BREAST CANCER

This study tests a personalized approach for people with HER2-positive breast cancer that has spread. Doctors use blood tests (ctDNA) and scans to adjust treatments over time, adding local therapies and brain-protecting steps. The goal is to see if this can lead to long-lasting r…

This study tests a personalized vaccine made from a patient's own leftover tumor after chemotherapy and surgery. The goal is to see if the vaccine is safe and can train the immune system to fight any remaining cancer cells. The trial enrolls 16 people with high-risk triple negati…

This early-phase trial tests an investigational vaccine designed to teach the immune system to recognize and attack HER2-positive breast cancer cells. The study includes 36 adults with locally advanced HER2-positive breast cancer. The main goals are to check the vaccine's safety …

This study is for women and men with a certain type of advanced breast cancer (HR+, HER2-). It tests whether adding targeted radiation to each tumor site, along with standard hormone therapy and a targeted drug, can help keep the cancer from growing longer. About 102 participants…

This study compares two breast-conserving surgery methods: standard surgery versus adding a systematic shaving step to remove a thin layer around the tumor cavity. The goal is to see if shaving reduces the chance of leftover cancer cells at the surgical margin, which often requir…

This early-phase trial tests a new drug called MDX2001 in about 285 adults with advanced solid tumors (cancers that have spread). The main goals are to check the drug's safety and find the right dose. Researchers will also see if it shrinks tumors. This is not a cure, but it may …

This study tests whether adding a new drug (JS105) to two existing drugs (dalpiciclib and fulvestrant) helps people with a certain type of advanced breast cancer live longer without the disease getting worse. The cancer must have a PIK3CA mutation and be hormone-receptor-positive…

This study tests a new drug, datopotamab deruxtecan (Dato-DXd), alone or with durvalumab, against standard chemotherapy for people with a type of advanced breast cancer called PD-L1 positive triple-negative breast cancer that cannot be removed by surgery or has spread. About 625 …

This study tests if a new hormone therapy called elacestrant, taken for 5 years, can better prevent breast cancer from coming back compared to standard hormone therapy in people with high-risk HR+/HER2- early breast cancer. About 1,520 participants will receive either elacestrant…

This study tests if injecting a very dilute hydrogen peroxide solution into breast tumors can make standard radiotherapy work better. It is for people with advanced or returning breast cancer. The treatment involves a few injections during radiation, and early results from Japan …

This study is tracking how well a single dose of radiation given during breast cancer surgery (IORT) controls the disease and what side effects occur. It involves 500 women aged 45 and older with early-stage breast cancer who are suitable for partial breast radiation. The goal is…

This study is observing 800 Chinese adults with advanced HER2-positive or HER2-low breast cancer who are taking trastuzumab deruxtecan (T-DXd). Researchers will track how long the drug controls the cancer and note any side effects in real-world settings. The goal is to understand…

This early-phase study tests an experimental oral drug called BBI-940 in people with advanced or metastatic breast cancer. The drug works by breaking down a protein that cancer cells need to grow. The study will find the safest dose and see if it works alone or with another drug.…

This early-stage study tests a new drug, RLY-2608, designed to target a specific genetic mutation (PIK3CA) found in some advanced solid tumors and breast cancers. The trial will enroll about 930 adults whose cancer has not responded to other treatments. Researchers aim to find th…

This early-phase study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find a safe dose and check for side effects. About 319 participants will receive the drug to see…

This early-phase trial tests whether freezing a tumor (cryoablation) can boost the immune system's response to the drug pembrolizumab in people with advanced triple-negative breast cancer. About 30 participants will either receive the combination or pembrolizumab alone. The goal …

This study is for people with triple-negative breast cancer that has spread and does not have a protein called PD-L1. It compares a standard chemotherapy-like drug (sacituzumab govitecan) alone versus the same drug combined with an immunotherapy (pembrolizumab). The goal is to se…

This study tests whether two drugs, sacituzumab govitecan and atezolizumab, can clear leftover cancer cells in the breast or lymph nodes of people with triple negative breast cancer. About 40 participants who still have cancer after standard chemotherapy will receive the combinat…

This study is for people with breast cancer who cannot have surgery due to health reasons or choose not to for cosmetic concerns. It tests a device that uses extreme cold and heat to destroy tumors, which are then absorbed by the body. The goal is to see if this minimally invasiv…

This study looks at whether switching between two different targeted therapy combinations (HP+chemo and HPy+chemo) can help control advanced HER2-positive breast cancer when the first treatment stops working. About 600 women with advanced or metastatic breast cancer will be assig…

This study tests a new drug (177Lu-NeoB) that delivers radiation directly to cancer cells, combined with the chemotherapy capecitabine, in people with a specific type of advanced breast cancer (ER+/HER2-) that has stopped responding to hormone therapy and a CDK4/6 inhibitor. The …

This study tests whether adding a drug called axatilimab (which targets immune-suppressing cells) and radiation to standard immunotherapy (pembrolizumab) can help eliminate high-risk triple-negative breast cancer before surgery. About 35 women with low immune activity in their tu…

This study looks at two ways to treat breast cancer that has spread to lymph nodes under the arm after chemotherapy. One method is surgery to remove those lymph nodes, and the other is radiation therapy. The goal is to see if radiation works just as well as surgery but causes les…

This study tests a treatment called cryoablation, which uses extreme cold to freeze and destroy small, low-risk breast tumors. It aims to see if freezing the tumor works as well as surgery, while also improving quality of life, reducing pain, and avoiding general anesthesia. Abou…

This study tests a new drug called JSKN003 against standard chemotherapy for people with HER2-low breast cancer that has spread or come back. About 400 adults who have already tried at least one chemotherapy will be randomly assigned to get JSKN003 or a doctor-chosen chemo. The m…

This study tests whether women with certain aggressive breast cancers (triple negative or HR-/HER2+) who have a complete response to chemotherapy and radiation can safely avoid breast surgery. 200 participants will receive the combined treatment and be monitored for 5 years to se…

This study is testing a new way to treat early-stage breast cancer without traditional surgery. It uses a technique called irreversible electroporation (IRE), which delivers short electric pulses to destroy cancer cells. The study will enroll 24 women with small, early-stage tumo…

This early-phase study is testing a combination of two drugs, alpelisib and pembrolizumab, in people with metastatic breast cancer or melanoma that has spread to the brain. The main goal is to find a safe dose and check for side effects. About 50 adults whose cancer has not respo…

This study is for people with early-stage HER2-positive breast cancer who have had surgery. It compares two treatment plans: one uses the drug T-DM1 followed by trastuzumab, and the other uses paclitaxel plus trastuzumab. The goal is to see which plan has fewer side effects and b…

This study looks at women who have had breast surgery and radiation before and need another breast surgery. It compares three options after surgery: a week of antibiotics, a wound vacuum device, or no extra treatment. The goal is to see which approach best prevents wound complica…

This study tests a new device that uses focused ultrasound waves guided by MRI to partially destroy breast tumors. About 34 women with breast cancer will have half of one tumor treated with this method before their standard surgery. The goal is to see if the procedure is safe, to…

This study is for people with advanced breast cancer who cannot or choose not to have surgery. It tests whether adding radiation therapy to standard medications can shrink the cancer and keep it from getting worse. The goal is to control the disease, not to cure it, and participa…

This study tests whether adding immunotherapy to standard hormone therapy and targeted radiation can train the immune system to fight HR+ breast cancer. About 100 post-menopausal women with early-stage disease will receive letrozole plus radiation, with or without immune-boosting…

This study tests whether adding a CDK4/6 inhibitor to standard hormone therapy can help prevent breast cancer from returning in women with a high-risk, hormone receptor-positive and HER2-positive early breast cancer who have already completed anti-HER2 treatment. About 1,900 wome…

This study looks at whether high-intensity interval training (short bursts of hard exercise) can lower the risk of heart disease in women who finished chemotherapy for breast cancer. About 158 women who completed chemo 6 to 18 months ago will be assigned to either high-intensity …

This study tests whether injecting a drug that activates immune cells (CD40 agonist) directly into breast tumors, alone or with another immune-boosting drug (PD-1 inhibitor), is safe and can be done before planned surgery. About 32 adults with early-stage or recurrent breast canc…

This study is for women 45 and older with early-stage breast cancer or DCIS who have had a lumpectomy. It tests whether a very short course of targeted radiation (over a few days instead of weeks) is safe and works as well as standard treatment. The main goal is to see if this ap…

This study tests two different chemotherapy combinations (nab-paclitaxel plus carboplatin vs. nab-paclitaxel plus epirubicin) given before surgery to shrink tumors in people with triple-negative breast cancer. The goal is to see which combo works better at eliminating cancer cell…

This study tests a personalized, lighter chemotherapy approach for women with early-stage triple-negative breast cancer. Treatment is adjusted based on immune cell levels in the tumor and imaging results. About 40 women with stage I or II disease will receive fewer chemo drugs if…

This study tests whether adding zanidatamab to standard chemotherapy can completely eliminate cancer in the breast and armpit before surgery in people with early-stage HER2-positive breast cancer. About 125 participants with stage II or III disease will receive the combination an…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses the patient's own T cells, which are modified in…

This study looks at whether taking CDK4/6 inhibitor pills after surgery can help prevent breast cancer from returning in people with hormone receptor-positive, HER2-negative breast cancer. About 229 adults will take these drugs as part of their standard follow-up care. The goal i…

This study tests a new drug, elacestrant, against standard hormone therapy in 4,220 people with a common type of early breast cancer that has spread to lymph nodes and has a high chance of returning. The goal is to see if elacestrant can better prevent the cancer from coming back…

This study tests two drugs, tucatinib and Doxil, together in people with HER2+ breast cancer that has spread. The goal is to see how well the combination shrinks tumors and to track any side effects. About 36 adults with advanced disease will take part.

This study tests a drug called atezolizumab in about 200 adults with advanced solid tumors (like breast, lung, or colon cancer) whose tumor DNA suggests the drug might help. Participants get the same dose every 3 weeks, and researchers check if their cancer shrinks or stops growi…

This study tests a new three-drug combination (VS-6766, abemaciclib, and fulvestrant) in people with a common type of advanced breast cancer (HR+/HER2-). The goal is to find the safest dose and see if the drugs can shrink tumors or stop them from growing. About 63 participants wi…

This study is for women whose breast cancer has returned after previous lumpectomy and radiation. It tests whether a second round of targeted radiation can allow them to keep their breast instead of needing a mastectomy. The main goal is to check safety and side effects in 120 pa…

This study is for people with a type of advanced breast cancer (ER+/HER2-) that has stopped responding to standard pills (CDK4/6 inhibitors). Researchers want to see if testing a blood sample for genetic markers can help pick a more effective treatment. About 484 participants wil…

This study tests whether proton radiation, a precise type of radiation, can control early-stage breast cancer in women aged 50 and older. The goal is to see if targeting only the tumor area can prevent cancer from coming back while reducing side effects. About 132 women will rece…

This study tests two drugs, trastuzumab deruxtecan and durvalumab, given before surgery to people with stage III inflammatory breast cancer that has a protein called HER2. The goal is to see if the combination can eliminate all signs of cancer in the breast and lymph nodes at the…

This study checks if a generic version of the chemotherapy drug paclitaxel works the same as the brand-name version in people with breast cancer. About 24 patients will receive both versions at different times to compare drug levels in their blood. The goal is to ensure the gener…

This study tests whether women with breast cancer whose armpit lymph nodes appear cancer-free on ultrasound after chemotherapy can safely avoid surgery to remove those nodes. Half the participants will skip armpit surgery, while the other half will have the standard sentinel node…

This study tests whether adding a drug called entinostat to a standard treatment (dalpiciclib plus letrozole) works better at shrinking tumors before surgery in people with a common type of early breast cancer (HR+/HER2-). About 60 women will be randomly assigned to one of two tr…

This study tests two different drug combinations given before surgery to people with HER2-positive early breast cancer. The goal is to see which combo clears more cancer from the breast and lymph nodes. About 100 adults with stage II or III disease will take part. Results will he…

This study tests whether adding two drugs (entinostat and anlotinib) to the standard hormone therapy fulvestrant can shrink tumors or slow cancer growth in people with a common type of advanced breast cancer (HR+/HER2-). The trial enrolls 118 adults whose cancer returned or worse…

This study tests a drug called Dato-DXd in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has stopped responding to hormone therapy. The goal is to see if Dato-DXd can slow or stop the cancer from growing. About 100 participants will receive…

This study tests a new experimental drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The main goal is to check the drug's safety and find the right dose. About 80 adults will take part in two p…

This study tests whether adding doxycycline, a common and safe antibiotic, to standard chemotherapy can better target cancer stem cells in early-stage ER+/HER2- breast cancer. About 50 participants will receive doxycycline alongside chemo before surgery. The goal is to see if thi…

This study tests a new drug called HRS-8080 against standard hormone therapy in people with intermediate or high risk early breast cancer who have already had at least 2 years of hormone treatment. The goal is to see if HRS-8080 can better prevent the cancer from coming back or s…

This study compares a new oral drug, D-0502, to a standard injected drug (fulvestrant) in people with a common type of advanced breast cancer (ER-positive, HER2-negative). The goal is to see if D-0502 can delay cancer growth better than the current treatment. About 640 adults who…

This study tests whether adding the drug QL1706 to standard chemotherapy can eliminate more cancer before surgery in people with early HR+/HER2- breast cancer. About 238 participants will receive either the combination or chemo alone for 6 cycles, then have surgery. After surgery…

This study looks at whether proton therapy can safely treat tumors that have returned after previous radiation. Unlike standard X-ray radiation, proton beams are more targeted and may spare healthy tissue. The trial will enroll 1,800 adults with various cancers to see if this app…

This study tests a new treatment for several types of cancer that have a specific marker called CD70. Researchers take a patient's own white blood cells, modify their genes in the lab to help them recognize and attack CD70-positive cancer cells, and then return them to the patien…

This early-phase trial tests an experimental drug called ALTA2618 in about 110 adults whose advanced solid tumors (like breast or endometrial cancer) have a specific AKT1 E17K gene change. The main goal is to check the drug's safety and find the right dose. Participants must have…

This study tests whether adding a low-dose chemotherapy pill (capecitabine) to the standard two-drug combination of dalpiciclib and hormone therapy can help control advanced breast cancer that has spread to organs like the liver or lungs. About 258 women with HR+/HER2- breast can…

This study tests a drug called talazoparib in people with metastatic breast cancer that has a BRCA1 or BRCA2 mutation in the tumor (not inherited). The goal is to see if the drug can slow or stop cancer growth. About 30 participants will take the pill and be monitored for tumor r…

This early-phase study tests a new drug called BL-M07D1 in adults with advanced HER2-positive solid tumors (including breast, lung, stomach, and ovarian cancers) that have not responded to at least two prior treatments. The main goals are to check the drug's safety, find the best…

This study tests a new drug called NBQ72S in 10 breast cancer patients whose cancer has spread to the lining of the brain or spinal cord. Participants receive the drug every 28 days. The goal is to see if the drug can control the cancer and improve survival, but it is not expecte…

This early-phase trial tests whether combining two drugs, neratinib and ruxolitinib, is safe and can shrink tumors in people with metastatic triple-negative breast cancer that has come back in the chest wall after chemotherapy. About 20 women aged 18 or older will take both pills…

This study is for people with a high-risk type of breast cancer (triple-negative) who still have cancer cells left after standard chemotherapy and surgery. Researchers will use a simple blood test to look for tiny bits of cancer DNA (ctDNA) that might signal the cancer is coming …

This early-phase study tests a new combination of three drugs (cyclophosphamide, axatilimab, and retifanlimab) in 24 people with metastatic triple negative breast cancer that has spread or come back. The main goal is to find the safest dose and check for side effects. This is not…

This study compares two ways of giving radiation before breast cancer surgery: the standard longer course versus a shorter course with fewer doses. About 126 adults with advanced breast cancer who plan to have a mastectomy followed by immediate tissue-based reconstruction will ta…

This early-stage trial tests a new drug, AVA6000, designed to deliver chemotherapy directly to tumor cells while reducing harm to healthy tissue. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to standard treat…

This study tests an experimental drug called ACE-86225106 in adults with advanced solid tumors (like ovarian, breast, or prostate cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tu…

This study tests whether customizing radiation, surgery, and additional drug therapy based on how well the tumor responds to initial treatment can improve outcomes for women with advanced breast cancer that has spread to nearby lymph nodes. About 157 participants will receive a p…

This early-phase study tests a new drug, CLSP-1025, designed to direct immune cells to attack tumors that have a specific p53 R175H mutation. The trial enrolls adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have worsened after standard treatments.…

This study tests a new hormone therapy drug, elacestrant, given alone or with a drug that temporarily stops ovarian function, in premenopausal women with early-stage ER+/HER2- breast cancer. Participants take the drug for 4 weeks before their planned breast surgery. The goal is t…

This study tests whether adding two drugs (sacituzumab govitecan and zimberelimab) to targeted brain radiation can help people with a tough-to-treat type of breast cancer that has spread to the brain. About 31 adults with triple negative breast cancer and brain metastases will ta…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. Participants continue their usual drug therapy while receiving SBRT. The goal is to see if this appr…

This study looks at whether people with early-stage HR+HER2- breast cancer can stay on a higher, FDA-approved dose of abemaciclib (150mg twice daily) for longer. About 50 participants will take the drug alongside hormone therapy after surgery. The goal is to see if this approach …

This study tests whether a daily pill called dapagliflozin (a diabetes drug) can prevent heart damage in breast cancer patients receiving anthracycline chemotherapy. About 70 women aged 18-70 with low to medium heart risk will take the drug during their chemo. The goal is to see …

This study tests whether adding the antifungal drug posaconazole to standard immunotherapy and chemotherapy can help more people with triple-negative breast cancer achieve a complete response before surgery. About 72 women with early-stage, high-risk disease will participate. The…

This study tests a new handheld robotic tool, HandX, to help surgeons perform nipple-sparing mastectomy through a small side incision, reducing scarring and improving comfort. About 15 women with early breast cancer or high genetic risk will take part. Researchers will track surg…

This study aims to help Latina women who have a higher chance of getting breast cancer due to genetics or life challenges. Researchers will provide three phone sessions to guide participants toward recommended screening and genetic testing. The goal is to see if this support help…

This study tests a new drug, MGC026, in 250 adults with advanced solid tumors that have not responded to other treatments. The goal is to check the drug's safety, find the right dose, and see if it can shrink tumors. Participants receive the drug by IV and are closely monitored f…

This study is for women with early-stage breast cancer that has not spread to lymph nodes. After chemotherapy and lumpectomy (surgery to remove the tumor), if the cancer is completely gone, researchers want to see if it is safe to skip radiation therapy. The goal is to avoid the …

This study tests whether a 1-week course of focused radiation after surgery is safe and effective for women whose breast cancer has come back in the same breast after prior radiation. About 171 women with small, early-stage recurrences will receive this short treatment. The goal …

This study tests whether shorter courses of radiation to the lymph nodes are safe and effective for people with breast cancer who have had surgery and are at higher risk of the cancer coming back. About 768 participants will receive either standard or shorter radiation schedules.…

This early-stage study tests a new treatment for triple-negative breast cancer that has come back or stopped responding to standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goal is …

This study looks at premenopausal women with a common type of early breast cancer (ER-positive, HER2-negative). It compares two treatments: hormone therapy alone versus hormone therapy plus chemotherapy. The goal is to see if adding chemotherapy helps prevent the cancer from comi…

This study tests an experimental immunotherapy called GLSI-100 in people with HER2-positive breast cancer who have a high risk of the cancer returning after standard treatment. The treatment is given as a series of shots over a year and aims to train the immune system to attack a…

This early-stage trial tests a new oral drug, RGT-419B, in people with a common type of advanced breast cancer (HR+, HER2-) that has worsened despite prior treatments. The study aims to find a safe dose and see if the drug works alone or with hormone therapy. About 64 adults with…

This study tests a new drug called YL202 in about 200 people with advanced solid tumors, including lung, breast, and head/neck cancers. The goal is to see if the drug can shrink tumors and how safe it is. Participants must be between 18 and 75 years old and have tried other treat…

This study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The goal is to find a safe dose and see if it can shrink tumors. About 216 adults with tumors that have sp…

This study tests a new way to rebuild breasts in women who have had breast cancer or have Poland syndrome. The approach uses a special tissue expander to stretch the skin, followed by fat grafting and a permanent implant. The goal is to see if this method is safe and gives good r…

This study tests a new experimental drug combination (BMS-986507) in about 416 adults with advanced lung or breast cancer that has spread. The main goals are to find safe doses and see if the drugs can shrink tumors. Participants must have tried other treatments and be in relativ…

This study is testing a new 3D-printed biodegradable mesh used during breast reconstruction after mastectomy for breast cancer. The mesh is designed to support the implant and help tissue heal, with the goal of improving cosmetic results and patient satisfaction. About 25 women a…

This study looks at women with breast cancer that has spread to 1 or 2 lymph nodes. It compares giving radiation to a larger area of the armpit versus a smaller area. The goal is to see if the smaller area works just as well to prevent the cancer from coming back. About 1,600 wom…

This study tests a new drug called HRS-6209 combined with other treatments for breast cancer. About 80 women whose cancer has worsened after prior therapy will receive the combination. The goal is to check safety, find the best dose, and see if it helps shrink tumors.

This program provides access to an experimental drug called AVM0703 for people with various solid tumors or blood cancers who have not responded to other treatments. It is available in the US upon a doctor's request. So far, 37 patients have received the drug, and side effects ha…

This study tests a new drug called OP-1250 (palazestrant) against standard treatments (fulvestrant or an aromatase inhibitor) in 510 people with a common type of advanced breast cancer (ER+, HER2-). Participants must have already tried hormone therapy plus a CDK4/6 inhibitor. The…

This early-phase study tests a new drug, BG-68501, in people with advanced solid tumors (like breast, ovarian, lung, or stomach cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors when used alone or with other…

This study tests a personalized gene therapy for people with metastatic cancers that haven't responded to standard treatments. Doctors take a patient's own white blood cells, genetically engineer them in a lab to recognize and attack unique mutations in their tumor, and infuse th…

This study tests a new drug, PF-07248144, combined with fulvestrant for people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after previous treatment. About 400 adults will be randomly assigned to receive either the new combination or…

This study tests a new approach for people with stage 2 or 3 breast cancer. Before standard chemotherapy, participants receive targeted radiation and an immunotherapy drug (pembrolizumab) injected into the tumor. The goal is to see if this combination can improve the chance of el…

This study tests whether adding ribociclib to standard hormone therapy can help prevent breast cancer from returning in people with a specific type of early breast cancer (HR+/HER2-) who still have cancer cells after initial chemotherapy. About 446 participants will be randomly a…

This study tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). About 55 p…

This early-phase study is testing whether giving radiation therapy along with two targeted drugs (abemaciclib and letrozole) before surgery is safe for people with a common type of early-stage breast cancer (HR+/HER2-). The study involves 15 participants and focuses on side effec…

This study looks at whether a supervised exercise program during chemotherapy can help eliminate breast cancer more effectively. About 712 people with breast cancer will either do high-intensity interval and resistance training or receive usual care. The main goal is to see if ex…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…

This study tests new drug combinations for people with early-stage breast cancer (stage II or III) who need chemotherapy before surgery. The goal is to see if these new treatments can eliminate all cancer cells in the breast and lymph nodes better than standard therapy. About 100…

This study tests a new drug called MBRC-201 in people with advanced solid tumors (like prostate, breast, lung, colorectal, or pancreatic cancer) that have not responded to standard therapies. The drug is an antibody-drug conjugate, designed to deliver a cancer-killing agent direc…

This phase 3 study tests whether adding capivasertib to standard hormone therapy helps people with HR+/HER2- advanced breast cancer stay on treatment longer and maintain quality of life. About 250 adults whose cancer worsened after prior hormone therapy will take capivasertib plu…

This study is for women aged 51 or older whose breast cancer has returned in the same breast or who have a new breast cancer in that breast. The goal is to see if giving a focused, short course of radiation before surgery is safe and effective enough to allow breast-conserving tr…

This early study tests if a mild electrical pulse to a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. Researchers will measure heart function and inflammation markers in 104 adults who recently started chemo. The goal i…

This study tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers (like breast, stomach, lung, or ovarian cancer) that have worsened after at least one prior treatment. The goal is to see if the drug can shrink tumors and how long that effect last…

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and effective for people with metastatic triple-negative or hormone-receptor-positive/HER2-negative breast cancer. About 34 part…

This study is for people with a certain type of advanced breast cancer (ER+/HER2-). It tests the drug elacestrant together with other targeted therapies to see if these combinations are safe and can help control the cancer. About 435 adults will take part. The goal is to find the…

This study is for people with a common type of breast cancer (ER+/HER2-) who have a high chance of the cancer coming back. Researchers will use a simple blood test to look for tiny bits of tumor DNA. If the test finds cancer DNA, participants will be randomly assigned to get eith…

This study tests whether a drug called leucogen can prevent severe neutropenia (dangerously low white blood cell counts) in women with early-stage hormone receptor-positive, HER2-negative breast cancer who are receiving ribociclib plus hormone therapy. About 94 participants will …

This early-phase study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. AGX101 is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to find the safest dose and to check for sid…

This study is testing a treatment for early-stage breast cancer that combines breast-conserving surgery with a single dose of radiation given during the operation. It involves 620 women aged 55 or older with small, HER2-negative tumors. The goal is to see if this approach lowers …

This study tests a new drug, palazestrant, combined with ribociclib against the standard letrozole with ribociclib for people with ER+, HER2- advanced breast cancer that has not been treated before. About 1,000 adults with locally advanced or metastatic breast cancer will take pa…

This study tests whether combining two drugs—elacestrant and trastuzumab deruxtecan—can shrink tumors in people with a certain type of advanced breast cancer (HR+, HER2-low or ultra-low) that has stopped responding to standard hormone therapy and CDK4/6 inhibitors. About 65 parti…

This program provides ribociclib (LEE011) to people with serious or life-threatening breast cancer who have no other treatment options and cannot join a clinical trial. It is only available through a doctor's request and aims to offer potential benefit when standard therapies are…

This study tests a program to help people with early-stage breast cancer take their hormone therapy and heart medications regularly. About 350 participants who have trouble sticking to their pills will receive extra support. The goal is to see if this program improves medication …

This early-stage study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells and boost the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatments.…

This study tests a new way to choose pre-surgery treatment for postmenopausal women with stage II or III ER-positive, HER2-negative breast cancer. By using biomarkers, doctors aim to improve treatment response and possibly avoid chemotherapy for some patients. The trial enrolls 8…

This early-phase study tests a new drug, OKI-219, designed to block a specific cancer-driving mutation (PI3KαH1047R). It is for people with advanced solid tumors or breast cancer that has not responded to other treatments. The study will first find the safest dose of OKI-219 alon…

This study tests whether removing lymph nodes in the armpit during initial breast cancer surgery (lumpectomy or mastectomy) can lower the chance of cancer coming back. It includes women aged 45 and older with ER+ HER2- breast cancer that has spread to lymph nodes seen on ultrasou…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have tried at least one prior therapy. The main goals are to find a safe dose and check for early signs of tumor shrinkage. About 27 adults will…

This early-phase study tests a new drug called GNC-077 in 20 people with advanced breast cancer or other solid tumors that have spread. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. Participants must have a tumor that can be measu…

This study tests a new drug, STX-478, designed to attack cancer cells with a specific genetic change (PI3Kα mutation). It is for adults with advanced solid tumors, including breast cancer, that have not responded to other treatments. The study will first test STX-478 alone, then …

This study follows 1,000 people with HER2-positive breast cancer to see how a biosimilar version of pertuzumab is used in everyday care. It looks at treatment patterns, tumor response, and side effects in two groups: those getting the drug before surgery and those receiving it as…

This study tests a shorter, 5-day radiation treatment for early-stage breast cancer or DCIS after surgery. The goal is to see if this approach causes fewer side effects and is as effective as longer treatments at preventing cancer from coming back. About 90 women aged 50 and olde…

This study is testing a new robotic method for nipple-sparing mastectomy in people with breast cancer or a high risk of developing it. The goal is to see if the robotic single-port approach is as safe and effective as traditional open surgery, while possibly improving nipple sens…

This study tests a medicine called disitamab vedotin in 100 adults with advanced HER2-positive breast cancer that has spread and is hard to treat. Participants receive the drug as an IV infusion every two weeks. The goal is to see if the drug can shrink tumors and to check its sa…

This study is testing a surgical method that combines fat grafting with a muscle flap from the back to rebuild the breast after mastectomy. The goal is to see if this approach reduces complications like wound infection or separation. The study will include 20 women who have had a…

This study tests whether an artificial intelligence model can identify patients with advanced HR+ HER2- breast cancer whose tumors might still respond to a second CDK4/6 inhibitor after the first stopped working. About 105 participants will either receive the AI-recommended drug …

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Instead of the usual approach of mastectomy, delayed reconstruction, and radiation after surgery, researchers are testing whether giving radiation before surgery allows for im…

This early-stage trial tests a new approach for women with metastatic triple-negative breast cancer that has already been treated with standard chemotherapy. The study uses bortezomib first to make cancer cells more vulnerable, then gives pembrolizumab and cisplatin to attack the…

This study tests an experimental drug called BG-75202, alone or with other treatments, in people with advanced breast cancer or other solid tumors that have stopped responding to standard therapies. The main goals are to check safety, find the best dose, and see if the drug can s…

This study is for women with low-risk breast cancer that has spread to nearby lymph nodes or is a certain size. It compares standard care (which includes radiation to the lymph nodes and chest wall) against skipping that extra radiation. The goal is to see if avoiding regional ra…

This study tests a new drug called inavolisib, given with other medicines, to people with a specific type of early-stage breast cancer (PIK3CA-mutated, ER-positive, HER2-negative). About 60 participants will receive the treatment before surgery to see if it safely shrinks or elim…

This study looks at whether a 16-week cardiac rehabilitation exercise program can improve heart health in women who have had early-stage breast cancer. About 100 participants will take part in the program, and their fitness, heart function, and quality of life will be measured be…

This study is for people with operable, lymph node-positive triple negative breast cancer. It tests whether adding low or high dose radiation to standard chemo and immunotherapy before surgery can improve outcomes. Participants receive radiation to the breast tumor over 3 days, t…

This study tests whether a new drug, RLY-2608, combined with fulvestrant works better than another drug combo (capivasertib + fulvestrant) for people with a specific genetic mutation (PIK3CA) in advanced hormone-receptor-positive, HER2-negative breast cancer. About 540 adults who…

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. It includes 311 participants aged 40 and older with favorable tumor types. The goal is to see if the one-time treatment controls cancer just…

This study compares a new drug, trastuzumab deruxtecan (T-DXd), to standard treatment given before surgery for HER2-positive breast cancer that has not spread. About 370 adults will receive either T-DXd or standard care for three cycles, then further treatment is chosen based on …

This study looks at how well the drug Disitamab vedotin works and how safe it is for people with breast cancer. It includes 45 patients who have used this drug before or are currently using it. The main goal is to see how long the cancer stays under control before it grows again.

This study is checking the safety of a drug called trastuzumab deruxtecan in 100 Indian adults with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. Participants have already tried another anti-HER2 treatment. The study will track side effects…

This early-phase trial tests three different doses of the experimental drug CLR 125 in 60 people with advanced triple-negative breast cancer that has not responded to prior treatments. The main goals are to find the safest dose and to understand side effects. Participants receive…

This early-phase study tests a new drug, LNCB74, in about 145 people with advanced solid tumors (ovarian, breast, lung, and others). The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to check safety and find the best dose for futur…

This study is for people with early-stage ER+ breast cancer who still have hidden cancer cells in their bone marrow after standard treatment. Researchers are testing three drug combinations—hydroxychloroquine, avelumab, and palbociclib—to see if they can clear these dormant cells…

This early-phase study tests a new drug called BL-M17D1 in about 20 adults with advanced breast cancer (HER2-positive or negative) or other solid tumors that have spread. The main goals are to check safety, find the right dose, and see early signs of tumor shrinkage. Participants…

This study tests a new treatment called Bria-IMT combined with an immunotherapy drug (retifanlimab) for people with advanced metastatic breast cancer who have run out of standard options. About 404 participants will be randomly assigned to receive either this new combination or a…

This study is for women with a certain type of breast cancer (ER+HER2-) who have already had radiation once and now need a second lumpectomy. Researchers want to see if giving radiation again is safe and helps prevent the cancer from coming back. About 114 participants will be fo…

This study tests a new way to give radiation before surgery for early-stage ER+ breast cancer. About 53 women will receive a single high dose of radiation, then wait to see if the tumor disappears. If it does, they may avoid surgery. The study also tests a special ultrasound to c…

This early-stage trial tests a new drug called BL0175 in postmenopausal women with advanced hormone receptor-positive breast, ovarian, or endometrial cancer. The main goals are to check safety, find the best dose, and see if it helps shrink tumors. Only 9 participants will be enr…

This study follows 100 breast cancer patients who cannot have surgery for medical or personal reasons. Instead, doctors use a needle to freeze and destroy the tumor. The goal is to see if this freezing treatment is safe and helps control the cancer over time.

This study tests a combination of three drugs (tucatinib, eribulin, and trastuzumab) in 30 people with advanced HER2+ breast cancer that has not responded to prior treatments. The goal is to see if the combination is safe and can shrink tumors or slow cancer growth. Participants …

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in 120 women with low-risk, early-stage breast cancer. The goal is to see if freezing is as safe and effective at controlling the disease, with fewer complications and better quality of lif…

This study looks at whether giving immunotherapy less often (extended dose intervals) works as well as the standard schedule for people with advanced triple-negative breast cancer. The goal is to keep the cancer under control while reducing side effects and improving quality of l…

This study tests if a shorter, 3-week course of proton radiation is as safe and effective as the standard 5-week course for women with breast cancer who need radiation to the breast or chest wall and nearby lymph nodes. About 276 participants will receive either the shorter or lo…

This study is testing whether a breast MRI before surgery can identify women with early breast cancer who have a very low risk of the cancer coming back, allowing them to skip radiotherapy after surgery. About 1,400 women aged 50 and older with certain types of breast cancer will…

This early-stage study tests a new drug called OCT-598 in about 51 adults with advanced solid tumors (breast, lung, prostate, head/neck, or stomach cancer). The main goals are to check safety, find the best dose, and see how the drug works alone or with standard treatments. Parti…

This study tests whether giving chemotherapy more frequently (dose-dense) works better for people with a common type of breast cancer (HR+/HER2-) that grows quickly. The trial will enroll 64 women with high-risk, early-stage breast cancer to see if this approach reduces tumor bur…

This study tests whether adding elacestrant to standard chemotherapy (capecitabine) can help people with advanced estrogen receptor-positive (ER+) breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to get either the combi…

This study looks at whether women with early breast cancer that spread to lymph nodes can avoid additional lymph node surgery or radiation after chemotherapy, if scans show the cancer is gone. The goal is to see if skipping this extra treatment is just as safe for preventing canc…

This early-phase study tests a new drug, QXL138AM, for safety and tolerability in about 100 people with advanced solid tumors (like ovarian, pancreatic, or lung cancer) or multiple myeloma. Participants must have tried standard treatments without success. The study will also look…

This early-phase study tests a new drug, KIVU-107, in about 76 adults with advanced solid tumors that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to deliver a cancer-killing agent directly to tumor cells. The main goal is to find the…

This study tests whether a new drug called tinengotinib, combined with fulvestrant, can shrink tumors in people with a certain type of advanced breast cancer (HR-positive, HER2-negative or low). About 94 participants will receive the combination to find the best dose and see if i…

This study tests a precise, high-dose radiation technique called SBRT as an alternative to surgery for breast cancer in elderly or frail patients who cannot have or refuse surgery. The goal is to find the safest highest dose that can control the tumor. About 36 participants aged …

This study tests a new drug called HMBD-501 in people with advanced melanoma, lung, or breast cancers that have stopped responding to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 180 adults will take part in two phases: first t…

This study is testing a newer, less invasive surgical technique for breast cancer. It uses a tiny camera (endoscope) to help the surgeon remove the breast (mastectomy) and rebuild it right away. The goal is to see if this approach is as safe and effective as standard surgery, whi…

This early-stage study tests a treatment called TIL therapy for people with advanced breast cancer who have run out of standard options. Doctors take immune cells from a patient's tumor, grow them in a lab, and give them back after a short chemotherapy. The goal is to see if this…

This study tests whether adding an oral probiotic (Biolosion) to standard chemotherapy before surgery helps more women with early-stage triple-negative breast cancer achieve a complete response. About 192 participants will be randomly assigned to receive either standard therapy a…

This early-phase study tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are modified in a lab to better attack cancer. The trial enrolls 18 adults with advanced solid tumors (including breast, lung, and gastrointestinal cancers) who have not re…

This study tests a new drug (GDC-4198) alone or with another drug (giredestrant) for people with advanced ER+/HER2- breast cancer that worsened after prior treatment. About 285 participants will be randomly assigned to receive either the new combo or a standard combo (abemaciclib…

This early-phase study tests a new radioactive drug (lutetium [177Lu]-BL-ARC001) in 22 adults with advanced lung, breast, head/neck, or other solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug s…

This study tests whether a special low-calorie diet that mimics fasting can make standard chemoimmunotherapy work better for people with early or locally advanced triple-negative breast cancer. About 80 women will follow the diet for a few days before each treatment cycle. The ma…

This study tests a new daily pill, INX-315, in 150 people with advanced breast, ovarian, or other solid tumors that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink or control tumors. The study includes three parts: testing the…

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help control tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for…

This study looks at whether a mobile app can help people with hormone-receptor-positive, HER2-negative stage II or III breast cancer stick to their prescribed treatment of ribociclib plus an aromatase inhibitor. About 240 participants will either use the app or not, and researche…

This study tests two different drug combinations given before surgery for early or locally advanced HER2-positive breast cancer. The goal is to see which combination clears cancer DNA from the blood faster, which may predict better outcomes. About 60 participants will be randomly…

This study tests different doses of the drug abemaciclib given together with radiation therapy for people with advanced hormone receptor-positive, HER2-negative breast cancer that has spread to the bone. The goal is to find the safest dose of abemaciclib when used alongside stand…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in people with advanced breast cancer that has low levels of a protein called HER2 or no HER2 at all. The goal is to see how long the drug can control the cancer before another treatment is needed. About 250 participan…

This early-phase study tests an experimental oral drug, RGT-490, in adults with advanced solid tumors (including breast, ovarian, and endometrial cancers) that have a specific genetic change called PIK3CA. The main goals are to check safety, find the right dose, and see if the dr…

This study tests a new drug called AZD8205, alone or with other cancer drugs, for people with advanced solid tumors like breast, ovarian, or lung cancer that have stopped responding to standard treatments. The main goals are to check safety and find the right dose. About 460 adul…

This study tests a new two-drug combination for people with a specific type of advanced breast cancer (HR+/HER2-) that has stopped responding to standard treatments. The drugs, Sac-TMT and Tagitanlimab, aim to shrink tumors or slow their growth. The trial will enroll 35 participa…

This study looks at how well a drug called Trop-2 ADC (sacituzumab govitecan) works for breast cancer patients whose cancer has spread to the brain. Researchers will track 100 patients from multiple hospitals to see if the drug shrinks brain tumors and how safe it is. The goal is…

This study tests a drug called zanidatamab in people with early-stage, low-risk HER2-positive breast cancer. The goal is to see if the drug can make the cancer disappear before surgery. About 20 adults with small tumors and no spread to lymph nodes will take part.

This study tests whether adding a new drug called inavolisib to two standard drugs (ribociclib and fulvestrant) works better than a placebo plus the two standard drugs for people with a certain type of advanced breast cancer (HR+/HER2- with chromosome 8p loss). About 80 adults wh…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by a common type of chemotherapy (anthracycline) in women with breast cancer. About 100 participants will take either dapagliflozin or a placebo daily during their chemo. Researchers…

This study tests a personalized cancer vaccine made from patients' own tumor cells. The goal is to train the immune system to fight metastatic cancers like melanoma, breast, lung, and colorectal cancer. Participants receive eight injections over 16 weeks. The study is for adults …

This program provides access to the drug alpelisib (BYL719) for patients with serious conditions like PIK3CA-related overgrowth spectrum (PROS) or breast cancer who have no other treatment options and cannot join a clinical trial. It is not a standard study but a managed access p…

This study is for people whose breast cancer has come back after previous breast-conserving surgery and whole breast radiation. The standard treatment after a second surgery is radiation twice a day for 30 sessions. This trial tests if giving radiation once a day for 15 sessions …

This early-phase trial tests an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the …

This study is for people with breast cancer that has spread to only a few spots in the body (oligometastasis). It tests whether adding focused treatments like radiation or surgery to standard drug therapy can help people live longer. About 340 participants will first receive 12 w…

This study looks at whether giving hormone therapy before surgery can lower the chance of cancer cells being found at the edges of removed tissue in women with stage 2 to 3 invasive lobular breast cancer. About 176 postmenopausal women with ER+/HER2- tumors will receive neoadjuva…

This phase 2 trial tests a combination of two hormone-blocking drugs (elacestrant and exemestane) in 26 people with advanced HR+/HER2- breast cancer that has stopped responding to initial treatments. Only patients whose tumors still show high estrogen receptor activity on a speci…

This early-phase study is testing a new drug combination for people with a specific type of advanced breast cancer (ER+, HER2-) that has stopped responding to standard hormone therapy. The treatment adds a targeted radioactive drug (177Lu-NeoB) to two existing hormone-blocking me…

This study tests a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) in 20 people with a common type of advanced breast cancer (HR-positive, HER2-negative). The goal is to see how well the treatment shrinks or controls the cancer. Participants either have new…

This study tests a new drug called OP-1250 (Palazestrant) combined with other targeted therapies in people with advanced or metastatic ER-positive, HER2-negative breast cancer. About 190 adults will receive one of four drug combinations to find the safest dose and understand side…

This study tests a personalized approach to breast radiotherapy, adjusting treatment based on each patient's risk of cancer returning and their risk of side effects. The goal is to reduce long-term damage like fibrosis or radiation-induced sarcoma while still controlling the canc…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer and other solid tumors that have spread or cannot be removed. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. About 470 adults will take part.

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to activate the immune system, followed by an infusion…

This study tests a combination of three drugs (disitamab vedotin, pertuzumab, and toripalimab) given before surgery to people with HER2-positive breast cancer. The goal is to see if the treatment can completely eliminate the cancer in the breast and lymph nodes. About 40 adults w…

This early-stage study is testing a new treatment called CAR-T cells that are designed to find and attack cancer cells carrying a protein called CEA. The study includes adults with advanced non-small cell lung cancer or breast cancer that has not responded to standard treatments.…

This study is testing a new drug called patritumab deruxtecan in people with a type of advanced breast cancer (HER2-positive) that has spread or cannot be removed by surgery. The main goals are to see if the drug is safe and if it can shrink or eliminate tumors. About 81 particip…

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This study tests whether adding the drug abemaciclib to standard hormone therapy can help prevent breast cancer from coming back in people whose cancer has already returned in the same area (chest, breast, or nearby lymph nodes). About 290 participants will receive either hormone…

This study tests an experimental drug called GDC-0587, alone or with another drug (giredestrant), in people with a certain type of advanced breast cancer (ER-positive, HER2-negative) that has gotten worse after previous treatment. The goal is to find a safe dose and see if the dr…

This study tests two drugs, Sac-TMT and KL-A167, given before surgery to people with early-stage triple-negative breast cancer. The goal is to see if the combination can eliminate or shrink the tumor enough to improve long-term outcomes. About 40 participants will receive the tre…

This study tests if a special program can prevent lymphedema (arm swelling) in women having lymph node removal for breast cancer. About 285 women will be followed for at least a year to see if the program reduces swelling and improves quality of life. The goal is to find a better…

This study tests a new drug called YL202 combined with other cancer treatments in people with advanced solid tumors, including breast and lung cancer. The goal is to find a safe dose and see if the combination shrinks tumors. About 414 adults aged 18-75 who have tried standard tr…

This study tests whether adding a vitamin A-like drug (ATRA) to a platelet-boosting medication (romiplostim N01) works better than the platelet drug alone for cancer survivors whose platelet counts stay low after chemotherapy. About 220 adults with gynecologic, breast, or lung ca…

This study tests a new drug called TER-2013 in people with advanced solid tumors (like breast, endometrial, ovarian, lung, head and neck, esophageal, or cervical cancer) that have specific changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and shrinks tu…

This study tests whether adding a new drug called inavolisib to standard hormone therapy and a CDK4/6 inhibitor can help people with a specific type of advanced breast cancer (PIK3CA-mutated, HR+, HER2-). About 450 adults whose cancer has not been treated for advanced disease wil…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This study tests two experimental drugs, SI-B003 alone or combined with BL-B01D1, in people with advanced HER2-negative breast cancer that has spread or cannot be removed. The goal is to see if these treatments can shrink tumors or slow the disease. About 58 adults who have not r…

This study is for people with early-stage breast cancer that has spread to a few lymph nodes. Researchers want to see if a genetic test called RecurIndex can identify who can safely avoid radiation to the lymph nodes without increasing the chance of cancer coming back. About 540 …

This study tests a new combination of three drugs (CDK4/6 inhibitors, Fulvestrant, and L-Ornithine L-Aspartate) in 20 women with HR-positive/HER2-negative advanced breast cancer that has worsened after standard treatments. The goal is to see if this triple therapy can shrink tumo…

This study tracks about 300 women with HER2-positive breast cancer that has spread. They receive a three-drug combination (tucatinib, capecitabine, trastuzumab) as part of their normal care. The goal is to see how well the treatment works and how safe it is in everyday medical pr…

This study tests whether aggressively lowering blood pressure during breast cancer treatment is safer and more effective than standard care at preventing heart damage. About 130 women with breast cancer and high blood pressure will be assigned to either intensive or standard bloo…

This study is for premenopausal women with a common type of breast cancer (HR+/HER2-). It tests a drug called elacestrant, given alone or with another drug (triptorelin), for 4 weeks before surgery. The goal is to see if the treatment lowers a marker of cancer growth (Ki67) in th…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The drug targets a protein called HER3 found on some cancer cells. About 740 adults with various cancers like lung, breast, or melanoma w…

This study tests two antibody drug conjugates (datopotamab deruxtecan and trastuzumab deruxtecan) given one after the other in people with HER2-negative metastatic breast cancer that has worsened after prior treatment. The goal is to see if this sequence can shrink tumors or slow…

This study tests if dapagliflozin, a drug used for diabetes, can protect the heart from damage caused by anthracycline chemotherapy in breast cancer patients. Forty adults with breast cancer will take dapagliflozin or a placebo alongside their chemo. Researchers will measure hear…

This early-stage trial tests a new treatment called ES2B-C001, given alone or with an adjuvant, for people with HER2-positive breast cancer that has spread and hasn't responded to at least two prior therapies. The main goal is to check safety and find the best dose. About 40 adul…

This early-stage study tests an experimental drug called VSV-02 in 6 adults with advanced solid tumors (like melanoma, breast, or lung cancer) who have run out of standard treatments. The drug is given both into a vein and directly into the tumor to see if it can shrink or contro…

This early-stage trial tests a new drug called IKS014 in people with advanced HER2-positive breast, stomach, or gastroesophageal cancers that have not responded to other treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells that have high leve…

This study is for breast cancer patients who have finished initial treatment but still have cancer cells hiding in their bone marrow. Researchers want to see if taking two pills—abemaciclib and hydroxychloroquine—can reduce or eliminate these leftover cells, which may lower the c…

This early-phase study tests a new drug, BL-M07D1, in about 26 adults with advanced HER2-positive or HER2-low breast cancer or other solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the best dose, and get an early look at …

This study tests two different doses of the drug inavolisib, given with fulvestrant, in people with a specific type of advanced breast cancer (PIK3CA-mutated, HR-positive, HER2-negative). The goal is to see if a lower dose works as well as a higher dose with fewer side effects. A…

This study tests whether tirzepatide, a weight-loss drug, can help eliminate tiny amounts of cancer left after standard treatment in 48 patients with obesity or overweight and a high-risk type of early breast cancer. The goal is to see if weight loss leads to metabolic changes th…

This early-phase study tests a new drug called BL-B01D1 in people with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. About 36 adults aged 18 to 75 will take part.

This study tests a program to help Black women with breast cancer follow their prescribed treatment plan, including chemotherapy and hormone therapy. Researchers will compare the program to standard care in 250 participants to see if it improves treatment start, reduces delays, a…

This study is for people with metastatic breast cancer (cancer that has spread). It aims to see if choosing treatments based on specific tumor markers (biomarkers) can help control the disease longer. About 700 participants will receive standard therapies matched to their biomark…

This study tests a completely oral (pill-based) chemotherapy combination called CMC for people with early-stage breast cancer who have had surgery. The goal is to see if this all-oral regimen is as effective and safer than standard IV chemo. About 25 adults will take three differ…

This early-stage study is testing a new drug called SYN818 combined with olaparib in adults with advanced solid tumors (like ovarian or breast cancer) that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. About 110 part…

This study tests whether giving a combination of three drugs (neratinib, an aromatase inhibitor, and trastuzumab) for 24 weeks before surgery can eliminate all signs of cancer in the breast tissue of people with ER-positive, HER2-positive breast cancer. About 30 postmenopausal wo…

This study is for people with breast cancer that has spread to the brain. It tests a treatment plan that starts with focused radiation plus a drug called olaparib, followed by an immunotherapy drug (durvalumab) and standard chemotherapy. The goal is to see if this combination is …

This study tests a technique called cryoablation, which uses liquid nitrogen to freeze and destroy small breast cancer tumors. It is for postmenopausal women with early-stage, hormone-sensitive breast cancer. The goal is to see if freezing the tumor can be as effective as surgery…

This early-phase study tests a new drug called BL-B16D1 in 21 adults with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. Participant…

This study is testing how well the drug ribociclib, combined with standard hormone therapy, prevents breast cancer from coming back in people with HR+ HER2- stage II or III breast cancer. About 2,766 participants in Russia will be followed for up to 5 years. The goal is to see if…

This study tests if dapagliflozin, a drug used for diabetes, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. About 46 adults with early-stage breast cancer who have not had chemo before will take dapagliflozin or a placebo during th…

This study tests a new minimally invasive treatment that freezes and then heats breast tumors, comparing it to standard breast-conserving surgery. About 264 women aged 50+ with early-stage, hormone-positive breast cancer will be randomly assigned to one of the two treatments. The…

This study looks at how well and how safely the drug dalpiciclib works for people with a type of advanced breast cancer called HR-positive. Researchers will follow 420 patients who are already taking or about to take dalpiciclib as part of their normal care. The goal is to see ho…

This study looks at whether doing Pilates exercises for 12 weeks can help prevent bone loss in breast cancer survivors who are taking hormone therapy (aromatase inhibitors). These women are at higher risk for osteoporosis because the treatment lowers estrogen. The study will meas…

This study tests whether adding the drug gedatolisib to standard hormone therapy and CDK4/6 inhibitors can help people with a certain type of advanced breast cancer (HR+/HER2-) live longer without their cancer growing. About 674 adults with advanced or metastatic breast cancer wi…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This study looks at whether giving antibody-drug conjugates (ADCs) a second time is safe and effective for people with advanced breast cancer that has spread. About 160 adults who have already received ADCs will be enrolled. The goal is to see if the tumors shrink or stop growing…

This study compares a new targeted therapy (dalpiciclib plus an aromatase inhibitor) against standard chemotherapy for postmenopausal women with a specific type of early breast cancer (ER-positive, HER2-negative, low growth rate). The goal is to see if the new combo works just as…

This study tests a combination of two drugs, abemaciclib and bicalutamide, for people with a specific type of advanced breast cancer that has spread (metastatic). The cancer must test positive for androgen receptors and negative for HER2. The goal is to find the best dose and see…

This study tests a combination of two drugs, ribociclib and anastrozole, in people with a common type of advanced breast cancer (hormone receptor-positive, HER2-negative) that has spread or come back. The goal is to see if the combination works better and is safe. About 86 adults…

This study tests whether the drug sacituzumab govitecan (SG) can still shrink tumors in people with a certain type of advanced breast cancer (HR+/HER2 low) who have already received a similar drug called T-DXd. About 75 adults will receive SG at its standard dose. The goal is to …

This study is for Nigerian women with a specific type of breast cancer called HER2-positive. Doctors want to see if giving a combination of targeted drugs before and after surgery can destroy the cancer completely. About 74 women will receive the treatment, and researchers will c…

This early-stage study tests a new cancer treatment called FT836, a ready-made immune cell therapy, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers. The treatment is given alone or with chemotherapy and/or antibod…

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goal is to find a safe dose and check for side e…

This study tests whether the drug ribociclib can safely replace chemotherapy for women with a common type of early breast cancer (HR+ HER2-) that has an intermediate risk of coming back. About 3,900 participants will receive either standard chemotherapy followed by hormone therap…

This study tests a combination of two drugs, neratinib and capecitabine, in people with a type of breast cancer that has spread to the brain. The cancer is HER2-negative by standard tests but shows abnormal HER2 activity on a special test. The goal is to see if this treatment can…

This study tests a new way to care for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It brings together cancer doctors and primary care providers to improve communication and support. The goal is to help patients better manage their …

This study tests whether adding an antivascular drug to standard chemotherapy helps prevent breast cancer from returning in people with a specific, high-risk type of triple-negative breast cancer. About 764 women with stage II to III cancer will receive either the combination or …

This study tests whether adding a new drug (patritumab deruxtecan) to standard chemotherapy and immunotherapy before surgery can eliminate more cancer cells in people with high-risk early-stage triple-negative or hormone-receptor-low breast cancer. About 372 participants will be …

This study tests a device that uses heat to destroy any remaining cancer cells in the tissue around a removed breast tumor. Ten women aged 50 and older with a specific type of breast cancer will receive this treatment right after their lumpectomy. The goal is to see if the device…

This study is testing a special PET/CT scan that uses a form of tryptophan (a building block of protein) to see if it can make tumors stand out more clearly from healthy tissue. About 24 adults with certain brain, breast, neuroendocrine, or rectal cancers will get this scan. The …

This study tests a new device that uses special lights and artificial intelligence to check, during surgery, whether all breast cancer has been removed. Up to 20% of women need a second operation because cancer cells are left behind. The device scans the removed tissue and alerts…

This study is testing a new type of PET scan that uses a special tracer to find cancers like pancreatic, breast, lung, and others. The goal is to see if this scan can better detect and stage tumors compared to standard scans. About 26 adults with suspected or confirmed cancer, pl…

This study looks at whether a special PET scan (68Ga-FAPI PET/CT) can accurately tell if breast cancer has spread to lymph nodes after chemotherapy. About 150 women with lymph node-positive breast cancer will get this scan before surgery. If it works well, it might help doctors d…

This study tests a special PET scan that uses a radioactive tracer to see how well breast cancer patients respond to a type of drug called an antibody-drug conjugate (ADC). The goal is to see if changes in tracer uptake can predict treatment success. About 50 adults with HER2-pos…

This study is testing a new way to detect breast cancer using a person's breath. About 1,200 women scheduled for routine breast cancer screening will breathe into a mask. The breath samples will be analyzed by trained dogs and an AI system to see if they can accurately identify b…

This study is testing a new ultrasound technique called Contrast Enhanced Super-Resolution (CESR) imaging to see if it can better find and tell apart cancerous and non-cancerous lesions in the breast, liver, and kidney. About 40 people will take part, including 10 healthy volunte…

This study looks at whether adding a special type of mammogram (contrast-enhanced mammography) every two years to the usual yearly 3D mammogram can find breast cancer earlier in women who have already had breast cancer. About 1,500 women will take part. The goal is to improve det…

This study tests two newer breast imaging methods—contrast-enhanced mammography and a shorter MRI—to see if they can find breast cancers earlier in women with extremely dense breasts. Dense breast tissue makes tumors harder to see on standard mammograms and raises cancer risk. Th…

This study tests whether contrast-enhanced mammography (CEM) can safely reduce the number of breast biopsies for women with low-suspicion findings. About 2,100 women scheduled for biopsy will first get a CEM scan. If CEM shows the abnormality is likely benign, the biopsy may be a…

This study compares AI-assisted mammogram reading to the standard method of two radiologists reading each scan. About 150,000 women in Norway's breast screening program will participate. The goal is to see if AI can detect breast cancers just as well, potentially making screening…

This study tests a new device called SPCTRone that helps surgeons check if all cancer has been removed during breast-conserving surgery. About 100 women with breast cancer will have their removed tissue scanned by the device, and the results will be compared to standard lab tests…

This pilot study tests whether a newer PET tracer, 68Ga-FAPI-46, can find more cancer spots than the standard tracer (18F-FDG) in people with ER-positive breast cancer. About 20 women with advanced or recurrent breast cancer will receive both tracers to see which one detects more…

This study compares two imaging methods—MBI and MRI—to see which is better at finding breast cancer in women at high risk. About 300 women will get both scans, and researchers will check how well each test spots tumors. The goal is to find a more comfortable or accessible option …

This study tests if a safe green dye (ICG) can help surgeons find cancer-spreading lymph nodes through the same cut used for mastectomy, avoiding a second incision. About 90 women with breast cancer will receive the dye during surgery. The goal is to see if this method works as w…

This study tests whether a special ultrasound with contrast dye can find the first lymph node where cancer might spread, instead of using the standard radioactive method. About 91 adults with melanoma, breast cancer, or head & neck cancer will take part. If it works, it could mak…

This study is testing whether a breathalyzer-like device can detect breast cancer by analyzing chemicals in a person's breath. Researchers will collect breath samples from 5,175 women aged 40-74 who are already scheduled for a breast biopsy or MRI. The goal is to see if the breat…

This study compares a special type of mammogram that uses a contrast dye (CESM) with standard 3D mammography (DBT) to see which finds more breast cancers and causes fewer false alarms. About 2,000 women with dense breast tissue and no breast symptoms will be screened with both me…

This study is testing two new imaging agents that light up breast cancer cells on PET scans. Researchers want to see if these agents can find tumors and their spread more accurately than current methods. About 200 women with breast cancer or suspected breast cancer will receive t…

This study compares robotic ultrasound to traditional sonographer-led screening for breast cancer in 70,000 women aged 35-64. Participants receive a breast ultrasound either by a robot or a human, and researchers track how many cancers are detected and how well women follow up on…

This study is gathering images from up to 800 women with suspicious breast findings to see if a new 3D automated ultrasound system (ATUSA) can accurately detect cancer. Participants will have their standard imaging and biopsy results compared with the ATUSA scans. The goal is to …

This study is testing whether non-experts can use AI-supported ultrasound to screen for breast cancer in communities with limited resources. About 4,800 women, both with and without symptoms, will take part. The goal is to see if this method is safe, practical, and accurate compa…

This study is testing two experimental methods—a blood test called liquid biopsy and a special camera called PEM—to see if they can help doctors find and understand breast abnormalities better in women at high risk for breast cancer. About 100 women who are already scheduled for …

This study compares a newer imaging method, contrast-enhanced mammography (CEM), to standard mammography for detecting breast cancer in women with dense breasts. Dense breast tissue can make cancers harder to see on a standard mammogram. The study will enroll 1,000 women aged 30-…

This early-phase study tests a new PET scan that uses a radioactive tracer (89Zr-trastuzumab) to see how much HER2 protein is in breast cancer tumors. The goal is to find out if this scan can predict which patients will respond to HER2-targeted therapy. About 10 adults with newly…

This study tests a new imaging system that uses light to monitor how well breast cancer responds to chemotherapy before surgery. Researchers want to see if it can accurately predict when the cancer is completely gone, which could help some patients avoid additional treatments. Th…

This study compares a contrast-enhanced digital mammogram (CEDM+CEDBT) with standard breast MRI to see if it can accurately predict whether breast cancer has been eliminated by chemotherapy before surgery. About 30 women with locally advanced breast cancer will get 1-2 of these s…

This study is testing a new device called ARTIDIS that measures how stiff breast tissue is to help doctors tell if a suspicious lump is cancer. About 2,700 people with breast lumps will have their biopsy samples tested with ARTIDIS, and the results will be compared to standard la…

This study trains Nigerian radiologists to perform ultrasound-guided breast biopsies using portable tablet devices. The goal is to make breast cancer diagnosis more accessible in areas with limited resources. About 900 women with suspicious breast lumps will take part to help eva…

This study involves 20 women recently diagnosed with breast cancer to test a new imaging platform that combines MRI with near-infrared light. The goal is to see if adding light-based measurements can help doctors better identify and understand tumors. Participants will undergo th…

This early-phase study tests a new imaging device that combines a special PET scan with 3D mammography to get a clearer picture of estrogen-receptor-positive breast cancer. About 20 adults with newly diagnosed breast cancer will receive an injection of a radioactive tracer that b…

This study is testing a new blood test that uses laser light and artificial intelligence to find signs of five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will collect blood samples from 1,400 people aged 45 and older who are su…

This study compares a newer X-ray-based breast imaging method (contrast-enhanced digital breast tomosynthesis, or CE-DBT) with standard MRI to see how confident radiologists are in identifying breast lesions. About 20 women with suspected breast lesions will receive both scans. T…

This study is testing a new blood test that looks at tiny particles from breast cancer cells to determine the cancer's subtype. The goal is to see if this test is as accurate as the standard tissue biopsy. 1500 adults with advanced breast cancer will provide blood and tissue samp…

This study tests whether a special imaging scan called PYLARIFY PET-CT can accurately detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will receive the scan to see if it matches standard methods. The goal is to improv…

This study tests a new device called MammoWave that uses very low-power microwaves to find breast lesions, without the radiation of a standard mammogram. It aims to enroll 600 women aged 18 and older who have had a mammogram in the past month. The exam is quick, comfortable, and …

This study is testing a new device that uses engineered bacteria and special laser technology to find and study rare tumor cells in the blood of breast cancer patients. The goal is to improve early detection and help doctors choose the best treatment for each patient. The study w…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection and moni…

This study is testing a special PET/MRI scan that uses a radioactive tracer to see if breast cancer is responding to hormone therapy before surgery. About 53 postmenopausal women with newly diagnosed breast cancer will get two scans—one before and one after starting treatment. Th…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study aims to improve how doctors find and treat breast cancer that has spread to the brain. Twenty adults with ER-positive breast cancer and brain metastases will receive an extra brain scan (FES PET/CT) before their standard radiation treatment. Researchers will compare th…

This study is testing a new type of PET/CT scan that uses a special tracer called 18F-T2 to find cancers that have high levels of a protein called CAIX. About 200 adults with cancers like kidney, bladder, lung, or breast cancer will get this scan to see if it works better than th…

This study tests whether a simple handheld ultrasound can help tell apart harmless breast lumps from ones that might be cancer. 600 women in Indonesia who have a breast lump found during a physical exam will get an ultrasound. The goal is to see if this approach can safely reduce…

This study is testing a new blood test that looks for tiny molecules called MicroRNA in people with breast cancer. The goal is to see if this test can accurately detect the disease. Researchers will compare results from 100 participants, including healthy volunteers, to measure h…

This study tests if a special green dye called indocyanine green (ICG) can find cancer in lymph nodes as accurately as the standard two-dye method in people with breast cancer who have already had chemotherapy. About 100 adults will receive both the new dye and the standard dyes …

This study tests a new way to find sentinel lymph nodes in breast cancer patients using a fluorescent dye called indocyanine green (ICG). The dye is injected near the tumor and glows under special light, helping surgeons locate the first lymph nodes that cancer might spread to. T…

This early-phase study aims to develop a new blood test that detects cancer by measuring specific enzyme activity in plasma. Researchers will compare enzyme levels in 120 patients with localized breast, lung, or pancreatic cancer against 100 healthy volunteers. The goal is to see…

This study tests a new way to find the first lymph node where breast cancer might spread. Instead of using a radioactive tracer, doctors use a green dye and a special camera during surgery. The goal is to make the procedure safer, easier, and more available in hospitals across th…

This study tests a new dye called pHLIP ICG that makes breast cancer cells glow during surgery, helping surgeons see and remove all cancer. About 55 adults with early-stage breast cancer will get the dye before surgery. The goal is to see if this method is safe and improves cance…

This study tests if a special antibiotic material called Stimulan Rapid Cure can lower the chance of infection in women who get temporary breast expanders after mastectomy. About 392 women will take part, and half will get the antibiotic placed in the surgical site. The goal is t…

This study tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during thei…

This study aims to increase breast cancer screening among Native American women in the Navajo Nation. Participants will receive a culturally-tailored education program on a tablet, with some also getting monthly one-on-one support from a peer navigator. The goal is to see if this…

This study compares two ways of screening for breast cancer: the usual annual mammogram versus a personalized schedule based on each woman's personal risk. Researchers will use family history, genetics, and breast density to tailor screening frequency. The goal is to see if perso…

This study tests whether a low dose of exemestane or tamoxifen can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year, and researchers will measure changes in quality of life and hormone levels. The goal is t…

This study looks at whether different types of preventive surgery can lower the chance of getting ovarian cancer in women who have a high genetic risk. About 480 women with certain gene changes (like BRCA1/2) will choose either standard surgery, delayed ovary removal, or close mo…

This study tests whether acupuncture, compression therapy, or both can prevent nerve damage (peripheral neuropathy) caused by taxane chemotherapy in breast cancer patients. About 384 people with early or intermediate-stage breast cancer will be enrolled. The goal is to find a saf…

This study looks at whether an online program can help women at higher-than-average risk of breast cancer adopt healthier habits, like better diet and more exercise, to lower their risk. About 1,500 women from a larger European screening study will be invited to try the program. …

This study tests whether a gel containing diclofenac (a common anti-inflammatory drug) can prevent skin rashes caused by radiation therapy. About 156 adults with head/neck or breast cancer who are starting radiation will use the gel on their skin. The goal is to see if it reduces…

This study looks at how exercise might lower breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood and breast tissue in 46 women who either join an exercise program or stay on a waitlist. The goal is to find out if exercise can reduce can…

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests whether giving the numbing drug lidocaine through a vein during breast cancer surgery can prevent persistent pain that often lasts for months after the operation. About 1,600 adults having a lumpectomy or mastectomy will be randomly assigned to receive either lid…

This study tests if solifenacin can reduce hot flashes better than clonidine in breast cancer patients taking hormone therapy. About 110 women who have at least 14 hot flashes per week will take one of the two drugs for three weeks. Researchers will track how often hot flashes oc…

This study tests whether a smartphone app that connects young adults (ages 18-40) with trained peer navigators can help them feel more in control of their health after finishing cancer treatment. About 138 people who had breast cancer, testicular cancer, lymphoma, or sarcoma will…

This study tests whether inhaling scents from Asian plants can reduce distress and anxiety in breast cancer patients before their first radiotherapy session. Researchers will measure changes in stress scores, anxiety levels, and stress hormones in 300 participants. The goal is to…

This study tests a special pain management program for breast cancer survivors who have joint and muscle pain caused by their hormone therapy (aromatase inhibitors). The program uses cognitive behavioral therapy (CBT) and other techniques to help reduce pain, improve thinking and…

This study tests whether avoiding opioids during breast cancer surgery can reduce side effects like nausea and breathing problems, while still controlling pain. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard …

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at whether a 16-week high-intensity interval training (HIIT) program can improve brain function and heart health in women with breast cancer who are receiving chemotherapy. About 30 women will participate, and their thinking skills and fitness will be measured be…

This study tests whether taking tart cherry concentrate and fish oil together can reduce joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. The study involves 30 women with obesity who have joint pain from their cancer therapy. Participants…

This study tests whether a telehealth exercise program can reduce cancer-related fatigue in rural breast and prostate cancer survivors. About 134 participants will either start the program right away or wait 12 weeks before beginning. They will do virtual fitness assessments, col…

This study looks at whether offering personalized sexual health support early on (proactive) is better than waiting for patients to ask for it. About 264 breast cancer patients who finished standard treatment within the last 3 months will take part. The goal is to see which appro…

This study tests a new type of radiation therapy that adjusts the beam in real time to better target the area where breast cancer was removed. About 40 women who had breast cancer surgery will receive either a moderate or very short course of this adaptive radiation. The goal is …

This study tests if nurse-delivered hypnosis before and during breast cancer surgery can reduce the amount of strong painkillers (opioids) needed after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standard…

This study tests a new care plan that uses technology to help doctors better manage the health of older adults (70+) who have cancer and other medical conditions. The goal is to see if this approach improves their quality of life over six months. About 720 people with breast, lun…

This study tests a stress management program called Vietnamese Self Help Plus (vSH+) for women with breast or gynecologic cancer in Vietnam. About 285 participants will either receive the program or standard care. The goal is to see if the program reduces anxiety and depression a…

This study is testing whether a mobile app can help young women (ages 18-45) with breast cancer feel less distressed. About 120 participants will use the app for 26 weeks, and researchers will check if their distress scores improve. The goal is to see if the app is a useful tool …

This study tests whether a program of exercise, nutrition advice, and geriatric care before surgery can help adults aged 65+ with breast cancer maintain physical function and reduce complications. About 90 participants will follow the 8-week program, and researchers will track ch…

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who had chemotherapy for breast cancer. Chemo can weaken the heart and reduce physical ability, but exercise might help. Researchers will compare a structured exercise pr…

This study looks at how different group exercise programs affect fitness and muscle strength in women who have finished breast cancer treatment. About 15 women will try one of four supervised resistance training routines. The goal is to see which approach best improves heart heal…

This study tests whether a new type of exercise prescription, based on how you feel during activity, helps breast cancer survivors become more active. About 85 people who finished cancer treatment in the last 5 years will be assigned to either the affect-based or an effort-based …

This study looks at whether time-restricted eating (eating all food within an 8-hour window each day) is practical and helpful for people starting chemotherapy for early-stage or advanced breast cancer. Researchers will test three different eating windows compared to a control gr…

This study tests if 12 weeks of supervised dragon boat racing improves body composition, physical function, and quality of life more than unsupervised home exercise in women who had breast cancer surgery. 72 participants will be randomly assigned to either group. The goal is to f…

This study tests a telemedicine program called FOCUS for people with advanced cancer. The program uses counseling techniques to help manage common symptoms like trouble sleeping, worry, tiredness, and low mood. Researchers will enroll 120 adults with advanced lung, breast, prosta…

This study compares a new care pathway called AMADeuS, where women have awake mastectomy with immediate breast reconstruction and go home the same day, to standard hospital care. Researchers want to see if it controls pain just as well and is as safe during the first month after …

This study looks at whether a short upper-body massage after each radiation treatment can reduce muscle and joint pain, improve arm and shoulder function, and enhance quality of life for people with breast cancer. About 55 participants will receive chair massages during their rad…

This study looks at a new way to do a special arm massage (manual lymphatic drainage) to prevent lymphedema, a common side effect of breast cancer surgery. About 30 women having lymph node removal will be assigned to either standard massage or massage guided by a green dye that s…

This study looks at whether simple mindfulness-based breathing exercises can help control symptoms and lower stress in breast cancer patients getting chemotherapy. About 72 women with early-stage breast cancer will take part, with half learning the breathing technique and the oth…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months post-surgery will be enrolled. Participants will do supervised exercises, …

This study looks at whether upper arm aerobic exercise can reduce stiffness in the arteries caused by breast cancer treatments like chemotherapy. Researchers will measure artery health in 18 women aged 40-69 who are at least 15 months past breast cancer surgery. The goal is to se…

This study tests whether a simple breathing muscle training program can help obese breast cancer survivors exercise longer and with less difficulty. About 78 participants who finished breast cancer treatment will do breathing exercises for 8 weeks. The goal is to see if this impr…

This study tests whether a series of online group discussions can help Black American women with breast cancer feel less depressed and less tired. About 90 women will take part in either the online groups or receive materials to use on their own. The goal is to see if sharing exp…

This early-phase study is testing the safety of adding the drug ribociclib to standard radiation therapy for women with a high-risk type of breast cancer (HR+/HER2-). About 30 participants will take ribociclib daily for up to 6 weeks while receiving radiation. The main goal is to…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce diarrhea and colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for side ef…

This study is testing whether giving radiation therapy for breast cancer in just 3 sessions over 2 days is safe and effective. It involves 170 women aged 45-79 who have had a lumpectomy for early-stage breast cancer. The goal is to see if this shorter treatment causes fewer side …

This study looks at whether women aged 60 and older with early-stage, low-risk breast cancer can safely skip hormone therapy after lumpectomy and just receive radiation. The goal is to see if this approach maintains good disease control while improving quality of life by avoiding…

This study follows 104 breast cancer patients whose cancer has spread to the chest wall and who are having surgery to remove the affected area. The goal is to see how the surgery impacts their quality of life, pain, and survival. Researchers hope to provide better evidence for tr…

This study looks at whether a simple strength training program can help breast cancer survivors manage fatigue. Researchers want to see if the program works equally well for people from different income backgrounds. About 60 participants will follow a 3-month exercise guide and t…

This study tests two walking programs for women undergoing chemotherapy for early-stage breast cancer. One program has a fixed weekly walking goal, while the other adjusts the amount of walking based on how each woman responds. The goal is to see which approach better improves ca…

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a tailored nutrition and exercise program helps them eat better and move more. About 306 survivors and healthcare providers will take part. The goal is to see if survivors …

This study tests whether a nutritional supplement called Epidiferphane can reduce common side effects of taxane chemotherapy, such as nerve damage and anemia, in breast cancer patients. About 74 participants will take Epidiferphane alongside their standard chemo to see if it help…

This study tests whether giving lidocaine (a numbing medicine) through a vein during breast cancer surgery can prevent long-term pain. About 4,300 women having a mastectomy or lumpectomy will be randomly assigned to receive lidocaine or a placebo. The main goal is to see if fewer…

This study tests whether a 15-week cycling program (one session per week) can help breast cancer patients maintain their physical fitness during chemotherapy. The trial will include 156 women with early-stage breast cancer who are receiving a common chemo combination. Half will d…

This study looks at two ways to manage side effects from aromatase inhibitors, a hormone therapy for early-stage breast cancer. About half of women stop taking these pills early due to side effects, raising the risk of cancer returning. Researchers will compare switching to a dif…

This study is testing a mobile app called TEAMWork that gives breast cancer patients advice on how to talk to their employers and doctors about work. The goal is to help patients keep their jobs during and after treatment. About 546 adults with breast cancer who are about to star…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. About 172 participants will be randomly…

This study looks at whether changing the order of mammogram pictures can reduce pain and improve satisfaction for women who have had breast cancer. About 400 women who had breast-conserving surgery within the last five years will be randomly assigned to one of four different sequ…

This study tests whether the MIND diet, a diet rich in brain-healthy foods, can improve memory and thinking in breast cancer survivors who have ongoing mental fogginess after treatment. About 200 survivors will follow the diet for 12 weeks, then a maintenance phase for another 12…

This study looks at 250 women who have had early-stage breast cancer and now struggle with both insomnia and being overweight. Researchers want to see if a special sleep therapy before a weight loss program helps them lose more weight than just learning about sleep. The goal is t…

This study tests a community-based, peer-led course called BBCSI designed to improve quality of life for Black breast cancer survivors. About 46 Black women who had early-stage breast cancer will take the course, and researchers will track safety and well-being. The goal is to se…

This study tests whether a program of resistance training (like lifting weights) plus a high-protein drink after workouts can help women with breast cancer maintain muscle and reduce fat while they undergo chemotherapy. About 30 women will be randomly assigned to start the progra…

This study looks at whether taking short walks after meals or doing quick 'activity snacks' can help breast cancer survivors control their blood sugar better than a standard 30-minute walk. The researchers will compare these strategies in 24 women who have had breast cancer and a…

This study tests whether a headband with special semiconductors can help with memory and thinking problems (chemo brain) after breast or gynecologic cancer treatment. About 50 adults who finished chemotherapy within the last 90 days will wear the headband for 18 hours a day for 3…

This study is testing a virtual program called Mindful After Cancer (MAC) to help breast and gynecologic cancer survivors with sexual health and body image concerns. About 60 participants will be randomly assigned to either the 8-week MAC program or receive educational materials …

This study is testing a smartphone app called iCareBreast+ designed to help women with breast cancer manage the challenges of chemotherapy. The app provides self-care tools and information to boost confidence and knowledge about treatment. Researchers will enroll 40 women to see …

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer complete their full chemotherapy schedule. Participants will be assigned to either the exercise program or a health education group. The goal is to s…

This study looks at whether a supervised program of moderate aerobic and resistance exercise is safe and helpful for breast cancer survivors who still have pain after treatment. Ten women who finished cancer therapy at least six months ago will take part. The goal is to see if ex…

This study tests whether combining electroacupuncture with self-acupressure can improve quality of life for people with early-stage breast cancer who are undergoing chemotherapy. About 192 participants will be randomly assigned to receive the acupuncture treatment or standard car…

This study tests a new type of radiation therapy that adapts to changes in the body during treatment, aiming to reduce side effects like skin burns and scarring. It includes 500 women with high-risk breast cancer who have already had surgery. The goal is to see if this adaptive a…

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part, and researchers will check changes in quality of life, stress, and other …

This study tests a decision aid for women aged 70 and older with early-stage, low-risk breast cancer. The tool helps them and their doctors discuss treatment options, aiming to reduce aggressive treatments like mastectomy or radiation when they may not be needed. About 400 partic…

This study tests a new, less invasive way to remove breast cancer through a single small cut in the armpit, avoiding a large scar on the breast. It includes 10 women with early-stage breast cancer who are getting a nipple-sparing mastectomy with immediate breast reconstruction. T…

This study tests whether a diet called MIND (a mix of Mediterranean and DASH diets) can help protect memory and thinking skills in women with breast cancer who are receiving chemotherapy or other systemic treatments. The study will enroll 43 postmenopausal women with stage II-IV …

This study tests whether walking exercise—done at a center or at home—can help reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who finished cancer treatment in the past year will take part. The goal is to find a simple, effective way to ease tire…

This study looks at whether a community-based exercise program called Get Real and Heel can help people with metastatic breast cancer become more physically active. Researchers want to see if the program improves quality of life, physical function, and social support. About 50 pa…

This study tests if a community-based exercise program can improve memory, attention, and brain health in 160 breast cancer survivors aged 50 and older. Participants will either exercise or receive health education. The goal is to find a safe, accessible way to ease the 'chemo br…

This study tests whether a remotely supervised online cognitive stimulation program can reduce memory and thinking complaints in breast cancer patients who have finished chemotherapy. About 300 participants will either get the supervised program or do unsupervised brain exercises…

This study tests two different nerve block techniques to control pain after mastectomy in 40 women with breast cancer. The goal is to see which method reduces the need for strong painkillers like morphine. Both techniques are guided by ultrasound and aim to improve recovery and r…

This study looks at whether a 4-month yoga program can reduce joint pain and stiffness in women with breast cancer who are on hormone therapy. About 140 women who have joint pain from their treatment will either take yoga classes or be placed on a waiting list. The goal is to fin…

This study is testing a web-based application that lets cancer patients report side effects from radiation therapy in real time. About 30 people with gynecologic, urologic, or breast cancer will use the app to answer simple questionnaires. Their responses are sent securely to the…

This study tests a 6-week online program to help breast cancer survivors feel better emotionally and reduce worry about cancer coming back. It involves 72 women who finished treatment at least a year ago. Participants will join weekly video sessions focused on coping skills and w…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking in breast cancer patients undergoing chemotherapy. About 90 women with early-stage breast cancer will be split into three groups: memantine plus exercise, mema…

This study looks at whether a 6-week online mindfulness-based stress reduction (MBSR) program can lower stress, anxiety, depression, and other side effects in women with breast cancer who are starting chemotherapy. About 200 participants will be randomly assigned to either the MB…

This study looks at whether a gentle energy therapy called Medical Reiki, given before breast cancer surgery, can improve emotional well-being and recovery in 32 women. The goal is to see if this approach is practical and helps reduce stress and improve quality of life after surg…

This study looks at whether a 16-week virtual exercise program (aerobic and strength training) can improve fitness, muscle mass, and quality of life in 100 adults with indolent metastatic breast cancer (cancer that hasn't worsened in the past year). Participants must not be on ch…

This study compares a standard physiotherapy program to one that adds visual biofeedback using the MotionGuidance system for women recovering from breast cancer surgery. The goal is to see if the visual feedback helps improve shoulder strength, range of motion, and daily function…

This study is testing a 5-session radiation treatment (stereotactic body radiotherapy) for people with early-stage breast cancer who have already had a lumpectomy. The goal is to see if this shorter course is safe and causes fewer side effects than standard longer radiation. Abou…

This study tests a nasal spray given before breast-conserving surgery to help women relax and stay sedated while awake. About 394 women will receive either the spray or a placebo. The goal is to see if it improves sedation, reduces anxiety, and speeds recovery after surgery.

This study tests whether an AI tool can help doctors better manage chemotherapy side effects in people with breast or colorectal cancer. About 174 adults will be split into two groups: one where doctors use AI suggestions for side effect care, and one with standard care. The goal…

This study tests whether a special recovery plan (ERAS) helps people who have breast cancer surgery feel better with less pain and fewer opioid painkillers. About 260 adults with early-stage breast cancer will be randomly assigned to either the ERAS plan or standard care. Researc…

This study tests two digital mindfulness programs—one live on Zoom and one self-paced app—to see if they can reduce depression in younger breast cancer survivors (diagnosed at or before age 50). About 402 women who finished primary cancer treatment at least 6 months ago and have …

This study tests whether adding acupuncture to standard anti-nausea medicine works better than medicine alone for people with nausea caused by chemotherapy. About 90 adults with breast, prostate, lung, gynecologic, colorectal, or metastatic pancreatic cancer will be split into tw…

This study aims to describe sexual quality of life in 25 women with breast cancer who receive photobiomodulation (a type of light therapy) for genitourinary syndrome of menopause, which includes vaginal dryness and pain during sex. Participants are women aged 18 and older with br…

This study tests whether a high dose of the steroid dexamethasone can reduce hand-foot syndrome—a painful skin reaction—caused by a common breast cancer chemotherapy drug. About 182 adults with breast cancer will receive either high-dose, standard-dose, or no dexamethasone alongs…

This study tests whether using opioid-free anesthesia during mastectomy can lower the chance of chronic pain one year after surgery. Researchers will compare this approach to standard opioid-based anesthesia in 230 breast cancer patients. Participants will be randomly assigned to…

This study explores whether a group exercise program called Strength After Breast Cancer can be delivered in a physical therapy clinic to help women who have finished breast cancer treatment improve their physical function. About 40 participants will complete questionnaires and i…

This study tests whether a special nutrient supplement (APPORTAL®), taken alongside standard exercise recommendations, can help reduce cancer-related fatigue in women with breast cancer who are undergoing chemotherapy. About 92 participants will receive either the supplement or a…

This study tests a program that combines physical therapy, yoga, and patient education to reduce joint and muscle pain caused by hormone therapy in breast cancer patients. About 108 women with non-metastatic breast cancer and moderate-to-severe pain will be randomly assigned to e…

This study looks at whether a program of exercise and personalized nutrition, started right after diagnosis and before treatment begins, can help women with breast cancer feel better and recover faster. Researchers will measure fitness, strength, and quality of life in 66 women. …

This study looks at whether a 12-week online dance program can improve quality of life, reduce pain, and ease fatigue in breast cancer survivors who still have pain months after surgery. About 30 adults who had a lumpectomy or mastectomy and have moderate to severe pain will take…

This study tests whether a mobile app with educational and self-care tools can improve quality of life for people with early-stage breast cancer who are taking hormone therapy. About 180 participants will either use the app plus standard care, or standard care alone, for 12 weeks…

This study tests a remote stress-management program called PRISM for people recently diagnosed with metastatic breast cancer. The goal is to see if it improves resilience, quality of life, and possibly survival, especially for Black women who often face worse outcomes. About 120 …

This study tests whether a special spa therapy can improve skin-related quality of life in people who have skin hardening (fibrosis) after radiation for breast or head/neck cancer. About 110 adults who finished radiation at least 6 months ago will be randomly assigned to get spa …

This study tests whether Shengbai Oral Liquid (a herbal drink) works better than Leucogen Tablets for raising low white blood cells caused by breast cancer treatments. About 60 adults with breast cancer will take each medicine during different chemotherapy cycles. The goal is to …

This study compares two treatments for breast cancer that has spread to lymph nodes: radiotherapy versus surgical removal of those nodes. The goal is to see which approach better preserves arm function and reduces swelling (lymphedema) two years after treatment. About 1,060 adult…

This study tests if computer-based cognitive training can improve memory and thinking problems in breast cancer survivors. About 386 women who finished treatment for early-stage breast cancer will be randomly assigned to either a brain-training program or a placebo. The goal is t…

This study tests a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. Researchers will enroll 260 people …

This study tests whether a program of targeted exercise and psychological support before cancer treatment (surgery or radiation) can improve physical and mental recovery in patients with solid tumors like breast cancer. About 125 participants will either receive this prehabilitat…

This study tests a procedure called shoulder denervation to treat shoulder pain that can happen after breast cancer surgery and radiation. The treatment involves numbing specific nerves in the shoulder joint. The goal is to reduce pain and the need for painkillers. The study will…

This study looks at whether a genetic test can help doctors choose the best anti-nausea medicine for Chinese women with early breast cancer getting chemotherapy. About 200 patients will be split into two groups: one gets the genetic test and a personalized anti-nausea plan, the o…

This study looks at whether a new version of the chemotherapy drug docetaxel, which does not contain ethanol (alcohol), causes fewer alcohol-like side effects in breast cancer patients. About 1,052 people receiving chemo before or after surgery will be observed. The goal is to se…

This study is for women with early-stage hormone receptor positive breast cancer who are on hormone therapy. It tests whether joining a 12-week physical activity program can improve their quality of life and reduce pain. Researchers will track changes using standard questionnaire…

This study is testing whether brief, guided mindfulness meditations during daily radiation therapy can lower anxiety for people with breast or gynecologic cancer. About 34 participants will either listen to a guided meditation during treatment or receive standard care. Researcher…

This study looks at whether taking creatine supplements helps breast cancer survivors get stronger and have more energy from exercise. About 60 women who finished chemotherapy in the last 6 months will do virtual exercise sessions. Some will take creatine, some won't, and researc…

This study tests whether taking probiotics (beneficial bacteria) for 6 months can reduce common chemotherapy side effects like nausea, vomiting, and diarrhea in breast cancer patients. The goal is to help patients feel better and complete their full course of chemo. About 100 adu…

This study tests whether a negative pressure wound therapy (a special vacuum dressing) can reduce complications like infection, wound reopening, and slow healing after complex breast cancer surgery with immediate reconstruction. About 254 women at higher risk for scarring problem…

This study tests whether a 5-day course of whole breast radiation works as well as a 9-day course for women with early-stage breast cancer. About 144 participants will be randomly assigned to one of the two schedules. The main goal is to see if the shorter treatment leads to simi…

This study tests whether a gentle radiofrequency treatment inside the vagina can reduce dryness and pain in breast cancer patients taking hormone therapy. About 75 women will either receive standard moisturizers alone or moisturizers plus three radiofrequency sessions. The goal i…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study tests if a 4-week program combining exercise with a gentle, noninvasive brain stimulation technique (tACS) can help breast cancer survivors who struggle with memory, focus, and thinking after treatment. Researchers will enroll 40 survivors to see if the program is prac…

This study looks at whether coloring mandala patterns for 30 minutes during chemotherapy can help breast cancer patients feel less distressed and anxious, and more comfortable. About 60 women will be randomly assigned to either color mandalas or receive usual care. Researchers wi…

This study tests whether a treatment that uses radiofrequency (a gentle heat therapy) together with pelvic floor muscle exercises can reduce vaginal dryness and other menopause-related symptoms in women who have had breast cancer. About 50 participants will receive either the act…

This study looks at whether giving gabapentin before and after mastectomy can improve pain control and reduce the need for stronger opioid painkillers. About 1,896 adults having mastectomy at a single center will take part. The goal is to see if gabapentin should become a standar…

This study tests whether radiofrequency therapy, pelvic floor exercises, or both can reduce pelvic symptoms like pain and dryness in breast cancer survivors. About 117 women who finished breast cancer treatment at least a year ago will take part. The goal is to find a gentle, non…

This study tests whether regular phone or video calls from a nurse can help breast cancer patients on CDK inhibitor drugs catch and manage side effects early. About 124 women will be split into two groups: one gets standard care, the other adds structured telenursing check-ins. T…

This study tests whether avoiding opioids during breast reconstruction surgery can reduce the need for strong painkillers afterward. About 158 women will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. The goal is to see if the opioid-free …

This study tests whether a novel exercise program using both arms and legs can protect heart function in women with breast cancer who are undergoing chemotherapy. Researchers will measure blood vessel health and heart strain in 68 participants. The goal is to find a safe, tolerab…

This early-phase study tests whether a single dose of psilocybin, given with therapy, can reduce the intense fear of cancer returning in women who have completed treatment for early-stage breast or ovarian cancer and are now in remission. Twenty participants will receive preparat…

This study tests two types of ultrasound-guided nerve blocks to manage pain after breast cancer surgery. Fifty women having a mastectomy will receive either a newer SPSIP block or a standard ESPB block. The goal is to see which one reduces the need for morphine and improves recov…

This study is testing a free, personalized exercise program called 'Moving Together' for women with breast cancer. The program offers supervised or at-home options and is designed to fit each patient's needs and treatment stage. Researchers want to see if it improves quality of l…

This study tests whether a single 60-minute counseling session can reduce anxiety and depression in breast cancer patients who are waiting for ongoing therapy. Twenty participants will try the session and report how helpful it was. The goal is to see if this quick support can imp…

This study compares two standard pain-block methods for women having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers …

This study looks at two different exercise programs to see which one helps women gain muscle mass after finishing breast cancer treatment. Researchers will track changes in muscle and fat, as well as how well participants stick with the program. The goal is to find the best way t…

This study tracks how often skin discoloration happens after using Magtrace, a dye injected to find lymph nodes during breast cancer surgery. About 184 women having lumpectomy will be followed for up to 24 months. The goal is to understand how skin staining affects patients' dail…

This study is for women with early-stage breast cancer. It tests a single, focused dose of radiation given before surgery to remove the tumor. The goal is to find a safe and effective dose that limits side effects and improves comfort. About 50 participants will receive the radia…

This early study looks at whether breast cancer patients can use azelaic acid cream twice a day during radiation to help manage skin irritation. About 33 adults with darker or sun-sensitive skin who are getting radiation will try the cream. The goal is to see if it's practical an…

This study tests whether a short-term, periodic fasting-mimicking diet can safely lower high cholesterol and reduce side effects in post-menopausal women with early-stage breast cancer who are on hormone therapy (aromatase inhibitors). About 60 participants will be randomly assig…

This study tests whether Revaree Plus, a vaginal moisturizer, can improve vaginal dryness in women with hormone-receptor-positive breast cancer. About 60 participants who have completed primary cancer therapy or are on maintenance treatment will use the product for 8 weeks. The g…

This study looks at whether combining resistance and aerobic arm exercises can improve arm strength, function, and quality of life in breast cancer patients. About 40 women who are at least 15 months past surgery will take part. The goal is to find simple, safe ways to reduce com…

This study tests if a newer, less invasive mastectomy (endoscopic skin-sparing) leads to fewer wound complications and higher patient satisfaction compared to standard mastectomy. About 258 women with breast cancer will be randomly assigned to one of the two surgeries. The goal i…

This study tests if limiting when you eat (time-restricted eating) can reduce side effects from cancer treatment, improve mood, and even affect tumor biology. Researchers will enroll 175 adults with rectal or breast cancer who are receiving treatment. Participants will follow a s…

This study is testing whether a wearable activity tracker can be used by people with pancreatic or breast cancer to track fatigue during treatment. About 46 participants will wear the device for 14 days and share heart rate data. The goal is to see if patients find the tracker ea…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer. The samples will be stored and used in future research to better understand how cancers grow and respond to treatment. No new treatments are being tested; the goal…

This study looks at how hormone receptor-positive, HER2-negative breast cancer cells get their energy. Researchers will give 16 participants a special glucose (sugar) infusion before surgery, then analyze tumor and healthy tissue samples. The goal is to map the cancer's metabolic…

This study is collecting blood, tissue, urine, and saliva from 7,000 people with many types of cancer to look for tiny bits of cancer DNA left after treatment. The goal is to find out if this DNA test can spot remaining cancer early and help doctors decide on next treatments. Par…

This study collects tissue, blood, and urine samples from up to 4,000 women with or without breast cancer. The goal is to create a large repository of biological samples for researchers to study the disease. Participants donate samples during routine care, no direct treatment is …

This study is testing a mobile decision tool for breast cancer patients who have had surgery. 20 participants will use the tool on their phones and share their thoughts out loud. Researchers will measure how much patients learn about reconstruction options and gather feedback to …

This study is looking at whether clusters of tumor cells found in the blood can help predict how well treatment works in people with high-risk early breast cancer. Researchers will follow 130 participants to see if those with these cell clusters have different outcomes. The goal …

This study is building a large registry of people diagnosed with breast cancer across the U.S., especially those from diverse backgrounds. Participants share their health information and samples over time to help researchers learn more about the disease. The goal is to improve ca…

This study tracks the safety and effectiveness of the drug capivasertib in 130 breast cancer patients in South Korea. It is a post-marketing surveillance study, meaning the drug is already approved and this research monitors how it performs in everyday medical practice. The goal …

This study looks at breast cancer risk and screening in people aged 30-75 who are on hormone therapy. Researchers will collect imaging data and interview participants to understand barriers to screening. The goal is to improve early detection and care for this group.

This study looks at two ways doctors mark non-palpable breast tumors before surgery: a magnetic clip or a thin wire. The goal is to see which method is more cost-effective and works better for patients. About 772 women with early-stage breast cancer will take part, and researcher…

This study is for women 18 and older who have a suspicious breast finding or a new breast cancer diagnosis. Researchers will collect tissue and blood samples and ask participants to fill out questionnaires during their regular care. The goal is to learn more about what factors af…

This study looks at whether women who finished breast cancer treatment can safely switch to a simpler follow-up plan. Instead of regular clinic visits, they would only get an annual mammogram. The goal is to see if this approach is just as safe and improves quality of life. About…

This study enrolls 3,000 women with at least twice the normal risk of developing breast cancer. Researchers collect breast tissue samples and blood to build a better risk prediction tool. No treatment or prevention drug is tested; the goal is to improve understanding and future p…

This study is for adults who carry a specific change in the CTNNA1 gene or are close relatives of someone who does. The goal is to find out how much this gene change raises the risk for stomach cancer, breast cancer, and other cancers. Researchers will collect family health histo…

This study looks at whether getting a brain MRI every 6 months can catch brain metastases earlier in people with stage IV breast cancer who have no brain symptoms. About 156 participants will be randomly assigned to either scheduled scans or standard care (scanning only if sympto…

This study looks at whether a 3-week ketogenic diet can change the immune cells inside breast tumors. Twelve postmenopausal women with early-stage breast cancer will follow the diet before their surgery. Researchers will measure changes in the tumor environment and quality of lif…

This study looks at whether women having breast reconstruction after mastectomy and their surgeons are comfortable with being randomly assigned to receive either a biological or synthetic mesh. Sixty women will take part and be followed for six months. The results will help plan …

This study watches how doctors decide on treatments for people with early-stage, hormone-sensitive breast cancer. It includes up to 2,000 participants and follows them for 10 years to see how well they do. The goal is to learn whether a test called EndoPredict helps guide better …

This study looks at how willing and able women with non-metastatic breast cancer are to change their diet to reduce cancer risks. About 200 women who have finished primary treatment will complete online surveys and review an educational flyer. The goal is to understand what helps…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors, plus healthy volunteers, to see if the test helps predict when cancer comes back. …

This study is testing a special PET-CT scanner that takes detailed pictures of cancer tissue right after it is removed during surgery. Researchers want to see if these images match the standard lab analysis and if they help doctors make better decisions. About 850 people with pro…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study looks at whether a precise type of radiation called SBRT can help control breast cancer that has spread to only a few other parts of the body. Researchers will review medical records from 300 patients to see if SBRT improves how long they live without the disease getti…

This study aims to understand why some breast cancer patients experience 'chemobrain'—problems with memory and concentration after chemotherapy. Researchers will measure thinking skills, take blood samples, and perform brain scans before, during, and after treatment in 50 adults …

This study follows 1,250 women who have had lymph nodes removed during breast cancer surgery to see how many develop lymphedema (arm swelling). Researchers will look at breast tissue for signs of inflammation that might raise risk, and ask participants about their quality of life…

This study is looking at how a breast cancer medicine called an aromatase inhibitor changes the bacteria in your gut. Researchers will collect stool and blood samples from 25 women before and after starting the drug to see how these changes affect estrogen levels. The goal is to …

This study looks at how common and severe menopause-related symptoms (like vaginal dryness and pain) are in breast cancer survivors. Researchers will compare women getting hormone therapy, women getting chemotherapy, and healthy women without cancer. The goal is to better underst…

This study is testing a new type of CT scan called HyperSight, which is built into a radiation therapy machine. The goal is to see if it produces clearer images than current scans, which could help doctors target tumors more accurately. About 50 adults with various cancers (head …

This study looks at people who have a gene variant (called a secondary finding) found during genetic testing. Researchers want to learn how these variants affect health and how people understand and share their results. Up to 5,000 participants will complete surveys, phone interv…

This study looks at how often breast cancer has silently spread to the brain in people with aggressive types (triple negative or HER2+). About 100 participants will get a brain MRI and give a blood sample. The goal is to learn how common these hidden brain tumors are and how pati…

This study looks at whether certain fats made from diet are linked to breast cancer and obesity. Researchers will measure these fats in 60 postmenopausal women, some with breast cancer and some without. No treatment is given; the goal is to understand connections between body fat…

This study aims to build an AI system that can predict if and where breast cancer will spread to other parts of the body, like the bones, lungs, liver, or brain. Researchers will analyze tumor samples and health data from 2000 women with breast cancer to train the AI. The goal is…

This study looks at whether taking cannabidiol (CBD) pills can change how breast cancer cells grow or die before surgery. About 84 women with invasive breast cancer will take either a low or high dose of CBD or a placebo for 5 to 56 days before their tumor is removed. The goal is…

This study looks at whether the phase of a woman's menstrual cycle when she starts chemotherapy affects how well the treatment works. Researchers will collect blood samples from 100 premenopausal women with triple-negative breast cancer on the day they begin neoadjuvant chemother…

This study looks at two methods for removing breast cancer in women with early-stage disease. One method removes extra tissue around the tumor routinely, while the other uses a special marker to remove tissue only where needed. The goal is to see which approach leads to fewer can…

This study examines blood samples from 120 women with early-stage HR+HER2- breast cancer to see if age-related blood components influence how well treatment works. Researchers will compare younger and older patients before and after two cycles of neoadjuvant therapy. The goal is …

This study collects tumor tissue and blood samples from 200 adults with breast cancer or precancerous breast conditions. Samples are taken during standard procedures like surgery, and researchers analyze them to identify biomarkers and genetic profiles. The goal is to better unde…

This study looks at how sleep troubles impact memory, focus, and quality of life in women treated for breast cancer. Researchers will track sleep patterns using a wrist monitor and ask participants about their thinking and well-being. The goal is to better understand these links …

This study uses artificial intelligence to analyze standard tissue samples from 400 women with breast cancer. The goal is to see if the AI can accurately predict whether the cancer will spread to other parts of the body years after surgery. If successful, this tool could help doc…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer. Researchers will use these samples to develop and improve tests that detect cancer DNA in the blood, which may help monitor for cancer return or how well treatment is working. …

This study will analyze the complete DNA of tumors and normal cells from 882 breast and prostate cancer patients treated through Brazil's public health system. The goal is to create a detailed map of genetic changes linked to these cancers and build a national genomic database. P…

This study is a registry for people with triple negative breast cancer or those with inherited genetic mutations linked to breast cancer. It aims to collect information on genetic mutations, treatment responses, and long-term survival. Up to 1500 participants will be followed ove…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study is testing a special device (GILUPI CellCollector) that captures cancer cells from the blood of women who have already had surgery and chemotherapy for breast cancer. The goal is to see if the number of these circulating tumor cells can help predict whether the cancer …

This study examines whether certain genetic differences make some women more likely to experience early menopause after chemotherapy for breast cancer or Hodgkin lymphoma. Researchers will analyze stored ovarian tissue from 50 women who had fertility preservation before treatment…

This study follows 750 women with breast cancer who have had or will have a mastectomy and radiotherapy. Researchers compare different reconstruction methods (implants vs. using your own tissue) and timing to see which gives the best patient satisfaction and quality of life. The …

This study looks at how social and economic factors (like stress or support) relate to inflammation in women newly diagnosed with breast cancer. About 200 participants will fill out questionnaires and give one blood sample. The goal is to better understand these connections, not …

This study explores whether genetic differences in the UGT1A1 gene can predict severe side effects from certain breast cancer drugs (antibody-drug conjugates). Researchers will enroll 70 adults with advanced breast cancer who are starting treatment with sacituzumab-govitecan, tra…

This study looks at how certain immune cells, called MDSCs, affect the body's ability to fight breast cancer. Researchers will collect blood and tumor samples from 99 adults with stage I-III breast cancer. The goal is to understand how these cells work and whether they can predic…

This study looks at whether artificial intelligence (AI) can help analyze tiny particles in the blood (liquid biopsies) from people with triple negative breast cancer. The goal is to find markers that show if the tumor is gone after chemotherapy or if more treatment is needed. Re…

This study looks at whether body composition (like total body fat and BMI) changes how the chemotherapy drug docetaxel behaves in the body. Researchers will compare drug levels in 48 women with early breast cancer who are obese, overweight, or lean. The goal is to learn if dosing…

This study is testing a new way to remove breast cancer through a small cut in the armpit, leaving no scar on the breast. It is for women with small breasts who need a mastectomy but want to keep their nipple. The goal is to see if this method is safe and works well in a French h…

This study is testing whether a decision aid tool called RECONJOINT can help women with breast cancer or a genetic risk make informed choices about breast reconstruction after mastectomy. Researchers want to see if it's practical to run a larger study on this tool. About 131 part…

This study tests whether special MRI scans can predict breast cancer response to chemotherapy earlier and more accurately than standard tumor size measurements. Researchers will measure changes in tumor blood vessels and cell density in 135 women receiving standard chemotherapy. …

This study is creating a Spanish version of a decision aid called BREASTChoice to help Spanish-speaking Latina breast cancer survivors learn about breast reconstruction options. About 50 women who prefer Spanish health information will test the tool. The goal is to improve knowle…

This study tests a training program called Just ASK™ that helps doctors and nurses talk about clinical trials with breast cancer patients. Researchers want to see if the training increases how often these conversations happen. About 80 healthcare workers and patients will take pa…

This study looks at how a 13-week physical activity program influences motivation and psychological symptoms in 80 women being treated for breast cancer. Participants will fill out questionnaires about their attitudes, confidence, and mood. The goal is to understand what helps th…

This study aims to understand why some breast cancers with BRCA mutations become resistant to PARP inhibitor drugs. Researchers will collect tumor and blood samples from 120 people with advanced HER2-negative breast cancer to measure certain proteins linked to DNA repair. The goa…

This study looks at whether a family history screening program can help more women in rural Georgia get tested for BRCA gene mutations linked to breast and ovarian cancer. About 3,200 women from public health clinics will take part. The goal is to see if the program increases the…

This study looks at whether routine brain MRIs can find cancer that has spread to the brain in people with metastatic or inflammatory breast cancer. About 214 participants will get screening MRIs to see how often brain metastases occur and how they affect quality of life. The goa…

This study takes leftover breast cancer tissue from patients who still have cancer after initial treatment. Researchers grow these samples in mice and in dishes to create living models of the cancer. These models will be used to test new drug combinations and understand why some …

This study looks at whether giving the chemotherapy drug paclitaxel over a longer time (2-3 hours) to cancer patients with low muscle mass can make the drug level in their blood similar to patients with normal muscle mass who get the standard 1-hour infusion. About 22 women with …

This study checks if a new device can properly prepare blood samples for liquid biopsy, which looks for cancer clues in the blood. It involves 20 healthy volunteers and 25 people with advanced breast cancer. No treatment is given—only blood is drawn to see if the tool works well.…

This study is developing an AI method to track the movement of tumors and nearby organs during radiation therapy without using physical markers. Researchers will use data from 300 patients receiving radiation for various cancers or heart arrhythmias to train and test the system. …

This study aims to find out how genes influence breast cancer risk. Anyone 18 or older living in the US can join, even if they don't have cancer. Participants fill out online surveys and mail in a saliva sample. As a thank-you, you may get free information about your genetic ance…

This study looks at whether a digital chatbot can help women who recently had a mammogram understand their results and follow up on screening recommendations. About 2700 English- or Spanish-speaking women from underserved communities will take part. Half will get usual care, and …

This study looks at the best times to send messages encouraging physical activity to older cancer survivors (age 65+) who have chronic pain. Researchers will track activity levels and pain ratings to see how messages affect movement and pain episodes. The goal is to learn how to …

This study is observing 50 adults with advanced cancers (lung, breast, colorectal, liver, stomach) who are starting immunotherapy. Researchers will track ctDNA levels in the blood to see if changes can predict early whether the treatment is working. They will also look at other m…

This study observes how hospitals currently process and diagnose tissue samples from people with suspected lung or breast cancer. Researchers will also test artificial intelligence (AI) programs to see if they can help pathologists read slides faster and more accurately. About 60…

This study looks at how near-complete estrogen deprivation (NCED) therapy, used to treat breast cancer, impacts heart function. Researchers will use heart scans to measure blood flow in 90 women aged 55 or younger who are premenopausal at diagnosis. The goal is to understand if t…

This study is testing a new blood test that looks for tiny bits of tumor DNA to see if breast cancer might return after chemotherapy. About 1,800 people with high-risk early breast cancer will give blood and tissue samples before and after treatment. The goal is to find out if th…

This study looks at better ways to find and treat lymph nodes in people with inflammatory breast cancer, a rare and aggressive type. Researchers will test imaging and dye techniques to see if they can reliably locate the sentinel lymph nodes during surgery. The goal is to improve…

This study looks at the genes and social factors that influence breast and prostate cancer in people of African descent. Researchers will collect blood and tumor samples from 1500 Black patients across the US, Africa, and the Caribbean. The goal is to find genetic changes and und…

This study aims to find out if tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. About 120 adults with certain cancers will give blood samples and answer questionnaires before, during, and after treatment. The goal is to …

This study collects small samples of breast tumor tissue from people with known or suspected breast cancer. The samples are stored in a tissue bank and used by researchers to study the biology of breast cancer, including how it grows and responds to treatments. The goal is to hel…

This study aims to create a computer algorithm that can predict whether a breast cancer tumor will completely disappear after chemotherapy given before surgery. Researchers will collect medical images, lab results, and genetic data from 300 early-stage breast cancer patients. The…

This study is testing a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with solid tumors like lung, breast, or colon cancer…

This study looks at how antibiotics change the bacteria in the gut and breast after mastectomy with implant reconstruction. Researchers want to see if certain bacteria make infections more likely. About 200 women with breast cancer or a strong genetic risk will provide tissue and…

This study looks at how BRCA gene changes and cancer treatments impact the ovaries in premenopausal women with early-stage breast cancer. Researchers will measure hormone levels in the blood before, during, and after treatment to understand who is at higher risk for early menopau…

This study is an audit of a surgical technique called targeted sentinel node biopsy (TSNB) for breast cancer patients whose cancer has spread to a few lymph nodes in the armpit. The goal is to see if this less invasive approach works as well as standard surgery, while causing les…

This study aims to see if a new telehealth program can safely reduce the number of in-person doctor visits for people with breast or prostate cancer. About 1,750 participants will be assigned to either enhanced telehealth or standard care. The goal is to make cancer care more con…

This study aims to find unique protein patterns (markers) in breast tissue and fluid that can distinguish breast cancer from non-cancerous tissue. Researchers will collect samples from 300 adults undergoing breast surgery and analyze them to develop better blood tests for diagnos…

This study looks at whether a blood test can find tiny bits of tumor DNA left after surgery in women with early-stage breast cancer. It includes 100 women, with a special focus on African American/Black women, who are often left out of this type of research. The goal is to see if…

This study is observing 150 women scheduled for breast cancer surgery to see if their sleep quality before the operation can predict how much pain and inflammation they will have afterward. Participants will fill out a sleep questionnaire, and researchers will track their pain le…

This study tests a new method for marking the area where breast cancer was removed during surgery. The goal is to help radiation doctors see the exact spot on scans, making radiotherapy more precise and reducing the need for repeat surgeries. About 50 adults with early-stage brea…

This study looks at how common severe fear of cancer recurrence is among people treated for breast or lung cancer. Researchers will survey 200 patients and interview 40 of them to understand their experiences and what kind of support they need. The goal is to improve how hospital…

This study is testing whether a simple blood test can help predict where breast cancer might spread in the body. Researchers will measure two types of markers in the blood: PTEN (a protein that normally stops tumors) and microRNAs (tiny molecules that can signal cancer activity).…

This study is a worldwide registry that will follow 5,000 adults with breast cancer, blood cancers, or those on certain immune therapies. Its goal is to collect data on patients' health, treatments, and heart events to better understand and predict heart problems caused by cancer…

This study looks at whether a special blood test (NovaGray RILA Breast®) can predict serious side effects from radiotherapy in women who have had a mastectomy with immediate breast implant reconstruction. About 250 adults with breast cancer will take the test before starting ches…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. Researchers will measure changes in food security, di…

This study collects blood and tumor samples from up to 3,300 people with a high genetic risk for breast, ovarian, or related cancers. Researchers aim to understand how these cancers develop and how treatments work. Participants include those with BRCA1/2 or other gene mutations, …

This study is for people with a common type of early breast cancer (HR+/HER2-) who have had surgery. Researchers will regularly test their blood for tiny bits of tumor DNA (ctDNA) to see if the cancer is coming back before it shows up on scans. If the test is positive, participan…

This study looks at whether giving routine brain scans to people with HER2-positive breast cancer that has spread can help find brain tumors early, before symptoms start. About 69 people will get a brain scan at the start, and if no tumors are found, they will be randomly assigne…

This study aims to create a registry of 400 women at high risk for breast cancer to test whether a shorter, abbreviated MRI scan works as well as a full-length MRI for early detection. Participants will be scanned every 6 months. The goal is to develop a personalized, faster scre…

This study examines genetic changes in HER2-low breast cancer, a type that is not easily treated with standard HER2 therapies. Researchers will analyze tumor and blood samples from 255 women to see how these gene patterns relate to survival. The goal is to better understand the d…

This study collects fluid from around the lungs (pleural fluid) from patients with lung cancer, breast cancer, or lung infections. The goal is to build a registry of samples and health information for future research. No new treatments are tested—this is purely for understanding …

This study looks at whether watching an animated video before DIEP flap breast reconstruction helps patients understand the procedure better and feel less anxious. About 300 women scheduled for surgery will answer surveys before and after watching the video, and again after their…

This study follows 475 women with breast cancer or lymphoma to understand how cancer treatments affect their sexual health, fertility, and ability to have children. Participants complete questionnaires and may optionally provide blood samples to measure ovarian function. The goal…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, researchers check participants' health each year for 15 years to watch for any long-term side effects. The goal is to make sure th…

This study looks at how much protein people with colorectal or breast cancer need to keep their muscles strong during treatment. Muscle loss is common in cancer patients and can lead to worse health outcomes. Researchers will use a simple, non-invasive test to measure protein nee…

This study looks at whether a blood test that measures TK1 activity can help doctors decide if it's safe to wait longer between routine scans for people with advanced breast cancer. About 55 participants will be followed to see if the test results lead to fewer imaging tests. The…

This study aims to create a living biobank of breast cancer organoids—tiny 3D tumor models grown from patient tissue. Researchers will collect samples from 60 women undergoing breast cancer surgery and grow these mini-tumors in the lab. The goal is to see if these organoids mimic…

This study looks at how hormone treatments for prostate and breast cancer affect sleep quality. Researchers will monitor 60 patients using sleep tests, questionnaires, and activity trackers before treatment starts and again at 6 and 12 months. The goal is to understand if these t…

This study tests whether a large language model (a type of AI) can help junior doctors write more accurate and efficient cancer treatment reports. 40 junior doctors will be split into two groups: one uses AI assistance, the other uses traditional methods. Their reports will be sc…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. Researchers will also analyze genes in the samples and link them to patient health details. The study does not provide any treatment, but pa…

This study looks at how chemotherapy for early-stage breast cancer might speed up aging in organs like the heart and brain. Researchers will measure aging markers in blood samples from 80 women before and after treatment. The goal is to find patients at higher risk for long-term …

This study aims to help Black individuals and their families in Houston learn about their risk for hereditary cancers like breast and colorectal cancer. Researchers will use a simple screening tool and offer genetic counseling and testing through trusted community organizations. …

This study aims to understand why some breast cancers become resistant to treatment. Researchers will analyze tumor and blood samples from 320 people with HER2-positive, hormone receptor-positive, or triple-negative breast cancer. The goal is to identify changes in proteins and g…

This study is looking at small molecules called microRNAs in the blood of 80 women with breast cancer who are about to start chemotherapy. Researchers will measure these molecules before and after treatment to see if changes can predict how well the cancer responds. The goal is t…

This study is for people with a certain type of advanced breast cancer (lobular) that is hormone receptor-positive. The goal is to find better ways to detect when the cancer becomes resistant to hormone therapy. Researchers will use special PET scans and blood tests to look for c…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study looks at how well the drug ribociclib works for people with early-stage breast cancer when used in regular medical practice. Researchers will track 3,000 patients to see if the cancer comes back and how patients feel about their treatment. The goal is to understand rea…

This study looks at how the cost of cancer treatment affects the finances of people with early-stage breast cancer. Researchers will follow about 864 patients for one year, asking them to fill out surveys about their financial stress. The goal is to understand what causes financi…

This study looks at whether holding your breath during breast cancer radiation can lower the amount of radiation reaching the heart. Researchers will compare heart doses in 400 women who use a special breathing device versus those who breathe normally. The goal is to find a safer…

This study is building a platform to better predict who is at risk for developing or having a recurrence of certain cancers, including breast, colon, ovarian, melanoma, and lung cancer. Researchers will analyze participants' blood and genetic information to find markers that coul…

This study follows 100 adults with high-risk, hormone-sensitive early breast cancer to see which treatments doctors choose in everyday practice. Participants take their prescribed medications and fill out questionnaires about their quality of life. The goal is to understand real-…

This study will collect genetic information and health records from 25,000 people who have cancer or are at risk for it. The goal is to learn more about what drives cancer and how to better tailor treatments. Participants will not receive a new therapy, but their data may help fu…

This study aims to understand the current state of breast cancer care by surveying both patients and their doctors. The goal is to identify gaps in communication and time management, and to develop new, patient-focused care models. About 2,000 adults with breast cancer and their …

This study gathers information from 200 people with stage III or IV inflammatory breast cancer (IBC) who have had or plan to have a blood test called Signatera to look for leftover cancer cells (MRD). Researchers will also ask participants about their quality of life using a stan…

This study is testing whether adding new experimental drugs to standard chemotherapy before surgery can improve outcomes for people with breast cancer. It includes up to 5,000 participants with early-stage or locally advanced breast cancer. The goal is to use MRI scans and tissue…

This study looks at whether a deep inspiration breath-hold (DIBH) technique during radiation therapy for breast cancer patients keeps the radiation dose on target and protects nearby organs. About 25 women who had breast surgery and need chest radiation will participate. Research…

This study follows 500 breast cancer patients whose cancer has returned in the same area. They will receive additional radiation therapy, some with and some without hyperthermia (heat treatment). The goal is to compare side effects, quality of life, and cancer control over five y…

This study looks at what breast cancer survivors and their family members know about chemicals in personal care products that might affect hormones. Researchers also want to see if there is a link between being overweight and these chemicals. About 30 people from the Acres Home c…

This study looks at whether a special decision-making guide can help women aged 80 and older who have had breast cancer make better choices about getting yearly mammograms. The guide helps them weigh the pros and cons with their doctor. The goal is to see if it changes how many m…

This study is testing whether a probiotic supplement called BIOHM can change the bacteria and fungi living in the breast tumors and guts of 100 women with breast cancer. The goal is to understand how these tiny organisms might affect cancer development. Participants will take eit…

This study collects mammogram images and survey answers from 20,000 adults to train artificial intelligence (AI) models. The goal is to help doctors read mammograms more accurately for different groups of people and types of breast cancer. Participants must be 18 or older, have h…

This study looks at how well breast cancer responds to treatment given before surgery and how that affects long-term survival. Researchers will compare different treatment plans and patient characteristics in 488 women with early or advanced breast cancer. The goal is to find whi…

This study explores whether using alternative or complementary therapies (like turmeric supplements) impacts how consistently patients take tamoxifen, a key hormone therapy for early-stage breast cancer. Researchers will follow 200 patients for one day to measure adherence and ta…

This study aims to improve how women in rural areas decide about getting mammograms. Researchers will test a decision aid called MyMammogram, with or without a summary sent to their doctor, compared to usual care. About 39 women aged 39-49 and their primary care providers will pa…

This study follows 126 people with early HER2-negative breast cancer who are taking the drug olaparib after surgery. Researchers want to see how many patients complete the full 12-month treatment course in everyday medical practice. The study does not test a new drug or treatment…

This study looks at why some hormone-positive breast cancers become resistant to anti-estrogen treatment. About 100 women with early-stage breast cancer will receive standard hormone therapy for 4-12 weeks before surgery. Researchers will analyze tumor samples to find changes in …

This study looks at how women with breast cancer do over time after oncoplastic breast surgery. Researchers will track cancer stage, recurrence, and patient satisfaction using surveys. About 1,000 women will take part. The goal is to better understand long-term surgical outcomes …

This study explores how regular video or phone check-ins between patients with advanced breast cancer, their caregivers, and their oncology team can improve the hospice experience at home. Researchers will enroll 200 participants in Massachusetts to see if this approach is practi…

This study collects blood or cheek swab samples from people with cancer who are being treated at the National Cancer Institute. Researchers want to learn how genetic differences may affect how the body processes cancer treatments and whether certain genes are linked to side effec…

This study looks at proteins called selenoproteins in people with a type of breast cancer (triple-negative) and in healthy women. Researchers want to see if these proteins can help predict how the disease will progress or be used as targets for future treatments. The study does n…

This study looks at whether teaching patients and their doctors about side effects from certain breast cancer drugs (called antibody drug conjugates) can improve how those side effects are managed. About 30 breast cancer patients and their clinicians will take part. The goal is t…

This study collects tumor tissue from 10,000 women having breast cancer surgery. The samples are stored and used for laboratory research to help scientists learn more about breast cancer. No treatment or direct benefit is offered to participants.

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking performance in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants complete sho…

This study aims to find out if younger women (45 and under) experience more pain from pegfilgrastim, a drug that helps boost white blood cells during chemotherapy, compared to older women. About 115 women with non-metastatic breast cancer will report their pain levels and have th…

This study looks at whether using surgical mesh during breast reconstruction after mastectomy is safe and helpful. About 120 women will be randomly assigned to get reconstruction with or without mesh. The goal is to compare complication rates and patient satisfaction to guide fut…

This study tests a community-based program to help underserved adults get screened for lung, breast, and prostate cancers. About 200 people who meet screening guidelines will be offered navigation support at community resource spots. The goal is to see if this approach increases …

This study looks at how a woman's immune system reacts to breast cancer, especially if she has been pregnant before. Researchers will follow 800 young women with breast cancer to understand these interactions. The goal is to learn more, not to test a new treatment.

This study is for people with advanced cancers who are taking targeted treatments for months or years. Researchers will interview 75 participants to understand their experiences and needs. The goal is to find better ways to support patients living with chronic cancer treatments.

This study is creating a 'live biobank' by collecting tumor samples from 400 breast cancer patients at key moments—like diagnosis, surgery, and if the cancer returns. Researchers will grow mini-tumors from these samples and study their genes and immune interactions. The goal is t…

This study looks back at the results of two types of breast-conserving surgery for breast cancer: one done with a robot and one done with an endoscope. The goal is to see which method leads to fewer complications and better cosmetic results. About 200 women aged 18 to 80 with ear…

This study looks at 300 people with HER2-positive breast cancer that hasn't spread. It checks if having very high HER2 levels (called ultra-high) changes how well a two-drug treatment works. The goal is to see if these patients have different survival rates without cancer coming …

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy guided by an MR-Linac, a machine that combines an MRI scanner with a radiation beam. The goal is to see if this technology helps people live longer, controls tumors better, and imp…

This study is collecting tissue and blood samples from 500 people with breast cancer who are receiving treatment before surgery. Researchers will analyze these samples to learn why some cancers respond well to therapy while others do not. The goal is to find better ways to predic…

This study aims to see if watching a video before genetic testing helps people with certain cancers better understand their hereditary cancer risk. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Resear…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback on the m…

This study takes tumor samples from people with breast, colorectal, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to find personalized treatment options and lear…

This study is testing whether DNA mutations found in the blood (ctDNA) can help predict if breast cancer will return in patients who have had chemotherapy before surgery. Researchers will take blood samples over time from 180 patients whose tumors did not fully disappear after ch…

This study looks at whether a protein called PSMA, usually found in prostate cancer, is present in a certain type of advanced breast cancer (HER2-negative, AR-positive). Researchers will use a special PET/CT scan to measure PSMA levels in up to 15 participants. The goal is to see…

This study aims to gather information from cancer patients (breast, lung, ovarian, multiple myeloma, or AML) who use a remote symptom monitoring system during their routine treatment. Participants will complete weekly surveys about their symptoms for at least 12 weeks. The goal i…