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AI spots silent heart condition in seconds

NCT ID NCT06469372

Diagnosis Sponsor: Pierre Elias Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a computer model that uses a patient's age, sex, medical history, and heart tests (ECG and echocardiogram) to estimate their risk of having cardiac amyloidosis, a serious but often undiagnosed heart condition. Researchers invited 50 high-risk patients for further testing to see if the model could find new cases. The goal is to see if this AI tool can help doctors catch the disease earlier than usual.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep learning model (device)
What this could lead to
If successful, this could lead to earlier detection of cardiac amyloidosis, a serious heart condition that is often missed.
What could go wrong
This is a small, single-center study with only 50 participants. The model may not work as well in other populations or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

May 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * High predicted probability of having cardiac amyloidosis as determined by deep learning model. * Age ≥ 50 years. * Electronically stored ECG and echocardiogram within 5 years of study start date. * Ability for the patient or health care proxy to understand and sign the informed consent after the study has been explained. Exclusion Criteria: * Primary amyloidosis (AL) or secondary amyloidosis (AA). * Prior liver or heart transplantation. * Active malignancy or non-amyloid disease with expected survival of less than 1 year. * Previous testing for cardiac amyloidosis such as amyloid nuclear scintigraphy, cardiac, or fat pad biopsy. * Impairment from stroke, injury or other medical disorder that precludes participation in the study. * Disabling dementia or other mental or behavioral disease * Nursing home resident.

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Conditions

The condition(s) this trial relates to.

Amyloid Neuropathies, Familial amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac amyloidosis

Contacts and locations

Locations

  • Columbia University Irving Medical Center / NewYork-Presbyterian Hospital

    New York, New York, 10032, United States

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