Could a Once-Every-Few-Weeks shot replace daily pills for schizophrenia?
NCT ID NCT07722728
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This trial compares a new long-acting injectable form of the schizophrenia drug cariprazine (called B2227) with the standard oral version, Vraylar. Researchers want to see how the body absorbs and processes each version, and whether the injectable is safe and tolerable. The study involves 84 adults with schizophrenia who receive either a single injection of B2227 or multiple doses of oral Vraylar.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a long-acting injectable form of the schizophrenia drug cariprazine, called B2227
- What this could lead to
- If successful, this could offer people with schizophrenia a longer-acting treatment option that requires less frequent dosing.
- What could go wrong
- This is an early-to-mid-stage trial with only 84 participants, so results may not apply broadly. Side effects of cariprazine can include movement disorders and sedation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for SCHIZOPHRENIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a video call strengthen families facing schizophrenia?
- Virtual family therapy may tame schizophrenia symptoms — a trial investigates
- Can a tailored self-management program improve health outcomes for those with serious mental illness?
- PET scans reveal how antipsychotics target key brain receptors in schizophrenia
- Immune clues in schizophrenia: could inflammation subtypes guide treatment?
- Brain training tailored to you: a new approach for schizophrenia