Spinal adjustments may tame immune overreaction in MS
NCT ID NCT04972929
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This study investigates whether chiropractic spinal manipulation can reduce inflammation and improve symptoms in people with relapsing-remitting multiple sclerosis (MS). Participants receive either real or sham spinal adjustments over four weeks. Researchers measure changes in blood markers of inflammation, as well as fatigue, thinking speed, pain, mood, sleep, and movement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chiropractic spinal manipulation (Diversified technique) applied to the thoracic spine
- What this could lead to
- If it works, this could point toward a drug-free way to help manage inflammation and symptoms like fatigue and pain in multiple sclerosis.
- What could go wrong
- This is a small early-stage trial with only 26 participants, so results may not apply widely. The effect on inflammation may be small or temporary, and not all people with MS may benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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