Central nervous system disorder

This trial is testing whether a new formulation of the chemotherapy drug cisplatin, called LSAM-Cisplatin, can be safely infused directly into the brain tumors of children and young adults with diffuse midline glioma (DMG), including diffuse intrinsic pontine glioma (DIPG). The t…

This phase 3 trial tests whether an experimental drug called KP-100IT, injected into the spinal fluid, can help people with severe acute spinal cord injuries regain function. Participants, aged 18 to 89 with a complete loss of motor and sensory function (AIS grade A), receive fiv…

This clinical trial is testing whether a faster, more intensive schedule of a brain stimulation treatment called intermittent theta burst stimulation (iTBS) works better than the standard schedule for adults with major depressive disorder. Participants will be randomly assigned t…

This trial tests whether combining eye movements with different ways of reactivating a memory can reduce the frequency and distress of intrusive trauma memories in people with PTSD. Participants are randomly assigned to one of three procedures: unconscious trauma reactivation, ac…

This trial tests whether combining two non-invasive brain stimulation techniques—transcranial direct current stimulation (tDCS) and transcranial ultrasound stimulation (TUS)—can improve balance and posture in people with Parkinson's disease. Participants are randomly assigned to …

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

This study tests whether huperzine A, an injected drug, can help prevent or reduce memory and thinking problems that often follow surgery for a bleeding brain aneurysm. Adults aged 18-70 who had an aneurysm bleed and underwent endovascular or surgical treatment will receive eithe…

This early-stage trial is testing an experimental oral drug called E2511 in people with early Alzheimer's disease, including those with mild cognitive impairment or mild dementia. The study aims to see if E2511 affects a specific brain signal measured by PET scans, and to check i…

This trial tests whether ArtiFix®, a synthetic sealant graft, can safely and effectively prevent cerebrospinal fluid leaks after cranial and spine surgery. About 228 adults scheduled for such surgeries will be randomly assigned to receive either ArtiFix® or standard care. Partici…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This phase 2 trial is investigating whether adding a ketogenic diet and/or high-dose intravenous vitamin C to standard chemoradiotherapy and immunotherapy can improve outcomes for patients with locally advanced rectal cancer that is mismatch repair proficient (pMMR/MSS). The stud…

This trial tests a non-surgical treatment for advanced Parkinson's disease that uses focused ultrasound to create a tiny lesion in a brain pathway linked to motor symptoms. It compares treating one side of the brain versus both sides, against standard medication. The goal is to s…

This Phase 3 trial tests whether vatiquinone can slow the progression of Friedreich's ataxia, a rare genetic disorder that damages the nervous system and impairs movement. About 120 adults with moderate symptoms will take the drug for 24 months. Researchers will measure changes i…

This early study tests whether adding the steroid dexamethasone to standard hyperbaric oxygen therapy helps prevent long-term brain problems after carbon monoxide poisoning. Twenty adults who receive hyperbaric oxygen will be randomly given either dexamethasone or a placebo. Rese…

This phase 2 trial tests whether indapamide, a common diuretic, can slow the worsening of walking ability in people with progressive multiple sclerosis (MS). Participants take one tablet daily for 12 months, with walking speed measured regularly. The study aims to see if the drug…

This trial is testing whether adding an immunotherapy drug called penpulimab to a standard chemotherapy regimen can help people with primary central nervous system lymphoma, a rare type of brain cancer. Participants, who have not yet received treatment, are randomly assigned to r…

This trial is testing whether a personalized form of brain stimulation, called accelerated intermittent theta-burst stimulation (iTBS), can improve symptoms of depression and anxiety in people with treatment-resistant depression. The approach uses brain imaging to target specific…

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This study is testing a new approach for young adults (ages 18-26) with posttraumatic stress disorder (PTSD) who have experienced childhood trauma. The treatment combines the substance MDMA with talk therapy sessions, known as MDMA-assisted therapy. The main goals are to see if t…

This early-stage trial is testing a personalized cancer vaccine called BreakVax, designed from each patient's own tumor, in combination with standard chemotherapy and immunotherapy drugs. The goal is to see if this multi-pronged approach can safely and effectively boost the immun…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild brain injury, can reduce headache days and prevent short-term post-traumatic headaches from becoming long-term. About 80 adults with migraine-like post-traumatic headaches will receive eithe…

This study tests whether a single dose of valproic acid, given soon after a moderate to severe traumatic brain injury, can improve patients' recovery and reduce disability. About 432 adults aged 18 to 65 will be randomly assigned to receive either valproic acid (at a low or high …

This trial tests whether adding lumbrokinase, an enzyme derived from earthworms, to standard aspirin treatment can improve recovery in people who have had a moderate-to-severe ischemic stroke. Participants receive either lumbrokinase capsules or a placebo, along with aspirin, for…

This trial tests whether pairing vagus nerve stimulation (VNS) with structured upper limb rehabilitation can improve arm and hand function in people with moderate to severe traumatic brain injury (TBI). Participants will have a small VNS device implanted under the skin that deliv…

This trial tests whether citicoline, a compound that may support brain cell repair, can improve outcomes in newborns with hypoxic-ischemic encephalopathy (HIE) — brain injury from oxygen deprivation at birth. About 86 infants with signs of birth asphyxia will receive either citic…

This trial tests whether aspirin and a non-invasive physical therapy called ischemic conditioning can slow the progression of moyamoya disease, a rare brain vessel disorder that can cause strokes and cognitive decline. The study enrolls adults with moyamoya disease or syndrome wh…

This trial tests whether giving magnesium sulfate soon after a moderate traumatic brain injury can reduce harmful inflammation in the brain. Adults aged 18–60 with a moderate head injury will receive either magnesium sulfate or a saltwater placebo within 8 hours of injury. Resear…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This early-stage trial tests an experimental gene therapy called VY1706 in people with early Alzheimer's disease. The goal is to see if it is safe and tolerable, and whether it can reduce tau protein buildup in the brain, a hallmark of the disease. Participants receive one of thr…

This early-phase trial tests whether immune cells (CD8+ T cells) given through a spinal tap are safe for people with melanoma that has spread to the lining of the brain. Only 8 participants will receive the treatment. The main goal is to check for side effects, not to cure the di…

This clinical trial is testing an experimental medication called TJ0113 in people with early-onset Parkinson's disease. The study aims to see if TJ0113 can improve movement symptoms compared to a placebo. About 300 participants will take either TJ0113 or a placebo for 26 weeks, f…

This trial asks whether adding motor imagery—mentally rehearsing hand movements without physically moving—to robot-assisted hand rehabilitation can improve daily living skills in people recovering from stroke. Forty participants will be randomly assigned to receive either robot-a…

This study tests whether giving the seizure medicine levetiracetam right after a brain bleed (intracerebral hemorrhage) can prevent seizures and improve long-term recovery. About 580 adults will receive either the drug or a placebo for up to 7 days, and their level of disability …

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This phase 2 study tests the drug zanzalintinib in 16 adults with recurrent or metastatic olfactory neuroblastoma, a rare cancer of the nasal cavity. The goal is to see if the drug can help control the disease and to check its safety. Participants must not have had prior treatmen…

This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restr…

This trial is testing whether an experimental medication called centanafadine, taken once daily as extended-release capsules, can help adults with attention-deficit/hyperactivity disorder (ADHD) who also experience emotional dysregulation—difficulty managing emotions like irritab…

This trial is testing a new medical device called FRED X, designed to treat brain aneurysms—weak spots in blood vessels that can bulge and potentially rupture. The study will enroll about 15 people with a single untreated aneurysm to see if the device, used with blood-thinning me…

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This phase 3 trial is testing the long-term safety of an oral drug called HS-10380 in Chinese adults with schizophrenia. Over about a year, 500 participants will take the medication daily, with doses adjusted to an optimal level. The study tracks side effects, serious adverse eve…

This trial investigates whether guanfacine or cromolyn sodium—two drugs already approved for other conditions—can improve physical functioning and reduce symptoms like fatigue, brain fog, and gastrointestinal issues in adults with postural orthostatic tachycardia syndrome (POTS).…

This phase 2 trial tests whether adding a combination of deferiprone (an iron-chelating drug) and N-acetylcysteine (an antioxidant) to standard antipsychotic treatment can reduce the negative symptoms of schizophrenia, such as apathy, lack of motivation, and social withdrawal. Ab…

This trial investigates whether adding tirofiban, a fast-acting anti-clotting drug, to standard aspirin treatment can improve recovery in people who have had a moderate ischemic stroke. Participants receive either tirofiban or a placebo, both with aspirin, within 24 hours of stro…

This trial tests whether nicotinamide riboside (NR), a form of vitamin B3, can slow the progression of early Alzheimer's disease. About 270 adults with early-stage Alzheimer's will take NR or a placebo daily for two years. Researchers will measure changes in memory, thinking, and…

This study tests an experimental drug called safusidenib in people with a slow-growing brain tumor (IDH1-mutant glioma) whose tumor got worse while on the standard drug vorasidenib. Up to 40 participants take safusidenib pills twice daily to see if the tumor shrinks or stops grow…

This study tests the long-term safety and tolerability of acoramidis, an oral medication that stabilizes the transthyretin protein, in people newly diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition that can lead to heart failure. Participants who complete…

This pilot trial compares a home-based cognitive-motor telerehabilitation program using exergames to standard outpatient rehabilitation for people recovering from traumatic brain injury. Participants will complete 20 sessions over 7 weeks, and researchers will measure changes in …

This early-stage trial is testing an experimental drug called DNL921 to see if it is safe and tolerable for people. It will involve healthy volunteers and people with Alzheimer's disease, who will receive either the drug or a placebo. The main goal is to gather safety data and un…

This trial compares three different embolic materials—particles, liquid embolics, and coils—used during a procedure called middle meningeal artery embolization to treat chronic subdural hematoma, a type of bleeding on the brain's surface. The study will enroll 30 adults undergoin…

This trial investigates the long-term safety of buntanetap, an experimental daily pill, in people with Alzheimer's disease who have already taken the drug in a previous study. About 400 participants will receive buntanetap 30 mg daily, with researchers tracking side effects and s…

This trial tests whether adding levetiracetam, a seizure medication, to the standard treatment for glioblastoma can improve outcomes. Glioblastoma is an aggressive brain cancer with poor survival despite current therapy. The study focuses on tumors with low oxygen levels, which a…

This trial tests whether a structured group therapy, blending EMDR and sensorimotor techniques, can help adults with trauma-related symptoms in a primary care setting. Participants are randomly assigned to either this group intervention or usual care. The study measures changes i…

This trial tests whether a single day of accelerated transcranial magnetic stimulation (TMS) can reduce depressive symptoms in adults with treatment-resistant depression. Participants are randomly assigned to receive one of two active TMS protocols—targeting the precuneus or the …

This study tests whether motor cortex stimulation – a device that sends mild electrical pulses to the brain's movement area – can reduce chronic pain after a stroke that affects the thalamus. Participants who do not get relief from standard pain treatments will have electrodes te…

This trial tests whether Cerebrolysin, given after a procedure to remove a blood clot from the brain, can reduce tissue damage and improve recovery in people with acute ischemic stroke. The study involves 100 adults aged 18 to 80 who undergo successful clot removal within 6 to 24…

This trial tests whether a device delivering synchronized 40-Hz light and sound stimulation can safely improve cognitive function in people with early Alzheimer's disease. Sixty participants with mild cognitive impairment or mild dementia due to Alzheimer's will receive either ac…

This study explores whether robot-guided repetitive transcranial magnetic stimulation (rTMS) can effectively treat postpartum depression (PPD). Researchers will compare brain activity, heart signals, blood markers, and body awareness in women with PPD versus healthy controls. Par…

This phase II trial is testing whether an experimental drug called LT3001 can help people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will include about 300 participants who receive either a high or low dose of …

This phase 2 trial explores whether fecal microbiota transplantation (FMT) is safe, tolerable, and practical for adolescents aged 13–17 with ADHD. Participants receive oral FMT capsules after bowel prep, alongside antibiotics, to see if changing gut bacteria can influence ADHD sy…

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This Phase 2 trial tests efgartigimod PH20 SC, a drug that lowers harmful antibodies, in 170 adults and teens with autoimmune encephalitis (AIE). Participants receive either the drug or a placebo, and researchers measure changes in disability and symptoms over up to 3 years. The …

This trial tests an experimental therapy called SYS6020 for people with relapsing or progressive multiple sclerosis that hasn't responded well to standard treatments. SYS6020 uses a patient's own immune cells, engineered to target and potentially reduce harmful B cells involved i…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This study tests whether a home-use device called the Motus Nova Foot can improve walking and balance in people aged 12-20 with hemiplegia, a condition where one side of the body is weak. The device moves the ankle and foot while guiding users through video activities, and it tra…

This pilot study will test whether deep brain stimulation (DBS) can help people with schizophrenia who still hear voices and have delusions despite trying multiple medications. Fifteen adults will have electrodes placed in a brain region linked to schizophrenia symptoms. The goal…

This clinical trial is investigating whether a traditional Chinese medicine formula called Qingxin Jiaotai Decoction (QXJTD) can help adults who have both insomnia and obesity. Participants will receive either the herbal granules or a placebo, along with personalized diet and exe…

This trial asks whether adding intranasal insulin or empagliflozin to standard anti-amyloid therapy can improve outcomes for people with mild cognitive impairment or early Alzheimer's disease. Participants will receive one of the two study drugs or a placebo, alongside their pres…

This phase II trial is asking whether adding the drug lenvatinib to the standard STUPP regimen (temozolomide plus radiation) can improve outcomes for people newly diagnosed with a type of brain cancer called glioblastoma that has a specific genetic marker (MGMT promoter methylati…

This trial tests whether deep brain stimulation (DBS) targeting the cerebellum is safe and feasible for people with spinocerebellar ataxia types 1 and 3, a group of inherited disorders that cause progressive problems with movement and coordination. The study will enroll 12 adults…

This phase 3 trial is testing whether Angong Niuhuang, a traditional Chinese medicine, can improve recovery in people who have had a bleeding stroke (intracerebral hemorrhage). About 1,100 adults who are eligible for non-surgical management will receive either the herbal pill or …

This study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…

This trial tests an oral drug called JBI-778 in people with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The drug is designed to block a protein that may help tumors grow. The study aims to find the safest dose and see if the drug can shrink tumors or…

This trial tests whether the Adacolumn device, which filters certain white blood cells from the blood, can reduce brain swelling in people who have had a severe stroke. Ten patients will receive the treatment within 24 hours of their stroke. The goal is to see if it prevents wors…

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 …

This study tests a laser treatment for tumors that have spread to the spine. The goal is to see if the laser can control tumor growth as well as traditional surgery, but with less risk. About 25 people with spine tumors will receive the laser treatment and be followed with MRI sc…

This trial tests a blended caregiver-led intervention for autistic toddlers under 3, combining social-communication strategies with social-emotional support. Caregivers are coached over 12 weekly sessions to embed these techniques into daily routines and play. The study aims to s…

This early-stage trial is testing an investigational drug called RO7845860, given as an injection under the skin, in people with relapsing multiple sclerosis (MS). The main goals are to check the drug's safety, how the body handles it, and its effects on immune cells. The study w…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This trial tests whether trigger point bloodletting—a procedure that pricks and cups specific facial points—can reduce pain in people with trigeminal neuralgia, a condition causing severe facial pain. Adults aged 18-75 with classic trigeminal neuralgia and trigger points in the u…

This study tests a drug called ocrelizumab in children and teens aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). The goal is to see how the drug moves through the body, if it is safe, and how it affects the immune system. Participants will receive the drug as a sh…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This study tests whether a short couples therapy, called MERA-C, can help reduce intimate partner violence and improve emotional health in veteran couples. The therapy involves four weekly sessions with both partners, focusing on managing emotions to prevent aggression. Researche…

This early-stage trial is testing an investigational injection called GT802 in people with relapsing or refractory multiple sclerosis (MS) — meaning their disease is active despite standard treatments. The study aims to check whether GT802 is safe and to get a first look at wheth…

This trial tests whether strength training combined with blood flow restriction can increase deltoid muscle thickness and improve upper limb function in children aged 4 to 6 with hemiplegic cerebral palsy. Participants will do a specially designed physical therapy program plus lo…

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecte…

This study tests whether doulas can successfully deliver an 8-week program called YouMatter to new or expecting mothers at risk for postpartum depression. The program combines mental health support, parenting tips, and self-care. Forty mothers with mild depression symptoms will p…

This trial tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in people with spinocerebellar ataxia type 3, a genetic condition that affects coordination and balance. The stimulation targets a deep brain region involved i…

This study tests whether the drug ganaxolone can reduce seizures in children aged 6 months to 2 years with CDKL5 deficiency disorder, a rare genetic condition causing hard-to-control seizures. Twenty children will receive either ganaxolone or a placebo alongside their usual seizu…

This trial tests whether a personalized, context-guided form of brain stimulation works better than the standard approach for adults with major depressive disorder. Participants receive either standard intermittent theta burst stimulation (iTBS) or a version where the stimulation…

This trial tests a medical device that has not yet been approved by the U.S. FDA. The goal is to see if it can help control a specific disease. Participants will use the device as directed, and researchers will monitor its effects on symptoms and disease progression.

This phase 3 trial is testing whether lumateperone (Caplyta), taken alone, can reduce symptoms of major depressive disorder (MDD) compared to a placebo. About 585 adults with MDD will receive one of two doses of lumateperone or a placebo for six weeks, followed by a long-term ext…

This pilot trial tests whether a digital inhaler cap, which gives real-time guidance on inhaler technique, can help adolescents with intellectual and developmental disabilities (IDD) manage their asthma at home. The study will compare active use of the smart inhaler to passive us…

This trial tests whether an online training for preschool teachers, called WE PLAY, can increase physical activity among young children with autism. About 150 teacher-child pairs will be randomly assigned to either the WE PLAY training or a control training. The study measures ch…

This trial is testing a robotic exoskeleton called ABLE Kids to see if it is safe and practical for children who have trouble walking due to conditions like cerebral palsy, spinal cord injury, or muscle weakness. Fifteen children will use the device in up to ten one-hour training…

This trial explores whether personalized brain imaging can predict who responds best to three rapid-acting treatments for suicidal ideation in people with depression or PTSD. Participants receive either real-time brain feedback (neurofeedback), a form of magnetic brain stimulatio…

This phase 2 trial is testing whether the combination of avutometinib and defactinib can stop or shrink malignant peripheral nerve sheath tumors (MPNST) that have returned or cannot be removed with surgery. The study enrolls people over 12 years old with relapsed, refractory, met…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests a precise, MRI-guided radiation treatment for people with cancer that has spread to the spine and is pressing on the spinal cord. The goal is to shrink the tumor enough to avoid surgery. About 24 adults with solid tumors like breast, prostate, or lung cancer will…

This pilot study tests whether combining a gentle brain stimulation technique called tDCS with aerobic exercise can improve cognitive functions like memory and attention in people with schizophrenia. Participants will be randomly assigned to receive either the combined treatment …

This early-stage trial is testing whether combining a robotic exoskeleton with spinal cord stimulation can help people with chronic spinal cord injury walk more easily. The study will include a small group of adults who already have a spinal stimulator implanted and have complete…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This trial investigates whether a robotic gait training system called Lokomat can improve standing, walking, and quality of life in children and young adults with cerebral palsy. Participants will receive 20 sessions of robot-assisted training over eight weeks, in addition to the…

This study looks at people with COMISA, a condition where obstructive sleep apnea and insomnia occur together. Many people with this combination struggle to use CPAP, a standard treatment for sleep apnea, consistently. The study will compare those who take daridorexant, a sleep a…

This trial tests whether home-based virtual reality cognitive exercises, done on a tablet, can help slow mental decline in people with mild-to-moderate Alzheimer's disease. Some participants will also have online sessions with a neuropsychologist. The study aims to find a practic…

This study tests whether adding a mild electrical stimulation to the spinal cord (tSCS) during walking therapy can improve leg movement in people with recent spinal cord injury (within 6 months). Forty participants will receive either real or sham stimulation during 20 training s…

This trial is testing a new extended-release injection of brexpiprazole, a medication already used for schizophrenia, to see how it behaves in the body and whether it is safe and tolerable. About 16 adults with schizophrenia will receive a single dose of either 45 mg or 100 mg un…

This trial is testing an experimental drug called NTS-521, given as an intravenous infusion, to see if it can help people recover better after an acute ischemic stroke. The study will include about 140 adults aged 45 to 80 who have moderate to severe weakness on one side of the b…

This clinical trial is testing an experimental oral medication called KH607 in adults with major depressive disorder. Participants will receive either KH607 or a placebo once daily for several weeks, and researchers will measure changes in depression severity using a standard rat…

This clinical trial is testing an investigational drug called KH607 in adults with major depressive disorder (MDD). The study compares KH607 against an existing antidepressant, vortioxetine, to see which is more effective at reducing depression symptoms. Participants will take ei…

This pilot study tests a deep brain stimulation device that sends electrical pulses to two brain areas (STN and CM) to reduce seizures in adults with drug-resistant motor epilepsy. Ten participants will have the device implanted and will be monitored for changes in seizure freque…

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This study tests an experimental pill called RP902 in 360 people with mild cognitive impairment caused by Alzheimer's disease. Participants will take the drug or a placebo for 48 weeks to see if it slows memory decline. The trial is conducted at about 50 sites in China and may ex…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

This trial is testing whether an experimental drug called HRS-4029 can improve outcomes for people who have had an acute ischemic stroke, which happens when a blood clot blocks blood flow to the brain. The study will compare the drug against a placebo in about 340 participants wh…

This trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and tolerable for people who have had a traumatic spinal cord injury within the past ten years. The study will monitor participants for side effects and…

This early-stage trial tests an experimental drug called CT-179 in people with glioblastoma, an aggressive brain cancer. The study has two parts: one for patients whose cancer has returned, and another for newly diagnosed patients who will also receive radiation therapy. The main…

This phase 2 trial is testing an oral drug called PLX-200 (gemfibrozil) in children aged 2 to 15 with certain lysosomal storage disorders (LSDs), including CLN2, CLN3, Sandhoff disease, and Krabbe disease. The study aims to see if the drug is safe, tolerable, and may slow the pro…

This trial tests whether mirror therapy or action observation therapy can improve hand grip and dexterity in children with hemiplegic cerebral palsy. Children aged 5-10 will be randomly assigned to one of the two therapies, added to their usual physical therapy, for 12 weeks. The…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This trial explores whether an archery exercise program can improve sleep quality, emotional well-being, and brain function in college students who have depressive symptoms. Participants will be randomly assigned to either an 8-week archery training program or their usual routine…

This trial tests whether a 12-week program of core stabilization exercises can improve balance, trunk control, and gross motor function in children with spastic diplegic cerebral palsy. Sixty children who can walk with some assistance will be randomly assigned to receive either s…

This study tests whether a supervised group exercise program, called EINTER, can improve muscle strength and walking ability in adults recovering from stroke. The program combines cycling and strength training, tailored to each person, and runs for up to four weeks. Researchers w…

This trial investigates whether a structured exercise and physical activity program can improve health-related quality of life and daily physical activity in adults who have had an acquired brain injury. Thirty participants will either receive the exercise program plus usual care…

This trial tests whether a combined surgical procedure — endoscopic third ventriculostomy plus choroid plexus cauterization (ETV+CPC) — can effectively treat hydrocephalus in children without needing a permanent shunt. The surgery aims to create a new fluid pathway and reduce flu…

This trial investigates whether a 12-week home-based circuit training program can reduce intraocular pressure and improve retinal health in people with glaucoma. Participants are randomly assigned to either the exercise program plus standard care or standard care alone. The study…

This pilot study tests whether a Mediterranean diet and regular exercise can alter the gut microbiome in people with Parkinson's disease. Researchers will track changes in gut bacteria and look for links to symptom severity and quality of life. The study involves 80 participants …

This study looks back at medical records of children with spinal muscular atrophy (SMA) type 1 who received a one-time gene therapy called onasemnogene abeparvovec (Zolgensma). Researchers want to see if treated infants can sit independently for 30 seconds or more within a year. …

This trial tests whether a probiotic called IBNI617 can reduce depression symptoms in adults with moderate to severe major depressive disorder. Participants take either the probiotic or a placebo capsule twice daily for 8 weeks. The study measures changes in depression scores and…

This trial tests whether pregnenolone, a natural hormone, can help adults with both alcohol use disorder and major depression. Participants take either pregnenolone or a placebo for 12 weeks, while researchers track drinking, cravings, and mood. Brain scans will also look at how …

This early-stage trial is testing whether a single injection of XT-150, a gene therapy that produces an anti-inflammatory protein, is safe for people with ALS. Eight adults with ALS will receive one of two doses and be followed for six months. The goal is to check for side effect…

This trial investigates whether tirzepatide, a drug approved for diabetes and obesity, can improve recovery in people who have had a severe stroke caused by a large artery blockage. Participants receive two injections of tirzepatide—one before a clot-removal procedure and another…

This trial tests whether a year-long, home-based cognitive training program can improve memory, attention, and emotional understanding in people with multiple sclerosis. Participants use the COGWEB platform plus exercises for recognizing facial expressions, with most sessions don…

This trial tests whether adding a procedure called expansile duraplasty — opening and expanding the tough membrane around the spinal cord — to standard spinal surgery can improve neurological recovery in adults with acute severe spinal cord injury. Participants are randomly assig…

This trial tests whether implanting dopamine-producing cells into the brain can improve motor function in people with Parkinson's disease. The cells, made from stem cells, are surgically placed into the putamen. The study focuses on safety and whether the treatment can reduce sym…

This early-phase trial is testing whether an experimental drug called NLG802, taken as a pill, can be safely combined with the chemotherapy drug temozolomide for children and young adults (ages 5 to 21) with progressive brain or spinal cord cancer. The study aims to find the high…

This trial is investigating whether ATH434, an experimental drug taken twice daily as a tablet, can help control multiple system atrophy (MSA), a rare and progressive brain disorder. The study enrolls people who have already completed a prior phase 2 trial of ATH434 and may benef…

This study tests whether deep brain stimulation (DBS) — a device that sends gentle electrical pulses to a key brain region — is safe and usable for people with chronic moderate to severe traumatic brain injury. Forty adults who are at least two years past their injury will receiv…

This pilot study tests whether an antioxidant cocktail called Rett-T can improve motor function in children and adolescents with Rett syndrome, a rare genetic disorder that affects movement and coordination. Participants, aged 2 to 21 and at least partially able to walk, will rec…

This pilot trial is testing a medical device called GlioHook, which is implanted in the brain after surgery to remove a high-grade glioma. The implant is designed to trap any remaining tumor cells and make follow-up radiotherapy more effective. The study includes about 15 adults …

This trial tests whether a gradual dosing schedule of cannabidiol oral solution (CBD-OS) can help reduce seizures in adults with Lennox-Gastaut syndrome, a severe form of epilepsy. Participants will take CBD oil alongside their usual seizure medications. The study measures how ma…

This trial investigates whether a specific type of breathing exercise — functional inspiratory muscle training — can improve walking patterns in people who had a stroke more than six months ago. Sixty participants will be randomly assigned to either this new training or conventio…

This trial tests whether the schedule of maintenance transcranial magnetic stimulation (rTMS) affects the risk of depression relapse. Adults who responded to an initial course of theta burst stimulation are randomly assigned to receive 20 maintenance sessions either clustered tog…

This trial tests whether an 8-week upper-limb resistance training program can improve cardiovascular autonomic function in adults with chronic spinal cord injury. Participants are randomly assigned to either supervised arm exercises three times per week or a control group. Resear…

This trial tests whether adding either high-repetition task-oriented training or high-intensity gait training to standard neurodevelopmental therapy helps people with chronic stroke walk farther and move more easily. Forty-five participants who had a stroke at least six months ag…

This phase 3 trial is testing whether a cannabidiol oral solution (CBD-OS) can safely reduce seizures in people aged 1 year and older with developmental and epileptic encephalopathy (DEE), a group of severe epilepsy syndromes. Participants receive either CBD or a placebo twice da…

This trial tests whether an experimental drug called JZP926 can safely reduce the number of days people aged 10 and older experience myoclonic seizures—brief, shock-like jerks—due to juvenile myoclonic epilepsy. Participants are randomly assigned to receive either JZP926 or a pla…

This trial compares a new long-acting injectable form of the schizophrenia drug cariprazine (called B2227) with the standard oral version, Vraylar. Researchers want to see how the body absorbs and processes each version, and whether the injectable is safe and tolerable. The study…

This trial tests whether adding a posterior cervical fusion (using the CORUS PCSS 3D device) to the standard anterior cervical discectomy and fusion (ACDF) improves bone fusion success for people with two-level degenerative disc disease in the neck. About 225 adults with neck or …

General anesthesia in early childhood may raise the risk of ADHD-like behaviors and learning problems later on. This trial tests whether a non-invasive device delivering synchronized 40-Hz light and sound can help restore brain function after surgery. Researchers will monitor bra…

This phase 1 trial tests whether disulfiram, a drug long used for alcohol dependence, can reduce immune suppression caused by high-grade gliomas. Participants take disulfiram for 3 to 14 days before their scheduled tumor-removal surgery. The goal is to see if the drug can dampen …

This early trial tests a gene therapy called ZR001 in people with moderately advanced Parkinson's disease. ZR001 is injected into a brain region involved in movement, and a very low dose of an existing drug is then used to activate the therapy. The goal is to see if this approach…

This trial tests whether a TeleStroke network can help peripheral hospitals in Oman safely give clot-busting drugs (alteplase or tenecteplase) to people having an acute ischemic stroke. A remote neurologist will assess patients via video, review scans, and guide the local medical…

This study looks at infants with a birth-related nerve injury called neonatal brachial plexus palsy, which can weaken the arm and sometimes cause the shoulder joint to slip out of place. Researchers will use ultrasound to measure the shoulder joint and compare those images with a…

This study tests whether an eye-tracking device can help detect autism in toddlers born prematurely (before 37 weeks). Children aged 14-48 months referred for autism evaluation will use the device, and researchers will see if the eye-tracking data points to autism. The goal is to…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This study tests whether two advanced MRI techniques, called Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI), can improve the assessment of optic neuritis—inflammation of the optic nerve that can affect vision. Researchers will compare MRI measurements of the a…

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This trial tests whether a new ultra-rapid genetic test, using third-generation sequencing, can diagnose familial lymphohistiocytosis (FHL) in children within 5 days instead of the usual 6-8 weeks. FHL is a rare, life-threatening genetic condition where the immune system attacks …

This trial is testing whether using a genetic test to choose antidepressants leads to better outcomes for people with major depressive disorder. Half of the 220 participants will have their treatment guided by a cheek swab that analyzes genes affecting drug metabolism, while the …

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This trial is testing whether a special PET/CT scan that uses a radioactive form of tryptophan can provide better information about gliomas (a type of brain tumor) than standard MRI. The study has three parts: seeing if the scan can better define the tumor for radiation planning,…

This study tests whether a new eye-tracking device called SONDA can accurately measure visual field loss in people with pituitary tumors. Standard visual field tests require patients to press a button when they see lights, which can be tiring and unreliable. The SONDA test instea…

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

This study is developing a computer-assisted tool that uses a camera to objectively measure movement problems caused by antipsychotic medications. Researchers will enroll 180 people—half with these movement disorders and half healthy—to see how well the tool's results match stand…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether anticoagulant medications (like rivaroxaban or apixaban) are better than aspirin at preventing a second stroke in people who have had an ischemic stroke of unclear cause. Participants are adults who had a stroke within the past two weeks and show signs th…

This trial tests whether combining electroacupuncture with a sedative drug called dexmedetomidine can prevent depression in people who recently had an ischemic stroke. Participants at high risk for post-stroke depression will receive either the combined treatment, a sham version,…

This study follows 121 people who carry the APOE-ε4 gene variant and have noticed subtle memory slips—a group at higher risk for Alzheimer's. They previously completed a 12-month program combining diet, exercise, cognitive training, and a green tea extract (EGCG). Now, researcher…

This phase 3 trial tests whether zastaprazan, a stomach-acid-blocking drug, can prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or anticoagulant medications. Participants take…

This phase 3 trial tests whether taking rimegepant once daily can prevent migraine attacks in people with chronic migraine (15 or more headache days per month). About 400 adults will receive either rimegepant or a placebo for 12 weeks, then all participants may receive rimegepant…

This study tests whether the experimental drug trontinemab can prevent or delay memory loss and dementia in people who have early biological signs of Alzheimer's but no cognitive symptoms. Participants receive either trontinemab or a placebo intravenously for several years. The g…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This study tests whether a year of music training can improve thinking, memory, and quality of life in children who have recovered from brain tumors. About 236 children aged 7-16 will either receive regular care or join a ukulele program with weekly group and online sessions. Res…

This trial tests whether light therapy glasses can reduce depression in people with end-stage kidney disease who undergo hemodialysis three times a week. Participants wear either active glasses (1000 lux) or a sham device (50 lux) for 30 minutes each session over five weeks. The …

This trial tests whether a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can improve bladder control in people who have had a stroke. Participants will receive either real or sham tDCS alongside standard pelvic floor muscle training, thr…

This study will test whether a wearable device called Apollo Neuro is practical and acceptable for autistic children aged 6 to 14 who hurt themselves. The device delivers low-intensity vibrations through the skin. For about a month, 18 children will wear it at least 3 hours a day…

This trial tests whether an AI-driven personalized exercise feedback program can help people with mild traumatic brain injury (TBI) stay consistent with a walking routine. Participants follow a 12-week walking plan, with intensity adjusted to their heart rate and effort, while we…

This trial tests whether cognitive behavioural therapy for insomnia (CBT-I), with or without bright light therapy, can improve sleep and other outcomes in adolescents with ADHD who also have insomnia and a late sleep schedule. Participants aged 10-24 will receive CBT-I plus eithe…

This trial tests whether giving patients a prescription for haloperidol to use as needed at home can help control symptoms of cannabinoid hyperemesis syndrome — a condition marked by severe nausea, vomiting, and abdominal pain from heavy cannabis use. The goal is to see if having…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This trial investigates whether a traditional Chinese medicine formula, Xingqi Daozhi Decoction, can relieve constipation that often occurs as a side effect of antipsychotic medications in people with schizophrenia. The study will enroll 46 adults with schizophrenia who have deve…

This study tests whether an 8-week mobile app program, based on Transition Theory, can help first-time expectant fathers reduce anxiety, strengthen their bond with the unborn baby, and improve marital adjustment. About 96 fathers whose partners are 26-28 weeks pregnant will be ra…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This trial tests whether using a virtual reality headset during regional anesthesia can lower patients' anxiety and pain. Adults aged 18 to 64 having elective surgery with regional anesthesia will either receive VR distraction or standard care. Researchers will measure anxiety an…

This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. P…

This trial tests whether applying a numbing medicine (lidocaine) to a nerve cluster inside the nose can quickly relieve migraine headaches, facial pain, and neck pain. Adults who have frequent headaches and facial pressure will receive either lidocaine or a saltwater placebo duri…

This study tests whether a six-session online program that helps young adults explore meaning in life can reduce symptoms of depression and anxiety. Participants are randomly assigned to either the program or a waitlist. The goal is to see if building a sense of purpose improves …

This study explores whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help pregnant and postpartum women who have PTSD and a history of substance misuse. Participants receive five weekly telehealth sessions where they write about a traumatic experi…

This trial investigates whether the Healthy Minds Program, a mobile meditation training app, can reduce symptoms of depression in adults. About 1,500 participants with elevated depressive symptoms will complete a 4-week well-being program using the app. Researchers will measure c…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This trial tests whether a wearable device emitting near-infrared light during sleep can improve sleep quality and reduce the need for sedative-hypnotic medications in adults with chronic insomnia. Sixty adults who use sleeping pills at least four nights a week will use either th…

This study tests whether adults with chronic, stable mental health conditions will actively engage in a 4-month musical immersion program called Résonance(s), which includes rehearsals with a professional orchestra, listening sessions, and a final public concert. The main questio…

This trial tests whether a neck-focused rehabilitation program can reduce the burden of chronic migraine. Adults aged 18-55 with chronic migraine will be randomly assigned to either an eight-week program of cervical sensorimotor exercises or conventional physiotherapy. The study …

This study tests whether AI-based cognitive training, using the Lumosity app, combined with a tailored physical-therapy program can improve sleep and quality of life in people with multiple sclerosis. Participants aged 25-40 with mild to moderate disability will undergo the train…

This trial tests whether an AI-based system can provide preoperative counseling for elective cesarean delivery as effectively as a physician. Women scheduled for a C-section will be randomly assigned to receive either standard doctor-led counseling or AI-delivered counseling with…

This trial tests whether adding a second nerve block—targeting the greater auricular nerve—to the standard occipital nerve block provides better pain relief for people with chronic migraine. About 80 adults with chronic migraine will receive either the combined block or the stand…

This study tests whether a 12-week program of dance, yoga, and mindful movement can improve the lives of adults aged 18 to 35 with autism spectrum disorder (ASD). Researchers want to see if the program can enhance social skills, communication, quality of life, and overall well-be…

This pilot study tests a new model of mental health support for siblings aged 10-17 of children with medical complexity. The model uses screening and assessments by social workers, who can provide talk therapy or refer to a child psychiatrist for diagnosis and treatment. The goal…

This study tests a new group program designed for young people at clinical high risk for psychosis who also have suicidal thoughts or behaviors. The program, led by a clinician and a peer with lived experience, focuses on building hope, setting recovery goals, and strengthening s…

This trial tests whether brief behavioral sleep therapy and mindfulness, alone or combined, can reduce how often older women wake up at night to urinate. Women aged 65 and older with frequent nocturia and poor sleep will be randomly assigned to one of four groups: sleep therapy, …

This trial tests whether a structured reading rehabilitation module can improve reading speed and reduce errors in people with glaucoma, a condition that often impairs vision. Participants will practice the module for 20-30 minutes daily, at least 3 days a week, for 6 months. The…

This study tests four different supplement formulas, called Qualia Sleep A, B, C, and D, to see if any can improve sleep quality and satisfaction in adults who report poor sleep. About 100 healthy adults will take one of the four formulas as capsules each night for 28 days. Parti…

This trial tests whether a non-wearable audiovisual display, like a mobile screen showing calming content, can reduce anxiety in children aged 6 to 12 during emergency department procedures such as blood draws or stitches. Participants are randomly assigned to either use the dist…

This trial tests whether wearing lavender-sandalwood aromatherapy tabs for 24 hours can improve mood, reduce pain, and increase satisfaction in women recovering from a scheduled cesarean section. Participants wear the scented tabs on their hospital gown and complete mood and pain…

Many cancer patients feel anxious before radiotherapy, partly due to unfamiliar equipment and procedures. This trial tests whether adding a simulation-based education session — a virtual preview of the treatment environment — before standard education can reduce that anxiety and …

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This trial tests whether a non-invasive brain stimulation method called transcranial temporal interference stimulation (tTIS) can improve sleep in people with chronic insomnia. Participants will be randomly assigned to receive either active tTIS or a sham (inactive) version, with…

This trial is testing whether a specially adapted form of cognitive behavioral therapy, called CBT-DAY, can reduce depressive symptoms in autistic youth aged 11 to 17. Participants will be randomly assigned to receive either CBT-DAY or standard care, and researchers will compare …

This trial tests whether a 12-week Latin dance program—featuring Rumba, Cha-cha, and Jive—can improve psychological health in primary school children aged 6 to 12. Participants are randomly assigned to either the dance program or regular physical education classes. Researchers wi…

This trial tests whether a set of self-help booklets, based on cognitive behavioural therapy for insomnia (CBT-I), can improve sleep quality in adults with pulmonary hypertension (PH). Participants will be randomly assigned to receive the booklets during the study or after a wait…

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This trial tests whether inhaling bitter orange oil before bed can improve sleep quality and reduce fatigue in adults with type 2 diabetes. One hundred participants will be randomly assigned to inhale either bitter orange oil or plain water for three nights. On the fourth morning…

This study tests whether a daily fermented soy product, Haelan 951, can help ease hot flashes and improve sleep in women going through menopause. About 25 peri- and postmenopausal women aged 45-65 will take the product for 45 days and track their symptoms. The goal is to see if t…

This pilot trial tests a structured cognitive rehabilitation program called CanCOG® for cancer survivors who experience thinking difficulties—often called 'chemo brain'—after treatment for cancers outside the brain. Sixty adult survivors will be randomly assigned to either the si…

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study compares two types of brain stimulation—accelerated theta burst and high-frequency TMS—against a sham (fake) treatment to see if they can improve cognitive problems like memory and attention in people with treatment-resistant schizophrenia. Ninety adults on clozapine w…

This study tests whether a nurse-led program delivered via WhatsApp, using a digital booklet on sleep hygiene and relaxation, can improve sleep in older adults who feel lonely and have insomnia. Participants are randomly assigned to either the WISE program or usual care. The tria…

This study tests whether a simple online computer game can help children with brain tumors think faster. 300 kids will do 15 minutes of cognitive training, 5 times a week for 8 weeks. Researchers will check if the training is easy to do at home and if it actually improves process…

This Phase 2 trial tests whether combining psilocybin—a compound from certain mushrooms—with daily cognitive training can enhance brain plasticity in adults aged 65 and older. Participants include healthy older adults and those with mild cognitive impairment or early-stage Alzhei…

This study tests whether a daily probiotic supplement, Bifidobacterium longum 1714™, can improve wellbeing in adolescents aged 15-17 who report mild-to-moderate anxiety. Over 8 weeks, participants take one capsule daily and report changes in anxiety, sleep, fatigue, and cognitive…

This pilot trial tests whether NeuroEyeCoach, a computer-based eye movement training program, can help stroke survivors who have lost part of their visual field. Sixty participants will be randomly assigned to receive either the training plus usual care or usual care alone. The s…

This trial tests whether taking a daily capsule of Nepalese pepper extract (Zanthoxylum armatum) for 42 days can improve cognitive speed, reduce mental fatigue, and enhance gaming performance in healthy young action video gamers aged 16 to 39. Participants will take either the pe…

This study tests whether LEGO®-Based Play Therapy can help children with autism spectrum disorder improve their social and play skills. Children aged 6 to 12 will participate in weekly group sessions for 12 weeks, working together to build LEGO models while taking on roles like E…

This pilot trial tests a digital program called Together in Parenting (TIP) designed to help fathers who are experiencing symptoms of depression or anxiety after their child is born. The program includes short podcasts and educational materials based on interpersonal therapy. The…

This large citizen-science trial is testing whether two prebiotic products can reduce feelings of anxiety and improve related outcomes like sleep in adults. Around 1,000 participants will be randomly assigned to take either an active prebiotic or a placebo for 12 weeks, without k…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve sleep and reduce anxiety in adults over 60 who have chronic insomnia. Sixty participants will receive tACS sessions, and researchers …

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This study tests whether a safe, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve attention, memory, and problem-solving in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personalized …

This study tests a personalized, non-invasive brain stimulation device for 10 people with mild cognitive impairment (MCI). The device uses AI to tailor electrical stimulation to each person's brain patterns while they do memory exercises. The goal is to see if this approach can i…

This trial tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help cancer survivors and their spouses cope with the fear that cancer might return. It compares ACT to a more traditional therapy, Cognitive Behavioural Therapy (CBT), in a two-arm…

This trial tests a soft, wearable robotic exoskeleton designed to assist arm and hand movements in people with acquired brain injury. Participants, including healthy volunteers, perform a set of arm movements with and without the device's help. The study measures how usable the d…

This trial tests whether ischemic conditioning — brief cycles of blood-flow restriction using pressure cuffs on the arms — can improve motor function and cognitive performance in people with Parkinson's disease. Over 12 weeks, 34 participants will receive 24 sessions of the thera…

This trial tests a 12-week, physiotherapist-led online exercise program called POSH-Ex for women who recently gave birth. The program combines pelvic floor training, breathing exercises, and whole-body movements to improve sexual function and overall well-being. Researchers will …

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This trial tests whether Snoezelen therapy—a calming, multisensory experience using lights, sounds, and textures—can improve health in adults with schizophrenia (including those needing institutional care) and women with alcohol dependence. Participants will attend 30-minute sess…

This study tests whether adding short mindfulness sessions (5-10 minutes) before physical therapy can reduce anxiety, depression, and body image concerns in people with non-flaccid facial paralysis. Twenty-four adults with conditions like Bell's palsy or Ramsay Hunt syndrome will…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This trial tests whether a structured, culturally adapted home-based exercise program helps Afghan women with mild to moderate depression stay active compared to routine exercise advice. About 60 women aged 18-50 will be randomly assigned to either the exercise program or usual c…

This trial tests whether box breathing — a technique of inhaling, holding, exhaling, and holding for 4 seconds each — can reduce anxiety, pain, and improve lung function in people undergoing colonoscopy. Half of the 68 participants will practice the breathing exercise before the …

This trial tests whether hippotherapy—therapy involving horseback riding—can improve physical function, bladder and bowel symptoms, and family quality of life in children with cerebral palsy. Thirty children aged 7-15 will receive weekly 30-minute hippotherapy sessions for 8 week…

This trial tests whether spinal cord stimulation (SCS) can reduce muscle spasticity in adults who have had a stroke. Participants will have a small device implanted that sends electrical pulses to the spinal cord. Half will receive active stimulation for six weeks, while the othe…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This trial tests whether using virtual reality (VR) before an upper gastrointestinal endoscopy can reduce patient anxiety, improve psychological readiness, and boost satisfaction after the procedure. About 52 adults scheduled for the procedure will be randomly assigned to either …

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce the number of headache days in people with chronic migraine. Participants will receive either real or sham (inactive) stimulation over the motor co…

This pilot trial tests whether adding virtual pain neuroscience education to standard spinal cord stimulation can help chronic pain patients better manage their condition. The education teaches how the brain processes pain, aiming to reduce fear, anxiety, and catastrophizing. Par…

This trial tests whether adding hippotherapy—therapeutic horseback riding—to a standard special education program can improve physical function, bladder and bowel symptoms, and social communication in children with autism spectrum disorder. Thirty children will receive either the…

This trial tests whether Gocovri, an extended-release form of amantadine, can reduce disability and improve cognitive function in adults who have brain damage from radiation therapy. Participants take the drug daily for about 24 weeks, with the dose increasing after the first mon…

This study asks whether the timing of an autism diagnosis affects how well children respond to occupational therapy. Researchers will compare sensory processing and executive function improvements in children diagnosed early versus late. The therapy focuses on daily living skills…

This study tests whether an online mindfulness-based cognitive therapy (MBCT) program can reduce depression in people with multiple sclerosis (MS) who also have mild to moderate depression. The program involves live group sessions over eight weeks. Researchers will compare change…

This trial tests whether a structured mindfulness program can reduce pain in adults with multiple sclerosis. Participants are randomly assigned to either the mindfulness group or an educational program, and their pain, fatigue, sleep, mood, and quality of life are tracked over se…

This study tests whether a 6-week group training program, designed for managing chronic conditions, can help adults with traumatic brain injury (TBI) feel more confident and improve their quality of life. Participants will take part in a virtual community-based course and report …

This study tests whether virtual reality (VR) can reduce pain, fear, and distress in children aged 6 to 12 during burn dressing changes. Half of the participants will receive standard care plus VR distraction, while the other half receives standard care alone. Pain, fear, and dis…

This study tests a 3-week digital program delivered through the VIPPSTAR app, designed to help children and adolescents with visual impairment build a healthier body image and become more critical of social media content. Participants aged 10-18 will complete daily exercises and …

This study looks at whether improving sleep can help memory and thinking in older adults with mild memory problems and sleep issues. Fifty participants aged 60-85 will receive either talk therapy for insomnia or gentle sound stimulation during sleep. Researchers will track change…

This study tests whether a new medication, KarXT + KarX-EC, can reduce irritability in children and teens (ages 5 to 17) with autism. About 176 participants will receive either the drug or a placebo. The main goal is to see if the drug improves irritability scores after 8 weeks.

This trial tests whether hands-on manual therapy, tinnitus retraining therapy, or a combination of both can reduce the severity and daily impact of somatosensory tinnitus — a type of ringing in the ears that can be triggered by neck, jaw, or head movements. Sixty-five adults with…

This trial tests whether a structured education program, given to both breast cancer patients and their primary caregivers together, can improve self-care behaviors and reduce anxiety for patients, while also easing caregiver anxiety and burden. The program involves four weekly s…

This pilot trial tests whether a new short therapy, called Painhunting Therapy, can ease depression symptoms as well as standard cognitive behavioural therapy (CBT) in adults whose depression is linked to a stressful life event. Around 60 adults with depressive symptoms will be r…

This trial tests whether a telehealth program called Babble Boot Camp can improve early communication in babies born very preterm (before 32 weeks). Parents in the treatment group join weekly 15-minute coaching sessions with a speech pathologist for six months, learning activitie…

This trial tests whether gentle electrical stimulation of a nerve in the ankle, called posterior tibial nerve stimulation (PTNS), can reduce the sudden, urgent need to urinate that often follows a stroke. The study will include women aged 40 to 70 who have had a stroke at least s…

This trial tests whether a culturally tailored mobile health program, called Self-Compassion, Health, and Empowerment (SHE), can improve mental health in Chinese immigrant women who have experienced intimate partner violence. Participants receive six weekly sessions covering safe…

This study compares transanal irrigation (using a device to rinse the bowel) against standard care (diet, fluids, laxatives) for treating severe constipation in people with Parkinson's disease. Researchers will also check if the treatment affects gut bacteria and motor symptoms. …

This pilot study tests whether playing a collaborative virtual reality game during the first walk after scoliosis surgery can reduce pain and anxiety in teens aged 10 to 17. Half of the participants will use a VR headset to explore a magical jungle with a physiotherapist, while t…

This trial tests whether systemic couple therapy (SCT) can reduce depression and improve relationship quality in married couples where at least one partner has mild to moderate depression. Participants will either receive 8 weekly SCT sessions or standard care. Researchers will m…

This trial tests whether a 6-week online program delivered via WeChat or WhatsApp can help pregnant women and their partners sleep better and feel less stressed. The program includes videos, quizzes, and professional support. Researchers will measure sleep quality, heart rate, an…

This trial tests whether a four-week improv comedy program can reduce anxiety and improve mental well-being in Chinese young adults in Hong Kong who have mild-to-moderate anxiety but no diagnosed mental disorder. Participants attend weekly three-hour improv workshops and complete…

This trial investigates whether a home-based self-management program called HOBSCOTCH can improve thinking, memory, and quality of life in young adults (ages 18–29) and youth (ages 13–17) with epilepsy. Participants attend nine weekly one-on-one coaching sessions by phone or comp…

This trial tests whether mirror therapy — a low-cost technique where a child watches the reflection of their good arm moving, creating the illusion that their affected arm is moving — can improve arm and hand function in children with hemiparetic cerebral palsy. Twenty-six childr…

This trial tests whether a non-invasive device that gently stimulates the vagus nerve through the ear is tolerable for children who have had a stroke. One child will receive ear stimulation paired with occupational therapy sessions over four weeks. The goal is to see if the child…

This trial tests whether daridorexant, a newer sleep medication that works differently from older drugs, can help people with insomnia safely stop taking benzodiazepine receptor agonists (BZRAs). About 156 adults aged 18 to 70 will gradually replace their current sleep medication…

This trial is testing a new type of therapy called Augmented Depression Therapy (ADepT) for adults with major depression. ADepT blends techniques from cognitive, behavioral, and acceptance-based treatments to help manage depression and increase wellbeing. The study will enroll 40…

This trial is testing whether a bilingual (English and Urdu) mobile app can help stroke survivors improve movement in their affected arm and hand. The app guides users through structured exercises over eight weeks, starting with gentle range-of-motion activities and progressing t…

This trial tests whether adding sensory integration therapy—play-based activities like swinging and weight-bearing exercises—to standard physical therapy can improve walking symmetry, balance, and daily movement skills in children aged 5 to 12 with spastic hemiplegic cerebral pal…

This trial is developing and testing a peer-led program called the Trauma Recovery Program for family members and significant others of people with borderline personality disorder. The program aims to reduce posttraumatic stress symptoms that can arise from living with or caring …

This trial tests an 8-week eHealth program called eMindExCare that combines mindfulness practices with home-based aerobic and resistance exercises for prostate cancer patients undergoing active treatment. The study aims to see if the program is feasible and acceptable, and whethe…

This trial tests whether two simple distractions — watching a betta fish or playing with a hand puppet — can lower pain, fear, and anxiety in children aged 5 to 7 during a blood draw. One group will use the fish, another the puppet, and a third will receive standard care. Researc…

This randomized trial tests whether adding animal-assisted therapy (AAT) — structured sessions with a trained dog and/or rabbits — to standard rehabilitation can improve motor abilities, independence, and quality of life in older adults with dementia who are hospitalized in a med…

This trial tests whether a six-week personalized behavioral sleep program, called ISleepFAST, can improve sleep and daily functioning in adults who have had a stroke and still struggle with sleep or circadian problems. Forty participants will be randomly assigned to either the sl…

This study adapts a psychosocial support program called Caregiver Speaks for parents of children with Rett syndrome. Delivered through a private Facebook group over six weeks, the program aims to reduce caregiver stress and improve well-being. Researchers will test whether the ap…

This trial tests whether a smartphone app called LISTEN can help people with brain tumors who have trouble speaking (aphasia) communicate more easily. The app uses artificial intelligence to adapt to each user's needs and can be used with voice input and output. Researchers will …

This trial tests whether a 16-week remote physical activity program, including online newsletters and video coaching, can improve motivation and behavior in people newly diagnosed with multiple sclerosis (within the last 2 years). Participants will wear a Fitbit and log steps whi…

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

This trial tests whether listening to white or pink noise through headphones can reduce pain and anxiety in children aged 7–12 during a routine IV insertion. One hundred fifty children will be randomly assigned to hear white noise, pink noise, or receive standard care. Researcher…

This study tests whether personalized feedback, based on real-time data from smartphones and wearable devices, can help Veterans with PTSD who use cannabis. The feedback aims to show how PTSD symptoms, cannabis use, and daily behaviors like sleep and activity are connected. The g…

This trial tests whether watching a 15-minute comedy video right before urodynamic testing — a procedure that can be uncomfortable and anxiety-provoking — helps reduce pain, anxiety, and improve readiness. About 68 adults having the test for the first time will be randomly assign…

This trial tests whether a guided digital program delivered through a mobile app can reduce anxiety and depression in young adults (ages 18–40) who have fertility-related distress after a cancer diagnosis. Participants use the app to complete four modules covering coping skills, …

This trial tests whether coloring mandalas for 20 minutes can lower anxiety, pain, and improve vital signs and satisfaction in men undergoing transurethral resection of the prostate (TURP). Half of the 64 participants will color a mandala before surgery; the other half will recei…

This trial tests whether a meditation-based program called Mantram Repetition Program (MRP) can help veterans who have both posttraumatic stress disorder (PTSD) and chronic pain. Participants will be randomly assigned to either MRP or a health education group. The study measures …

This trial tests whether a wearable device that gently stimulates the vagus nerve through the ear can reduce pain and PTSD symptoms in veterans who have both conditions. Participants receive six sessions of a brief PTSD therapy along with either active or sham stimulation over fo…

This trial tests whether a single injection of platelet-rich plasma (PRP), made from a woman's own blood, can reduce pain and improve healing after perineal tears or episiotomies during vaginal birth. About 160 women will receive either PRP or a placebo injection right after deli…

This trial tests whether a structured, task-focused occupational therapy program delivered at school can improve handwriting, fine motor skills, and visual-motor integration in second- and third-graders who struggle with these skills. Children will be randomly assigned to either …

Stroke survivors often face unmet needs long after the initial event, especially younger adults who must balance rehabilitation with work and family. This trial tests a 12-month digital education and peer support program, co-designed with patients and delivered through LINE commu…

This trial tests whether self-guided digital programs can reduce both insomnia and depression in breast cancer survivors. Participants use an online insomnia program or a mental health program, either alone or in sequence, to see which approach works best. The goal is to find a s…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This trial tests whether squeezing a stress ball during coronary angiography — a common heart-imaging procedure — can lower patients' anxiety, fear, and physical stress while improving comfort. About 64 adults scheduled for elective angiography will be randomly assigned to either…

This trial tests whether different types of pressure garments can improve touch sensation in the hand after a stroke. Adults aged 21 to 60 with hand stiffness will wear one of three garment designs for at least 12 hours daily over four weeks. Researchers will measure how the pres…

This trial tests whether watching a calming nature video through a virtual reality headset can reduce fear of childbirth and anxiety in high-risk pregnant women who are on bed rest in the hospital. Participants in the intervention group will view a VR nature scene with relaxing s…

This trial tests whether a simple mandala coloring activity can reduce perceived stress and anxiety in women hospitalized with high-risk pregnancies. Sixty participants will be randomly assigned to color mandalas daily for three days or to receive standard care. Stress and anxiet…

This 12-week trial tests whether a two-part dietary supplement system — a PM powder taken before bed and AM capsules taken with breakfast — can improve sleep quality, mood, mental clarity, and digestive comfort in generally healthy adults aged 18 to 65 who have trouble sleeping. …

This study tests whether a powered hip-flexion device called Hypershell X can immediately improve walking in people with multiple sclerosis who have hip weakness. Ten participants will walk short distances with the device set to different levels of assistance. Researchers will me…

This early study tests whether a single session of focused ultrasound—using sound waves to gently stimulate a specific brain region—can safely reduce emotional symptoms like agitation, irritability, and anxiety in people with mild dementia. Fifteen participants aged 45 to 80 with…

This trial tests whether a two-week tongue-strengthening exercise, done with a non-invasive device, can improve speech fluency in people with tongue-tie or slurred speech. The exercise relies on muscle resistance training, not medication or electronics. Researchers will measure c…

This trial tests whether taking 2 grams of spirulina daily for 8 weeks can improve metabolic health, body composition, sleep quality, and mood in mildly overweight postmenopausal women. Researchers will measure changes in blood sugar, cholesterol, weight, waist size, depression s…

This trial investigates whether daily aromatherapy foot baths with lavender essential oil can help cancer patients manage pain, sleep quality, and fatigue. Over five days, one group receives a 20-minute foot bath with lavender oil, while a control group receives routine care only…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This study looks at the medical records of 300 people treated for meningitis at a hospital in Sohag, Egypt, to understand what factors influence their chances of recovery. Researchers will review past cases and follow new patients for a year, tracking who survives, who recovers f…

This study compares sleep quality between adolescents with idiopathic scoliosis and healthy peers of similar age and sex. Researchers will use questionnaires to assess sleep, and in the scoliosis group, they will also look at curve severity, pain, body image, and brace use. The g…

This study tests whether an AI-driven mobile app, paired with a Fitbit, can deliver personalized exercise plans that older adults find feasible and acceptable. Over 8 weeks, participants aged 65 and older will receive daily and weekly exercise prescriptions tailored to their acti…

This study explores whether brain activity and sleep patterns can predict how well people with PTSD respond to Written Exposure Therapy, a brief therapy involving structured writing about a traumatic event. About 200 adults with PTSD will be randomly assigned to either this thera…

This natural history study will explore how life experiences and environmental factors affect heart health and metabolism among 50 Bhutanese adults living in the US. Participants will complete a survey and discuss their views on providing biological samples. The goal is to identi…

This study explores whether a single low-dose ketamine infusion can reduce depressive symptoms in adults with epilepsy who are already undergoing brain monitoring for their seizures. Participants receive one intravenous dose of ketamine while their brain activity is recorded dire…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study follows 80 people with spinal muscular atrophy (SMA) in Japan who receive Zolgensma (onasemnogene abeparvovec) as an intrathecal injection. The goal is to track safety issues, such as liver problems or blood clotting abnormalities, and to measure changes in motor funct…

This study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…

This study aims to classify the different types of chronic pain experienced by people with multiple sclerosis (MS). Researchers will use a detailed clinical assessment to categorize pain as nociceptive, neuropathic, nociplastic, or mixed. The goal is to see if different pain type…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study evaluates whether several sleepiness questionnaires are reliable for children and adolescents aged 6 to 17. It includes three groups: children from the general population, those with sleep disorders or conditions like narcolepsy or ADHD, and healthy volunteers. The goa…

This study follows 400 adults with generalized anxiety disorder (GAD) to understand how symptoms and health change over time. Researchers will collect clinical assessments, blood samples, and brain measurements at multiple visits. The goal is to identify factors that may predict …

This registry study follows 400 Alzheimer's patients in Canada who are prescribed LEQEMBI, a medication for the disease. The goal is to track the frequency and severity of known side effects, such as brain swelling (ARIA-E), microbleeds (ARIA-H), and larger brain hemorrhages, dur…

This study follows 180 people with early relapsing-remitting multiple sclerosis (MS) to understand why some experience disability progression even without relapses. Researchers will use MRI scans, eye tests, and blood biomarkers to see if they can predict this type of progression…

This study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…

This study explores whether electrical signals from the eye and brain can serve as a noninvasive marker of dopamine activity. About 50 adults—half with Parkinson's disease and half without—will have their eye and brain responses measured using sensors on the skin. People with Par…

This study looks at whether brain activity patterns, measured by EEG, can help predict long-term thinking problems in people with sepsis. Researchers will monitor brain waves for 72 hours in 78 ICU patients with different types of inflammation. They will then track cognitive func…

This study compares screening for postpartum depression at 2 weeks after birth versus the usual 6-8 weeks. Researchers will randomly assign 428 new mothers to either early or routine screening using a simple questionnaire. The goal is to see if earlier screening helps identify de…

This study investigates how the brain processes social decisions like trust and cooperation. Participants play a modified trust game, either in an MRI scanner or online, where their choices affect monetary gains or losses. The goal is to link brain activity and behavior to person…

This study measures specific substances (metabolites) in the breath and blood of people with inherited metabolic disorders, those on a special ketogenic diet for epilepsy, and healthy volunteers. The goal is to see if a simple breath test can reliably track these metabolites, pot…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This study looks at whether the ratio of the second to fourth finger (2D:4D) is linked to anxiety and work stress in anesthesiology residents. Researchers will measure finger lengths and use a questionnaire to assess worry and anxiety in about 116 residents aged 20-35. The goal i…

This trial tests whether taking tyrosol, a compound found in olive oil, together with creatine can improve endurance, strength, and thinking in healthy, active adults. Over eight weeks, participants take either creatine alone, creatine plus tyrosol, or a placebo, and complete cyc…

This early study at Mayo Clinic tests a new implantable device called the Brain Interchange System in up to 8 people with drug-resistant epilepsy. The device records high-speed brain signals and can deliver targeted electrical stimulation to prevent seizures. Unlike current syste…

This study uses brain scans to see how epilepsy changes a brain chemical called adenosine in areas that control breathing and wakefulness. Researchers will compare 50 people with drug-resistant epilepsy to healthy volunteers. The goal is to better understand why some epilepsy pat…

This study tests a new way to deliver two common Parkinson's medications, carbidopa and levodopa, using a small pouch placed between the cheek and gum. The pouch releases the drugs slowly, allowing absorption through both the cheek lining and the stomach. Researchers are measurin…

This study will use artificial intelligence and video analysis to assess how well children with cerebral palsy can walk and move. Researchers will collect data from 200 children aged 4 to 18 who can walk with or without help. The goal is to see if AI can accurately predict mobili…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether inflammation levels differ on either side of a blood clot in the brain during a stroke treatment called mechanical thrombectomy. Researchers will compare blood samples taken from before and after the clot to see if the difference is linked to how well …

This study uses a non-invasive brain stimulation technique called TMS to temporarily change activity in a brain region linked to anxiety. Researchers will use fMRI scans to see how this affects brain connections and anxiety-related startle responses. 140 adults with anxiety will …

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This early-stage study looks at how a new drug called ABBV-932 moves through the body when taken with another drug, itraconazole. Twenty healthy adults will take both drugs and have their blood levels measured. The goal is to check for side effects and see if itraconazole changes…

This trial investigates whether taking lithium for a week changes how the eyes and brain respond to light in healthy adults aged 18 to 40. Participants will undergo light exposure sessions with and without lithium, while researchers measure melatonin suppression, alertness, mood,…

This study explores whether the type of symptoms a person has at the start of a stroke influences how quickly they get to the hospital and how well they recover. Researchers will follow 120 adults with a first-ever ischemic stroke, comparing those with classic, high-urgency sympt…

This exploratory study looks at whether the community of bacteria in the gut and certain related chemical byproducts differ between people with Parkinson's disease and healthy individuals. Researchers will collect one stool sample from 15 people with Parkinson's and 15 matched he…

This study looks at whether an AI-based tool that helps doctors shape a microcatheter can improve the safety and success of coil embolization, a procedure to treat brain aneurysms. Researchers will follow about 1,400 adults who are scheduled for this procedure, comparing cases wh…

This study looks at whether patients recovering from a first acute stroke do better in a specialized stroke unit than in a conventional neurology ward. Researchers will follow 140 adults admitted within 48 hours of symptom onset, comparing outcomes like daily independence, disabi…

This study investigates how brain signals relate to freezing of gait and balance problems in people with Parkinson's disease. Participants, who already have a deep brain stimulation (DBS) device, will walk in a virtual reality home-like environment while their brain activity is r…

This study uses an online questionnaire to gather information from 15,000 Spanish-speaking adults about their sexual health, behaviors, and any experiences of altered consciousness during orgasm. The goal is to better understand the range of sexual function and pleasure, and to e…

This study asks whether routine medical data can predict which survivors of an emergency intensive care unit (EICU) stay will develop post-traumatic stress disorder (PTSD) one month after leaving the hospital. Researchers will follow about 800 adult patients, collecting details f…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can change how people remember the order of emotional movie clips. Researchers will compare active TBS to a sham (fake) version in 120 healthy adults. The goal is to understan…

This trial tests whether a scenario-based simulation training session can reduce anxiety, boost self-confidence, and improve clinical skills in nursing students when counseling pregnant women about nutrition. Half of the participants will take part in a 20-minute simulated counse…

This study explores how financial insecurity—such as trouble paying for housing, food, or healthcare—affects the mental health of university students and whether it keeps them from seeking help. Researchers will conduct in-depth interviews with 30 students from two French univers…

This study investigates how often older adults in China experience anxiety and depression before undergoing major non-cardiac surgery. Researchers will use standard questionnaires to screen 8,000 patients aged 65 and older across multiple hospitals. The goal is to better understa…

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study aims to develop models that combine clinical assessments with biological data (multi-omics) to improve diagnosis of major depressive disorder and predict how patients will respond to antidepressants. Researchers will follow 150 participants aged 14-45 with depression, …

This study looks at how ketamine, a drug already used for depression, might reduce suicidal thoughts by affecting stress-related brain pathways. Researchers will give 12 adults with major depressive disorder a single ketamine infusion, then use smartphone tracking and PET brain s…

This study is testing whether a simple, non-invasive brain wave recording (EEG) taken within days of a stroke can help predict how well a person will recover. Researchers will record the brain activity of 400 stroke patients and track their recovery over three to six months. The …

This study will enroll 35 Spanish-speaking adults with ALS and a similar group without ALS to see if a smartphone app can reliably measure changes in speech and breathing over time. Participants will use the app to record speaking and breathing tasks, and researchers will compare…

This study is looking for biological markers in the body that might predict how well people with treatment-resistant psychiatric disorders—like schizophrenia, depression, bipolar disorder, OCD, and catatonia—respond to new treatments. Researchers will collect blood, stool, cerebr…

This study follows 180 children who received a meningitis vaccine (ACYW135 conjugate) years ago to see if their immune protection lasts. Researchers will measure antibody levels in blood samples taken 3 and 5 years after vaccination. The goal is to understand how long immunity pe…

This trial tests whether a medical artificial intelligence (AI) tool can assist primary care doctors in managing chronic conditions like heart disease, atrial fibrillation, heart failure, and stroke. Doctors in the intervention group use the AI to help make decisions about assess…

This study asks whether a simple questionnaire, called SSPedi, can capture the symptoms that children with brain or spinal cord tumors experience while on new cancer therapies. Children aged 2 to 18 who are already part of a larger French study (SACHA) will use an app to report t…

This study looks back at the medical records of 60 adults with head and neck cancer who received radiation therapy, with or without chemotherapy, and used a topical mouth rinse made from olive oil, betaine, and xylitol. The goal is to see how often severe mouth sores (oral mucosi…

After a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predicti…

This study examines the most common symptoms of genitourinary syndrome of menopause (GSM) in postmenopausal women and how these symptoms impact quality of life. Researchers will also look at whether using a non-hormonal topical gel called XCM INTIM for at least 8 weeks is linked …

ALS is a progressive nerve disease with no simple test for early diagnosis or tracking. This study is collecting blood samples and medical data from 200 people with ALS to look for patterns in proteins, genes, and immune markers. The goal is to build a biomarker panel that could …

This study follows adults with a family history of genetic prion disease to see how and when the condition first appears. Participants undergo regular check-ins and genetic testing over many years. The goal is to map the natural course of the disease and identify early markers th…

This study explores whether estrogen influences how the brain processes fear, focusing on postmenopausal women who experience natural declines in the hormone. Participants will take an estradiol tablet and undergo brain scans while viewing shapes that sometimes predict a mild ele…

This study investigates whether a familiarization session before a treadmill time-to-exhaustion test can reduce learning effects and improve measurement consistency. Healthy, physically active adults will complete a practice trial followed by an experimental trial. Researchers wi…

This observational study tests whether wearable sensors and digital health tools can reliably measure falls, movement, speech, and thinking skills in people with progressive supranuclear palsy, Parkinson's disease, or multiple system atrophy. Participants wear a pendant sensor an…

This lab study tests whether gold nanoparticles can carry lithium directly to brain cells, potentially reducing side effects. Researchers will use neural cells grown from blood samples of people with bipolar disorder and healthy volunteers, plus a mouse model of mania. The goal i…

This study investigates how common depression is among adults who received a liver transplant more than five years ago. Researchers will use questionnaires and interviews to assess mental health and identify factors that may predict depressive symptoms. The goal is to better unde…

This study is testing whether a new digital tool—using AI-powered video games and a single camera—can accurately measure movement problems in people with Friedreich ataxia, a rare inherited condition that affects balance and coordination. Participants play short movement-based co…

This study looks at whether the angle of the thigh bone (quadriceps angle) and body mass index are linked to dynamic balance in children aged 6 to 10 with spastic diplegic cerebral palsy. Researchers will measure balance using a special platform and compare it to each child's leg…

This study tests whether a non-invasive finger sensor, called the Nociception Level (NOL) Index, can objectively measure pain, anxiety, and uterine activity in awake women undergoing elective cesarean delivery under spinal anesthesia. Researchers will monitor 100 women and compar…

This study looks at whether deep brain stimulation (DBS) — a standard surgical treatment for Parkinson's disease — affects a person's thinking and movement in ways that could increase their risk of falling. Researchers will assess 20 patients before and three months after DBS sur…

This observational study investigates whether cardiac autonomic neuropathy (nerve damage affecting the heart) changes the risk of death and cardiovascular events in people who have diabetes, coronary heart disease, and sleep apnea. Researchers will follow 326 participants, dividi…

This study investigates how a drug called Cobenfy KarXT, which affects the brain's cholinergic (acetylcholine) system, alters brain activity during memory and thinking tasks. About 30 people with essential tremor or epilepsy who are already scheduled for deep brain stimulation (D…

This study investigates why some people develop long-term thinking and memory problems after surgery to repair a ruptured brain aneurysm. Researchers will review past medical records and then bring in 150 adult survivors for brain scans and cognitive tests. The goal is to identif…

This study tests whether measuring the optic nerve sheath diameter — the nerve that connects the eye to the brain — with a simple bedside ultrasound can predict a dangerous rise in brain pressure when a pressure-lowering drug (mannitol) is reduced or stopped. Researchers will fol…

This study looks at whether insurance claims data can be used to reliably identify two serious complications in people with Alzheimer's disease: brain hemorrhages larger than 1 cm and new-onset seizures. Researchers will analyze records from 600 Alzheimer's patients, linking insu…

This study uses an anonymous online questionnaire to examine how medical students, midwifery students, and academic hospital staff use substances like alcohol, tobacco, and stimulants, and how these behaviors relate to mental health, stress, and social factors. The goal is to ide…

This study investigates whether physical activity and other lifestyle factors are linked to changes in myelin—the protective coating around nerve fibers—in people aged 50 to 70 who have had multiple sclerosis for over a decade. Participants will undergo MRI scans to measure myeli…

This study looks for brain and behavioral markers that could predict how people with suicidal thoughts respond to ketamine or electroconvulsive therapy (ECT). Researchers will use brain scans, EEG, and clinical assessments before and after treatment in 60 adults with major depres…

This study asks whether post-traumatic stress disorder (PTSD) influences how well epilepsy surgery works. Researchers will follow 42 adults with drug-resistant focal epilepsy for two years after surgery, comparing seizure freedom and quality of life between those with and without…

This study uses questionnaires and focus groups to understand the challenges children with spinal muscular atrophy (SMA) and their families face when moving between schools or starting a new educational stage. Researchers aim to identify barriers to inclusion and support, and to …

This pilot study is investigating how quickly C-reactive protein (CRP), a key marker of inflammation, drops after starting steroid treatment in people newly diagnosed with giant cell arteritis. By measuring CRP levels daily, then weekly and monthly for up to a year, researchers h…

This study investigates whether nerve ultrasound patterns and biomarkers in blood and spinal fluid can predict how people with chronic inflammatory demyelinating polyneuropathy (CIDP) respond to treatment. Researchers will follow 30 adults with CIDP, including newly diagnosed and…

This study looks at how well people hospitalized for a COPD flare-up perceive internal body signals — a skill called interoception — and whether that relates to their breathlessness, depression, and sleep quality. Researchers will assess 50 patients using questionnaires and clini…

This observational study asks whether a parent can accurately gauge the pain their child feels during a dental local anaesthetic. Children aged 6 to 15 and their parents each rate the child's pain on a 0-10 scale after the procedure. The goal is to see if parents can serve as rel…

This study tests whether a mild electrical pulse to a nerve in the ear can reduce pain caused by a capsaicin cream (the stuff that makes chili peppers hot). Researchers will also use brain scans and magnetic pulses to watch how the brain's pain circuits change during stimulation.…

This study uses advanced MRI to examine whether a deformity in the upper spinal canal is linked to syringomyelia (fluid-filled cavities in the spinal cord) in people with Chiari malformation type I. Researchers will compare MRI scans from 50 adults with Chiari malformation, with …

This study looks at how depression changes a person's sense of control over events in their life, and whether antidepressant medication can help restore it. Researchers will track 124 adults with depression over 8 weeks of standard SSRI or SNRI treatment, using computer tasks to …