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Could this injection help slow Alzheimer's?

NCT ID NCT04592874

Disease control Sponsor: Alector Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called AL002 in 356 people with early Alzheimer's disease. The goal was to see if it could slow down memory and thinking problems compared to a placebo. Participants received either the drug or a dummy injection, and their symptoms were tracked over 96 weeks using standard dementia rating scales.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

356 people

The number who actually took part.

Started

Jan 2021

Finished

Sep 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of Early AD including evidence of brain amyloidosis by CSF or PET * MMSE score ≥ 20 points, CDR Global Score of 0.5 - 1.0, and RBANS score on the DMI ≤95. * Study partner who consents to study participation and who cares for/visits the participant at least 10 hours a week * Written informed consent must be obtained and documented (from the participant or, where jurisdictions allow it, from their legal decision maker). Exclusion Criteria: * Dementia due to a condition other than AD including, but not limited to, FTD, Parkinson's disease, dementia with Lewy bodies, Huntington disease, or vascular dementia. * Known history of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric, human, or humanized antibodies or fusion proteins. * Current uncontrolled hypertension, diabetes mellitus or thyroid disease. Clinically significant heart disease, liver disease or kidney disease. * History or evidence of clinically significant brain disease other than AD. * Females who are pregnant or breastfeeding, or planning to conceive within the study period. * Any experimental vaccine or gene therapy. * History of unresolved cancer. * Current use of anticoagulant medications. * Residence in a skilled nursing facility, convalescent home, or long term care facility at screening; or requires continuous nursing care. * Participant is positive for presence of APOE e4/e4 genotype.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease

Contacts and locations

Locations

  • AMITA Health Clinical Research Institute

    Elk Grove Village, Illinois, 60007, United States

  • ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia

    Brescia, 25123, Italy

  • ATP Clinical Research

    Costa Mesa, California, 92626, United States

  • Abington Neurologic Associates

    Abington, Pennsylvania, 19090, United States

  • Advanced Clinical Institute

    Neptune City, New Jersey, 07753, United States

  • Alzheimers Research and Treatment Center

    Wellington, Florida, 33449, United States

  • Axiom Clinical Research FL

    Tampa, Florida, 33609, United States

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126, Italy

  • Azienda Policlinico Umberto I

    Rome, Lazio, 00185, Italy

  • Banner Alzheimer's Institute

    Phoenix, Arizona, 85006, United States

  • Baycrest Health Sciences

    Toronto, Ontario, Ontario, Canada

  • Boston Center for Memory

    Newton, Massachusetts, 02459, United States

  • Box Hill Hospital

    Box Hill, Victoria, 3128, Australia

  • Brain Matters Research - ERG

    Delray Beach, Florida, 33445, United States

  • Brain Research Center Amsterdam

    Amsterdam, 1081 GN, Netherlands

  • Brain Research Center Den Bosch

    's-Hertogenbosch, North Brabant, 5223 GV, Netherlands

  • Bruyère Research Institute

    Ottawa, Ontario, K1N 5C8, Canada

  • CGM Research Trust

    Christchurch, 8083, New Zealand

  • Centre Hospitalier Universitaire de Toulouse

    Toulouse, 31059, France

  • Centro de Atencion Especializada Oroitu

    Getxo, Basque Country, 48993, Spain

  • Centro de Psiquiatría Biológica Instituto Senecta

    Mendoza, 5500, Argentina

  • Centrum Medyczne NeuroProtect

    Warsaw, Masovian Voivodeship, 01-684, Poland

  • Charite Campus Buch

    Berlin, 13125, Germany

  • Charité - Universitätsmedizin Berlin (CBF)

    Berlin, 12203, Germany

  • Charter Research

    Lady Lake, Florida, 32159, United States

  • ClinCloud, LLC

    Maitland, Florida, 32751, United States

  • Clinical Trial Network

    Houston, Texas, 77074-2085, United States

  • Columbia University College of Physicians and Surgeons

    New York, New York, 10032-3725, United States

  • Conquest Clinical Research (Winter Park)

    Winter Park, Florida, 32789, United States

  • EUROMEDIS Sp. z o.o.

    Szczecin, West Pomeranian Voivodeship, 70-111, Poland

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Feinstein Institute For MR

    Manhasset, New York, 11030, United States

  • Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Fondazione IRCCS Di Rilievo Nazionale Istituto Nazionale Neurologico Carlo Besta

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario A Gemelli

    Rome, Lazio, 00168, Italy

  • Fundacion ACE Instituto Catalan de Neurociencias

    Barcelona, 08028, Spain

  • Fundacion CITA Alzheimer Fundazioa

    Donostia / San Sebastian, Guipuzcoa, 20009, Spain

  • Georgetown University Medical Center

    Washington D.C., District of Columbia, 20007, United States

  • Gerontopole

    Toulouse, 31059, France

  • Glasgow Memory Clinic

    Motherwell, ML1 4UF, United Kingdom

  • Greater Manchester Mental Health NHS Foundation Trust

    Manchester, M8 5RB, United Kingdom

  • Hattiesburg Clinic

    Hattiesburg, Mississippi, 39401, United States

  • Hopital Lariboisiere

    Paris, 75010, France

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario Doctor Peset

    Valencia, 46017, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Viamed Montecanal

    Zaragoza, 50012, Spain

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, Catalonia, 08041, Spain

  • Hôpital Roger Salengro

    Lille, Nord, 59037, France

  • Hôpital de la Pitié Salpétrière

    Paris, 75013, France

  • IRCCS - Centro S. Giovanni di Dio Fatebenefratelli

    Brescia, Lombardy, 25125, Italy

  • Instituto Kremer

    Córdoba, X5004AOA, Argentina

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • K2 The Villages

    The Villages, Florida, 32159, United States

  • K2 Winter Garden Ocoee

    Ocoee, Florida, 34761, United States

  • KaRa Institute of Neurological Disease

    Macquarie Park, New South Wales, 2113, Australia

  • Kawartha Regional Memory Clinic

    Peterborough, Ontario, K9H 2P4, Canada

  • Klinikum rechts der Isa der Technischen Universitaet Muenchen

    München, 81675, Germany

  • LMU Klinikum der Universität München

    München, 81377, Germany

  • NZOZ Wroclawskie Centrum Alzheimerowskie

    Wroclaw, Lower Silesian Voivodeship, 53-110, Poland

  • Okanagan Clinical Trials

    Kelowna, British Columbia, V1Y 1Z9, Canada

  • Ospedale Civile di Baggiovara

    Modena, 41126, Italy

  • Ospedale S Giovanni Calibita Fatebenefratelli

    Rome, Lazio, 00186, Italy

  • Ospedale degli Infermi

    Ponderano, 13875, Italy

  • Parkwood Institute

    London, Ontario, N6C 0A7, Canada

  • Progressive Medical Research

    Port Orange, Florida, 32127-5170, United States

  • Re: Cognition Health - Guildford

    Guildford, Surrey, GU2 7YD, United Kingdom

  • Re:Cognition Health Bristol

    Bristol, BS32 4SY, United Kingdom

  • Re:Cognition Health London

    London, W1G 9JF, United Kingdom

  • Re:Cognition Health Plymouth

    Plymouth, Pl6 8BT, United Kingdom

  • SMarT Minds WA

    Nedlands, Western Australia, 6009, Australia

  • SOMED CR

    Warsaw, 01-737, Poland

  • SUNY Upstate Medical Center

    Syracuse, New York, 13210, United States

  • South Florida Neurology Associates

    Boca Raton, Florida, 33487, United States

  • Summit Research Network

    Portland, Oregon, 97210, United States

  • The Alfred Hospital

    Parkville, Victoria, 3050, Australia

  • The National Hospital for Neurology and Neurosurgery

    London, WC1N 3BG, United Kingdom

  • Toronto Memory Clinic

    Toronto, Ontario, M3B 2S7, Canada

  • True North Clinical Research - Halifax

    Halifax, Nova Scotia, B3S 1N2, Canada

  • True North Clinical Research - New Minas

    New Minas, Nova Scotia, B4N 3R7, Canada

  • University Clinic Heidelberg

    Mannheim, 68159, Germany

  • University of Cincinnati MC

    Cincinnati, Ohio, 45219, United States

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

  • University of Rochester Medical Center

    Rochester, New York, 14620, United States

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Woodlands Research Network, LLC - ERG

    Rogers, Arkansas, 72758, United States

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