington, 98195, United States
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University of Wisconsin - Madison
Madison, Wisconsin, 53792, United States
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Universitätsklinikum Münster
Münster, 48149, Germany
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Universitätsklinikum Würzburg
Würzburg, 97078, Germany
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Universitätsklinikum des Saarlandes
Homburg, 66421, Germany
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Vanderbilt Heart and Vascular Institute
Nashville, Tennessee, 37232, United States
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Vseobecna Fakultni Nemocnice v Praze
Prague, 116 36, Czechia
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Weill Cornell Medicine Cardiology
New York, New York, 10021, United States
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Westmead Hospital
Westmead, 2145, Australia
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Ziekenhuis Oost-Limburg - Campus Sint-Jan
Limbourg, 3600, Belgium
Conditions
Explore the condition pages connected to this study.