Two-Drug cocktail aims to boost chemo against tough lung cancer

NCT ID NCT07680764

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether adding two experimental drugs, imzokitug and pumitamig, to standard chemotherapy helps people with advanced non-small cell lung cancer (NSCLC) who have not had prior treatment. About 160 participants will receive either the three-drug combination or pumitamig plus chemo alone. The main goal is to see if the combination shrinks tumors more effectively, while also monitoring side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: imzokitug and pumitamig
What this could lead to: If successful, this combination could offer a more effective first-line treatment for advanced non-small cell lung cancer, potentially shrinking tumors and delaying progression.
What could go wrong: This is an early-phase trial with a small number of participants. The added drug may increase side effects without improving outcomes, and results may not apply to all lung cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC) METASTATIC NON-SMALL CELL LUNG CANCER (NSCLC)

Contacts and locations

Locations

Local Institution - 0001
NOT_YET_RECRUITING

São Paulo, 01246-000, Brazil
Local Institution - 0003
NOT_YET_RECRUITING

Natal/RN, Rio Grande do Norte, 59062-000, Brazil
Local Institution - 0005
NOT_YET_RECRUITING

Barretos, São Paulo, 14784, Brazil
Local Institution - 0006
NOT_YET_RECRUITING

Porto Alegre, Rio Grande do Sul, 91610-000, Brazil
Local Institution - 0008
NOT_YET_RECRUITING

Cluj-Napoca, 400015, Romania
Local Institution - 0010
NOT_YET_RECRUITING

Majadahonda, 28222, Spain
Local Institution - 0011
NOT_YET_RECRUITING

Rozzano (MI), 20089, Italy
Local Institution - 0014
NOT_YET_RECRUITING

Ravenna, 48121, Italy
Local Institution - 0019
NOT_YET_RECRUITING

Paris, Île-de-France Region, 75005, France
Local Institution - 0020
NOT_YET_RECRUITING

Málaga, 29010, Spain
Local Institution - 0027
NOT_YET_RECRUITING

Barcelona, 08035, Spain
Local Institution - 0034
NOT_YET_RECRUITING

Lexington, Kentucky, 40503, United States
Local Institution - 0035
NOT_YET_RECRUITING

London, Greater London, SE19RT, United Kingdom
Local Institution - 0037
NOT_YET_RECRUITING

Guildford, GU2 7XX, United Kingdom
Local Institution - 0038
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100142, China
Local Institution - 0041
WITHDRAWN

Madrid, 28041, Spain
Local Institution - 0042
NOT_YET_RECRUITING

Haile, 06120, Germany
Local Institution - 0043
NOT_YET_RECRUITING

Bari, 70124, Italy
Local Institution - 0047
NOT_YET_RECRUITING

Grenoble, 38043 Cedex 09, France
Local Institution - 0048
NOT_YET_RECRUITING

Perth, Western Australia, 6150, Australia
Local Institution - 0050
NOT_YET_RECRUITING

Wuhan, Hubei, 430030, China
Local Institution - 0065
NOT_YET_RECRUITING

Cologne, 51109, Germany
Local Institution - 0068
NOT_YET_RECRUITING

Barcelona, 08041, Spain
Local Institution - 0074
NOT_YET_RECRUITING

Gosford, New South Wales, 2250, Australia
Local Institution - 0075
NOT_YET_RECRUITING

Craiova, 200347, Romania
Local Institution - 0076
NOT_YET_RECRUITING

Bucharest,  022328, Romania
Local Institution - 0080
NOT_YET_RECRUITING

New York, New York, 10021, United States
Local Institution - 0081
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 7500713, Chile
Local Institution - 0082
NOT_YET_RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
Local Institution - 0084
NOT_YET_RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Local Institution - 0085
NOT_YET_RECRUITING

Saint-Herblain, 44800, France
Local Institution - 0087
NOT_YET_RECRUITING

Montpellier, Languedoc-Roussillon, 34070, France
Local Institution - 0092
NOT_YET_RECRUITING

Viedma, Río Negro Province, R8500ACE, Argentina
Local Institution - 0094
NOT_YET_RECRUITING

Buenos Aires, C1426ANZ, Argentina
Local Institution - 0095
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Local Institution - 0100
NOT_YET_RECRUITING

Heidelberg, Victoria, 3084, Australia
Local Institution - 0105
NOT_YET_RECRUITING

Nashville, Tennessee, 37212, United States
Local Institution - 0109
NOT_YET_RECRUITING

Paris, 75014, France
Local Institution - 0110
NOT_YET_RECRUITING

Marseille, Bouches-du-Rhône, 13385, France
Local Institution - 0113
NOT_YET_RECRUITING

Timișoara, Timiș County, 300239, Romania
Local Institution - 0114
NOT_YET_RECRUITING

Florești, Cluj, 407280, Romania
Local Institution - 0115
NOT_YET_RECRUITING

Iași, 700106, Romania
Local Institution - 0116
NOT_YET_RECRUITING

Iași, 700483, Romania
Local Institution - 0119
NOT_YET_RECRUITING

Villejuif, Val-de-Marne, 94800, France
Local Institution - 0123
NOT_YET_RECRUITING

Baltimore, Maryland, 21224, United States
Local Institution - 0125
NOT_YET_RECRUITING

Hessen, 60590, Germany
Local Institution - 0126
NOT_YET_RECRUITING

Stuttgart, Baden-Wurttemberg, 70376, Germany
Local Institution - 0128
NOT_YET_RECRUITING

Misterbianco, Catania, 95045, Italy
Local Institution - 0131
NOT_YET_RECRUITING

Nice, Alpes-Maritimes, 6100, France
Local Institution - 0132
NOT_YET_RECRUITING

Badalona, Barcelona, 8916, Spain
Local Institution - 0134
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia
Local Institution - 0135
NOT_YET_RECRUITING

Madison, Wisconsin, 53792, United States
Local Institution - 0137
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310016, China
Local Institution - 0138
NOT_YET_RECRUITING

Fuzhou, Fujian, 350014, China
Local Institution - 0140
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200030, China
Local Institution - 0144
NOT_YET_RECRUITING

Chengdu, Sichuan, 610213, China
Local Institution - 0147
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210029, China
Local Institution - 0148
NOT_YET_RECRUITING

Bergamo, 24128, Italy
Local Institution - 0149
NOT_YET_RECRUITING

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0152
NOT_YET_RECRUITING

Homburg, Saarland, 66424, Germany
Local Institution - 0156
NOT_YET_RECRUITING

Marburg, Hesse, 35043, Germany
Local Institution - 0159
NOT_YET_RECRUITING

Milan, 20142, Italy
Local Institution - 0162
NOT_YET_RECRUITING

Seville, Seville, 41013, Spain
Local Institution - 0163
NOT_YET_RECRUITING

Barcelona, 8036, Spain
Local Institution - 0167
NOT_YET_RECRUITING

Greenslopes, Queensland, 4120, Australia
Local Institution - 0169
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Local Institution - 0170
NOT_YET_RECRUITING

Athens, Georgia, 30607, United States
Local Institution - 0171
NOT_YET_RECRUITING

Lexington, Kentucky, 40509, United States
Local Institution - 0180
NOT_YET_RECRUITING

Hattiesburg, Mississippi, 39401, United States
Nebraska Cancer Specialists
RECRUITING

Grand Island, Nebraska, 68803, United States
Oncology Hematology West PC
RECRUITING

Omaha, Nebraska, 68130, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.