Disease

Researchers compare two topical treatments for plantar warts: hydrogen peroxide 40% applied once weekly and salicylic acid 40% applied daily. The trial enrolls 70 people aged 12 and older with clinically diagnosed plantar warts. The main goal is to see how many participants achie…

Researchers are testing a conditioning regimen built around thiotepa before a haploidentical, or half-matched, stem cell transplant in people aged 50 and older with severe aplastic anemia. The regimen also includes busulfan, fludarabine, anti-thymocyte globulin, and basiliximab, …

Researchers are testing AMP-101, an experimental gene therapy, in people with DOK7 congenital myasthenic syndrome, a rare inherited disorder that causes muscle weakness and exercise intolerance. About 4 participants with moderate to severe DOK7 CMS will receive a single intraveno…

Researchers are testing two experimental gene therapies, VV-14299 and VV-14300, in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin pump. The therapies are injected into muscle and are designed to work togeth…

Researchers are testing a minimally invasive laser procedure to treat chronic pilonidal sinus, a painful condition near the tailbone. The trial enrolls adults with sinus tracts between 2 and 9 centimeters, excluding those with acute abscesses or prior surgery. During the procedur…

Newborns who suffer a stroke or oxygen loss around birth can develop cerebral palsy and other lifelong disabilities, and no treatment can repair the damage. Researchers at UMC Utrecht are testing whether a single dose of bone marrow-derived mesenchymal stromal cells, sprayed into…

Researchers are testing a gene therapy called VV-14300 in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin delivery system. The therapy uses a harmless virus to deliver the glucokinase gene into muscle, where…

Researchers are testing an experimental cell therapy called HS-IT101 in people with advanced non-small cell lung cancer. The treatment uses tumor-infiltrating lymphocytes (TILs), immune cells taken from the patient's own tumor, multiplied in the lab, and given back. Before receiv…

Researchers are testing CHANK-101, a therapy made from a patient's own natural killer (NK) cells, in adults with glioblastoma that has returned after standard treatment. The study enrolls 60 participants who receive intravenous infusions of these cells every two weeks for up to 1…

Researchers are testing an experimental therapy called SNC116 in adults with B-cell acute lymphoblastic leukemia that has returned or stopped responding to treatment. The early-stage study enrolls about 28 people and focuses on safety, side effects, and how the body processes the…

Researchers are testing an experimental therapy called SRN-101 in adults with recurrent high-grade glioma, an aggressive brain cancer that has returned after standard treatment. Participants receive SRN-101 directly into the tumor before planned surgery to remove it. The trial's …

Researchers are comparing two ways of performing robotic surgery to remove stomach cancer: a single-port approach and a standard multi-port approach. The trial enrolls 212 adults with stomach cancer that can be removed with distal gastrectomy. The main question is whether the sin…

This phase 3 trial tests whether adding sintilimab, an immunotherapy drug, to chemotherapy before surgery helps people with early-stage oral squamous cell carcinoma. Participants are adults aged 18 to 75 with cT2N0M0 oral cancer that can be removed by surgery. Half receive sintil…

Researchers test whether daily oral immunotherapy can safely treat food allergy in children aged 0 to 2 with peanut, tree nut, or sesame allergy. Half the children receive the therapy, starting with tiny amounts of the allergen and building up over about six months, then a year o…

Researchers are testing a new dengue vaccine called VLPDEN-02 in 42 healthy adults who have never had a flavivirus infection. The vaccine combines four virus-like particles, one for each dengue virus type, with an adjuvant to boost the immune response. Participants receive three …

Researchers are testing three experimental malaria vaccines (LYB014, LYB017, and LYB027) in healthy adults aged 18 to 50. Participants receive either a low or high dose of one vaccine combined with an immune-boosting adjuvant, or the adjuvant alone as a comparison. The trial trac…

This early-stage trial will test a new HIV vaccine in 22 infants who were exposed to HIV during birth but are not infected. The vaccine is designed to train the immune system to recognize and fight HIV. The main goal is to see if the vaccine is safe and whether it triggers an imm…

This study tests a new type of COVID-19 booster vaccine given as a nasal spray. The vaccine uses a weakened live virus to train the immune system, potentially offering stronger protection in the nose and throat where the virus enters. Researchers are enrolling 80 healthy adults a…

This trial is testing whether an experimental mRNA vaccine can safely reduce moderate-to-severe acne in adolescents aged 12 to 17. Participants receive either the vaccine at different dose levels or a placebo, and researchers monitor safety and changes in facial acne lesions. The…

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

Researchers are testing whether CM336, a bispecific antibody that helps the immune system target myeloma cells, works safely and effectively when combined with daratumumab and lenalidomide. The trial enrolls adults aged 18 to 75 with newly diagnosed multiple myeloma who are not p…

Researchers compare two radiotherapy schedules for women who had breast reconstruction after mastectomy for breast cancer. One schedule gives larger daily doses over 3 weeks; the other gives smaller daily doses over 5 weeks. The trial checks whether the shorter schedule controls …

This early-stage study tests a genetically-modified pig liver used outside the body to temporarily take over liver functions for people with acute-on-chronic liver failure. About 20 adults who are not eligible for a transplant will receive this treatment for a short time. The goa…

Dentists often replace a failed filling in a baby tooth by drilling it out and starting over. This trial tests a gentler option: repairing just the broken part and leaving the healthy filling in place. Researchers will assign 824 baby molars from children aged 4 to 8 to either re…

This phase III trial will enroll 854 Hispanic adults who smoke and want to quit. Participants will use the iCanQuit smartphone app, which teaches skills to manage cravings and prevent relapse. Half will also receive nicotine replacement therapy (gum, patch, or lozenge) to ease wi…

This study tests a combination of two experimental drugs, obrixtamig and ZL-1310, designed to help the immune system fight cancer. It is for adults with advanced small cell lung cancer or other neuroendocrine cancers. The trial has two parts: the first finds a safe dose of the tw…

Researchers are testing whether a doctor can remotely steer a robotic bronchoscope over a 5G network to freeze small lung tumors from inside the airway. The study enrolls about 15 adults with non-small cell lung cancer or controlled metastatic lung tumors, each no larger than 3 c…

This study tests whether adjusting chemotherapy doses for each patient can improve outcomes after a stem cell transplant for blood cancers caused by a RUNX1 gene mutation. Up to 98 people aged 4 to 70 with these cancers will receive a transplant from a half-matched donor. The goa…

Researchers are testing a new oral drug called JNJ-101556143 in people with metastatic prostate cancer that has stopped responding to hormone therapy. The trial aims to see if the drug can shrink tumors or make them disappear. About 100 participants will receive the drug, and doc…

Researchers are testing an experimental drug called 7MW3711 against the standard chemotherapy docetaxel in people with locally advanced or metastatic squamous non-small cell lung cancer. All participants have already received platinum-based chemotherapy and immunotherapy, and the…

Researchers are testing veligrotug, an intravenous antibody, in adults with moderate to severe thyroid eye disease that returned after they responded to teprotumumab. The trial enrolls about 30 participants who completed a full course of teprotumumab at least nine months earlier …

This phase 1 trial is testing an experimental drug called ATG-201 in adults with systemic lupus erythematosus, systemic sclerosis, or Sjögren's disease. ATG-201 is designed to bind to specific proteins on immune cells, potentially quieting the overactive immune response that driv…

Researchers are testing whether combining albumin-bound paclitaxel with gemcitabine helps people with metastatic pancreatic cancer who have not yet received systemic treatment. The study enrolls about 59 adults aged 18 to 75 with confirmed metastatic pancreatic adenocarcinoma. Pa…

Researchers are testing a combination of three drugs, belantamab mafodotin, cevostamab, and pomalidomide, in adults whose multiple myeloma has returned after at least two prior treatments. The phase 1b trial aims to find the best dose and see how well the combination controls the…

Researchers are testing whether a carbohydrate drink before gastrointestinal surgery can reduce insulin resistance and improve blood sugar stability in adults with type 2 diabetes. Participants are randomly assigned to one of three groups: standard fasting without a carb drink, a…

Researchers are testing an experimental antibody drug called zuberitamab in people with primary membranous nephropathy, a kidney condition that causes protein to leak into the urine. The trial compares zuberitamab injections with cyclosporine, a standard immune-suppressing drug, …

This trial tests a new approach for people with solid tumors that have returned or not responded to standard treatments. The therapy uses the patient's own myeloid cells, a type of immune cell, which are genetically modified in a lab to produce a cancer-fighting protein called IL…

This trial tests whether B-OK bottles, which use beads to visually explain how HIV affects health and how treatment lowers viral load, can help people with HIV stick to their medication. Researchers will roll out the bottles across HIV case management agencies in Philadelphia and…

Researchers are testing whether adding the experimental drug RC148 to platinum-based chemotherapy helps people with advanced non-squamous non-small cell lung cancer live longer without their disease worsening, compared with tislelizumab plus the same chemotherapy. The trial enrol…

This study tests a minimally invasive procedure called SESAME for people with thickened heart muscle that blocks blood flow from the heart. The procedure uses a catheter to make a controlled slice in the muscle, aiming to relieve symptoms like shortness of breath. Researchers wil…

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

Researchers are testing UrDiaCare, an Urdu-language app that gives diabetes self-management education and support through WhatsApp or Android. The trial includes 406 adults aged 30 to 70 in Pakistan who have type 2 diabetes and higher-than-recommended blood sugar levels. Particip…

Kaiser Permanente researchers are testing whether digital outreach helps adults with heart failure refill medications they have let lapse. Participants are assigned to receive either interactive text messages or automated phone calls encouraging refills, or usual care with no ext…

Researchers are testing whether a five-fraction course of stereotactic body radiotherapy (SBRT) works as well as the standard 20-fraction radiotherapy for men who need radiation after prostate cancer surgery. The trial enrolls 206 adults and randomly assigns them to either the sh…

Researchers are testing whether giving targeted therapy before and after surgery helps people with stage III non-small cell lung cancer that has specific rare gene changes. The study includes 190 adults whose tumors have alterations in genes like EGFR, ALK, ROS1, MET, RET, or KRA…

Many people who lose weight with GLP-1 drugs like semaglutide or tirzepatide face a choice: stay on the drug indefinitely or stop and risk regaining the weight. This pilot trial compares three approaches in 60 adults with obesity who have reached or nearly reached their target we…

This trial tests whether a 7-day course of antibiotics after draining a first-time perianal abscess can stop an anal fistula from forming. Adults with a first abscess are randomly assigned to receive antibiotics or not, then followed for up to 12 months. The goal is to see if ant…

This trial tests a medical device that has not been approved or cleared by the U.S. FDA. Researchers want to learn whether the device is safe and whether it can help people with a specific condition. Participants receive the device as part of the study, and the team monitors thei…

This trial tests a drug called ripertamab in people with neuromyelitis optica spectrum disorder (NMOSD), a rare condition where the immune system attacks the optic nerves and spinal cord. Participants receive the drug by IV infusion four times over 73 weeks and are monitored for …

Researchers are testing a drug combination for people with advanced hepatocellular carcinoma, a type of liver cancer that cannot be removed by surgery. Participants receive lenvatinib plus tislelizumab, and some also receive gefitinib. The trial compares how long people live with…

This trial is testing whether a targeted therapy called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with newly diagnosed advanced ovarian cancer live longer without their cancer growing. Participants have already completed first-line platinum-…

Researchers are testing whether a combination of rituximab, pirtobrutinib, lisaftoclax and liposomal mitoxantrone can shrink tumors in adults whose chronic lymphocytic leukemia has transformed into the aggressive cancer Richter syndrome. The trial plans to enroll 23 adults who wi…

Researchers are testing whether adding entacapone to bevacizumab is safe and can slow tumor growth in adults with glioblastoma that has returned after standard treatment. The trial enrolls about 96 participants who have not previously received bevacizumab and for whom repeat surg…

This study will test whether a nutrition supplement with different forms of certain nutrients works better than standard supplements for adults with cystic fibrosis. Sixty participants will take the supplement for six weeks, and researchers will measure nutrient levels in their b…

This trial investigates whether a single dose of psilocybin, given during a supervised session and paired with brief cognitive behavioral therapy, can help adults with moderate to severe methamphetamine use disorder reduce or stop their use. Participants receive one of two dose l…

Researchers are testing whether adding finerenone to standard heart failure care can protect heart function and prevent worsening heart failure in people with heart failure with preserved ejection fraction (HFpEF). The trial enrolls adults with HFpEF who are randomly assigned to …

Researchers are running a Phase 3 trial to see whether hydroxychloroquine or corticosteroids can reduce heart valve damage in children and young people with acute rheumatic fever. The trial enrolls about 600 participants aged 4 to 25 who are hospitalized with confirmed valve infl…

This trial tests whether an experimental drug called RO7568282 can slow the progression of early Alzheimer's disease. About 450 people with mild cognitive impairment or mild dementia due to Alzheimer's will receive either the drug or a placebo for 72 weeks. Researchers will measu…

Researchers are testing denecimig, an experimental antibody given as an injection under the skin, in adults newly diagnosed with acquired haemophilia A. This rare condition causes the immune system to attack a clotting protein, leading to sudden and sometimes severe bleeding. The…

This phase 2 trial is testing whether an experimental drug called RO7568282 can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. Participants, aged 40 to 85, must be on stable levodopa monotherapy. The study compares the drug against a placebo …

This early-phase trial tests a new therapy called META 10-19 for people with autoimmune hemolytic anemia (AIHA) that has not responded to standard treatments. AIHA is a condition where the immune system mistakenly destroys red blood cells, causing anemia. META 10-19 uses a patien…

Researchers are testing resmetirom, an oral drug, in adults who have metabolic dysfunction-associated steatohepatitis (MASH) and heart failure with preserved ejection fraction (HFpEF). The trial assigns participants to receive resmetirom or a placebo for 24 weeks. The main goals …

Researchers are testing whether adding zolbetuximab to standard chemotherapy is safe and helps control advanced stomach or gastroesophageal junction cancer in Indian patients. The trial enrolls 50 adults whose tumors carry the Claudin 18.2 protein but not HER2. Participants recei…

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This early study tests an experimental drug called zeprumetostat in people with a rare type of leukemia (T-cell large granular lymphocyte leukemia) that has not responded to or has come back after other treatments. Ten participants take the drug twice daily for two 28-day cycles.…

Researchers at UT Southwestern Medical Center are testing whether tirzepatide, a drug approved for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder reduce or stop using the drug. The trial enrolls 228 adults aged 18 to 65 who are over…

This trial is investigating whether ATH434, an experimental drug taken twice daily as a tablet, can help control multiple system atrophy (MSA), a rare and progressive brain disorder. The study enrolls people who have already completed a prior phase 2 trial of ATH434 and may benef…

This Phase 2 trial tests whether combining the supplement alpha-lipoic acid with the drug mirabegron can improve how the body processes sugar in people with obesity. Sixty adults aged 18 to 65 with a BMI between 30 and 45 will take the combination or a placebo for 4 weeks. The st…

Researchers are testing whether QL1203, a proposed biosimilar of the drug Vectibix (panitumumab), behaves similarly in the body to the original Vectibix when both are combined with chemotherapy (mFOLFOX6). The trial enrolls adults with RAS wild-type metastatic colorectal cancer t…

Researchers are running a phase 1 trial of SHR-4595, an experimental injectable drug, in adults with advanced solid tumors that have not responded to standard treatments. The study checks how safe and tolerable the drug is, how the body processes it, and what dose might work best…

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

Researchers are testing an oral drug called safusidenib in adults newly diagnosed with IDH1-mutant grade 3 oligodendroglioma or astrocytoma, two types of brain tumor. Safusidenib is designed to cross into the brain and block the mutated IDH1 enzyme that drives these tumors. All 2…

This study tests two new ways to treat talaromycosis, a serious fungal infection in people with HIV. It compares a single high dose of a newer antifungal drug (liposomal amphotericin B) against two weeks of the standard drug, and also checks if adding another medicine (flucytosin…

Acute uncomplicated diverticulitis is often treated with antibiotics, but evidence suggests they are not always needed. This study evaluates whether a standardized treatment approach based on clinical findings, lab results, other health conditions, and CT scans can reduce unneces…

This phase 2 trial tests a combination of a vaccine (TriAdeno) and an immune-boosting drug (N-803) in 52 men with early-stage, low- or medium-risk prostate cancer who are currently on active surveillance. The vaccine targets three proteins found in prostate cancer cells, while N-…

Researchers are testing a combination of three oral drugs, imlunestrant, abemaciclib, and selinexor, in people with low grade serous ovarian cancer or endometrioid endometrial cancer. The trial enrolls 60 participants in two separate groups, one for each cancer type. Everyone rec…

Researchers are testing whether adding cryoablation, a procedure that freezes tumors, to two drugs can help people with advanced biliary tract cancer that worsened after first-line treatment. The drugs are QL1706, a dual immunotherapy, and lenvatinib, a targeted therapy. The tria…

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

Researchers are testing a drug called CBX-12 in children and young adults with solid tumors that have returned or stopped responding to treatment, including rhabdomyosarcoma and Ewing sarcoma. CBX-12 pairs a tumor-seeking peptide with exatecan, a chemotherapy drug that blocks can…

This study tests a medicine called tirzepatide to see if it can help people with moderate to severe cannabis use disorder use less cannabis or stop altogether. One hundred adults aged 18 to 70 will receive either the drug or a placebo, and researchers will track their cannabis us…

Researchers are testing whether waiting until 41 weeks to induce labor leads to fewer cesarean deliveries than inducing at 40 weeks in first-time mothers with diet-controlled gestational diabetes. The trial enrolls 1,500 women who manage their blood sugar through diet and exercis…

Researchers are comparing a drug-coated balloon procedure plus intensive medical care against intensive medical care alone in people with severely narrowed brain arteries that have caused stroke or mini-stroke symptoms. The trial enrolls 570 adults aged 18 to 80. Everyone receive…

Researchers are testing whether adding sacituzumab tirumotecan and subcutaneous pembrolizumab to chemoradiotherapy helps people with muscle-invasive bladder cancer live longer without the cancer growing or returning. The trial enrolls about 400 people who have chosen bladder pres…

This early-phase trial tests a new therapy for people with advanced small cell lung cancer or similar neuroendocrine cancers that have not responded to prior treatment. The approach involves collecting a patient's own immune cells, modifying them in a lab to recognize a protein c…

After an allogeneic stem cell transplant, patients often face weeks with dangerously low platelets and need frequent transfusions. This trial tests whether romiplostim, a drug that stimulates platelet production, helps platelets recover faster. Researchers randomly assign 87 adul…

This study tests a combination of four drugs (epalrestat, HAIC, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this approach can control the cancer for at …

Researchers compare dapagliflozin, a diabetes drug, with metformin, the standard insulin-sensitizing treatment, in women with polycystic ovary syndrome. The trial enrolls 70 women aged 18 to 40 who have PCOS and infertility. Over the study, the team measures changes in follicle-s…

Researchers are testing whether adding atrasentan to standard supportive care improves kidney structure and function in adults with IgA nephropathy, a condition where the immune system damages the kidneys. About 20 participants will take atrasentan 0.75 mg once daily for 52 weeks…

Researchers at Yale are testing a decision-support tool called EMBED CDS that alerts emergency department doctors when a patient with opioid use disorder might be eligible for buprenorphine, a medication that eases withdrawal and cravings. The study involves 100 adults with moder…

This study tests whether a vitamin D-based cream (calcipotriol) works as well as steroid injections for regrowing hair in people with patchy alopecia areata. Sixty adults with less than half their scalp affected will use one of the two treatments for 12 weeks. The goal is to see …

This phase 2 trial tests an oral drug called nemtabrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has stopped responding to other targeted therapies. Participants take nemtabrutinib once daily in 28-day cycles until the …

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

Researchers are testing an experimental drug called YMI024 in adults with stable coronary artery disease and high levels of a blood marker of inflammation called hsCRP. The trial assigns about 180 participants to one of five doses of YMI024 or a placebo, with neither participants…

This study tests an experimental pill (cadisegliatin) taken alongside insulin in people with type 1 diabetes who already use a hybrid closed-loop insulin pump. The goal is to see if the pill helps keep blood sugar in a healthy range more consistently. About 40 adults will receive…

This phase 3 trial tests a drug called tralesinidase alfa in 14 children aged 1-5 with Sanfilippo syndrome type B, a rare genetic disease that causes severe brain damage. The drug is given directly into the brain fluid to replace a missing enzyme. The goal is to see if it can slo…

This study tests a radioactive drug called 177Lu-DOTA-EB-TATE in 18 adults with a rare thyroid cancer (Hurthle cell) that has spread and not responded to standard radioactive iodine treatment. The drug is designed to seek out and attach to cancer cells. Participants will receive …

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

Researchers are testing whether a liver-sparing form of chemoembolization, called partial TACE, can boost the anti-tumor effects of the drug lenvatinib in people with liver cancer that cannot be removed by surgery. The trial enrolls about 40 adults with hepatocellular carcinoma w…

Researchers test whether a short course of targeted radiation followed by the immunotherapy drug adebrelimab and NALIRIFOX chemotherapy can shrink locally advanced pancreatic cancer enough to allow surgery. The trial enrolls 36 adults with previously untreated pancreatic ductal a…

Researchers are testing a radiopharmaceutical called 161Tb-PSMA-1 in adults with metastatic clear cell renal cell carcinoma that has worsened after at least two prior treatments, including immunotherapy and drugs that block blood vessel growth. The trial has two parts: a dose-esc…

Researchers are observing how satisfied people with relapsing-remitting multiple sclerosis are when they receive ocrelizumab as an injection under the skin instead of an intravenous infusion. The study follows about 1,800 participants across multiple countries for 12 months, incl…

This trial tests whether mazdutide, an experimental weekly injection, can reduce fat buildup in the pancreas of adults with overweight or obesity. About 194 participants will receive either mazdutide or a placebo, alongside standard lifestyle advice, for 48 weeks. Researchers wil…

This trial is testing an experimental eye gel called BETA-TT8 for people with wet age-related macular degeneration (AMD), a condition that causes rapid vision loss. The gel is applied to the eye up to three times daily for 12 weeks, and standard injections remain available if nee…

This study looks at the safety and effectiveness of Rybelsus, a pill for type 2 diabetes, in everyday medical practice in Korea. About 600 adults will take the medicine as their doctor prescribes, and researchers will track side effects and blood sugar control for 26 weeks. The g…

This trial tests an experimental drug called SFL-0821 in adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes progressive muscle weakness. Researchers give the drug by intravenous infusion, either once or multiple times, and compare it agains…

Researchers are testing an experimental oral drug called VC005 in teenagers aged 12 to 17 who have non-segmental vitiligo, a condition where patches of skin lose their color. The study measures how the drug moves through the body and checks for safety over up to 24 weeks of treat…

This study tests whether adding digital nutrition education—via SMS or group sessions—to daily micronutrient supplements can lower anemia rates in 1,200 adolescents aged 15-19 in Dar es Salaam, Tanzania. All participants get supplements and basic nutrition info; some also receive…

Researchers are studying whether patients can safely leave the hospital within 48 hours after minimally invasive colorectal surgery. The trial follows 97 adults having elective laparoscopic or robotic surgery for benign or malignant disease. It checks how many meet predefined cli…

Researchers are testing whether combining BL-B01D1, an experimental antibody-drug conjugate, with glecirasib, a targeted KRAS G12C inhibitor, can shrink tumors in adults with locally advanced or metastatic non-small cell lung cancer that carries a KRAS G12C mutation. The phase 2 …

Researchers are testing whether adding an experimental drug called F182112 to isatuximab and lenalidomide is safe and can help people with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The trial enrolls about 10 adults aged 18 to 70. Participants r…

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

Researchers are testing a three-drug regimen called VAM for older or unfit adults with newly diagnosed acute myeloid leukemia (AML). The regimen combines liposomal mitoxantrone, azacitidine, and venetoclax. The trial aims to find the safest and most tolerable dose of liposomal mi…

Researchers test whether rituximab helps maintain lung function in adults with systemic sclerosis and interstitial lung disease whose disease has stabilized after initial rituximab treatment. Participants receive rituximab or placebo infusions at months 0, 6, and 12. The main mea…

Researchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This study tests whether a one-time infusion of specially engineered immune cells (CAR T cells) can improve lung function and skin hardening better than current treatments for people with active systemic sclerosis, a rare autoimmune disease. About 92 adults with lung involvement …

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

Researchers are testing whether drug testing in patient-derived organoids can guide chemotherapy for low-grade non-muscle invasive bladder cancer. Adults with primary or recurrent low-grade bladder cancer receive one of four chemo drugs, epirubicin, mitomycin C, gemcitabine, or d…

Many people who have bariatric surgery do not lose as much weight as expected or regain it over time. This trial tests whether tirzepatide, a weekly injection that acts on two gut hormones, helps adults with obesity lose more weight after surgery. Participants receive either tirz…

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

Researchers are testing REGEND001, a therapy made from a patient's own airway basal stem cells, to see if it can improve lung function in people with chronic obstructive pulmonary disease (COPD) and emphysema. The trial enrolls adults aged 40 to 75 with moderate to severe COPD. P…

This study tests whether a continuous glucose monitor (CGM) is better than standard finger-prick tests for managing blood sugar in 100 pregnant women with gestational diabetes. Participants will either wear a small sensor or continue finger-pricking. The goal is to see if CGM is …

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

Researchers are testing whether a shared checklist used during lung cancer surgery helps surgeons achieve cleaner, more complete tumor removal. The trial enrolls adults with early-stage non-small cell lung cancer who are scheduled for surgery. Half the participating hospitals use…

This study provides continued access to alpelisib for people who are already benefiting from it in a previous Novartis trial. It focuses on tracking long-term safety, including any side effects, in participants with PIK3CA-related overgrowth spectrum or certain breast cancers. Pa…

Researchers are testing an experimental topical gel called PP405 in men with androgenetic alopecia, the most common form of male pattern hair loss. The trial enrolls about 600 men aged 18 to 55 with moderate hair loss at the top of the scalp. Participants apply either the PP405 g…

Researchers are testing a chemotherapy combination built around albumin-bound paclitaxel (II) for people with pancreatic cancer. The study has three groups: one for advanced cancer that cannot be removed by surgery, one for cancer that may be removable and receives treatment befo…

Researchers are testing a new immunotherapy called Lm-LLO-TT in adults with advanced pancreatic ductal adenocarcinoma that has already been treated with chemotherapy. Lm-LLO-TT uses a weakened form of Listeria bacteria engineered to carry a tetanus toxoid antigen, aiming to spark…

Researchers test whether Bacillus probiotics, given alongside standard four-drug antibiotics for H. pylori infection, reduce gut side effects and improve treatment tolerance. The trial enrolls 336 adults with H. pylori who receive either a single-strain probiotic, a multi-strain …

Researchers are testing a new biological therapy called BI 4060107 in adults with advanced solid tumors that cannot be removed by surgery. The trial is for people who have tried all available treatments and have no other options. The main goal is to find the highest dose that peo…

Researchers are testing whether an oral drug called vepugratinib can clear low-grade, intermediate-risk bladder cancer that has not invaded muscle, or low-grade upper tract urothelial cancer. The trial enrolls adults whose tumors carry a specific change in the FGFR3 gene. Partici…

This early study tests a new, noninvasive laser treatment called Nano-Pulsed Laser Therapy (NPLT) for people with moderate to severe traumatic brain injury (TBI). The goal is to see if the treatment is safe and can be given soon after injury. Researchers will also check if the la…

Researchers at the University of Oklahoma are testing whether adding pentamidine, an antiparasitic drug, to standard modified FOLFIRINOX chemotherapy is safe and helps shrink tumors in people with advanced or metastatic pancreatic cancer. Up to 30 adults with confirmed locally ad…

This trial tests whether efgartigimod, a drug that lowers harmful antibody levels, can improve recovery in people with Guillain-Barré syndrome (GBS), a rare nerve condition that can cause weakness and paralysis. Adults aged 18 to 70 with recent GBS onset will receive either efgar…

This trial is for people with ER-positive, HER2-negative advanced breast cancer whose disease has started to grow in a few spots while on hormone therapy and a CDK4/6 inhibitor. It tests whether adding targeted radiation (SABR) to those spots allows patients to stay on their curr…

Researchers are testing whether combining an experimental dual immunotherapy drug called QL1706 with standard chemotherapy (docetaxel, oxaliplatin and S-1) before surgery can help patients with locally advanced gastric or gastroesophageal junction cancer. The study enrolls 34 adu…

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

Researchers are studying giredestrant, an experimental daily pill, in people with estrogen receptor-positive, HER2-negative early breast cancer. The trial enrolls about 1,500 participants, including some who switch to giredestrant after other treatments. It tracks how many people…

Researchers are comparing an experimental oral drug called VT3989 with standard chemotherapy drugs gemcitabine or vinorelbine in adults with advanced epithelioid pleural mesothelioma. All participants have already received platinum-based chemotherapy and immunotherapy, and their …

Researchers are testing an experimental oral drug called ONO-2808 in adults with the Parkinsonian subtype of multiple system atrophy (MSA-P), a rare and progressive brain disorder. The phase 3 trial enrolls about 486 people in the early stages of the disease, within five years of…

Researchers are testing whether a standardized care pathway helps adults with advanced heart failure in Latin America complete a multidisciplinary evaluation and receive a documented treatment decision within 90 days. The trial includes 360 adults with acquired or structural hear…

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

Researchers are testing whether adding CT-guided thermal ablation of liver or lung metastases to standard systemic therapy improves tumor response in people with nasopharyngeal carcinoma. The trial enrolls 138 adults whose primary tumor was cured but who later developed up to fiv…

This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The mai…

This study tests an experimental drug called centhaquine in 80 adults with moderate to severe ARDS, a life-threatening lung condition. The drug is added to standard care to see if it improves oxygen levels and reduces deaths. Participants must be in the ICU and start treatment wi…

Researchers are testing whether adding an experimental drug called HLX22 to standard trastuzumab and chemotherapy helps people with locally advanced or metastatic HER2-positive breast cancer that has already been treated with a HER2 ADC. About 90 adults will receive either HLX22 …

Researchers are running a first-in-human Phase 1 trial of JUR-003, an intravenous biologic, in adults with metastatic prostate cancer. The study has two parts: a dose-escalation phase to find the highest dose people can tolerate, and a dose-expansion phase to look at early anti-t…

Researchers are testing a new way to deliver antibiotics to the brain in people with moderate to severe bacterial meningitis who are not improving on standard intravenous treatment. The approach combines standard IV antibiotics with a continuous infusion of three antibiotics (van…

Researchers are testing whether adding two oral drugs, avutometinib and defactinib, to standard chemotherapy (mFOLFIRINOX) is safe and can slow or shrink pancreatic ductal adenocarcinoma. The trial has two parts: one for people whose cancer has spread, and one for people whose ca…

Researchers are running a Phase I trial of HEC-921, an experimental drug given by intravenous infusion, in adults with advanced malignant solid tumors. The study first gives HEC-921 alone to find the highest dose people can tolerate, then tests it in combination with oxaliplatin,…

Researchers are testing whether infusions of bone marrow-derived mesenchymal stem cells, called MesenCell, are safe for adults with moderate or severe chronic graft-versus-host disease that has not responded to steroids and other standard treatments. The trial enrolls up to 20 pe…

This study tests a new imaging and guidance system called VERAFEYE that creates a 3D model of the heart to help doctors navigate during catheter ablation for atrial fibrillation. About 50 adults with paroxysmal or persistent atrial fibrillation will have their standard ablation p…

People with end-stage kidney disease need a reliable blood vessel connection, called a fistula, for hemodialysis. This study tests a device called the ePATH System, which creates that connection from inside the blood vessels rather than through open surgery. Researchers will foll…

Researchers are testing whether women aged 65 and older with early-stage, lymph node-positive, ER+/HER2- breast cancer can safely skip chemotherapy. Participants receive CDK4/6 inhibitors, with or without endocrine therapy, after surgery. The trial tracks how many women remain fr…

This study tests a new immunotherapy designed to help the immune system recognize and attack cancer cells in people with high-risk Ewing sarcoma or desmoplastic small round cell tumor (DSRCT). The treatment targets a specific genetic change found only in these cancer cells, aimin…

This study tests a program for new mothers who had high blood pressure during pregnancy. Participants wear a FitBit and receive weekly messages with personalized activity goals. The goal is to see if this approach increases daily steps and improves blood pressure, and whether mom…

Researchers want to know whether leftover bile fluid can reveal genetic changes in tumors of people with advanced biliary tract cancer, such as bile duct or gallbladder cancer. Collecting tumor tissue for genetic testing can be difficult or risky in this cancer, so the study coll…

Researchers at M.D. Anderson Cancer Center are testing whether comprehensive genomic sequencing can identify specific subtypes of large B-cell lymphoma and provide information that may help guide treatment decisions. The trial enrolls about 60 adults with stage 3 or 4 diffuse lar…

Placenta accreta spectrum happens when the placenta grows too deeply into the uterus, which can cause dangerous bleeding during delivery. Doctors struggle to predict how severe each case will be before surgery. This study measures a new ultrasound angle, the placenta-cervical int…

Researchers are testing a new PET imaging agent called [68Ga]Ga-OncoACP3 that targets a protein called ACP3, which is found in prostate cancer cells. The study enrolls 50 men with suspected or confirmed high-risk prostate cancer, or suspected recurrence after treatment. Each part…

This study checks if a special thinking test (MoCA Blind) can find memory or thinking problems after cornea surgery. It includes 200 adults with cornea disease who will take the test before and 90 days after surgery. The goal is to give doctors a better way to spot these issues i…

Sepsis is hard to spot early because its first symptoms look like many other conditions. Researchers at emergency departments in Taiwan are studying whether two blood markers, presepsin and immature granulocytes, can help doctors tell sepsis apart from other causes of inflammatio…

Researchers in Qinghai Province, China, are testing whether artificial intelligence can help primary care doctors spot congenital heart disease during school-based screening. Schools are randomly assigned to either standard listening with a stethoscope or listening plus AI analys…

Researchers are building an artificial intelligence system that analyzes chest CT images and offers decision support to doctors reading those scans for lung cancer. They use deidentified CT exams from routine care to develop and lock the AI models. In the prospective stage, about…

This study tests advanced CT scans to find dangerous blockages in heart arteries without needing to insert a tube into the heart. About 142 adults with moderate blockages will get two types of CT scans, and results will be compared to the standard invasive test. The goal is to se…

Researchers are testing whether a smartphone app called Stethophone can help primary care doctors find moderate or severe aortic stenosis in adults aged 70 and older. The app turns a phone into a digital stethoscope and analyzes heart sounds for murmurs that may signal the condit…

Autistic children in the emergency department often miss full vital sign checks because standard equipment can be distressing. This pilot study randomizes 100 children aged 2 to 17 to have their heart rate, breathing, oxygen and temperature measured either with wireless wearable …

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers are testing a new PET/CT imaging tracer called [68Ga]-LY4257529 that targets a protein called GRPR, which some cancers make in large amounts. The study includes up to 60 adults with breast cancer or other tumors known or suspected to express GRPR, such as prostate, ov…

Researchers at Mayo Clinic are testing an investigational radioactive tracer called 68Ga-FAPI-46 to see how it distributes in the lungs of people with interstitial lung disease. About 10 participants with a clinical diagnosis of ILD and lung abnormalities on a recent CT scan rece…

Researchers are testing whether adding a brain-injury blood test to standard clinical guidelines can safely reduce the number of brain CT scans ordered for adults who come to the emergency department with a suspected head injury. The blood test measures two proteins, GFAP and UCH…

Researchers are studying whether immune markers in a blood sample taken before pancreatic cancer surgery can predict a serious complication called postoperative pancreatic fistula, where digestive fluids leak from the surgical connection. Adults scheduled for curative-intent panc…

Researchers at Corewell Health West are testing whether medical assistants can use a handheld ultrasound device to estimate heart pumping function in people with new heart symptoms. The trial enrolls up to 100 adults at rural outpatient clinics who have not had a recent echocardi…

Researchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …

Researchers at Assiut University are testing whether a specialized MRI technique called multi-echo fast field echo (mFFE) can detect cortical bone changes in knee osteoarthritis as accurately as CT scans. The study enrolls 80 adults aged 40 and older with suspected or confirmed k…

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

Doctors usually send colorectal tissue to a lab and wait days for results. This pilot study tests a miniaturized device called MULTISCOPE that uses light-based imaging to tell healthy tissue from cancerous tissue in real time. Researchers will examine 30 tissue samples removed du…

Researchers are studying whether the total time from heart attack symptom onset to balloon inflation during angioplasty helps predict contrast-induced nephropathy, a kidney complication that can occur after the procedure. The trial enrolls 400 adults with ST-segment elevation myo…

Researchers are reviewing medical records from about 1,125 women in Italy with newly diagnosed advanced high-grade epithelial ovarian cancer. The study focuses on how hospitals test tumors for homologous recombination deficiency (HRD), a DNA repair flaw that can make PARP inhibit…

This trial tests a new AI device that helps surgeons see brain tumors on ultrasound images during surgery. The AI highlights tumor tissue in real time, which may help remove more of the tumor while protecting healthy brain. The study involves 100 adults scheduled for brain tumor …

This study checks if a simpler way to collect blood samples works as well as the standard method for the HepQuant DuO liver test. The test involves drinking a natural substance and taking blood samples 20 and 60 minutes later. Researchers will compare different blood collection t…

Doctors often wait days for genetic tests to classify acute myeloid leukaemia (AML) and guide treatment. This trial tests whether breath analysis can detect metabolic products from leukaemia and classify the disease faster. Participants give breath samples and extra blood tests d…

This trial tests whether Epidiolex, a prescription CBD medication, can delay or prevent the first seizure in infants with Sturge-Weber syndrome, a rare condition that often leads to seizures and developmental challenges. The study enrolls babies aged 1 to 18 months who have brain…

Researchers are testing whether Sinovac's Anflu flu vaccine produces a strong immune response in pregnant women compared with Sanofi's Vaxigrip. The trial enrolls 150 healthy pregnant women between 22 and 34 weeks of pregnancy. Each participant receives one dose of either vaccine…

Older adults who are hospitalized often lose the ability to do everyday tasks, a problem called hospital-associated disability. Researchers at Hvidovre University Hospital are studying physical activity during and after hospitalization in people aged 65 and older. Participants wi…

Researchers are testing whether a diet high in stearic acid, a type of saturated fat found in cocoa butter, improves blood vessel function compared with a diet high in oleic acid, the main fat in olive and canola oils. The trial enrolls 40 overweight or obese adults aged 40 to 70…

This study will test a mobile app called HealthMPowerment designed to help Black adolescents and young adults in Alabama take PrEP, a daily pill that prevents HIV. Ten teens and their adult supporters will use the app for a few weeks, and researchers will check if it's easy and a…

Researchers are testing whether primary care doctors can deliver a brief lifestyle intervention to older adults at risk of dementia. The trial enrolls 300 people aged 60 and older with elevated dementia risk scores. Doctors at community health centers provide the intervention, an…

Researchers are testing a community-led prevention program called Qungasvik-Healthy Hearts in three rural Alaska Native communities. The program adapts traditional Yup'ik practices such as hunting, gathering, and fishing to see whether they can reduce risk factors for heart and c…

Pancreatitis is a painful inflammation of the pancreas that can happen after an ERCP procedure. Doctors often give rectal indomethacin around the time of ERCP to lower that risk, but it still occurs. This trial randomly assigns adults having ERCP to receive either rectal indometh…

Researchers are testing whether giving an anti-PD-1 immunotherapy drug together with anlotinib after surgery can prevent or delay the return of esophageal squamous cell carcinoma. The trial enrolls adults aged 18 to 75 who had chemotherapy plus immunotherapy before surgery, then …

This study tests a school-based weight management program using a WeChat digital platform to help children in Fangshan District, Beijing, avoid excessive weight gain. About 1,400 children in grades 2 and 3 will either receive the program (health classes, daily physical activity, …

Trastuzumab deruxtecan (T-DXd) treats metastatic breast cancer but can cause interstitial lung disease (ILD), a form of lung inflammation that sometimes forces patients to stop treatment. Researchers are testing whether giving dexamethasone before each T-DXd infusion lowers the c…

Researchers test a hybrid breast cancer education program for women aged 20 to 65 who visit an obstetrics and gynecology clinic. The program combines a face-to-face session using a breast model with four weeks of educational messages and reminders sent through a mobile app. The t…

Researchers at the University of Washington are studying whether an online community of practice helps pharmacists learn to prescribe PrEP, a daily pill that prevents HIV. The study enrolls about 500 pharmacists and pharmacy staff across the United States whose pharmacies do not …

Researchers are testing an experimental vaccine called AV-1959R in adults aged 55 to 80 who have amyloid buildup in the brain but no memory or thinking problems. The trial compares the vaccine with a placebo to see whether it is safe, triggers an immune response, and lowers brain…

Researchers are testing whether a single dose of the antiviral drug baloxavir marboxil can stop influenza from spreading among people who live with someone who has the flu. The trial enrolls households in China where one person has confirmed influenza and up to five other members…

Researchers are testing a behavioral program that sends supportive text messages and offers small rewards to pregnant women who test positive for alcohol, tobacco, or cannabis use in South Africa. The program aims to reduce substance use during pregnancy and breastfeeding, which …

Paraffin disease happens when people inject paraffin oil into muscle for cosmetic enlargement, causing chronic inflammation, high blood calcium, kidney stones, and kidney damage. Researchers are testing whether empagliflozin or losartan, two drugs already used for kidney protecti…

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

Clesrovimab is an FDA-approved antibody shot for infants under 8 months entering their first RSV season when their mothers did not get an RSV vaccine in pregnancy. Researchers at Emory University are measuring antibody levels in the blood and noses of 24 healthy infants who recei…

This study tests whether the drug rituximab can safely clear Epstein-Barr virus (EBV) from the blood of people who have received a solid organ transplant. High levels of EBV can lead to a serious cancer called post-transplant lymphoproliferative disorder (PTLD). The trial will en…

Researchers are testing an AI chatbot that gives personalized, culturally tailored advice on nutrition, physical activity, and goal setting to adults at risk for type 2 diabetes. About 30 adults aged 18 to 55 will use the chatbot for 6 weeks. The study will check whether the chat…

This trial tests whether a nursing care bundle created with the help of artificial intelligence can prevent medical device-related pressure injuries in intensive care patients. These injuries, which can be painful and serious, affect about 1 in 5 ICU patients. The study will comp…

Researchers are testing whether an artificial intelligence tool can sort children by their risk of nearsightedness and guide personalized prevention, such as more outdoor time and special glasses. The trial enrolls about 1,600 students in grades 1 through 3 from public primary sc…

This trial tests whether adding a structured yoga therapy program to standard surgery for endometriosis can reduce chronic pain and improve quality of life. About 188 women scheduled for endometriosis surgery will either receive standard care alone or standard care plus 32 guided…

This trial tests whether a smartphone-based mindfulness program can help adolescents and young adults with sickle cell disease manage chronic pain and sleep problems. Participants are randomly assigned to either use the mindfulness app for about 8 weeks or receive usual care. The…

Researchers compare two sedatives, remimazolam and propofol, for patients with heart disease who need a transesophageal echocardiogram (TEE), a procedure that uses a tube in the esophagus to take pictures of the heart. Adults scheduled for an elective TEE receive one of the two d…

People treated with radiation for oropharyngeal cancer can later develop damage to cranial nerves, especially the nerve that controls the tongue. This trial tests four approaches to see if they are safe and practical: high-dose prednisone, the injectable drug fremanezumab, a home…

This study tests a medicated foam (AMZEEQ®) on a rare skin condition called CARP, which causes brown, scaly patches. About 35 people aged 9 and older will apply the foam to one side of their body and a plain moisturizer to the other for 5 weeks. The goal is to see if the foam is …

Researchers are testing whether a school-based program called Unstuck and On Target for Early Childhood can help 4- and 5-year-olds with executive function deficits. Executive function covers skills like planning, staying flexible, and managing emotions. The program uses storyboo…

Researchers are testing whether a dietary supplement called Galactol improves overall well-being and reduces gastrointestinal symptoms in adults with celiac disease who have functional abdominal bloating. The study enrolls 50 people aged 18 to 70. Participants take either Galacto…

People on hemodialysis must closely manage fluid, diet, and their vascular access between sessions, and sticking to these routines is hard. Researchers at the University of Rome Tor Vergata built DialysisBot, an AI chatbot that answers patient questions using only a hospital-appr…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

Researchers are testing a noninvasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in adults with major depressive disorder. The trial randomly assigns 60 participants to receive either active stimulation targeting the amygdala or a sha…

This study will test whether Pycnogenol, a supplement from French maritime pine bark, can reduce symptoms of Gulf War Illness like fatigue, pain, and brain fog. Twenty male veterans who have already been in a related study will take either Pycnogenol or a placebo for up to 12 mon…

This pilot study will test whether a high-fat, low-carbohydrate ketogenic diet can reduce symptoms of bipolar disorder when added to standard treatments. The study will enroll 100 adults in rural Alabama and measure changes in mania severity. The goal is to see if a dietary appro…

This pilot study explores whether a personalized telerehabilitation program can help adults who notice cognitive slips in daily life. Participants include older adults and adults with Ehlers-Danlos Syndrome who report subjective cognitive complaints. Over six weeks, they receive …

Researchers are testing whether a noninvasive device called Hypersound can reduce chronic neuropathic or radicular pain in adults. The system uses external antennas to deliver radiofrequency energy to peripheral nerves without implants or needles. About 71 participants receive te…

Researchers at the University of Miami are testing a non-invasive ear stimulation treatment to understand nerve pain in older adults living with HIV. The study enrolls 70 people with HIV-associated peripheral neuropathy, a condition that causes tingling, numbness, or pain in the …

Duke University researchers are studying whether hearing aids help adults who report hearing difficulty in daily life even though standard hearing tests show normal hearing. The trial enrolls 125 adults who have not used hearing aids before. Participants try hearing aids with dif…

Stanford researchers are testing whether a single 120-minute pain relief class called Empowered Relief can help women with severe pain after cesarean delivery. The class teaches pain education, relaxation, deep breathing, and cognitive behavioral skills, and participants receive …

This early-stage trial tests whether a single dose of pembrolizumab (Keytruda), a drug used for cancer, can safely reduce long-term neurological symptoms like brain fog and dizziness in people with long COVID. Fifteen adults who had COVID-19 at least six months ago and still have…

Many people with liver cirrhosis struggle with poor sleep, which can affect daily life and thinking. This trial tests daridorexant, a sleep medication, against placebo in 180 adults with cirrhosis and sleep disturbance, including some with mild hepatic encephalopathy. Participant…

Researchers are testing whether enhanced external counterpulsation (EECP), a noninvasive treatment that uses inflatable cuffs on the legs and buttocks timed to the heartbeat, can improve blood pressure and erectile function in men aged 60 to 75 who have both hypertension and erec…

This early-stage trial will test whether higher-than-standard doses of memantine, a drug already approved for Alzheimer's, are safe and tolerable in 25 adolescents and young adults with Down syndrome. The study also looks for early signs that the drug might improve memory and thi…

Children scheduled for angiography often feel anxious, which can affect their heart rate, blood pressure and cooperation during the procedure. This trial tests whether a short virtual reality guided breathing exercise, delivered through a headset showing calming scenery, can redu…

This trial tests whether ischemic conditioning — brief cycles of blood-flow restriction using pressure cuffs on the arms — can improve motor function and cognitive performance in people with Parkinson's disease. Over 12 weeks, 34 participants will receive 24 sessions of the thera…

Researchers are testing a six-week, nurse-led program that helps Chinese prostate cancer survivors and their female partners talk about sex, rebuild intimacy, and cope together after treatment. About 72 couples join the study, with half receiving the program plus standard survivo…

People hospitalized after a traumatic injury often face post-traumatic stress, depression, and substance use problems. This study tests a program called Trauma Resilience and Recovery Program Portal 2.0, which adds bedside screening, education, text-message check-ins, and follow-…

Researchers test whether optokinetic stimulation without a reading task improves reading speed in adults with hemianopic alexia after stroke. Participants receive 4 weeks of stimulation without a reading task and 4 weeks with a reading task, in random order. The study compares re…

Researchers at Indiana University are testing whether a home-based virtual reality program can help people with mild dementia practice everyday activities like preparing food, washing dishes, or managing money. Forty participants will be randomly assigned to either VR training or…

Researchers are testing whether a single injection of an experimental gene therapy called GNSC-001 can reduce knee osteoarthritis pain and improve joint function in adults. The trial enrolls about 240 people with moderate knee arthritis confirmed by X-ray. Participants receive on…

Researchers are testing whether brexanolone, an intravenous drug approved for postpartum depression, can reduce PTSD symptoms and stress-related drinking in veterans who have both PTSD and alcohol use disorder. The study enrolls 40 veterans aged 21 to 70. Participants receive one…

Stroke survivors often walk more slowly and struggle to produce the movements needed for efficient walking. This study tests whether small wearable devices that vibrate during walking can help people with chronic stroke change specific walking movements linked to speed, propulsio…

Researchers at the University of Zurich are testing whether neurofeedback can ease chronic tinnitus, the persistent ringing or buzzing that affects hearing and quality of life. The study enrolls 24 adults with moderate to severe tinnitus for about nine months. Participants attend…

This pilot study will test whether active music therapy (with a therapist) or passive music therapy (just listening to music) can improve exercise ability and motivation in 28 people with Parkinson's disease. Participants will do sit-to-stand and walking tests while receiving mus…

This study tests whether a structured laughter yoga program can reduce burnout, stress, and compassion fatigue in nurse managers. Eighty nurse managers will either join laughter yoga sessions twice a week for 8 weeks or continue as usual. Researchers will measure changes in stres…

Researchers compare Er:YAG laser cavity preparation with conventional rotary drills in adults who have permanent premolars scheduled for extraction as part of orthodontic treatment. Each participant receives both methods on two different teeth, at separate visits, and rates pain …

Researchers at Tongji Hospital are testing a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in 26 people with Parkinson's disease. The study uses MRI scans to customize electrode placement so the stimulation reaches deep brai…

Researchers are testing whether Qigong, a mind-body exercise, can improve spinal mobility and reduce pain in women with fibromyalgia. The trial randomly assigns 36 women aged 30 to 50 to one of two online Qigong programs: one focused on fluid, mobility-intensive movements, the ot…

Researchers are testing whether dexamethasone, a steroid that reduces inflammation, works as well when taken by mouth as when given through a vein. The trial enrolls 40 adults with periodontitis who need two similar gum flap surgeries. Each participant has both surgeries and rece…

Researchers at Hospital Universitario Austral in Argentina are testing whether a structured three-session music therapy program called MUSPAL360 can be delivered to hospitalized adults with advanced cancer receiving palliative care. The program combines live music therapy with 36…

Researchers compare two monthly replacement silicone hydrogel multifocal toric contact lenses in people over 40 who already wear soft contacts. The study measures how easy the lenses are to handle, especially removal, and other performance factors. About 60 participants with asti…

People with Parkinson's disease often struggle with balance and anxiety, and the two can make each other worse, especially when they try to walk and think at the same time. High-intensity aerobic exercise may help both, but Parkinson's symptoms make it hard for many to reach that…

Researchers at the University of Iowa are testing whether an online wellness program can reduce fatigue and improve mood and quality of life in people aged 45 to 70 with progressive multiple sclerosis. Participants are randomly assigned to get the program right away or to continu…

Researchers at MD Anderson Cancer Center are studying whether routine electronic symptom monitoring improves quality of life and care experience for patients with pancreatic adenocarcinoma receiving chemotherapy or radiation before surgery. About 200 adults with operable or local…

Researchers are testing whether a standardized Enhanced Recovery After Surgery (ERAS) pathway improves recovery for women who have a cesarean delivery because of placenta previa. The study includes 100 women with a singleton pregnancy and a confirmed placenta previa who are sched…

Researchers are testing whether signaling molecules made by a patient's own fat-derived stem cells can help synthetic bone grafts build stronger jawbone. The trial enrolls 20 adults with severe upper-jaw bone loss who need sinus floor augmentation before dental implants. Each par…

Researchers are testing an experimental drug called olatorepatide in adults with moderate to severe hidradenitis suppurativa who also live with overweight or obesity. Hidradenitis suppurativa causes painful lumps and tunnels under the skin. The trial compares olatorepatide with a…

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

Researchers are studying a surgical method for repairing rotator cuff tears that uses two rows of anchors and sutures without knots, called the Montgolfier technique. The sutures spread tension evenly around the repair, similar to the cables of a hot air balloon. Adults scheduled…

Researchers are testing whether transcranial magnetic stimulation (TMS) can improve social perception in adolescents with autism spectrum disorder. The trial targets the right posterior superior temporal sulcus, a brain region involved in processing social information. Sixteen pa…

Researchers at Sveti Ivan Psychiatric Hospital are testing whether high-frequency repetitive transcranial magnetic stimulation (rTMS) with the H7 coil reduces gambling disorder symptoms. The trial enrolls 60 men aged 18 to 64 who are starting treatment at a gambling disorder day …

This study tests whether giving high-flow oxygen through special nasal prongs during a less-invasive heart valve replacement (TAVR) can prevent low oxygen levels and breathing complications. About 452 older adults undergoing TAVR under sedation will be randomly assigned to receiv…

Researchers are studying whether a broad-spectrum oral tincture containing CBD, CBN, and CBG changes anxiety symptoms in adults with generalized anxiety disorder. About 60 participants will take the tincture under the tongue or by mouth roughly every 12 hours for 8 weeks, with fo…

Researchers are testing whether a structured educational program based on Kolcaba's Comfort Theory can improve quality of life for adults with epilepsy. The program addresses physical, emotional, social, and environmental comfort needs through planned sessions delivered alongside…

This early-phase trial tests whether giving adults with autism a 6-week course of vancomycin followed by a fecal transplant from a close relative can improve social and language problems. Ten participants will be tracked for changes in autism symptoms, quality of life, and gut he…

Researchers are testing an experimental oral drug called soquelitinib in adults with moderate-to-severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and tunnels. The trial aims to see if the drug is safe and can reduce the number of inflammatory le…

Researchers compare two rehabilitation approaches for children with cerebral palsy and immature brain injury: virtual reality training and task-oriented circuit training. Both aim to improve upper limb sensorimotor function, pinch grip, and quality of life. Forty-four children ag…

This trial tests whether a single, two-hour online class called Empowered Relief can help American Indian adults with cancer-related pain. Participants learn three pain relief skills, create a personal plan, and get access to a free audio app for daily practice. The study aims to…

Researchers are comparing two forms of shockwave therapy, focused and radial, for adults with chronic plantar fasciitis, a common cause of heel pain. About 150 participants receive three weekly treatment sessions and then answer questions about pain and foot function for up to a …

Researchers are testing whether an AI chatbot on WeChat helps early-stage cancer patients quit smoking. The chatbot uses the Multi-Theory Model to offer personalized advice, emotional support, and habit tracking around the clock. The trial compares the chatbot with phone-based pr…

Researchers at the University of North Carolina are testing a support program for young adults aged 18 to 39 who are receiving cancer treatment. A trained navigator contacts each participant at least once a month for four months by phone, text, email, or video, based on what the …

Adults with sickle cell disease often face severe pain crises that require hospital treatment with intravenous morphine. This trial compares standard morphine treatment with combinations that add paracetamol, ketamine, or nefopam. Researchers want to see if these combinations eas…

Researchers at the University of Bergen are testing whether a two-week, self-guided smartphone screen time reduction program can reduce depression symptoms in young adults. The trial enrolls 200 students in Oslo who have sought help at the student mental health service. Participa…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

This study tests whether a full-spectrum screen bar light can reduce eye fatigue and dry eye symptoms after two hours of computer work. Healthy adults aged 18 to 35 who use screens at least four hours daily will be randomly assigned to use the light or a standard screen without i…

Endometriosis causes chronic pelvic pain and painful periods, and current treatments do not work for everyone. Researchers are testing whether desloratadine, an antihistamine usually taken for allergies, can reduce pain and improve quality of life. The trial enrolls 60 women aged…

Researchers are testing a program that combines mindful eating and yoga-based movement for adults with type 2 diabetes. The trial enrolls 60 people aged 40 and older who have had diabetes for at least six months. Half receive the mindfulness program and half receive standard diet…

Endometriosis is a long-term condition where tissue like the uterine lining grows outside the uterus, often causing lasting pelvic pain. Surgery can help, but pain sometimes remains afterward. Researchers are testing whether a structured pelvic floor physiotherapy program done be…

Researchers are testing a five-session meaning-centered psychotherapy called CASA in Puerto Rican patients with Stage III or IV breast cancer and their caregivers. The trial compares CASA with usual care in about 114 people to see whether the therapy reduces psychological distres…

This pilot study tests a 12-month structured nursing program called RESPiraIA-Asma for adults with poorly controlled, non-severe asthma. The program combines education, inhaler training, home peak-flow monitoring, and personalized care plans, offered in-person, digitally, or mixe…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

Researchers compare two exercise-based therapies for children with spastic cerebral palsy: virtual reality therapy and plyometric exercise training. The trial enrolls 44 children aged 12 to 18 who can stand alone and have mild to moderate mobility limits. Children in the virtual …

Researchers test whether a combination of orofacial myofunctional therapy and cervical stabilization exercises can reduce jaw pain and improve function in adults with anterior disc displacement with reduction, a common temporomandibular disorder. The trial enrolls 80 adults aged …

Researchers compare how people with paraplegia perform and feel about four daily tasks when using a self-balancing exoskeleton versus a manual wheelchair. Five participants attend daily sessions where they do tasks like making coffee or brushing teeth with each device. The study …

Researchers test whether adding inspiratory muscle training to a walking program helps adults on hemodialysis who also have atrial fibrillation. Participants do breathing exercises through a mouthpiece and walk for six minutes, while the study tracks heart rate, blood pressure, k…

Researchers are testing whether older adults with high blood pressure who report insomnia can improve their sleep by pressing six acupoints on themselves each night for 28 days. The trial compares this self-acupressure routine with sleep hygiene training in 94 participants aged 6…

This pilot trial tests whether adding virtual pain neuroscience education to standard spinal cord stimulation can help chronic pain patients better manage their condition. The education teaches how the brain processes pain, aiming to reduce fear, anxiety, and catastrophizing. Par…

Researchers are testing whether mazdutide, a weekly injected drug, reduces the number of gout flares in adults who have both obesity and gout. The study enrolls 30 people aged 18 to 65 with a BMI of at least 30 and at least two gout flares in the past six months. Everyone receive…

Researchers at Dana-Farber Cancer Institute are testing Healing Gardens, a mobile game that delivers pain-focused cognitive behavioral therapy and cancer pain education. The study enrolls 46 adults with advanced solid tumors who have chronic pain related to cancer or its treatmen…

Many people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…

This study tests a spiritual health program called PATH for cancer patients struggling with feelings of disconnection, loss of meaning, or existential distress. Twenty adults with any stage of cancer will attend six workshops combining role-playing, psychology, and dignity therap…

Researchers are testing the F&P Licorice mask, a device used with PAP or NIV breathing machines, in people who have obstructive sleep apnea or other chronic respiratory conditions. The study follows about 45 adults who already use this type of therapy at home. Over roughly two we…

This study tests an online self-help tool called e-couch for adults with social anxiety. Over 5 weeks, 200 participants will use the program, which is based on cognitive behavioral therapy. Researchers will use surveys and computer tasks to predict who improves the most.

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

Doctors insert a chest tube to drain air or fluid from around the lungs, but the procedure often causes severe pain. This trial compares two ultrasound-guided nerve blocks, the serratus anterior plane block and the erector spinae plane block, to see which one better controls pain…

This trial tests whether an artificial intelligence chatbot can help men with prostate cancer better understand radiation therapy. Participants will use a plain-language chatbot alongside standard education from their care team. Researchers will measure changes in patients' confi…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

Researchers are testing whether intermittent fasting improves quality of life for adults with acute or chronic pancreatitis. Participants follow a daily 16-hour fast or receive standard calorie guidance. The study measures pancreas-related quality of life, pain, opioid use, weigh…

Aortic arch surgery temporarily cuts blood flow to the brain, which can leave patients with lasting thinking and memory problems. Researchers at Seoul National University Hospital are testing whether anesthesia with remimazolam, rather than propofol, lowers the chance of that cog…

Researchers compare two approaches to care after ileostomy reversal surgery in children. One group receives the Enhanced Recovery After Surgery (ERAS) protocol, which includes early feeding, early catheter removal, early walking, and multimodal pain control. The other group recei…

Researchers are testing whether a carbohydrate-rich clear drink given two hours before bariatric surgery helps patients with metabolic syndrome recover normal gastrointestinal function faster. About 208 adults scheduled for gastric bypass or sleeve gastrectomy will be randomly as…

This study tests whether prucalopride, a drug used for gut issues, can improve thinking and memory in people with schizophrenia. About 34 adults will take the drug for 4 weeks while staying on their usual medications. Researchers will measure changes in memory, attention, and pro…

Researchers are testing whether nurse-led lessons delivered through virtual reality or a tablet help people with coronary artery disease understand their heart risks and take their antiplatelet medicines as prescribed. The trial enrolls 54 adults aged 18 to 65 who have coronary a…

Researchers are testing whether a one-time injection of an experimental drug called paliroden into the middle ear is safe and can help adults with chronic, constant tinnitus in both ears. Participants, ages 18 to 75, have normal hearing thresholds but struggle to understand speec…

Researchers test whether adding lumateperone to ongoing antidepressant treatment reduces emotional blunting in adults with major depressive disorder. Emotional blunting means feeling numb or unable to experience pleasure or sadness. Thirty participants who score high on the Oxfor…

This study tests whether brief mindfulness and identity-affirming exercises can improve well-being and reduce mental health symptoms in LGBTQ youth aged 16-26 who are currently or recently unhoused. Two hundred participants will be randomly assigned to either the mindfulness prog…

Researchers are studying whether a procedure called fluoroscopy-guided transdiscal splanchnic nerve neurolysis can safely reduce severe upper abdominal pain in adults with pancreatic, gastric, or hepatobiliary cancer. Participants first receive a diagnostic nerve block with local…

This study tests two types of exercise for people with a common knee condition called patellofemoral pain. One group does neuromuscular control exercises (like balance and coordination), the other does muscle strengthening. Researchers will measure pain, function, and movement in…

Researchers are testing whether adding whole-body electromyostimulation (WB-EMS) to a supervised exercise program improves body composition, heart health, fitness, and quality of life in overweight or obese postmenopausal women. Thirty women aged 48 to 60 will join a 16-week prog…

Researchers test whether a single intravenous dose of anrikefon, given near the end of kidney stone removal surgery, can reduce opioid-related side effects such as nausea, vomiting, itching, oversedation, and breathing problems in the first 24 hours after surgery. All 160 adult p…

Researchers are testing whether a dietary supplement called KA-EX helps young elite football players recover after training. Players on the Udine Primavera team receive either KA-EX or a placebo powder mixed in water right after training for two months. The team tracks heart rate…

Many people treated with aromatase inhibitors for early-stage breast cancer develop joint pain and stiffness that can make it hard to continue the therapy. This Phase II pilot study tests whether hydroxychloroquine, an anti-inflammatory drug often used for inflammatory joint cond…

Researchers are testing whether time-restricted eating, where all food is eaten within a 10-hour window each day, can reduce fatigue and slow frailty in older adults living with prostate cancer or metastatic breast cancer. The trial enrolls 132 people aged 55 and older who typica…

This study investigates how eating three high-fat meals in a row changes vitamin E levels in the blood. Researchers will compare people with normal blood fats to those with high blood fats (hyperlipidemia). The goal is to understand whether fats in the blood can trap vitamin E, p…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study looks at 22 children with congenital heart disease who are getting a blood thinner called heparin. Doctors want to see if taking blood from a central line (a special IV) gives the same results as taking blood from an artery. They will compare three different ways of dr…

This study investigates clonal hematopoiesis, an age-related condition where blood stem cells acquire mutations, and how it triggers inflammation linked to heart disease. Researchers will compare immune cells from healthy people, those with high-risk mutations, and patients with …

Researchers want to understand the different ways pain works in people with rheumatic diseases such as lupus, rheumatoid arthritis, and Sjogren's syndrome. The study enrolls up to 225 people aged 9 to 85 who have or may have a rheumatic disease, plus healthy volunteers matched by…

This study looks at whether a blood-thinning method called citrate anticoagulation is safe and practical for critically ill patients with acute kidney injury who may not process citrate normally. It follows 50 ICU patients who need kidney replacement therapy and are at risk for c…

Women with multiple sclerosis face complex decisions about marriage, pregnancy, and motherhood. This study explores how women of reproductive age in Assiut Governorate, Egypt, make these choices. Researchers will survey married women using questionnaires and interview both marrie…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

Researchers ask whether surgical nurses' confidence in managing pain relates to how well their patients' pain is controlled after surgery. Nurses in general surgery clinics complete a questionnaire about their pain management self-efficacy, and their adult patients complete a sep…

Researchers at Assiut University are studying how to identify malnutrition in critically ill children aged 1 month to 5 years admitted to a pediatric intensive care unit. The team uses a four-part ABCD approach that combines body measurements, blood markers, physical signs, and d…

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy, such as from short-term to long-term use. The alert prompts doctors to review the patient's pain and goals, following CDC guidelines. Researchers will study…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

Researchers are testing whether people with non-small cell lung cancer can collect their own small blood samples at home using a finger-prick kit. Participants receive standard treatment with docetaxel, paclitaxel, alectinib, or lorlatinib, and the samples measure how much cancer…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

This study will give 180 healthy adults a daily probiotic supplement (Lactobacillus plantarum) for 1 or 6 months. Researchers will collect blood and stool samples and run online cognitive tests to see if the supplement changes gut bacteria, blood markers, or thinking skills. The …

Researchers at University Health Network in Toronto are reviewing the records of 150 adults who had septal myectomy for hypertrophic obstructive cardiomyopathy. They compare intraoperative echocardiograms with predischarge echocardiograms to see how often moderate or worse mitral…

Researchers are observing adults newly diagnosed with acute leukemia during their hospital stay to learn which factors raise the risk of venous thromboembolism, a serious blood clot condition. The study follows about 250 patients from admission to discharge or death, recording cl…

Researchers want to know whether migraine leaves a measurable biological trace in the body. They will collect blood, saliva and tear fluid from 60 adults with episodic migraine, both during an attack and between attacks, and compare the samples with those from people who do not g…

Researchers at Duke University are studying how natural estrogen changes across the menstrual cycle relate to sleep and ADHD symptoms in girls aged 11 to 15. Participants will wear a Garmin device to track sleep, provide hormone samples, and answer quick surveys about mood and fo…

Researchers at Al-Rajhi Liver Hospital in Assiut, Egypt, are studying drug-induced liver injury, a form of liver damage caused by prescription medicines, over-the-counter drugs, herbal products, or dietary supplements. The study has two parts: a review of past medical records fro…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

Researchers at Assiut University are studying adults with blood cancers who receive an autologous hematopoietic stem cell transplant, a procedure that uses a patient's own stem cells. The study follows 123 participants to measure survival, progression-free survival, complications…

This study follows 500 adults and children who are getting a stem cell transplant to see how their liver is affected. Researchers will track liver function, perform biopsies and scans, and look for factors that lead to liver damage. The goal is to better understand and eventually…

This study will follow 2,000 adults who receive a custom-made joint implant (knee, hip, foot/ankle, or shoulder) to see how they recover over 5 years. Participants fill out surveys from home about pain, function, and quality of life before surgery and at regular intervals afterwa…

Researchers are testing whether whole grain sorghum improves immune and metabolic health in adults with excess weight, and whether phenolic compounds in the grain drive those effects. Thirty participants eat foods made from high-phenolic sumac sorghum, low-phenolic white sorghum,…

This study follows 34 adults with moderate-to-severe hidradenitis suppurativa (HS) who are taking secukinumab as part of their routine care. Researchers will use a special CT scan to check if the drug affects the buildup of plaque in the heart arteries over 12 months. The goal is…

Researchers want to know whether weight loss from laparoscopic sleeve gastrectomy changes neck pain, posture, and neck function. The study follows about 25 adults scheduled for this weight-loss operation at one hospital. Participants complete neck questionnaires, strength and mot…

This natural history study looks at how life events during childhood might affect eating behaviors and weight gain in adults. Researchers will observe 110 healthy volunteers aged 18 to 60, measuring food intake, physical activity, blood sugar, and body fat. Participants will also…

Researchers at Assiut University Children Hospital are tracking 88 children with encephalitis to see which clinical, laboratory, and imaging findings at admission relate to early neurological outcomes. The study measures functional status at discharge using a standard scale, alon…

This study looks at how stress from being a refugee—like trauma, discrimination, and adjusting to a new culture—affects sleep in Bhutanese refugees living in Ohio. Researchers will hold focus groups and interviews with 70 adults to understand their sleep problems and coping strat…

Researchers want to know whether biological markers in blood and fat tissue can flag a young child's risk of becoming overweight later. The study enrolls 400 children under age 4 who are already scheduled for surgery, collecting a small blood sample and two tiny fat samples durin…

Researchers are studying how switching to efanesoctocog alfa (ALTUVOCT), a long-acting factor VIII therapy given once a week, affects adults and children with severe or moderate hemophilia A in routine care. The study tracks factor use, treatment satisfaction, and quality of life…

This study looks at how a short, home-based high-intensity workout affects steroid hormones in men with low-grade prostate cancer who are on active surveillance. About 49 men will do one supervised bodyweight HIIT session and provide saliva samples. The goal is to see if the exer…

This study will use special PET/MRI scans to look at changes in knee metabolism after a procedure called genicular artery embolization (GAE) for knee osteoarthritis. The goal is to understand why some people get good pain relief and others do not. About 25 adults with moderate to…

This natural history study will explore how life experiences and environmental factors affect heart health and metabolism among 50 Bhutanese adults living in the US. Participants will complete a survey and discuss their views on providing biological samples. The goal is to identi…

This study follows 400 children aged 5 to 7 with obesity or normal weight until age 12. Researchers will track puberty signs, hormones, genes, diet, and chemical exposures to see what predicts early puberty. No treatments are given; the goal is to gather information.

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

Researchers are studying blood samples from 150 adults with lower-risk myelodysplastic syndromes (MDS) who receive luspatercept, a drug that boosts red blood cell production. The goal is to find metabolites and other biomarkers linked to fatigue, a common side effect of the treat…

Researchers are studying whether a blood protein called adropin can signal blood vessel damage and disease severity in obese adults with obstructive sleep apnea. The trial compares adropin levels in obese patients with and without the sleep disorder, and checks how those levels r…

Researchers at Stockholm University are testing whether an autism program quality tool called APERS can help special education units improve. School staff in the experimental group receive feedback, training, and ongoing coaching from specially trained coaches, while a comparison…

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

Researchers at Assiut University are studying whether an underactive thyroid makes liver scarring worse in people with metabolic dysfunction-associated steatotic liver disease (MASLD). The trial enrolls 120 adults with MASLD, half of whom have overt or subclinical hypothyroidism …

Researchers at Suleyman Demirel University are surveying lawyers registered with the Isparta Bar Association to understand how physical activity, stress, burnout, and job satisfaction relate to musculoskeletal pain. About 102 lawyers with at least five years of experience answer …

Researchers at Marmara University are studying whether alexithymia, a trait where people struggle to identify and describe their feelings, relates to pain intensity, quality of life, anxiety, depression, and childhood trauma in adults with chronic coccydynia. Participants have ha…

Researchers at the University of California, San Francisco are testing whether short bursts of high-intensity exercise control blood sugar as well as longer, moderate workouts. The study enrolls 12 non-diabetic or pre-diabetic adults who wear a continuous glucose monitor for 11 d…

This trial tests whether a structured training program for ICU nurses, focusing on respiratory and renal care with case-based discussions, improves their clinical reasoning, knowledge, and collaboration with doctors. The study involves 140 participants, including nurses and mecha…

Researchers in Korea are reviewing medical records from about 2,000 patients with triple-negative breast cancer who received pembrolizumab plus chemotherapy before surgery. The study measures how many patients had no detectable cancer left in their breast and lymph nodes at surge…

Researchers at Marmara University are studying why some people with chronic low back pain and nerve-related leg pain respond better than others to a standard steroid injection near the spine. The team follows 60 adults who are already scheduled for this routine procedure. Before …

This study follows 125 pregnant women from 30 weeks of pregnancy through their baby's first year. Researchers want to learn how diet, food access, and other social factors affect mothers' health, breastfeeding success, and baby growth. Participants will complete remote visits and…

Researchers are observing 300 adults aged 60 and older with inflammatory bowel disease who are starting an advanced therapy chosen by their usual care team. The study tracks immune-aging markers such as CD4/CD8 ratio and IL-6, along with frailty and nutrition, over 52 weeks. The …

Researchers at the University of California, San Francisco are following 100 adolescents and young adults, ages 12 to 21, who are starting GLP-1 weight-loss drugs like Ozempic, Wegovy, or Mounjaro. Over one year, participants answer online surveys about their eating behaviors and…

Researchers at Poitiers University Hospital are studying whether changes in how people with Alzheimer's use their smartphones track with changes in their ability to handle daily tasks. About 100 participants aged 60 and older will have their Android phone usage and battery data c…

Researchers at Emile Muller Hospital in Mulhouse, France, want to estimate how many mothers develop post-traumatic stress disorder after giving birth. About 1,000 women who deliver at the hospital are asked to fill out the City Birth Trauma Scale and a short survey about their he…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

This study will follow 3,000 French patients with severe or complicated obesity who are taking semaglutide (Wegovy) as part of an early access program. Researchers will track weight changes, treatment patterns, and well-being over time using questionnaires. The goal is to underst…

Researchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…

Researchers at Changhai Hospital are setting up a nationwide system to monitor how well devices and procedures for cerebrovascular conditions perform after they reach the market. The study plans to enroll about 2,000 adults with acute ischemic stroke, narrowed brain or neck arter…

This study compares two approaches to notify relatives of people diagnosed with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. One method lets patients share information themselves; the other has the study team contact relatives directly. R…

Autoimmune hepatitis makes a child's immune system attack their liver. Researchers at Assiut University Children's Hospital want to know how many children with this liver condition also develop thyroid disorders such as Hashimoto thyroiditis or Graves' disease. The team will test…

This study will give 50 women a Fitbit Inspire 3 to wear before and after DIEP flap breast reconstruction surgery. Researchers will track steps, heart rate, and sleep, and compare that data with short questionnaires about recovery. The goal is to learn more about how patients rec…

This study is testing a new questionnaire (called the QLQ-OV39) to see how well it measures quality of life in people with ovarian cancer. About 50 adults with early or advanced ovarian cancer will fill out the questionnaire and give feedback. The goal is to make sure the questio…

This study will test whether cancer patients receiving chemotherapy and radiation therapy can use wearable health devices, like fitness trackers, to monitor their heart rate and activity levels. Twenty adults will wear the device during treatment and for four weeks after, uploadi…

Researchers want to know whether CGRP, a protein involved in migraine, also affects the vestibulo-ocular reflex, the automatic eye movement that keeps vision steady when the head turns. The trial gives 80 people at the University Hospital Zurich either a single dose of atogepant,…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

This study will measure normal blood clotting values in 240 children under 18 who are having surgery or a procedure with anesthesia. The goal is to establish reference ranges for the Quantra system, a device that checks how well blood clots. This information will help doctors bet…

Researchers want to understand why most IVF embryo transfers fail to implant and what goes wrong in pregnancies complicated by preeclampsia. They will collect small tissue samples from the womb lining of up to 500 women aged 18 to 50 who are already scheduled for a diagnostic hys…

This observational study will take small liver samples from 8 adults with hemophilia A or B who had gene therapy at least 6 months ago. Researchers want to see how the gene therapy affected liver cells, including how many cells still carry the therapy and whether there is any liv…

Multiple myeloma is a blood cancer in which abnormal plasma cells build up in bone marrow, and inflammation may shape how the disease behaves. Researchers at Assiut University plan to study 60 people newly diagnosed with myeloma before any anti-myeloma treatment begins. They will…

Researchers at Assiut University Children Hospital are studying whether abnormal brain-wave patterns on an EEG can predict how well children with encephalopathy recover. The study follows 147 children aged 1 month to 18 years who have altered consciousness from encephalopathy. Ea…

This study follows 80 people with spinal muscular atrophy (SMA) in Japan who receive Zolgensma (onasemnogene abeparvovec) as an intrathecal injection. The goal is to track safety issues, such as liver problems or blood clotting abnormalities, and to measure changes in motor funct…

This observational study gathers information from routine care on how localized rectal cancer is treated across Austrian hospitals. It aims to document the variety of treatment approaches, including total neoadjuvant therapy and immunotherapy, and their outcomes. By analyzing thi…

Researchers at Shanghai General Hospital are studying whether exercise relates to visual function in people with glaucoma. About 100 patients aged 18 to 100 answer a questionnaire about their physical activity. The team then measures central visual field, retinal nerve fiber laye…

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

Researchers are testing whether blocking three inflammation pathways at once (TL1A, IL-23, and α4β7) calms inflamed intestinal tissue more effectively than blocking each pathway alone. The study enrolls 30 people: 10 with ulcerative colitis, 10 with Crohn's disease, and 10 withou…

People with rheumatic heart disease and atrial fibrillation take warfarin to prevent strokes, but the drug only works safely when blood clotting stays in a narrow target range. Researchers at Assiut University are studying about 90 Egyptian adults on warfarin for at least six mon…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

Researchers at Assiut University Hospitals are following 250 adults with chronic heart failure and reduced ejection fraction who are on or starting guideline-directed medical therapy. Over three months, the team measures changes in heart pumping function, kidney filtration, quali…

This study will follow 200 children with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase drugs. Researchers will track how often serious toxicities occur during standard treatment and a newer therapy called SJALL2…

This study will measure how the body uses energy and burns fat in 10 people with extreme obesity (BMI of 60 or higher). Participants will spend 23 hours in a special metabolic chamber and drink a labeled water to track energy use over a week. The goal is to better understand meta…

Anti-VEGF injections treat conditions like diabetic macular edema, age-related macular degeneration, and retinal vein occlusion by adding fluid inside the eye, which can briefly raise eye pressure. This observational study at Assiut University follows 50 adults receiving these ro…

This study tests whether a new questionnaire called PLATO can help dentists track how well oral appliance therapy works for people with obstructive sleep apnea. The questionnaire, developed by the American Academy of Sleep Medicine, measures patient-reported outcomes. Researchers…