Neurodegenerative disease

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This Phase 2 study tested ABvac40, a vaccine designed to help the immune system target and clear a protein called amyloid-beta 40, which builds up in the brains of people with Alzheimer's. The trial included 134 adults aged 55-80 with mild cognitive impairment or very mild Alzhei…

This completed study checked the safety of the Hexaxim vaccine in 713 infants aged 2 months and older in South Korea. Researchers tracked side effects like injection site reactions, fever, and crying after routine vaccination. The goal was to confirm the vaccine's safety in every…

This long-term study is testing higher doses of nusinersen (Spinraza) in people with spinal muscular atrophy who already completed a previous nusinersen study. The main goal is to check safety over several years, including side effects, heart health, and growth. Participants rece…

This study is testing whether a subcutaneous (under the skin) injection of ocrelizumab works as well as the standard intravenous (IV) infusion for people with relapsing or primary progressive multiple sclerosis. The trial will compare how the drug is absorbed, its safety, and its…

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This study tests whether bosutinib, a drug currently used for certain cancers, can help people with amyotrophic lateral sclerosis (ALS), a progressive nerve disease. The trial has two parts: the first finds a safe dose, and the second checks if that dose slows the decline in dail…

This first-in-human study tested a new drug called IBC-Ab002 in 40 people with early Alzheimer's disease. The drug is an antibody that targets PD-L1, a protein involved in immune regulation. The main goal was to check safety and how the drug moves through the body, not yet to pro…

This phase III trial is testing whether a long-acting form of glatiramer acetate, called GA Depot, given as a monthly injection, can reduce the number of relapses in people with relapsing-remitting multiple sclerosis (MS). The study involves about 1,000 adults aged 18 to 55 with …

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This phase 2 trial tests a powerful mix of short-course radiation, chemotherapy (mFOLFOX6), an immunotherapy (PD-1 antibody), and a targeted drug (cetuximab or bevacizumab, depending on genetic markers) in people with high-risk rectal cancer that is mismatch repair proficient (pM…

The BEAT-AD study is testing whether a low-carb, high-fat ketogenic diet can improve thinking and memory in 120 adults with mild cognitive impairment, a precursor to Alzheimer's. Participants are randomly assigned to either a ketogenic diet or a low-fat diet for 16 weeks, with fo…

This study tests whether a week of intensive therapy involving horses can improve motor skills, posture, and breathing in children with spinal muscular atrophy (SMA). Children with SMA types I, II, or III will receive either horse-assisted physiotherapy or standard individual phy…

This trial tests a personalized treatment plan for people with advanced colorectal cancer that has spread to the liver and stopped responding to standard treatments. The approach combines a liver-directed chemotherapy (HAIC), a targeted therapy (fruquintinib or cetuximab), and an…

This trial tests whether cladribine tablets change key immune cells and nerve damage markers in the spinal fluid of people with relapsing forms of multiple sclerosis. Participants take cladribine as prescribed and undergo up to two lumbar punctures to measure these biomarkers ove…

This phase 2 trial is testing whether an experimental antibody called bepranemab can slow the progression of Alzheimer's disease in people with early-stage symptoms. Participants receive either bepranemab or a placebo by intravenous infusion over 80 weeks. The study measures chan…

This study tested a low dose of nilotinib, a drug used for leukemia, in 37 people with mild to moderate Alzheimer's disease. The goal was to see if the drug is safe and can reach the brain to affect proteins linked to Alzheimer's, like tau and amyloid. Participants took the drug …

This trial investigates whether plasmapheresis — a procedure that filters the blood to remove harmful antibodies — can slow the progression of amyotrophic lateral sclerosis (ALS) in patients who have a specific autoantibody against a protein called NRIP. The study will enroll 5 a…

This study investigates whether chiropractic spinal manipulation can reduce inflammation and improve symptoms in people with relapsing-remitting multiple sclerosis (MS). Participants receive either real or sham spinal adjustments over four weeks. Researchers measure changes in bl…

This study tests whether a smartphone app called Brain Safe can help older adults reduce their use of strong anticholinergic medications, which are linked to a higher risk of Alzheimer's disease. The trial enrolls 700 adults aged 60 and older who currently take such medications. …

This study tests whether bosutinib, a drug currently used for leukemia, can safely treat dementia with Lewy bodies (DLB). The trial involves 30 adults aged 25–90 with DLB, who will take either bosutinib or a placebo daily for three months. Researchers will monitor side effects an…

This early-phase study tests a lab-made protein (recombinant human serum albumin) in 30 people with mild to moderate Alzheimer's. Participants receive one of three doses to check safety and any effect on thinking skills. The goal is to see if this treatment can help control the d…

This early-phase trial tests whether MIB-626, a drug that activates sirtuin-NAD pathways, can reach the brain and affect aging-related markers in people with mild Alzheimer's. 22 participants will take either MIB-626 or a placebo for 90 days. The study primarily checks if the dru…

This study tests a 10-week nutrition program in 61 older adults (ages 55-85) from rural North Florida, some with mild cognitive impairment and some without. Participants follow either a Mediterranean diet or a modified Mediterranean-ketogenic diet. The goal is to see if the progr…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's disease who also had signs of brain inflammation. The goal was to see if the drug could improve memory, thinking, and daily function compared to a placebo over 24 weeks. Researchers also c…

This early study tested whether infusing a patient's own regulatory T cells (immune-calming cells) along with interleukin-2 injections is safe for people with ALS. Only 3 participants were enrolled, and the main goal was to check for side effects. The approach aims to slow diseas…

This study looked at 144 people with aggressive relapsing multiple sclerosis to compare two treatment plans over three years: monthly natalizumab infusions versus a six-month course of mitoxantrone followed by another immune-modulating drug. Researchers measured cost-effectivenes…

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This completed Phase 2 trial tested an oral drug called LY3372689 in 327 people with early symptomatic Alzheimer's disease. The goal was to see if the drug could safely slow down declines in thinking and daily living skills compared to a placebo. The study focused on participants…

This study tested the safety and effects of nilotinib, a cancer drug, in 43 people with Dementia with Lewy Bodies (DLB). DLB is a common type of dementia that shares features with Parkinson's and Alzheimer's. The goal was to see if nilotinib is safe and changes brain biomarkers, …

This early-phase trial tested a new treatment for relapsing-remitting multiple sclerosis (RRMS) that uses a patient's own red blood cells. The cells are coated with specific peptides and given back to the patient to teach the immune system to stop attacking the body. The study in…

This study tested whether people with ALS or Parkinson's disease, along with healthy volunteers, could follow the MIND diet — a mix of the Mediterranean and DASH diets thought to protect the brain. Over several weeks, 43 participants received a cookbook, educational materials, an…

This study tested whether adding slow, paced breathing exercises to computer-based brain training could improve thinking skills and slow dementia in older adults with mild cognitive impairment. Over 8 weeks, 113 participants either did both breathing and brain training, brain tra…

This study tested whether a special oil called triheptanoin can slow brain damage in people with early Huntington's disease. 100 participants took either the oil or a placebo for 6 months, followed by 6 months where everyone got the oil. The main goal was to see if it reduced bra…

This phase 2 trial tested whether TAK-341, given as an IV infusion every 4 weeks for a year, can slow the progression of multiple system atrophy (MSA), a rare and serious brain disorder. The study enrolled 158 adults with MSA across North America, Europe, and Asia. Researchers me…

This early-stage study tested whether multiple infusions of donor stem cells are safe for people with mild to moderate Alzheimer's disease. Six participants received the treatment and were monitored for serious side effects and changes in thinking skills. The goal was to check sa…

This large Phase 3 study tested an experimental drug called remternetug in over 1,600 people with early symptoms of Alzheimer's disease. The main goal was to see if the drug could safely clear amyloid plaques from the brain, a hallmark of Alzheimer's. Participants received either…

This study tested a malaria drug called artesunate in 20 people with Friedreich ataxia, a rare genetic disorder that affects movement and coordination. The goal was to find a safe dose that could help control iron levels in cells, which may slow the disease. Researchers started w…

This study tested whether a dietary supplement called propionic acid is safe and helpful for people with multiple sclerosis (MS). Twenty-two adults with stable MS took propionic acid capsules alongside their usual MS medications. Researchers measured nerve damage markers and thin…

This completed Phase 3 trial tested the oral drug dimethyl fumarate (Tecfidera) against an injected interferon in 156 children aged 10 to 17 with relapsing-remitting multiple sclerosis. The main goal was to see if the drug could prevent new brain lesions and control the disease s…

This study tested an oral drug called AZ-3102 in 13 people with GM2 gangliosidosis (Tay-Sachs or Sandhoff disease) or Niemann-Pick type C disease. The main goal was to check safety and how the drug moves through the body over 12 weeks. It was a randomized, double-blind, placebo-c…

This study tested three non-drug approaches—cognitive training, reminiscence therapy, and a personalized program—in 640 people with mild-to-moderate Alzheimer's. The goal was to see if these therapies could delay progression to severe dementia. Participants were followed for chan…

This study looked at over 2,600 people with multiple sclerosis to compare two drugs: Kesimpta and Ocrevus. Researchers used insurance claims data to see which drug led to fewer relapses and lower healthcare costs. The goal is to help patients and doctors choose the best treatment…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This study tested a treatment called extracorporeal photopheresis (ECP) in 15 people with multiple sclerosis. ECP is a procedure that filters a person's blood, treats it with light, and returns it to the body. The goal was to see if it is safe and if it can improve walking, hand …

This study tested whether a nerve block called stellate ganglion block can improve swallowing in people with bulbar palsy after an ischemic stroke. 124 participants were randomly assigned to receive either standard rehabilitation alone or standard rehabilitation plus the nerve bl…

This study tested an oral drug called ADX-629 in 8 people with Sjögren-Larsson syndrome, a rare inherited disorder that causes harmful fatty substances to build up in the skin, brain, and eyes. The main goals were to see if the drug is safe and can reduce these fatty aldehydes. P…

This early-stage trial tested an experimental drug called SHR-1707 in 33 people with mild memory problems or mild Alzheimer's disease. The drug is an antibody given through a vein, designed to target and clear amyloid plaques in the brain. The main goal was to check safety and si…

This study tested a daily ketone supplement (beta hydroxybutyrate ester) in 81 people with ALS to see if it could slow the disease. The idea is that ketones provide extra energy to cells, which may help counter the energy shortage seen in ALS. Participants took the supplement alo…

This study looked at whether it is safe for people with multiple sclerosis to receive their natalizumab (Tysabri) infusions at home instead of at a hospital. Researchers compared serious side effects, quality of life, and costs over one year in 295 patients. The goal was to see i…

This completed Phase 2b/3 trial tested the drug AMX0035 in 139 people with progressive supranuclear palsy (PSP), a rare brain disease that causes problems with balance, movement, and thinking. The study compared the drug to a placebo to see if it could slow the disease. The resul…

This Phase 3 trial tested a stem cell treatment called Lenzumestrocel in 123 people with ALS. The treatment uses the patient's own bone marrow stem cells and is given alongside the standard drug Riluzole. The goal was to see if it could slow the disease and improve survival and f…

This pilot study tested whether a short course of low-dose radiation to the brain could reduce amyloid plaques, a hallmark of Alzheimer's disease. Twenty people with early Alzheimer's and positive amyloid scans were enrolled. Half received radiation over 5 days, while the other h…

This early-phase trial tested whether combining two drugs—abatacept and interleukin-2—is safe for people with ALS. The goal was to boost the body's regulatory T cells, which may help slow disease progression. Only 5 participants were enrolled, and the study focused on safety and …

This study tested the drug D-cycloserine in a single patient with a rare genetic form of hereditary spastic paraplegia. The goal was to see if the drug is safe and can slow the disease by lowering certain fats (sphingolipids) in the body. The patient also took pyridoxine to help …

This Phase 3 trial tested a gene therapy called GS010 in 98 people with Leber hereditary optic neuropathy (LHON), a genetic condition that leads to rapid vision loss. Participants received injections of the therapy or a placebo into both eyes. The study measured changes in vision…

This study tested an experimental drug called vatiquinone in 146 people with Friedreich ataxia, a rare genetic disease that affects movement and coordination. Participants took either the drug or a placebo for 72 weeks to see if it slowed worsening of symptoms, measured by a stan…

This study tested a drug called TPN-101 in 42 people with progressive supranuclear palsy (PSP), a rare brain disease that affects movement and thinking. The main goal was to see if the drug is safe and tolerable over 48 weeks. Researchers also looked at how the drug moves in the …

This phase 2 trial tested darolutamide, a drug that blocks male hormones, in 57 people with a rare type of salivary gland cancer that has male hormone receptors. Some patients received darolutamide alone, while others also got goserelin to lower hormone levels. The goal was to se…

This trial tested a custom-made drug called nL-TARD-001 in one person with ALS caused by a specific genetic mutation in TARDBP. The drug is an antisense oligonucleotide designed to target the faulty gene. The study measured changes in muscle function, breathing, and thinking over…

This Phase 2 study tested a once-daily combination pill (polypill) in 121 adults aged 50–85 with very mild to severe Alzheimer's disease. Over 180 days, researchers measured changes in thinking, memory, and daily function using standard dementia scales. The goal was to estimate w…

This study tested a drug called TPN-101 in 42 people with ALS or frontotemporal dementia caused by a specific gene change (C9orf72). The main goal was to check if the drug is safe and tolerable over 48 weeks. Researchers also looked at how the drug moves in the body and whether i…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This study tested an online self-management program designed to help people with multiple sclerosis prevent falls. The program was developed with input from patients and covers various fall risk factors. 45 adults with MS participated to see if the program was easy to use and hel…

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This study looked at whether a plant-based ketogenic diet combined with intermittent fasting (called Ketoflex 12/3) could slow the progression of early-to-mid stage Alzheimer's disease. Sixty participants followed the diet, and researchers measured changes in memory and thinking …

This completed trial tested a ketogenic diet (high-fat, low-carb) in 32 people with mild to moderate Alzheimer's disease. Participants followed the diet or a placebo for 26 weeks. Researchers measured changes in cognitive function using a standard test. The goal was to see if the…

This study tested a drug called donanemab (LY3002813) in 272 people with early symptoms of Alzheimer's disease. The goal was to see if the drug is safe and can slow down memory loss and daily functioning problems. Participants received either the drug or a placebo, and researcher…

This early-stage trial tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The vaccine is designed to train the immune system to attack abnormal clumps of a protein called alpha-synuclein, which are linked to these brain disorders. The …

This study tested a gene therapy called OTL-200 in 10 children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. The treatment uses the child's own blood stem cells, modified to produce a missing enzyme, and aims to slow or stop disease progres…

This study tested whether a non-invasive brain stimulation method called tACS could reduce amyloid and tau proteins in people with mild to moderate Alzheimer's. Seventeen participants received daily sessions of tACS or a sham treatment for 2-4 weeks. The goal was to see if the st…

This study tested whether narrow dental implants work as well as standard-sized implants placed with bone regeneration in people with narrow jawbone in the back of the mouth. Thirty adults with a ridge width between 5 and 6.5 mm received either a 3.0 mm narrow implant or a 4.0 mm…

This study tested an experimental drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. Participants received different doses of the drug or a placebo every 2 or 4 weeks for 18 months. The go…

This phase 3 trial tested a single injection of GS010 gene therapy in 39 people with Leber Hereditary Optic Neuropathy (LHON) who had vision loss for 6 months or less. The treatment aims to improve vision by delivering a working copy of the ND4 gene to the eye. Results measured c…

This study tested a one-time gene therapy injection, GS010, in 37 adults with Leber Hereditary Optic Neuropathy (LHON), a genetic condition that causes rapid vision loss. Participants had vision loss for 6 to 12 months before treatment. The goal was to see if the therapy could im…

This study tested a gene therapy called GS010 in 19 adults with Leber Hereditary Optic Neuropathy (LHON), a rare inherited eye disease that causes rapid vision loss. The main goal was to see if the treatment is safe and tolerable at different doses. The therapy uses a harmless vi…

This study tested a monthly injection of ofatumumab in 180 people with very early relapsing-remitting multiple sclerosis (MS). The goal was to see if the drug could stop all signs of disease activity—like relapses, disability worsening, and new brain lesions—over 18 months. Resea…

This study looked at whether semaglutide, a medicine used for diabetes and weight loss, can reduce inflammation in the brain and body of people with early Alzheimer's disease. Twenty-three participants with mild memory problems or mild dementia received either semaglutide or a pl…

This study tested whether deferiprone, a drug that removes excess iron, could safely slow the progression of ALS. Researchers gave the drug to 23 adults with ALS for several months. The goal was to see if reducing iron buildup in the brain might protect nerve cells and delay wors…

This study tested whether a personalized treatment plan—based on each person's test results—works better than standard care for people with mild cognitive impairment or early-stage dementia. 73 adults aged 45-76 took part, receiving either the tailored plan or usual care for 9 mo…

This study tested a drug called GV1001 in 78 people with Progressive Supranuclear Palsy (PSP), a rare brain disease that affects movement and thinking. Participants received daily injections of either a low dose, a higher dose, or a placebo for 6 months. The goal was to see if th…

This study tested a mobile app designed to help gay and bisexual men reduce their methamphetamine use and risky sexual behaviors. The app includes games, lessons, and resources. 226 men who use meth took part. The goal was to see if the app could help them cut back on meth and lo…

This study tested a drug called DNL343 in 249 people with ALS, a serious nerve disease that weakens muscles over time. The goal was to see if DNL343 could slow the disease and help people live longer. The trial used a flexible platform design to test multiple treatments at once.

This phase 3 trial tested a one-time gene therapy called Zolgensma in 22 infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The treatment delivers a working copy of the missing SMN gene via an IV infusion. The main goals were …

This study tested a one-time gene replacement therapy in infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The main goal was to see if treated babies could sit without support for at least 10 seconds by 18 months of age. The …

This study tested a one-time gene replacement therapy in 33 infants under 6 months old with spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The treatment aims to replace the missing SMN1 gene to improve muscle function. Key results showed that many babies…

This study tested a single dose of Zolgensma gene therapy in 30 infants diagnosed with spinal muscular atrophy (SMA) before symptoms appeared. The goal was to see if the treatment helps them reach motor milestones like sitting or standing alone. The therapy delivers a working cop…

This study tested a device that uses focused ultrasound to temporarily open the blood-brain barrier in 35 people with Alzheimer's disease. The goal was to see if this procedure is safe and could help treatments reach the brain more effectively. Participants were between 50 and 85…

This study tests a new MRI technique called ENRAGED FLAIR that aims to capture two types of brain images (T2-FLAIR and T1-weighted) in a single sequence, instead of the usual two separate scans. Researchers will compare the image quality and time savings against standard MRI in 1…

This pilot study tests whether a special MRI contrast agent called ferumoxytol can highlight areas of active inflammation in the brains of people with secondary progressive multiple sclerosis (SPMS). The goal is to see if this imaging method can distinguish chronic-active lesions…

This study tests whether simple digital questionnaires can help primary care doctors identify new cases of Alzheimer's and related dementias during annual checkups. About 3,150 adults aged 65 and older without prior memory loss diagnosis will participate. The goal is to see if th…

This study tests a simple, low-cost method to find undiagnosed dementia in older adults during routine primary care. Researchers use an algorithm (eRADAR) that scans electronic health records to identify people who may have dementia but haven't been diagnosed. Those flagged are o…

This study tested a tablet-based platform called Tenèpsia® for remote cognitive assessments in 250 healthy adults and people with cognitive impairment. The goal was to collect normal test scores and validate the digital tool for diagnosing neurocognitive disorders. If proven reli…

This study tested whether digital analysis of voice recordings can help doctors tell apart Parkinson's disease and multiple system atrophy, two brain disorders with similar early symptoms. Researchers recorded the voices of 28 people (patients with each condition and healthy cont…

This study checked if a Turkish version of the MoCA-B test can correctly tell the difference between healthy people, those with mild memory problems, and those with dementia. The test was given to 166 adults aged 50-100 with little or no schooling. The goal was to find the best c…

This study tested a new PET imaging tracer to see if it can safely show signs of ALS in the body. Eight people (some healthy, some with ALS) received the tracer and were scanned. The goal was to check safety and how the tracer spreads, which could lead to earlier diagnosis and be…

This study looked at whether a portable sleep monitor used during a short hospital stay can accurately diagnose sleep apnea in people with multiple system atrophy (MSA), compared to the standard overnight lab test. Thirty adults with probable MSA took part. The goal was to see if…

This study tested whether an artificial intelligence system could detect mild cognitive impairment and Alzheimer's disease by analyzing simple self-figure drawings. Over 3,400 older adults drew themselves on paper, and the AI learned to spot patterns linked to cognitive decline. …

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This study tested whether a tablet-based eye-tracking device (ETNA-MS) can accurately estimate disability levels in people with Multiple Sclerosis. Sixty adults with MS took eye-tracking tests, and the device's estimates were compared to standard neurologist assessments. The goal…

This completed study looked at whether combining an online memory test with a blood test can help find Alzheimer's disease early in people 65 and older. Over 1,400 volunteers took part. The goal is to make early detection easier and faster, so treatment can start sooner.

This study tested whether a computer program called SCALE PET helps doctors more accurately spot signs of Alzheimer's disease in brain scans. Researchers looked at 190 past scans from people with Alzheimer's or mild memory problems. Four doctors read the scans twice—once with the…

This study looked at whether a 6-minute walk test done over a short 6-meter distance is a valid and reliable way to measure walking ability in people with multiple sclerosis. Twenty-one adults with MS participated. The goal is to see if this shorter version works as well as the s…

This study looked at whether measuring a protein called amyloid beta 1-40 in spinal fluid can help doctors diagnose Alzheimer's disease more accurately. Researchers collected spinal fluid from 204 people with memory problems. They want to see if adding this new measurement to exi…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This trial tests whether solanezumab, an antibody that targets amyloid plaques in the brain, can slow the progression of memory problems in people who have no symptoms but show early signs of Alzheimer's-related brain changes. Participants are older adults with normal thinking an…

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This trial tests a 12-week group program designed to help adults aged 65 and older address modifiable risk factors for dementia, such as high blood pressure and cognitive decline. Participants meet weekly for an hour to learn about brain health and practice evidence-based lifesty…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether a structured lifestyle program—including diet, exercise, and cognitive training—can help prevent cognitive decline in older adults at risk for dementia. Over 1,000 participants aged 60-77 from 12 Latin American countries took part. The goal was to see if…

This study looked at whether 6 months of moderate aerobic exercise could improve memory and brain health in older adults (ages 60-80) who are inactive but cognitively healthy. Some participants carried a gene (APOE-ε4) that raises Alzheimer's risk. They were randomly assigned to …

This early-stage trial tests a vaccine called AV-1959R, designed to prevent Alzheimer's disease by targeting a protein linked to the condition. Sixteen healthy adults aged 40-60 will receive three shots of the vaccine or a placebo over 14 weeks. Researchers will monitor for side …

This pilot study tests a mobile app called Brain CareNotes designed to reduce the burden on unpaid caregivers of people with Alzheimer's or related dementias who live in rural areas. About 60 caregivers will use either the Brain CareNotes app or a basic education app for six mont…

This study tests an online program called SAGE LEAF that teaches positive emotion skills to family caregivers of people with dementia. Over 6 weeks, participants learn techniques like gratitude and mindfulness through short lessons and daily practice. The goal is to see if the pr…

This study tested an experimental drug called AXS-05 to see if it can safely reduce agitation in people with Alzheimer's disease. About 408 participants took either the drug or a placebo for several weeks. The goal was to measure changes in agitation using a standard rating scale…

This study tests whether listening to music or metronome sounds that match your heart rate can reduce chronic pain in people with multiple sclerosis. 45 participants will be split into three groups: one does motor imagery with a heartbeat-synced metronome, one listens to relaxing…

This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researcher…

This study tests a mobile program called Compass for Care, designed to help people caring for a loved one with Alzheimer's or related dementias. The program delivers 12 weekly modules and tailored messages focusing on five self-care behaviors, such as taking time to recharge and …

This study tested a medicine called BXCL501 for calming sudden episodes of agitation in people with dementia. It involved 151 participants who took the medicine only when needed over 12 weeks. The goal was to see if it safely reduces severe restlessness, tension, or aggression.

This study tests whether a special therapy using sights, sounds, touch, and other senses can help people with moderate Alzheimer's think clearer, feel calmer, and behave better. It also looks at whether this therapy reduces stress for their caregivers. Twenty-four people aged 65 …

This pilot study is testing whether a low-cost, portable driving simulator can help retrain driving skills in people who have had a stroke or who live with Parkinson's disease or multiple sclerosis. Participants will be randomly assigned to train on either the portable simulator …

This study tests whether weekly live harp music sessions can reduce behavioral symptoms like agitation and anxiety in nursing home residents with moderate-to-severe dementia. Participants in memory care units will listen to a harp therapist play during the late afternoon, a time …

This study tests whether giving family caregivers of people with Alzheimer's or related dementias a tailored list of local resources – addressing needs like food, housing, and support services – can boost their confidence in caregiving. About 360 caregivers in specific Chicago zi…

This trial tests whether adding mental rotation and motor imagery training to standard physiotherapy can improve upper-extremity function in people with relapsing-remitting multiple sclerosis (RRMS). Participants receive either this cognitive-motor training or an active visual-at…

This study tests whether sensory integration therapy can improve walking stability and quality of life in people with multiple sclerosis (MS). About 44 adults with relapsing-remitting MS will be randomly assigned to receive either the therapy or standard care. The therapy uses sp…

This study tested whether repeated electrical brain stimulation could improve mental health and cognitive function in people with multiple sclerosis (MS). Fifty-three adults with MS received either real or fake stimulation in a double-blind setup. Researchers measured changes in …

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This study tested whether a low-histamine version of the Mediterranean diet could help people with relapsing-remitting multiple sclerosis (MS) feel better. 51 adults were split into three groups: one followed the low-histamine Mediterranean diet, another a standard Mediterranean …

This trial tests whether N-acetyl cysteine (NAC), an antioxidant supplement, can reduce fatigue in people with progressive multiple sclerosis. Participants take NAC or a placebo three times daily for four weeks, and researchers measure changes in fatigue scores and brain chemistr…

This trial tests whether a tailored lighting intervention, controlled by a wireless device, can improve sleep and mood in people with Alzheimer's disease. Participants receive either active lighting designed to affect the body's internal clock or a control lighting with no intend…

This study tests whether adding electroconvulsive therapy (ECT) to usual care can safely reduce severe agitation in people with moderate to severe dementia, including Alzheimer's and other types. Fifty participants will receive ECT sessions with anesthesia, and researchers will m…

This trial tests whether shared virtual reality (VR) experiences can improve quality of life, mood, and family closeness for older adults with mild cognitive impairment or dementia who live in senior communities, and for their adult children who live far away. Participants will t…

This trial investigates whether daily exposure to a bluish-white light (at least 300-500 lux for two hours) can improve sleep efficiency, reduce depression, and calm agitation in people with mild to moderate Alzheimer's or related dementias. Participants are assigned to one of th…

This study tested whether a high-intensity virtual reality boxing program is safe and feasible for people with multiple sclerosis. Five participants used a VR headset to exercise for 10 minutes twice a week over 8 weeks, alongside their usual therapy. Researchers measured side ef…

This trial compares two exercise programs—chin tuck against resistance (CTAR) and proprioceptive neuromuscular facilitation (PNF) neck stretches—for people with multiple sclerosis who have trouble swallowing. Over 8 weeks, participants perform supervised sessions three times a we…

This trial tests whether a structured memory training program, called Strategy-Based Training to Enhance Memory (STEM), can improve learning and recall in people with multiple sclerosis who report memory difficulties. Participants attend eight training sessions over four weeks an…

This study tests whether giving caffeine to adults aged 70 and older after major surgery can lower their risk of postoperative delirium—a state of sudden confusion. Researchers will compare low-dose and high-dose caffeine against a placebo in 250 participants. The goal is to see …

This study tested whether an online program for insomnia (called SHUTi) could help heavy drinkers reduce their alcohol use. 113 adults who drank heavily and had trouble sleeping took part. The goal was to see if improving sleep would also lead to less drinking and fewer binge epi…

This study tested a robotic exoskeleton called Atalante to see if it is easy and safe for people with multiple sclerosis (MS) to use. 15 adults with MS who had trouble walking tried the device. The goal was to see if the suit could help them walk better and if they liked using it…

This study tests a 12-week online program for mothers of infants (12-36 months old) with SMA Type 1. The program aims to teach mothers how to support their baby's development and improve their own knowledge. Thirteen mothers will take part, with 10 receiving the program and 3 rec…

This trial investigates whether a non-invasive technique called transcranial direct current stimulation (tDCS) can help with fatigue, depression, anxiety, and cognitive problems in people with multiple sclerosis (MS). tDCS uses a weak electrical current applied to the scalp to ge…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests whether adding task-oriented training—like walking on different surfaces, climbing stairs, and reaching for objects—to standard aerobic and strength exercises can improve functional mobility, balance, and fatigue in people with relapsing-remitting multiple sclero…

This study explores whether a 9-month online mind-body exercise program is practical and acceptable for people with multiple sclerosis (MS) living in Portugal and Spain. The program combines physical fitness, Pilates, Tai-Chi, mindfulness, and relaxation in small group sessions v…

This study tested whether older adults with mild cognitive impairment or early Alzheimer's can use a tablet-based brain-training app at home. 52 participants played 12 different games for 8 minutes each, daily for two weeks. The goal was to see if the app was easy to use and acce…

This study compares two gentle exercise programs—tai chi and square stepping—in women with multiple sclerosis. Researchers want to see if these activities improve knee joint awareness, leg strength, and fatigue. About 39 women aged 20-45 with mild MS will participate, helping to …

This study tests whether a special flickering light (40 Hz) can improve sleep and thinking in people with mild cognitive impairment or early Alzheimer's disease. Participants will sit under the light for one hour while researchers measure brain activity and memory. The goal is to…

This Phase 3 study tested the long-term safety of valbenazine in 154 people with Huntington disease who have chorea (uncontrolled movements). Participants either continued from a previous study or joined new. The goal was to see if valbenazine is safe and helps control chorea ove…

This pilot study tested whether adding a vibrating chest vest to a standard cough-assist machine could reduce lung infections and hospital stays in people with ALS who use breathing support. Fourteen patients were randomly assigned to use either the vest plus cough assist or the …

This study tested a program where a pharmacist worked with people living with dementia, their care partners, and their doctors to review and reduce unnecessary medications. The goal was to simplify medication routines and lower treatment burden. The study included 138 participant…

This study looked at whether a weekly hour of adapted physical activity for 12 weeks could improve self-esteem and motivation in 17 older adults with mild to major cognitive disorders like Alzheimer's. Researchers measured changes in self-esteem, motivation, and apathy. The goal …

This study tested whether combining a gentle brain stimulation technique called tDCS with memory and thinking exercises could help people with early Alzheimer's. Twenty-two participants received either real or fake stimulation during 10 sessions of cognitive training. Researchers…

This study tested whether playing a gentle sound called 'pink noise' during deep sleep could strengthen memory in people with early Alzheimer's disease. Nineteen participants wore a special headband that delivered the noise on some nights and not on others. The goal was to see if…

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve symptoms of chronic constipation in adults. One hundred participants took either the probiotic or a placebo for a period, and researchers measured changes in stool consistency and gut bacteri…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study tested if immersive virtual reality (VR) can improve memory and thinking in people with Alzheimer's disease. 33 participants wore VR headsets to explore scenes from 1960s Burgos, Spain, designed to trigger personal memories. Researchers measured changes in cognitive te…

This study tested a non-invasive brain stimulation technique called rTMS, guided by each person's unique brain activity map, to see if it could improve thinking and memory in 46 people with mild Alzheimer's disease. Participants received either real or fake (placebo) stimulation …

This study tested a gentle brain stimulation technique (HD-tDCS) combined with computer-based memory exercises in 60 people with early Alzheimer's. The goal was to see if this combination could improve thinking and memory more than either treatment alone. Researchers also used br…

This study looked at whether 8 weeks of low-load leg exercises with a blood flow restriction cuff is safe and doable for people with multiple sclerosis who have moderate to severe walking problems. Sixteen adults with MS took part, doing exercises like knee extensions and hip lif…

This study looked at how well and how safely deutetrabenazine works for Chinese adults with Huntington's disease who have chorea (uncontrolled movements). Fifty patients took the drug as part of their normal care. The main goal was to see if chorea scores improved, especially in …

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested a 12-week online peer support programme for family caregivers of people with motor neurone disease who are becoming dependent on breathing or feeding technology. The programme included private messaging, weekly chats, a discussion forum, and resources. Researche…

This study tested a safe, non-invasive brain stimulation technique called tACS in 26 people with mild cognitive impairment due to Alzheimer's. The goal was to see if a 40 Hz electrical current applied to the brain could improve memory. Participants completed memory tests before, …

This study looked at whether different lengths of light exposure can improve sleep, mood, and agitation in people with Alzheimer's disease. 135 participants were randomly assigned to receive 2 hours, 4 hours, or all-day morning light. The goal was to see which light schedule work…

This completed pilot study looked at whether a placebo treatment — sham TENS combined with positive verbal suggestions — could reduce fatigue in people with relapsing-remitting multiple sclerosis. 36 participants were enrolled. The main goal was to measure motor performance (numb…

This study tested an online training program called CHATO for nursing home staff who care for people with Alzheimer's or other dementias. The training aimed to improve how staff communicate, which may reduce behavioral symptoms like agitation or rejection of care. Over 5,000 staf…

This study tested whether a home-based program combining motor imagery (mentally practicing movements) and action observation (watching videos of movements) could help people with multiple sclerosis improve balance, walking, and fatigue. Twenty-nine adults with MS participated in…

This completed trial tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease build a habit of walking at least 250 steps each hour. The 12-week program used goal setting, action planning, self-monitoring, and prompts to encourage reg…

This study tested whether partnered rhythmic dance is safe and helpful for people with early Alzheimer's disease. 76 participants were randomly assigned to either dance classes or a walking program for 12 months. The goal was to see if dance improves the ability to think and move…

This study tested a portable knee training device in 13 children aged 6-12 with spinal muscular atrophy (SMA). The goal was to see if regular exercise with the device could improve leg muscle strength and function. Researchers measured muscle size, strength, and nerve activity ov…

This study tested whether personalized text messages could help 100 caregivers of people with Alzheimer's disease develop a regular walking habit. Over 12 weeks, participants received texts with goal-setting, action plans, and reminders to walk at least 1,000 steps in a set hour …

This study explores whether a powered exoskeleton—a wearable robot—can help people with moderate to severe walking problems due to multiple sclerosis (MS) exercise and walk better. Twenty-four participants will either use the exoskeleton or do standard exercises with a fitness in…

This study tested a program called EnACT for family caregivers of people with dementia. The program uses group sessions where caregivers watch scenarios, practice responses, and reflect on their choices. The goal is to help caregivers feel more prepared and less stressed when dea…

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This study tested a personalized counseling and support program for 130 people with multiple system atrophy (MSA) and their caregivers. The program aimed to identify individual needs and improve daily life management. Researchers measured quality of life and depression symptoms t…

This study tested a Dialectical Behavior Therapy skills training program for older adults (age 50+) who care for a family member with Alzheimer's disease or related dementias. The goal was to reduce suicidal thoughts and feelings. Nine caregivers participated, and the program foc…

This study tested whether plasma exchange (a blood-filtering treatment) helps people with multiple sclerosis who have severe flare-ups that don't get better with steroids. Thirty-eight adults took part, and researchers compared real plasma exchange to a sham procedure. The main g…

This study tested a set of tablet games called VibrantMinds, designed to be easy and fun for older adults, including those with dementia. 26 participants aged 65+ with mild cognitive impairment played games like Whack-A-Mole and Word Search. Researchers measured changes in thinki…

This study tested whether L-carnitine, a natural supplement, can reduce fatigue in people with multiple sclerosis (MS). About 60 adults with MS who had significant fatigue took either L-carnitine or a placebo, then switched. The goal was to see if L-carnitine improved fatigue sco…

This study tested whether a socially assistive robot could reduce apathy in older adults with mild cognitive impairment or Alzheimer's disease living in long-term care. 142 participants were randomly assigned to either usual activities or usual activities plus robot-led sessions.…

This study tested a personalized approach to manage agitation in people with Alzheimer's disease living at home. A nurse worked with doctors and caregivers to create a custom care plan, using video calls and training. The goal was to reduce hospitalizations and ease caregiver str…

This study looked at whether high-intensity walking exercise can help reduce fatigue and improve walking in people with multiple sclerosis (MS). Twelve adults with MS who had walking problems and significant fatigue took part. Researchers measured changes in fatigue, walking spee…

This study tested whether a long-term light treatment could improve sleep and memory in 73 people with mild cognitive impairment or mild Alzheimer's disease living at home. Participants used a special light device, and researchers measured changes in thinking skills and sleep qua…

This study tested a software system that uses a humanoid robot to give cognitive and motor tests to people with early Alzheimer's or other mild to moderate dementia. The goal was to see if the robot could effectively administer tests like the Mini Mental State Exam (MMSE) and hel…

This study tested a new drug called phenserine in 16 people with early or mild Alzheimer's disease. The goal was to see how it affects brain cell health and inflammation compared to the standard drug donepezil. Participants took the drug for 8 weeks and had regular checkups. The …

This study tested whether a 12-month therapeutic education program is feasible for people with multiple system atrophy (MSA) and their caregivers. The program includes in-person visits and online activities to help understand symptoms and adapt to daily life. Fifteen patient-care…

This study tested a home-based telerehabilitation system for veterans with multiple sclerosis. The system provided exercise instructions and tracked daily logs to help improve balance and mobility. Fifty-one participants used the system to see if it was feasible and acceptable, w…

This study tested a new behavioral program called SEMAT that teaches people with early-stage Alzheimer's or mild cognitive impairment how to use memory aids like calendars and reminders. The goal was to help them stay independent in daily life. 68 older adults took part, and rese…

This study tested whether acupressure, a technique where pressure is applied to specific points on the body, can help people with multiple sclerosis (MS) manage pain, fatigue, and sleep problems. Researchers enrolled 90 adults with relapsing-remitting MS who had moderate to sever…

This early-stage study tested the safety of a new drug called MK-8189 (elpipodect) in 29 people with Alzheimer's disease who also had symptoms like agitation, aggression, or psychosis. The main goal was to see if the drug was safe and tolerable. Researchers monitored side effects…

This study tested a training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to recreate familiar situations, aiming to improve orientation to time, place, and person. 126 participants were assigned to either the training…

This study tested whether a robotic walking system called Atalante could help people with multiple sclerosis walk better. Sixty participants were randomly assigned to either use the robot or receive standard physical therapy for 8 weeks. The main goal was to see if the robot impr…

This study tested whether virtual reality (using Xbox Kinect) or biofeedback training could improve motor function and balance in 24 children with neuromuscular diseases like Duchenne muscular dystrophy and spinal muscular atrophy. Participants were split into three groups: VR tr…

This study tested a ketogenic drink made from medium chain triglycerides (MCTs) in 43 people with Alzheimer's disease or a type of frontotemporal dementia. The goal was to see if it was safe and tolerable, and to measure ketone levels in the blood. It was a small, early-stage tri…

This completed study tested a structured music improvisation program for older adults with mild to moderate dementia and their caregivers. Seven participants took part in three-hour sessions led by professional musicians. The goal was to see if this non-drug approach could improv…

This study tested whether a 12-week exercise program using coordinated arm movements could improve brain function and movement in people with progressive multiple sclerosis (MS). Five adults with progressive MS did the exercises three times a week. Researchers measured brain acti…

This study tested two types of nerve stimulation—one using tiny needles (PENS) and one using skin pads (TENS)—to see if they could improve hand function in people with multiple sclerosis. 28 participants received a single session of stimulation, and their hand dexterity, strength…

This completed trial from Harvard University tested whether an online mindfulness program and social community could improve quality of life for 100 people with ALS and their primary caregivers. Participants used a three-week e-learning program with cognitive exercises and videos…

This Phase 3 study tested whether injections of MYOBLOC (a botulinum toxin type B) into the salivary glands can safely reduce troublesome drooling in adults. 187 participants received either MYOBLOC or a placebo. The main goals were to measure changes in saliva flow and overall i…

This study tested whether partial-body cryotherapy (standing in a very cold chamber for 2-3 minutes) could help reduce fatigue in people with multiple sclerosis during a rehabilitation stay. 43 participants received either real cryotherapy at -120°C or a sham version at -30°C ove…

This study tested whether a painless, non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's disease. Researchers used MRI…

This study tested whether adding transcranial magnetic stimulation (TMS) to standard exercise can reduce fatigue, pain, and improve walking in people with postpolio syndrome. 26 adults who had polio earlier in life and now have new symptoms took part. Half got TMS plus exercise, …

This study tested a drug called droxidopa (L-threo DOPS) in 107 adults with multiple system atrophy (MSA) who experience dizziness or fainting when standing up due to low blood pressure. Participants received either the drug or a placebo for 12 weeks. The goal was to see if the d…

This study tested whether applying shock wave therapy to the soles of the feet could improve balance and walking in people with multiple sclerosis (MS). Fifty-four participants received the therapy three times a week for six weeks. Researchers measured changes in foot sensation, …

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study tested a web-based program called RELOAD-C designed to reduce loneliness in people caring for a family member or friend with Alzheimer's disease. The program uses short videos and online group discussions based on Meaning-Centered Psychotherapy to help caregivers find …

This study tested an 8-week online program to help people with multiple sclerosis (MS) improve their problem-solving and coping skills. The goal was to see if the program was easy to use and if it helped reduce anxiety and depression. Thirty adults with MS in Lebanon took part. T…

This study tested a new way to follow up with gynecologic cancer survivors. Instead of seeing a doctor every time, patients saw a nurse at every other visit and used a smartphone app to help manage their health. The goal was to see if this approach improved self-management skills…

This study tested whether adding a virtual reality experience to an online education program could help reduce stress and anxiety in people caring for a loved one with mild-to-moderate Alzheimer's disease. About 127 unpaid caregivers took part, with some receiving only the educat…

This study tested whether mat and reformer Pilates can improve balance, walking, and postural control in people with multiple sclerosis. Thirty participants were split into mat Pilates, reformer Pilates, or a control group, training twice a week for eight weeks. Researchers measu…

This study tested whether a six-week sleep therapy program (CBT-I) could improve thinking and memory in older adults aged 60-85 with insomnia. Two hundred participants were randomly assigned to either CBT-I or a sleep education program. A small group also had brain scans to see i…

This study tested a sleep improvement program designed for both people with Alzheimer's disease and the family members who care for them. The program was tailored to address sleep problems in both the patient and caregiver at the same time. The goal was to see if this approach co…

This completed study tested whether wearing a special graphene cap that emits far-infrared heat could improve thinking and mood in older adults with mild cognitive decline or Alzheimer's. 126 participants were split into groups based on their cognitive level and received either t…

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This study tested whether a virtual group therapy program called Cognitive Stimulation Therapy (V-CST) could help slow cognitive decline in people with mild to moderate dementia. 133 participants were randomly assigned to either receive a referral for V-CST or continue with stand…

This study tested whether pelvic floor strengthening or relaxation exercises, done at home via video calls, could help women with multiple sclerosis who have bladder control problems. Twenty-four women were split into three groups: strengthening, relaxation, or both. They exercis…

This study tested a video-based program called Tele-STELLA for family members caring for someone with moderate to late-stage Alzheimer's or related dementia. The program connects caregivers with a guide to find ways to manage upsetting behaviors. The goal was to see if it could r…

This study tested whether an Arabic mobile app could help people with multiple sclerosis (MS) improve their self-care and quality of life. 74 adults with MS used the app or received usual care for 3 months. Researchers measured changes in self-care habits and well-being using sta…

This study tested a virtual program called MASC (Mindful and Self-Compassionate Care) for caregivers of people with Alzheimer's or related dementias. The program teaches mindfulness, self-compassion, and behavioral management skills through six group sessions and home practice. T…

This small pilot study tested whether a temporary spinal cord stimulator (like a pacemaker for the spine) could help people with spinal muscular atrophy types 3 and 4 move their legs better. Three adults who could stand independently received the implant for up to 29 days. The go…

This study tested two online programs designed to help people with multiple sclerosis manage spasticity (muscle tightness) in their legs. Participants attended two video classes that included education and stretching exercises. The goal was to see if these programs could reduce t…

This study looked at whether taking an NAD+ precursor (a vitamin-like supplement) along with exercise training can improve aerobic capacity (how well the body uses oxygen during exercise) in people with Friedreich's ataxia. The trial included 75 participants aged 10 to 40. Resear…

This study tested a drug called CT1812 in 130 people with mild to moderate Dementia with Lewy Bodies. Over 6 months, researchers checked if the drug was safe and if it helped with thinking, sleep, or other symptoms. The goal was to see if it might ease the burden of this challeng…

This study looked at whether adding cognitive behavior therapy (a type of talk therapy) to supervised Pilates exercises could improve balance, walking, and fatigue in people with multiple sclerosis. 90 adults with mild to moderate MS took part. The goal was to see if combining me…

This study tested whether a mind-body program called amygdala insula retraining, along with lifestyle changes, can help people with multiple sclerosis feel better. 132 participants were split into groups receiving the program, lifestyle changes, or usual care. The goal was to see…

This study tested a smartphone app called Compas-Y, designed to help people with cancer manage emotional distress through self-compassion exercises. 28 adults who had finished cancer treatment and felt low well-being used the app for 6 weeks. Researchers measured changes in self-…

This study tested whether caregivers prefer a fast-dissolving memantine tablet (Sinolvir®) or the standard tablet (Eutebrol®) for people with moderate to severe Alzheimer's disease. About 105 patients took one form daily for two months, and their primary caregivers filled out a s…

This study tested whether a special light therapy, used for 6 months, could improve sleep, mood, thinking, and daily behavior in 100 people with Alzheimer's disease or mild cognitive impairment. Participants either received the active light treatment or a placebo light. The goal …

This study tested a device that plays soft sounds during deep sleep to help memory in people with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's. 37 participants received either real or silent (placebo) sounds while sleeping. Researchers me…

This pilot study tested a 6-session virtual program called MASC that teaches mindfulness, self-compassion, and behavior management skills to caregivers of people with Alzheimer's or related dementias. 82 caregivers participated to see if the program is feasible and acceptable. Th…

This study tested a 16-week home exercise program called SPIN for people with multiple sclerosis who use a wheelchair. Twenty-four participants were randomly assigned to either the exercise program or a wellness program. Researchers checked if the program was safe, doable, and li…

This study looked at whether a moderate-intensity breathing exercise program is safe and doable for people with ALS. Nine adults with ALS did four 3-week cycles of respiratory muscle training at home, with weekly check-ins via video call. The main goal was to see if participants …

This study tested a program called MEMORI Corps, where trained volunteers aged 55+ provide companionship and personalized activities to people with dementia living at home. The program was delivered virtually over 12 weeks. Researchers measured changes in mood, quality of life, a…

This study tested whether watching 3D virtual reality videos of hand and arm movements could improve upper limb function in people with multiple sclerosis (MS). Thirty-two participants with recent MS and moderate disability completed six weeks of training. Researchers measured ha…

This study tested a non-invasive electrical stimulation device on the scalp in 80 adults aged 50+ with mild cognitive impairment. Participants learned word pairs while receiving either real or sham stimulation. Their memory was tested right after, and again at 7 and 28 days. The …

This study tested a web-based app called Gotcha! designed to help people with mild-to-moderate dementia remember names of people they know. 48 participants practiced daily for 6 weeks using a tablet at home. The goal was to see if the therapy improves name recall and whether it c…

This study tested whether a safe, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) could reduce fatigue in people with multiple sclerosis (MS). Ten adults with MS-related fatigue used a home-based tDCS device. The goal was to see if i…

This study tested whether a 5-week program of positive psychology exercises—like writing a gratitude letter or recalling a past success—could help people newly diagnosed with multiple sclerosis feel more hopeful and happy. Thirty participants were split into two groups: one start…

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning about their Alzheimer's-related brain scan results. It includes 100 Black and White adults with amnestic mild cognitive impairment. The…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study compares levels of a protein called VISTA in immune cells from people with multiple sclerosis (MS) or clinically isolated syndrome (CIS) and healthy volunteers. Researchers will take blood samples at the first attack and again at 6 and 12 months to see if VISTA levels …

This study investigates whether disease-modifying medications for relapsing-remitting multiple sclerosis (RRMS) can reduce cognitive fatigue—the tiredness that follows intense mental effort. Researchers will use functional MRI to measure brain activation in people starting either…

This observational study tests a mobile app that uses a dynamic difficulty adjustment system to personalize cognitive activities for people with mild cognitive impairment or mild Alzheimer's disease, as well as healthy older adults. The goal is to see if the app can reach a stabl…

This study explores whether the medication Tysabri can reduce cognitive fatigue—the tiredness that comes after intense mental effort—in people with relapsing-remitting multiple sclerosis (RRMS). Researchers will compare brain activity, measured with functional MRI, between RRMS p…

This study tests a gene therapy technique in the lab using skin cells from people with Huntington's disease. The goal is to see if the therapy can correct the genetic mistake that causes the disease. If it works in these cells, it could be a step toward a future treatment.

This study tested a new risk score that combines genetic and environmental factors to predict multiple sclerosis (MS). Researchers studied 181 people, including MS patients and their close relatives. The goal was to see if this score could identify who might develop MS in the fut…

This study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…

This study looks at how lung function, respiratory muscle strength, balance, and quality of life relate in Paralympic athletes. Researchers will measure breathing capacity, muscle strength, and balance in 24 athletes from sports like athletics, swimming, archery, and wheelchair b…

This study tested whether a pharmacist-led program could help older adults with dementia and their caregivers reduce unnecessary medications. The program included an educational brochure, a telehealth visit with a pharmacist, and tailored recommendations for the patient's doctor.…

This study follows people with relapsing-remitting multiple sclerosis who are starting immunosuppressant treatment. Researchers will track changes in cognitive abilities, fatigue, emotions, and overall quality of life over an extended period. The goal is to better understand how …

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This study follows 66 people with primary progressive multiple sclerosis (PPMS) and healthy volunteers for two years to understand how thinking and memory change over time. Participants take cognitive tests and undergo MRI scans to see how brain tissue damage relates to mental de…

This study tested whether a digital tool that scans electronic health records could help find older adults (65+) who might have undetected mild cognitive impairment or Alzheimer's disease. Over 3,400 patients from primary care clinics were identified as high-risk by the tool. Res…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

This study examines what happens when people with multiple sclerosis (MS) experience a relapse while on a standard treatment. It compares those who switch to a stronger, high-efficacy treatment with those who stay on their current therapy, looking at how many experience further r…

This study looked at how the brain uses energy in people with early Huntington disease. Ten adults had an MRI scan to measure brain energy levels while resting and watching flashing lights. The goal was to understand brain metabolism, not to test a new treatment.

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

This study follows 40 people with Friedreich's ataxia, a hereditary neurological condition that affects movement and speech, to see how their oral communication changes over one year. Researchers will assess speech clarity, voice quality, and hearing using speech therapy evaluati…

This study aims to understand if COVID-19 vaccines have any impact on brain health in healthy people. Researchers will use MRI scans to look for changes in the brain's blood vessels and structure. The study will follow 500 adults from Hong Kong who have already had a baseline bra…

This study is translating and testing a short questionnaire called the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) into Turkish. It will involve 120 adults with spinal cord injury or multiple sclerosis who have bladder problems. The goal is to make sure the Turkish vers…

This study gathers information from memory clinics across France to track how many people have Alzheimer's disease, how it progresses, and what factors affect diagnosis and care. Researchers will analyze anonymous medical records from over 500 centers to spot trends in health and…

This study looks at whether falls and mobility problems can signal very early, preclinical Alzheimer's disease in older adults who are still cognitively normal. Researchers will follow 355 volunteers aged 65 and older, some with and some without biological signs of Alzheimer's, t…

This study tests a CE-marked mobile app that scans a person's eyes to detect whether they have used certain drugs. Healthy volunteers will take a common medicine that mimics the effects of cannabis or amphetamines, then use the app to see if the eye measurements change. The goal …

This study looks at how young people with conditions like cerebral palsy, spina bifida, and spinal cord injury move from pediatric to adult medical care. Researchers will review medical records from the past 10 years and interview patients who have already made the switch. The go…

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study explores whether a dye called indocyanine green (ICG) can be used to track immune cells in the brain of people with Alzheimer's. Participants receive an ICG infusion, and a special light device measures the dye in the brain after 48 hours. The goal is to develop a non-…

This study investigates whether levels of the hormone ghrelin in the blood differ between people with various types of dementia, including Alzheimer's disease and dementia with Lewy bodies. Researchers will collect blood samples from 85 participants over age 60, both fasting and …

This study follows thousands of people with multiple sclerosis (MS) in the UK to see how COVID-19 affects them. Researchers track infections, hospital stays, and deaths using questionnaires and national health data. The goal is to understand the risks and outcomes for this group,…

This study investigates whether the ability to sense wrist position is linked to manual dexterity in people with multiple sclerosis (MS). Researchers will measure wrist position sense using a special device and assess hand skills with a pegboard test. The goal is to understand ho…

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…

This study follows about 74 adults with ALS who have already decided to take the drug Edaravone (Radicava). Researchers collect blood and urine samples over 24 weeks to measure various biomarkers—molecules that might show how the drug affects oxidative stress, inflammation, and n…

This study explores whether digital tools on a tablet can measure changes in speech and handwriting in people with motor neuron diseases like ALS. Participants complete a single session of speaking and tracing tasks. Researchers compare results between patients and healthy contro…

This study looked at whether asking people with multiple sclerosis (MS) to do two things at once — like walking while thinking — can uncover balance problems that standard tests miss. Researchers studied 24 people with mild MS and low disability. The goal was to see if this dual-…

This completed Phase 2 study tested whether a special PET scan using a tracer called UCB-J can measure synaptic density—the connections between brain cells—in people with Alzheimer's disease. Researchers scanned 100 participants across different stages, from healthy to dementia, …

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study aims to understand how satisfied both doctors and patients are with current multiple sclerosis (MS) treatments in everyday medical practice. Researchers will collect information from 261 patients and their physicians across several countries, including the UK, France, …

This study followed 115 people with relapsing-remitting multiple sclerosis for up to 5 years to see if early damage to the spinal cord could predict later walking difficulties. Researchers used MRI scans and walking tests to track changes. The goal was to better understand how ea…

This study looked at whether regular physical activity can improve thinking and memory in middle-aged adults (40-65) who have a family history of Alzheimer's disease. About 180 participants were randomly assigned to an exercise program or a comparison group and were followed for …

This study looked at how people with multiple sclerosis and their natural caregivers (like family members) feel about the quality of care they receive. Researchers surveyed over 1,000 participants to understand their expectations and experiences. The goal was to create a tool tha…

This study looked at how the brain chemical serotonin works in people with multiple system atrophy (MSA), a rare and serious nerve disease. Researchers used special PET scans to measure serotonin receptors in the brains of 53 adults with MSA or Parkinson's disease. The goal was t…

This study used a quick, painless eye scan called OCTA to compare blood flow in the optic nerve between 54 people with multiple sclerosis and healthy volunteers. The goal was to see if MS changes optic nerve blood vessels and if measuring this could help doctors track the disease…

This study used advanced MRI scans to look at energy use in the brains of 40 people with multiple sclerosis and 15 healthy volunteers. The goal was to see if energy problems in brain cells can predict nerve damage over two years. Researchers hope this will help understand how MS …

This study looks at how ALS (Lou Gehrig's disease) affects social thinking, like recognizing emotions in faces and voices. Researchers will compare 74 ALS patients to healthy volunteers using video-based tests. The goal is to better understand these challenges, which can impact d…

This study looked at 120 people with Friedreich's ataxia, a rare genetic disease that causes progressive movement problems. Researchers examined tiny interruptions in the DNA expansion that causes the disease to see if they influence when symptoms start and how severe they become…

This study looked at whether regular exercise can help slow down memory and thinking problems in older adults with early Alzheimer's disease and in healthy older adults. Researchers tested a program combining aerobic and strength exercises against stretching and balance exercises…

This pilot study tested whether a virtual reality reaction time test can help predict fall risk and cognitive decline in older adults with memory problems. Twenty participants aged 65 and older with cognitive impairment completed a VR task and standard tests. The goal was to see …

This study examined whether older adults with disrupted sleep or irregular daily rhythms show early brain changes linked to Alzheimer's disease. Researchers used wrist-worn activity monitors and brain MRI scans in 47 people over 65 without major memory problems. The goal was to s…

This study looked at whether vitamin D levels in the blood are linked to how fast ALS (Lou Gehrig's disease) gets worse. Researchers measured vitamin D in 127 people with ALS and tracked their motor decline, breathing, and weight loss. No treatment was given—the goal was simply t…

This study looked at 320 people whose brain scans showed signs that sometimes lead to multiple sclerosis (MS), even though they had no symptoms. Researchers analyzed blood and spinal fluid samples to find biological markers that could predict whether these silent signs would turn…

This study followed 307 people with relapsing multiple sclerosis in Germany who had recently switched to the drug Kesimpta (ofatumumab) from another treatment. Researchers collected information on why patients made the switch and how many doses they missed over one year. The goal…

This completed study tracked 42 women with multiple sclerosis who became pregnant around the time they received LEMTRADA infusions. Researchers aimed to measure rates of miscarriage and birth defects to better understand the drug's safety during pregnancy. The study did not test …

This study looked at how people with autoimmune diseases like multiple sclerosis or blistering skin conditions respond to COVID-19 vaccines while on B-cell depleting therapies. Researchers measured antibody levels and T-cell activity over time to understand vaccine effectiveness …

This study looked at whether a partnered dance program (adapted tango) could improve inflammation, memory, and mood in African-American women who care for a family member with Alzheimer's disease. Fifty women between 45 and 65 years old took part. Researchers measured changes in …

This study looked at whether a case management program called PartnerED could help reduce unnecessary hospital stays for people with Alzheimer's disease living in assisted living facilities. Researchers worked with care managers who gave emergency room doctors real-time informati…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study looked at how common dementia and memory problems are in older Mexican Americans compared to non-Hispanic whites. Researchers tracked changes in thinking skills over time and also asked caregivers what help they need. The goal is to find better ways to support patients…

This study collected blood samples from over 2,200 people with Alzheimer's or other dementias, plus healthy volunteers, to search for genes linked to these diseases. Researchers aimed to identify new genetic causes and better understand how genes affect disease risk and progressi…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This completed study looked at 75 people with relapsing-remitting multiple sclerosis (RRMS) who were taking the medication Aubagio. The goal was to see if virtual reality tests and real-world tasks could better detect cognitive (thinking) problems in everyday life compared to sta…

This study tested whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home, avoiding long trips to the clinic. It involved 40 patients and their caregivers, with half using the system for up to 18 months. The goal was to see…

This study used special brain scans (SPECT imaging) to look at two key brain chemicals—acetylcholine and dopamine—in people with dementia with Lewy bodies. Researchers aimed to see if differences in these chemicals could help diagnose the disease and identify subtypes. The study …

This study looked at brain scans of 304 retired farmers aged 65 and older living in rural France. None had memory complaints at the start. Researchers used MRI and PET scans to measure brain areas linked to Alzheimer's, like the hippocampus. The goal was to find very early imagin…

This study tested a short, computerized cognitive assessment in 421 French-speaking adults with multiple sclerosis and healthy controls. The goal was to see if a brief battery of computer tests can reliably detect early cognitive issues, like slowed thinking and memory problems, …

This study looked at whether a quick, painless eye scan can detect early signs of Alzheimer's disease. Researchers measured the thickness of the retina's nerve layer in 200 older adults, some with Alzheimer's and some without. The goal was to see if these eye changes could serve …

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This completed trial tested an online tool called 'Safety in Dementia' that guides caregivers through decisions about firearm access for a person with dementia. 500 informal caregivers across the U.S. participated. The tool helps clarify options, risks, and personal values, aimin…

This completed study looked at how the drug deferiprone affects blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers. Researchers measured markers of oxidative stress and iron levels in the lab. The goal was to better understand these diseases, not to t…

This study used brain scans to understand why some people with multiple sclerosis have trouble with social thinking, like reading emotions or intentions. Researchers compared 35 MS patients to healthy volunteers using MRI while they performed social tasks. The goal was to see whi…

This study looked at how older adults with and without Alzheimer's disease move in time with music. Researchers wanted to understand if this rhythmic movement relates to emotional expression and communication. The study involved 240 participants and measured how accurately they t…

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like…

This study used eye-tracking to see how people with Alzheimer's, Parkinson's, or frontotemporal dementia look at faces when trying to recognize emotions. Researchers compared their eye movements to healthy adults. The goal was to understand if different visual strategies explain …

This completed study looked at 344 frail older adults (70+) with memory issues to see how many have Alzheimer's-related brain changes. Participants had MRI and PET scans to detect amyloid plaques. The goal was to understand the link between frailty, memory loss, and Alzheimer's p…

This study examined a type of immune cell called 4BL B cells in people with multiple sclerosis (MS) and compared them to healthy controls. Researchers wanted to see if these cells are more common in MS and might contribute to inflammation. The study involved 125 participants and …

This completed study of 500 people with ALS (Lou Gehrig's disease) aimed to find biological signs, or biomarkers, that can predict how the disease will progress. Researchers collected clinical, imaging, and lab data to better understand different forms of ALS. The goal is to help…

This study looked at whether a multiple sclerosis (MS) drug called Ofatumumab (Kesimpta) can make immune cells less toxic to brain cells. Researchers took blood samples from 40 people with relapsing-remitting MS before and after 6 months of treatment. They tested if the chemicals…

This completed study at Brigham and Women's Hospital used special PET scans to look at brain inflammation and chemical activity in 10 people with multiple sclerosis. The goal was to understand what causes the severe fatigue many MS patients experience. Researchers measured brain …

This study looked at pain thresholds in people with multiple system atrophy (MSA) and Parkinson's disease. Researchers tested how levodopa, a common Parkinson's drug, affects pain perception. The goal is to better understand the causes of pain in MSA and improve future treatment.

This study looked back at the records of 1,000 adults who came to the emergency room with very low sodium levels. The goal was to find out how many had brain swelling from the low sodium itself, and how many later developed nerve damage from correcting the sodium too quickly. Res…

This study tested two training programs (in-person and online) for staff in long-term care facilities in Minnesota. The goal was to improve care for LGBTQ+ residents with Alzheimer's or other dementias. Over 700 staff members participated, and researchers measured changes in poli…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…

This completed study looked at 361 people recently diagnosed with multiple sclerosis to see if experiencing 'flow' (being fully absorbed in an activity) and mindfulness are linked to better mental health. Participants filled out online questionnaires about their mental health, an…

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study followed 67 children with Canavan disease, a rare genetic brain disorder, to learn how the condition naturally changes over time. Researchers reviewed medical records and conducted checkups to track symptoms, milestones, and disease progression. The goal was to better …

This study looked at how older adults, including those with Alzheimer's or mild cognitive impairment, make decisions about where to live as they age. Researchers followed 293 participants to understand what factors—like memory, health knowledge, and support from family—influence …

This completed study looked at over 11,000 adults in Trøndelag, Norway, to find out how many people have dementia and how many are undiagnosed. Researchers used standard tests to measure memory and thinking skills. The goal is to get a clearer picture of dementia rates across Nor…

This completed study involved over 2,200 people diagnosed with or suspected of having frontotemporal dementia (FTD). Researchers collected blood samples to look for genetic changes linked to the disease. The goal was to find out how common these genetic causes are in people with …

This study tested a program called PorchLight Project, where trained senior companions helped families caring for someone with Alzheimer's or dementia. The goal was to connect families with community services and improve their interactions with doctors. Researchers measured thing…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…

This study used brain imaging and memory tests to find early signs of Alzheimer's disease. Researchers followed 242 volunteers, including healthy young, middle-aged, and older adults, to track changes over time. The goal was to understand how the disease develops and identify mar…

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia remember personal events from their past. Researchers tested 39 participants using a detailed scale to see if memories were specific (like a single event in time and place) or more gener…

This study followed 44 adults with a confirmed VCP gene mutation to learn how their disease (IBMPFD) naturally progresses over one year. Participants completed walking tests, strength assessments, and surveys about daily function and quality of life. The goal was to gather data t…

This study looked at 102 people with multiple sclerosis to see how sleep quality relates to fatigue, body awareness, and arm and leg function. Participants were grouped by good or poor sleep, and their abilities were measured with tests like walking speed and a heartbeat counting…

This study looked at whether eye movements can help measure how severe multiple sclerosis (MS) is and how it affects thinking. 120 adults with MS had their eye movements tracked and compared to standard disability and cognitive tests. The goal was to build a database and train co…

This study looked at whether eye movements can help measure how severe multiple sclerosis (MS) is and how well the brain is working. Researchers tracked the eyes of 200 people with MS while they did tasks on a screen. The goal was to train computer programs to find patterns in ey…

This study looked at sleep disturbances in people with Alzheimer's disease. Researchers tracked sleep diaries, activity levels, and behavior in 70 participants to understand how disrupted sleep relates to daily cycles and daytime alertness. The goal was to learn more about the li…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This completed study looked at how women with multiple sclerosis (MS) respond to high-intensity interval training and strength training at different points in their menstrual cycle. Fifteen women with MS and 15 without MS took part in exercise sessions and reported their satisfac…

This study examined 186 people with Alzheimer's, Lewy body, frontotemporal, or corticobasal dementia, plus healthy controls, to see if subtle physical signs (like coordination or reflexes) differ between dementia types. Participants had simple exams and cognitive tests. The goal …

This study looked at a process called autophagy, which is how cells clean out damaged parts, in 82 women over 65 with osteoporosis. Some also had Alzheimer's disease. Researchers measured autophagy levels in bone cells from hip samples to see if poor cell cleanup links bone loss …

This study aimed to create a communication tool to help people with Alzheimer's or dementia and their caregivers discuss and plan for future medical care. Researchers worked with 38 participants to see if the tool improved their readiness to make advance care plans. The goal was …

This completed study looked at how people with Alzheimer's disease search for objects in realistic scenes and real-life settings. Researchers tracked eye movements in 48 participants to understand which attention and memory processes are impaired. The goal was to link visual expl…

This study analyzed medical records of 213 children with spinal muscular atrophy (SMA) in the Czech and Slovak Republics. Researchers looked at what treatments were used and how the children's motor skills, breathing, and feeding changed over time. The goal was to understand real…

This early study tested whether a special ultrasound technique could safely open the blood-brain barrier in the motor area of the brain in 4 people with ALS. The goal was to see if the procedure was safe and possible, not to treat the disease. Researchers measured side effects an…

This completed pilot study looked at 46 older adults with Alzheimer's disease to see if age-related hearing loss is linked to trouble finding words. Participants took a computer test to measure word-finding ability and answered a hearing questionnaire. The goal was to better unde…

This study tested whether a gentle electrical current applied to the scalp at 40 Hz can strengthen brain rhythms linked to memory in healthy adults aged 50-80. Thirty participants received the stimulation while performing a working memory task. The goal was to see if this approac…

This study looked at how the COVID-19 pandemic changed the way people with multiple sclerosis (MS) reported and managed their relapses. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April–June 2020) with those who had a relapse during t…

This study tested whether combining two non-invasive brain stimulation techniques (tACS and iTBS) can enhance gamma brain waves and working memory in 30 healthy adults. The goal is to develop better stimulation protocols that could one day help people with Alzheimer's disease. Pa…

This study looked at 46 people with progressive multiple sclerosis who have more weakness on one side of their body. Researchers used MRI scans to see how damage in the brain and spinal cord relates to muscle strength in each limb. The goal was to better understand what causes ph…

This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, …

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This study tested whether a daily NAD+ supplement can improve thinking and reduce inflammation in healthy women aged 40 to 80. Participants took either NAD+ or a placebo for 4 weeks and completed computer tests and blood draws. The goal was to see if NAD+ affects memory, attentio…

This study analyzed MRI scans from 732 people with primary-progressive multiple sclerosis who took part in the ORATORIO trial. Researchers wanted to see if ocrelizumab changes a part of the brain called the choroid plexus, which may be involved in inflammation. The study was obse…

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This study looked at whether bowel cleansing before colorectal surgery is linked to memory or thinking problems after the operation. Researchers measured certain brain-related proteins in the blood and gave thinking tests to 84 patients before and after surgery. The goal was to u…

This completed study involved 15 people with relapsing-remitting multiple sclerosis who were already taking alemtuzumab. Researchers measured anti-drug antibodies in their blood over 24 months to see if these antibodies affect treatment or cause infusion reactions. The goal was t…

This study looked at 44 people with a rare inherited eye condition called Leber Hereditary Optic Neuropathy (LHON) that causes vision loss. Researchers reviewed medical records and asked participants about their vision, health, and quality of life. The goal was to better understa…

This study followed 10 people with late onset Tay-Sachs disease to see how their symptoms and body chemistry changed over six months. Researchers measured balance, coordination, and brain chemicals. The goal was to gather information that will help design better clinical trials f…

This study followed 404 older adults for 10 years after hip fracture surgery. Researchers checked whether early signs of Alzheimer's in spinal fluid or cognitive tests were linked to how long patients lived. The goal is to understand if hidden Alzheimer's changes affect long-term…

This study aimed to translate and validate an Italian version of a tool that helps speech therapists assess swallowing difficulties (dysphagia) in people with neurodegenerative diseases like Parkinson's or ALS. Researchers tested the tool on 101 adults with such conditions to ens…

This study followed 544 older couples (ages 65+) over three years to see how dementia affects their relationship and well-being. Both partners answered surveys every six months about their mental health, physical health, and caregiving experiences. The goal was to learn how being…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This study looked at health records from nearly 295,000 older adults with gout to see if two common gout medications, probenecid and allopurinol, affect the risk of developing dementia or Alzheimer's disease. The goal was to find out if one drug might be better at protecting the …

This study looked at 67 adults with spinal muscular atrophy (SMA) types 2 and 3 to see if special electrical tests (MUNE and CMAP) can track nerve loss over time. The goal was to find better ways to measure how the disease changes, not to test a treatment. Participants had geneti…

This study looked at 18 adults with spinal muscular atrophy (SMA) who had taken the oral medication risdiplam for at least one year. Researchers measured how well nerves and muscles communicate by using electrical stimulation tests. The goal was to see if risdiplam improves these…

This study tested whether a medication used for sleep can boost the brain's natural waste-clearing system, called the glymphatic system, in healthy older adults. The goal was to see if this approach could help remove harmful proteins linked to Alzheimer's disease. Thirty-one part…

This study tested a new way to deliver the drug ozanimod using a skin patch instead of oral capsules. 24 healthy adults either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checked for skin reactions to see if the patch works well …

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study looked at 20 adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or multifocal motor neuropathy (MMN) who were starting intravenous immunoglobulin (IVIg) treatment. Researchers measured changes in IgG levels in the blood after the first dose to…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study tested a French version of a questionnaire that measures physical activity levels in people with physical disabilities. Fifty participants with conditions like stroke, multiple sclerosis, or Parkinson's disease filled out the questionnaire twice, two weeks apart. The g…

This study investigates how obesity affects the way the body processes intravenous immune globulin (IVIG), a treatment for immune deficiencies. Researchers measured body composition and blood levels of IVIG in 40 obese and normal-weight patients to find the best dosing strategy. …

This study looked at how the drug cladribine affects the immune system in people with multiple sclerosis (MS). Researchers analyzed blood samples from 77 MS patients and healthy donors to understand the drug's anti-inflammatory effects. The goal was to learn more about how cladri…

This study compared traditional pencil-and-paper tests with virtual reality tasks (like driving simulations and a virtual supermarket) to assess attention and executive function in 60 people with relapsing-remitting multiple sclerosis. The goal was to see if VR can better detect …

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study collected blood and DNA samples from 26 people with early-onset Alzheimer's disease and their close family members. Researchers analyzed the samples to find genetic changes and biomarkers that could help doctors diagnose, treat, and monitor the disease in the future. T…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This study analyzed health records of nearly 5,000 people with spinal muscular atrophy (SMA) to see how well three approved treatments work in everyday medical practice. Researchers looked at complications, medical equipment use, and hospital visits before and after starting each…

This completed study looked at how different types of brain damage—from strokes, tumors, infections, or degenerative diseases—affect thinking and memory. Researchers used brain scans (MRI) and cognitive tests in 346 patients and healthy volunteers to map which brain areas are res…

This study looked at whether certain gene variations (ABCB1) make it harder for the brain to clear a protein called amyloid beta, which is linked to Alzheimer's disease. Researchers compared 510 people with and without Alzheimer's to see if these gene changes are more common in t…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This completed study followed over 6,000 Medicare patients with memory problems to see if a special brain scan (amyloid PET) helps doctors make better care decisions. The study included a diverse group of participants to ensure findings apply to everyone. It did not test a new dr…

This study looked at how the oral medication cladribine changes different types of immune cells in people with relapsing-remitting multiple sclerosis (RRMS). Ten participants provided blood and spinal fluid samples over 96 weeks to track changes in B cells, T cells, and other imm…

This study analyzed insurance claims from over 4,000 people with spinal muscular atrophy to see how three approved treatments (Zolgensma, Spinraza, and Evrysdi) are actually used in daily practice and what they cost over time. Researchers looked at dosing patterns, yearly drug co…

This study tested whether advanced MRI scans can find new biomarkers for amyotrophic lateral sclerosis (ALS), a fast-progressing nerve disease. Researchers used high-field and very-high-field MRI to look at the brain, spinal cord, and muscles of 22 ALS patients over six months. T…

This study followed 10 adults with relapsing multiple sclerosis for 9 months to see how the drug ofatumumab affects microglia, the brain's immune cells. Researchers used special PET scans and blood tests to track changes. The goal was to understand how the drug works in the brain…

This study looked at the gut microbiome (the bacteria living in the digestive tract) of 44 people with mild cognitive impairment, early Alzheimer's, or healthy memory. Researchers wanted to see if lifestyle changes could alter the gut microbiome and whether those changes might be…

This study looked at fatigue in 60 people with multiple sclerosis (MS) to compare how patients describe their tiredness with results from physical and cognitive tests. Researchers used questionnaires, walking tests, grip strength, and balance assessments to get a fuller picture o…

This study looked at whether people with mild cognitive impairment or Alzheimer's-type dementia can understand and decide about receiving their PET scan results for amyloid and tau proteins. Researchers educated 152 participants and their care partners, then assessed their abilit…

This completed study looked for chemical markers in blood and urine that could help detect Alzheimer's disease early. Researchers analyzed samples from 95 people with mild cognitive impairment or Alzheimer's, comparing them to healthy older adults. The goal was to find biomarkers…