New study tracks brain decline in progressive MS

NCT ID NCT03455582

Completed Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times

Summary

This study follows 66 people with primary progressive multiple sclerosis (PPMS) and healthy volunteers for two years to understand how thinking and memory change over time. Participants take cognitive tests and undergo MRI scans to see how brain tissue damage relates to mental decline. The goal is to better understand the disease, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal how cognitive decline progresses in primary progressive MS and which brain changes are responsible, pointing toward future therapies.
What could go wrong: This is an observational study with only 66 participants, so results may not apply to all patients. It does not test any treatment, so no direct benefit is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis Cognitive Dysfunction primary progressive multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE

Contacts and locations

Locations

CHU de Bordeaux

Bordeaux, France
CHU de Limoges

Limoges, France
CHU de Poitiers

Poitiers, France

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