Two-Drug cocktail aims to boost chemo against tough lung cancer
NCT ID NCT07680764
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This phase 2 trial tests whether adding two experimental drugs, imzokitug and pumitamig, to standard chemotherapy helps people with advanced non-small cell lung cancer (NSCLC) who have not had prior treatment. About 160 participants will receive either the three-drug combination or pumitamig plus chemo alone. The main goal is to see if the combination shrinks tumors more effectively, while also monitoring side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
imzokitug and pumitamig
What this could lead to
If successful, this combination could offer a more effective first-line treatment for advanced non-small cell lung cancer, potentially shrinking tumors and delaying progression.
What could go wrong
This is an early-phase trial with a small number of participants. The added drug may increase side effects without improving outcomes, and results may not apply to all lung cancer types.
Disclaimer
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Contacts and locations
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Study contacts
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Locations
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Local Institution - 0001
São Paulo, 01246-000, Brazil
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Local Institution - 0003
Natal/RN, Rio Grande do Norte, 59062-000, Brazil
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Local Institution - 0005
Barretos, São Paulo, 14784, Brazil
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Local Institution - 0006
Porto Alegre, Rio Grande do Sul, 91610-000, Brazil
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Local Institution - 0008
Cluj-Napoca, 400015, Romania
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Local Institution - 0010
Majadahonda, 28222, Spain
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Local Institution - 0011
Rozzano (MI), 20089, Italy
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Local Institution - 0014
Ravenna, 48121, Italy
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Local Institution - 0019
Paris, Île-de-France Region, 75005, France
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Local Institution - 0020
Málaga, 29010, Spain
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Local Institution - 0027
Barcelona, 08035, Spain
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Local Institution - 0034
Lexington, Kentucky, 40503, United States
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Local Institution - 0035
London, Greater London, SE19RT, United Kingdom
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Local Institution - 0037
Guildford, GU2 7XX, United Kingdom
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Local Institution - 0038
Beijing, Beijing Municipality, 100142, China
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Local Institution - 0041
Madrid, 28041, Spain
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Local Institution - 0042
Haile, 06120, Germany
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Local Institution - 0043
Bari, 70124, Italy
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Local Institution - 0047
Grenoble, 38043 Cedex 09, France
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Local Institution - 0048
Perth, Western Australia, 6150, Australia
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Local Institution - 0050
Wuhan, Hubei, 430030, China
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Local Institution - 0065
Cologne, 51109, Germany
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Local Institution - 0068
Barcelona, 08041, Spain
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Local Institution - 0074
Gosford, New South Wales, 2250, Australia
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Local Institution - 0075
Craiova, 200347, Romania
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Local Institution - 0076
Bucharest, 022328, Romania
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Local Institution - 0080
New York, New York, 10021, United States
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Local Institution - 0081
Santiago, Santiago Metropolitan, 7500713, Chile
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Local Institution - 0082
Rosario, Santa Fe Province, 2000, Argentina
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Local Institution - 0084
Viña del Mar, Valparaiso, 2520598, Chile
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Local Institution - 0085
Saint-Herblain, 44800, France
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Local Institution - 0087
Montpellier, Languedoc-Roussillon, 34070, France
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Local Institution - 0092
Viedma, Río Negro Province, R8500ACE, Argentina
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Local Institution - 0094
Buenos Aires, C1426ANZ, Argentina
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Local Institution - 0095
Houston, Texas, 77030, United States
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Local Institution - 0100
Heidelberg, Victoria, 3084, Australia
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Local Institution - 0102
Omaha, Nebraska, 68130, United States
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Local Institution - 0105
Nashville, Tennessee, 37212, United States
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Local Institution - 0109
Paris, 75014, France
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Local Institution - 0110
Marseille, Bouches-du-Rhône, 13385, France
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Local Institution - 0113
Timișoara, Timiș County, 300239, Romania
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Local Institution - 0114
Florești, Cluj, 407280, Romania
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Local Institution - 0115
Iași, 700106, Romania
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Local Institution - 0116
Iași, 700483, Romania
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Local Institution - 0119
Villejuif, Val-de-Marne, 94800, France
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Local Institution - 0123
Baltimore, Maryland, 21224, United States
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Local Institution - 0125
Hessen, 60590, Germany
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Local Institution - 0126
Stuttgart, Baden-Wurttemberg, 70376, Germany
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Local Institution - 0128
Misterbianco, Catania, 95045, Italy
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Local Institution - 0131
Nice, Alpes-Maritimes, 6100, France
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Local Institution - 0132
Badalona, Barcelona, 8916, Spain
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Local Institution - 0134
Westmead, New South Wales, 2145, Australia
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Local Institution - 0135
Madison, Wisconsin, 53792, United States
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Local Institution - 0137
Hangzhou, Zhejiang, 310016, China
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Local Institution - 0138
Fuzhou, Fujian, 350014, China
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Local Institution - 0139
Hangzhou, Zhejiang, 310003, China
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Local Institution - 0140
Shanghai, Shanghai Municipality, 200030, China
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Local Institution - 0144
Chengdu, Sichuan, 610213, China
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Local Institution - 0147
Nanjing, Jiangsu, 210029, China
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Local Institution - 0148
Bergamo, 24128, Italy
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Local Institution - 0149
Santiago, Santiago Metropolitan, 8420383, Chile
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Local Institution - 0152
Homburg, Saarland, 66424, Germany
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Local Institution - 0156
Marburg, Hesse, 35043, Germany
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Local Institution - 0159
Milan, 20142, Italy
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Local Institution - 0162
Seville, Seville, 41013, Spain
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Local Institution - 0163
Barcelona, 8036, Spain
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Local Institution - 0167
Greenslopes, Queensland, 4120, Australia
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Local Institution - 0168
Hangzhou, Zhejiang, 310022, China
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Local Institution - 0169
Shanghai, Shanghai Municipality, 200032, China
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Local Institution - 0170
Athens, Georgia, 30607, United States
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Local Institution - 0171
Lexington, Kentucky, 40509, United States
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