New drug duo aims to wipe out leukemia cells in First-Line treatment
NCT ID NCT07557056
First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times
Summary
This phase 2 trial tests two oral drugs, nemtabrutinib and venetoclax, as a first treatment for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to see if the combination can make cancer cells undetectable in the blood. About 25 adults who have not had prior treatment will take the drugs for 14 cycles, and researchers will check for side effects and how well the cancer responds.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nemtabrutinib and venetoclax
- What this could lead to
- If successful, this combination could offer a highly effective frontline treatment for CLL/SLL, potentially achieving deep remission with undetectable cancer cells.
- What could go wrong
- This is a small, early-phase trial with only 25 participants. The combination may cause side effects, and results may not generalize to all patients. It is not yet recruiting.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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- Can a Two-Drug combo wipe out hidden leukemia cells?
- Can a Chemo-Free pill combo outsmart leukemia at first diagnosis?